Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

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1. Human and rodent type 1 11�-hydroxysteroid dehydrogenases are 7�-hydroxycholesterol dehydrogenases involved in oxysterol metabolism
   G. Tomas M. Hult, Björn Elleby, Naeem Shafqat, Stefan Svensson, A Rane, H. J�rnvall, Lars Abrahmsén, Udo C. T. Oppermann · 2004 · Cellular and Molecular Life Sciences
2. Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and lower STAT3 activity in adult rats
   Ananda Lages Rodrigues, Egberto Gaspar de Moura, Magna Cottini Fonseca Passos, Isis Hara Trevenzoli, Ellen Paula Santos da Conceição, Isabela Teixeira Bonomo, José Firmino Nogueira Neto, Patrícia Cristina Lisboa · 2010 · The Journal of Nutritional Biochemistry
3. 11β-Hydroxysteroid Dehydrogenase-1 Is a Novel Regulator of Skin Homeostasis and a Candidate Target for Promoting Tissue Repair
   Mika Terao, Hiroyuki Murota, Akihiro Kimura, Arisa Kato, Akiko Ishikawa, Ken Igawa, Eiji Miyoshi, Ichiro Katayama · 2011 · PLoS ONE
4. Crystal Structure of Murine 11β-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
   Jiandong Zhang, Timothy D. Osslund, Matthew Plant, Christi L. Clogston, Rebecca E. Nybo, Fei Xiong, John M. Delaney, Steven R. Jordan · 2005 · Biochemistry
5. Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species
   Spyridon Arampatzis, Bert Kadereit, Daniela Schuster, Zoltán Balázs, Roberto A.S. Schweizer, Felix Julius Frey, Thierry Langer, Alex Odermatt · 2005 · Journal of Molecular Endocrinology
6. Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevance
   Alex Odermatt, Christel Gumy, Atanas G. Atanasov, Anna A. Dzyakanchuk · 2006 · The Journal of Steroid Biochemistry and Molecular Biology
7. Adipose tissue 11β-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing’s syndrome
   Barbara Mariniello, Vanessa Ronconi, Silvia Rilli, Paolo Bernante, Marco Boscaro, Franco Mantero, Gilberta Giacchetti · 2006 · European Journal of Endocrinology
8. 11β-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents
   Craig D. Boyle, Timothy J. Kowalski · 2009 · Expert Opinion on Therapeutic Patents
9. Adiposopathy: why do adiposity and obesity cause metabolic disease?
   Harold Edward Bays, Christie Mitchell Ballantyne · 2006 · Future Lipidology
10. Local Amplification of Glucocorticoids by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Inflammatory Response
    Karen E. Chapman, Agnes E. Coutinho, Mohini Gray, James S. Gilmour, John Savill, Jonathan R. Seckl · 2006 · Annals of the New York Academy of Sciences
11. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice
    Alli M. Nuotio-Antar, David L. Hachey, Alyssa H. Hasty · 2007 · American Journal of Physiology-Endocrinology and Metabolism
12. 11 β ‐Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus
    Gregory F. Hollis, Reid Huber · 2010 · Diabetes Obesity and Metabolism
13. 11β-hydroxysteroid dehydrogenases: A growing multi-tasking family
    Elise P. Gómez-Sánchez, Celso E. Gómez-Sánchez · 2021 · Molecular and Cellular Endocrinology
14. Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1
    Gareth Geoffrey Lavery, Agnieszka E. Zielinska, Laura Gathercole, Beverly A. Hughes, Nina M. Semjonous, Phillip Guest, Khalid M. Saqib, Mark Sherlock, Gary M. Reynolds, Stuart Morgan et al. · 2012 · Endocrinology
15. Neuroendocrine and metabolic effects of adipocyte-derived hormones
    Jackson, Malaka B., Ahima, Rexford S. · 2006 · Clinical Science
16. Structure-based molecular modeling in SAR analysis and lead optimization
    Veronika Temml, Zsófia Kutil · 2021 · Computational and Structural Biotechnology Journal
17. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
    Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., Walker, B. R. · 2006 · Clinical Endocrinology
18. Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition
    Stimson, Roland H., Andrew, Ruth, McAvoy, Norma C., Tripathi, Dhiraj, Hayes, Peter C., Walker, Brian R. · 2011 · Diabetes
19. Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model
    Zhao‐Kui Wan, Eva Chenail, Jason S. Xiang, Huan‐Qiu Li, Manus Ipek, Joel Bard, Kristine Svenson, Tarek S. Mansour, Xin Xu, Xianbin Tian et al. · 2009 · Journal of Medicinal Chemistry
20. A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action
    Nicholas M. Morton, Valerie S. Densmore, Małgorzata Wamil, Lynne E. Ramage, Katherine Nichol, L. Bünger, Jonathan R. Seckl, Christopher J. Kenyon · 2005 · Diabetes
21. Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors
    Bryan K. Sorensen, Martin Winn, Jeff Rohde, Qi Shuai, Jiahong Wang, Steven Fung, Katina Monzon, William J.H. Chiou, DeAnne F. Stolarik, Hovis M. Imade et al. · 2006 · Bioorganic & Medicinal Chemistry Letters
22. Mineralocorticoid receptor activation in obesity hypertension
    Miki Nagase, Toshiro Fujita · 2009 · Hypertension Research
23. Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans
    Rita Basu, Ananda Basu, Meagan Grudzien, Paul Mark Jung, Peer B. Jacobson, Michael C. Johnson, Ravinder Jit Singh, Michael Gregory Sarr, Robert A. Rizza · 2008 · Diabetes
24. Adipose Tissue and Adrenal Glands: Novel Pathophysiological Mechanisms and Clinical Applications
    Atil Y. Kargi, Gianluca Iacobellis · 2014 · International Journal of Endocrinology
25. 11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
    Angelina Swali, E. A. Walker, Gareth Geoffrey Lavery, Jeremy Tomlinson, Paul M. Stewart · 2008 · Diabetologia
26. Dynamic CCAAT/Enhancer Binding Protein–Associated Changes of DNA Methylation in the Angiotensinogen Gene
    Fen Wang, Masashi Demura, Yuan Cheng, Aoshuang Zhu, Shigehiro Karashima, Takashi Yoneda, Yoshiki Demura, Yuji Maeda, Mikio Namiki, Katsuhiko Ono et al. · 2013 · Hypertension
27. Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity
    Fahumiya Samad, Leylla Badeanlou, Charmi Shah, Guang Yang · 2011 · Advances in experimental medicine and biology
28. Adipose Tissue and Endocrine-Disrupting Chemicals: Does Sex Matter?
    Brigitte Le Magueresse‐Battistoni · 2020 · International Journal of Environmental Research and Public Health
29. Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians
    Paul W. Franks, William C. Knowler, Saras Nair, Juraj Koška, Yong‐ho Lee, Robert S. Lindsay, Brian Robert Walker, Helen C. Looker, Paska A. Permana, Pietro Antonio Tataranni et al. · 2004 · Hypertension
30. Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene
    Timothy J. Pullen, Mark O. Huising, Guy A. Rutter · 2017 · Frontiers in Genetics
31. Mechanisms of disease: regulation of glucocorticoid and receptor levels – impact on the metabolic syndrome
    Witchel, Selma F, DeFranco, Donald B · 2006 · Nature Clinical Practice Endocrinology & Metabolism
32. Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
    Małgorzata Wamil, Jenny Helen Battle, Sophie Turban, Tiina M. J. Kipari, David Seguret, Ricardo De Sousa Peixoto, Yvonne B. Nelson, Dominika Nowakowska, David A. Ferenbach, Lynne E. Ramage et al. · 2011 · Diabetes
33. Obesity and Type 2 Diabetes Do Not Alter Splanchnic Cortisol Production in Humans
    Rita Basu, Ravinder Singh, Ananda Basu, Elizabeth G. Chittilapilly, Michael C. Johnson, GIANNA MARIA TOFFOLO, Claudio Cobelli, Robert A. Rizza · 2005 · The Journal of Clinical Endocrinology & Metabolism
34. 11?-Hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in metabolic and neurodegenerative disease
    Brian Robert Walker, Jonathan R. Seckl · 2003 · Expert Opinion on Therapeutic Targets
35. Role of mineralocorticoid receptor and renin–angiotensin–aldosterone system in adipocyte dysfunction and obesity
    Alessandra Feraco, Andrea Armani, Caterina Mammi, Andrea Fabbri, Giuseppe M.C. Rosano, Massimiliano Caprio · 2013 · The Journal of Steroid Biochemistry and Molecular Biology
36. Efficiency and specificity of RAAS inhibitors in cardiovascular diseases: how to achieve better end-organ protection?
