Flier, Jeffrey S.

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 5,522

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine

Cancer Cells and MetastasisWound Healing and Treatments

Cited by 4,391

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesImmune Response and Inflammation

Cited by 3,690

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 3,117

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,398

A transgenic model of visceral obesity and the metabolic syndrome

Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 1,766

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,660

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 1,495

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development

Adipose Tissue and MetabolismFibroblast Growth Factor Research

Cited by 1,478

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,428

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 1,075

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,014

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 924

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry

Regulation of Appetite and ObesityCytokine Signaling Pathways and Interactions

Cited by 890

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 887

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes

Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic Diseases

Cited by 830

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 791

Leptin Regulation of Neuroendocrine Systems

Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 767

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 737

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 644

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry

Regulation of Appetite and ObesityCytokine Signaling Pathways and Interactions

Cited by 639

Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function

Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 632

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsRegulation of Appetite and Obesity

Cited by 537

The gut and energy balance: visceral allies in the obesity wars

Badman, M. K., & Flier, J. S. (2005) · Science

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

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