PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Akune, Toru; Ohba, Shinsuke; Kamekura, Satoru; Yamaguchi, Masayuki; Chung, Ung-il; Kubota, Naoto; Terauchi, Yasuo; Harada, Yoshifumi; Azuma, Yoshiaki; Nakamura, Kozo; Kadowaki, Takashi; Kawaguchi, Hiroshi

doi:10.1172/jci19900

Cited by 869

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

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Akune, Toru, Ohba, Shinsuke, Kamekura, Satoru, Yamaguchi, Masayuki, Chung, Ung-il, Kubota, Naoto, Terauchi, Yasuo, Harada, Yoshifumi, Azuma, Yoshiaki, Nakamura, Kozo, Kadowaki, Takashi, Kawaguchi, Hiroshi·2004·Journal of Clinical Investigation

DOI 10.1172/jci19900

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Abstract

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a common progenitor, this study investigated the role of PPARgamma, a key regulator of adipocyte differentiation, in bone metabolism. Homozygous PPARgamma-deficient ES cells failed to differentiate into adipocytes, but spontaneously differentiated into osteoblasts, and these were restored by reintroduction of the PPARgamma gene. Heterozygous PPARgamma-deficient mice exhibited high bone mass with increased osteoblastogenesis, but normal osteoblast and osteoclast functions, and this effect was not mediated by insulin or leptin. The osteogenic effect of PPARgamma haploinsufficiency became prominent with aging but was not changed upon ovariectomy. The PPARgamma haploinsufficiency was confirmed to enhance osteoblastogenesis in the bone marrow cell culture but did not affect the cultures of differentiated osteoblasts or osteoclast-lineage cells. This study demonstrates a PPARgamma-dependent regulation of bone metabolism in vivo, in that PPARgamma insufficiency increases bone mass by stimulating osteoblastogenesis from bone marrow progenitors.

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Authors: Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U.-I., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., Kadowaki, T., & Kawaguchi, H.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-03-15
Volume: 113
Issue: 6
Pages: 846-855
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci19900
OpenAlex: W2124359549
Cited by: 869
References: 6
FWCI: 15.42
Type: journal article
Language: en
Open access: bronze

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This page: CoChat. (2026). Citation check: PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. https://app.cochat.ai/papers/10.1172/jci19900
The paper: Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U.-I., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., Kadowaki, T., & Kawaguchi, H. (2004). PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. Journal of Clinical Investigation. https://doi.org/10.1172/jci19900

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PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

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