Cited by 220Liver Diseases and ImmunityCell death mechanisms and regulationSystemic Lupus Erythematosus Research

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Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

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Odin, Joseph A., Huebert, Robert C., Casciola-Rosen, Livia, LaRusso, Nicholas F., Rosen, Antony·2001·Journal of Clinical Investigation

DOI 10.1172/jci200110716PMC PMC203018

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Abstract

The close association between autoantibodies against pyruvate dehydrogenase-E2 (PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is unexplained.Many autoantigens are selectively modified during apoptosis, which has focused attention on apoptotic cells as a potential source of "neo-antigens" responsible for activating autoreactive lymphocytes.Since increased apoptosis of bile duct epithelial cells (cholangiocytes) is evident in patients with PBC, we evaluated the effect of apoptosis on PDC-E2.Autoantibody recognition of PDC-E2 by immunofluorescence persisted in apoptotic cholangiocytes and appeared unchanged by immunoblot analysis.PDC-E2 was neither cleaved by caspases nor concentrated into surface blebs in apoptotic cells.In other cell types, autoantibody recognition of PDC-E2, as assessed by immunofluorescence, was abrogated after apoptosis, although expression levels of PDC-E2 appeared unchanged when examined by immunoblot analysis.Both overexpression of Bcl-2 and depletion of glutathione before inducing apoptosis prevented this loss of autoantibody recognition, suggesting that glutathiolation, rather than degradation or loss, of PDC-E2 was responsible for the loss of immunofluorescence signal.We postulate that apoptotic cholangiocytes, unlike other apoptotic cell types, are a potential source of immunogenic PDC-E2 in patients with PBC.

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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,402
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
Casciola-Rosen, L. A., Anhalt, G. J., & Rosen, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1317 · Cited by 1,723
Self-citation
Consequences of Cell Death
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes
Huang, F., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D., & MacPherson, G. G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.435 · Cited by 902
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
Poupon, R., Lindor, K., Cauch-Dudek, K., Dickson, E., Poupon, R., & Heathcote, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70183-5 · Cited by 648
Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis
Gershwin, M. E., Mackay, I. R., Sturgess, A., & Coppel, R. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3525 · Cited by 557
Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status
Casciola-Rosen, L. A., Andrade, F., Ulanet, D., Wong, W. B., & Rosen, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.815 · Cited by 492
Self-citation
ABERRANT EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT EPITHELIUM IN PRIMARY BILIARY CIRRHOSIS: RELEVANCE TO PATHOGENESIS
Ballardini, G., Bianchi, F., Doniach, D., Mirakian, R. M., Pisi, E., & Bottazzo, G. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91108-5 · Cited by 488

Show all 60 references

Research works printed but not linked: 11

Culp, 1982, Mayo Clin Proc, 57, 365
Tsujimoto, 1997, Leukemia, 11(Suppl. 3), 380
Charlotte, 1994, Am J Pathol, 144, 460
Vroman, 1996, Lab Invest, 74, 303
Watson, 1991, Am J Physiol, 261, G229
Alpini, 1998, Am J Physiol, 274, G767
Mendel-Hartvig, 1985, Clin Exp Immunol, 62, 371
Celli, 1998, Am J Physiol, 275, G749
Que, 1997, Am J Physiol, 272, G106
Dini, 2000, Eur J Histochem, 44, 217
Schultheiss, 1983, Clin Exp Immunol, 54, 648