    Ali Nehme, Kazem Zibara · 2017 · Hypertension Research
37. Modulation of glucocorticoid action and the treatment of type-2 diabetes
    Jeremy Tomlinson, Paul M. Stewart · 2007 · Best Practice & Research Clinical Endocrinology & Metabolism
38. Growth Hormone (GH) Substitution in GH-Deficient Patients Inhibits 11β-Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression in Adipose Tissue
    Søren Kildeberg Paulsen, Steen B. Pedersen, Jens Otto Lunde Jørgensen, Sanne Fisker, Jens Sandahl Christiansen, Allan Flyvbjerg, Bjørn Richelsen · 2006 · The Journal of Clinical Endocrinology & Metabolism
39. How Do Glucocorticoids Regulate Lipid Metabolism?
    Roldan M. de Guia, Stephan Herzig · 2015 · Advances in experimental medicine and biology
40. Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning
    Brian Robert Walker · 2007 · Proceedings of The Nutrition Society
41. Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome
    Xin Gu, Jasminka Dragovic, Gloria C. Koo, Samuel Koprak, Cheryl B. LeGrand, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Eugene Y. Tan, Rolf Thieringer et al. · 2005 · Bioorganic & Medicinal Chemistry Letters
42. 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story
    Alex Odermatt, Petra Klusoňová · 2014 · The Journal of Steroid Biochemistry and Molecular Biology
43. 1α, 25-Dihydroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor
    Xiaocun Sun, Michael B. Zemel · 2008 · International Journal of Obesity
44. Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function
    Patrick W. F. Hadoke, L. J. Macdonald, James J. Logie, Gary R. Small, Anna R. Dover, BR Walker · 2006 · Cellular and Molecular Life Sciences
45. Impact of Adrenal Steroids on Regulation of Adipose Tissue
    Marco Infante, Andrea Armani, Caterina Mammi, Andrea Fabbri, Massimiliano Caprio · 2017 · Comprehensive physiology
46. Augmentation of 11β‐hydroxysteroid dehydrogenase type 1 in LPS‐activated J774.1 macrophages – Role of 11β‐HSD1 in pro‐inflammatory properties in macrophages
    Takako Ishii, Hiroaki Masuzaki, Tomohiro Tanaka, Naoki Arai, Shintaro Yasue, Nozomi Kobayashi, Tsutomu Tomita, Michio Noguchi, Junji Fujikura, Ken Ebihara et al. · 2006 · FEBS Letters
47. Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice
    Yue-jing Wang, Suling Huang, Ying Feng, Mengmeng Ning, Ying Leng · 2012 · Acta Pharmacologica Sinica
48. Appropriate Function of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Endoplasmic Reticulum Lumen Is Dependent on Its N-terminal Region Sharing Similar Topological Determinants with 50-kDa Esterase
    Christoph Frick, Atanas G. Atanasov, Peter Arnold, Juris Ozols, Alex Odermatt · 2004 · Journal of Biological Chemistry
49. CCAAT/enhancer-binding proteins (C/EBPs) regulate the basal and cAMP-induced transcription of the human 11β-hydroxysteroid dehydrogenase encoding gene in adipose cells
    Johann Gout, Julien Tirard, C. Thevenon, Jean Paul Riou, Martine Bégeot, Danielle Naville · 2006 · Biochimie
50. 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice
    Lars Johansson, Christopher H. Fotsch, Michael D. Bartberger, Victor M. Castro, Michelle Chen, Maurice G. Emery, Sonja Gustafsson, Clarence Hale, Dean Hickman, Evert J. Homan et al. · 2008 · Journal of Medicinal Chemistry
51. Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond
    Panagiota Konstantakou, George P. Mastorakos, Nikolaos Vrachnis, Jeremy Tomlinson, Georgios Valsamakis · 2016 · The Journal of Maternal-Fetal & Neonatal Medicine
52. 11β-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches
    Judith Maria Rollinger, Denise V. Kratschmar, Daniela Schuster, Petra H. Pfisterer, Christel Gumy, Evelyne M. Aubry, Sarah Brandstötter, Hermann Stuppner, Gerhard Wolber, Alex Odermatt · 2010 · Bioorganic & Medicinal Chemistry
53. 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
    Stuart Morgan, Jeremy Tomlinson · 2010 · Expert Opinion on Investigational Drugs
54. Hypertension in Obesity
    L. Romayne Kurukulasuriya, Sameer N. Stas, Guido Lastra, Camila Margarita Manrique, James R. Sowers · 2008 · Endocrinology and Metabolism Clinics of North America
55. 11β-Hydroxysteroid Dehydrogenase Type 1 Induction in the Arcuate Nucleus by High-Fat Feeding: A Novel Constraint to Hyperphagia?
    Valerie S. Densmore, Nicholas M. Morton, John J. Mullins, Jonathan R. Seckl · 2006 · Endocrinology
56. Safety, efficacy and weight effect of two 11β‐ HSD1 inhibitors in metformin‐treated patients with type 2 diabetes
    Tim Heise, Linda Morrow, Marcus Hompesch, Hans‐Ulrich Häring, Christoph Kapitza, M. Abt, Markus Ramsauer, Maria Chiara Magnone, Sabine Fuerst‐Recktenwald · 2014 · Diabetes Obesity and Metabolism
57. 11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
    Matthew A. Bailey · 2017 · Current Hypertension Reports
58. Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
    Susan D. Aster, Donald W. Graham, Divya Kharbanda, Gool F. Patel, Mitree M. Ponpipom, Gina M. Santorelli, Michael J. Szymonifka, Steven S. Mundt, Kashmira Shah, Marty S. Springer et al. · 2008 · Bioorganic & Medicinal Chemistry Letters
59. Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11β-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice
    Janice M. Paterson, Megan C. Holmes, Christopher J. Kenyon, Roderick Carter, John J. Mullins, Jonathan R. Seckl · 2006 · Endocrinology
60. Endothelial effects of antihypertensive treatment: focus on irbesartan
    Roberto Negro · 2008 · Vascular Health and Risk Management
61. 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension
    Carmen Campino, Cristián A. Carvajal, Javiera Cornejo, Betty San Martín, Oliviero Olivieri, Gian Cesare Guidi, Giovanni Faccini, Francesco Pasini, Javiera Sateler, Rene F. Baudrand et al. · 2009 · Endocrine
62. Central and peripheral contributions to obesity‐associated hypertension: impact of early overnourishment
    Margaret J. Morris, Elena Velkoska, Tim James Cole · 2005 · Experimental Physiology
63. Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in Vivo
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64. Glucocorticoids and 11β-hydroxysteroid dehydrogenases: mechanisms for hypertension
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65. Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?
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66. Obesity
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67. Metabolic syndrome-interdependence of the cardiovascular and metabolic pathways
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68. Fatty Acid Metabolism and Vascular Disease
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69. The Metabolic Syndrome as a Risk Factor for Chronic Kidney Disease
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70. Bezafibrate regulates the expression and enzyme activity of 11β-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes
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71. Coffee inhibits the reactivation of glucocorticoids by 11β‐hydroxysteroid dehydrogenase type 1: A glucocorticoid connection in the anti‐diabetic action of coffee?
    Atanas G. Atanasov, Anna A. Dzyakanchuk, Roberto A.S. Schweizer, Lyubomir G. Nashev, Evelyne M. Maurer, Alex Odermatt · 2006 · FEBS Letters
72. Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
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73. Genetic manipulation of 11β-hydroxysteroid dehydrogenases in mice
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74. Inappropriate Diet Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease via Abdominal Obesity
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75. Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selective 11β-HSD1 Inhibitor
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76. Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension
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77. Active site variability of type 1 11β-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons
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78. Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
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79. Lack of Hexose-6-Phosphate Dehydrogenase Impairs Lipid Mobilization from Mouse Adipose Tissue
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80. Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
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81. Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome
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82. 11β-Hydroxysteroid dehydrogenase type 1 inhibitors as therapeutic agents
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83. Virtual screening applications in short-chain dehydrogenase/reductase research
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85. Estrogen Reduces 11β‐Hydroxysteroid Dehydrogenase Type 1 in Liver and Visceral, but Not Subcutaneous, Adipose Tissue in Rats
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86. The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
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89. Hepatic surgery-related hypophosphatemia
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90. Development and Application of a Scintillation Proximity Assay (SPA) for Identification of Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
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92. Visceral Obesity without Insulin Resistance in Late-Onset Obesity Rats
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93. Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Normal Weight Postmenopausal Women
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94. Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans
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95. 11β‐Hydroxysteroid dehydrogenase and the brain: Not (yet) lost in translation
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96. Polymorphisms of the GR and HSD11B1 genes influence body mass index and weight gain during hormone replacement treatment in patients with Addison's disease
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97. Synthesis of Potent and Orally Efficacious 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor HSD-016
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98. Synthesis, anti-diabetic evaluation and molecular docking studies of 4-(1-aryl-1H-1, 2, 3-triazol-4-yl)-1,4-dihydropyridine derivatives as novel 11-β hydroxysteroid dehydrogenase-1 (11β-HSD1) inhibitors
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99. Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women
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100. A Novel Promoter for the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene Is Active in Lung and Is C/EBPα Independent
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