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Self-citation
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Suljević, D., Fočak, M., Škrijelj, R., & Mitrašinović‐Brulić, M. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4015 · Cited by 1
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Sasaki, M., & Nakanuma, Y. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405877-4.00020-2 · Cited by 1
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Wang, L., Bowlus, C. L., Wang, F., & Gershwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-50168-0_8 · Cited by 1
The Onset Mechanism of Primary Biliary Cirrhosis
Shimoda, S. (2014) · Springer eBooks · doi:10.1007/978-4-431-54789-1_12 · Cited by 1
The Adaptive Immune System and Liver Toxicity
Ju, C. H., Phillips, E. J., Holt, M. R., Gao, Y., & Lammert, C. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95663-0 · Cited by 1
Characterization of the pro-apoptotic function of eIF5A in human cancer cell lines
Sun, Z. (2007) · UWSpace (University of Waterloo) · Cited by 1
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Heathcote, E. J., & Milkiewicz, P. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch11a · Cited by 1
GSH, Sulfur Amino Acids, and Apoptosis
Filomeni, G., Aquilano, K., & Ciriolo, M. R. (2008) · Wiley eBooks · doi:10.1002/9780470475973.ch10
Chapter 12 Primary Biliary Cirrhosis
Abdalian, R., & Heathcote, J. (2008) · Technical report · doi:10.1016/s1571-5078(07)00012-8
Apoptosis in Lupus Erythematosus
Andrade, F., Rosen, A., & Casciola-Rosen, L. A. (2005) · Springer eBooks · doi:10.1007/3-540-26581-3_17
Self-citation
Zur frage der endokrinen Aetiologie des juveniles Stars: La cuestión de la etiología endocrina de la catarata juvenil
Grönholm, V. (1928) · Archivos de Oftalmología Hispano-Americanos
Mal ollo!: comedia de ambente mariñeiro
González, C. A., Sánchez, X. F., Tato-Fontaíña, L., Seoane, A. A., & Ferreiro, M. (2004) · Dialnet (Universidad de la Rioja)
Xenobiotic Induced Model of Primary Biliary Cirrhosis
Arsenijević, A., Milovanović, J., Stojanović, B., Milovanović, M., Gershwin, E. M., Leung, P. S. C., Arsenijević, N., & Lukić, M. L. (2014) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2014-0019
Stellenwert von Schönheit bei männlichen Jugendlichen und Verfolgung ihrer Körperideale
Schneider, R. F. (2013) · University of Vienna · doi:10.25365/thesis.28422
Treatment of primary biliary cirrhosis
Poupon, R. Y., & Corpechot, C. (2013) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.870031
5 Piece Screwdriver
Lever, B. (2007)
Función antioxidante de la γ -glutamilcisteína mitocondrial. Aplicación en terapia génica neuroprotectora
Quintana–Cabrera, R. (2012) · doi:10.14201/gredos.115648

Authors: Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F., & Rosen, A.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Mayo Clinic (US)
Johns Hopkins University (US)
Corresponding author: Odin, Joseph A.
ORCID: Odin, Joseph A.
Huebert, Robert C.
Casciola-Rosen, Livia
LaRusso, Nicholas F.
Rosen, Antony
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2001-07-15
Volume: 108
Issue: 2
Pages: 223-232
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200110716
PMC: PMC203018
OpenAlex: W4249025813
Cited by: 220
References: 60
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 5 · 2015: 20 · 2014: 9 · 2013: 9 · 2012: 14
FWCI: 7.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK059653, R01DK024031, T32DK-07832)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 44684, R01AR044684)
National Institute of Dental and Craniofacial Research (R37DE012354, DE12354, R01DE012354)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords: primary biliary cirrhosis, pyruvate dehydrogenase E2, autoantigens, autoantibodies, apoptosis, Bcl-2, glutathione depletion, bile duct epithelial cells, cholangiocytes, mitochondrial proteins, neoantigens, caspase cleavage
MeSH terms: Autoantibodies, Autoantigens, Bile Ducts, Cell Line, Dithiothreitol, Epithelial Cells, Fluorescent Antibody Technique, Glutathione, Humans, Immune Sera, Liver Cirrhosis, Biliary, Lymphocyte Activation, Mitochondria, Pyruvate Dehydrogenase Complex, Transfection, Immunoblotting, Gene Expression Regulation, Enzymologic, Apoptosis, Genes, bcl-2, Dihydrolipoyllysine-Residue Acetyltransferase

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Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

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