The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Open accessAbstract
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used a targeted mutant mouse model to test the hypothesis that monoallelic deletion of beclin 1 promotes tumorigenesis. Here we show that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions. Molecular analyses of tumors in beclin 1 heterozygous mice show that the remaining wild-type allele is neither mutated nor silenced. Furthermore, beclin 1 heterozygous disruption results in increased cellular proliferation and reduced autophagy in vivo. These findings demonstrate that beclin 1 is a haplo-insufficient tumor-suppressor gene and provide genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression. Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In this case, the haploinsufficient mice developed tumours, indicating that autophagy might act as an important in vivo tumour suppressor 76, 77 .”
From The common biology of cancer and ageing (2007) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Self-citationCui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Autophagy as a Regulated Pathway of Cellular Degradation
Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Self-citationStereological Principles for Morphometry in Electron Microscopic Cytology
Weibel, E. R. (1969) · International review of cytology · doi:10.1016/s0074-7696(08)61637-x · Cited by 1,932
Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae
Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837
Self-citationTor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,303
Self-citationAutophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans
Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270
Self-citationPetiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168
Research works printed but not linked: 11
- Russell, 1990, Oncogene., 5, 1581
- Eccles, 1992, Oncogene., 7, 2069
- Cliby, 1993, Cancer Res., 53, 2393
- Tangir, 1996, Oncogene., 12, 735
- Futreal, 1992, Cancer Res., 52, 2624
- Saito, 1993, Cancer Res., 53, 3382
- Gao, 1995, Cancer Res., 55, 1002
- Liang, 2001, Cancer Res., 61, 3443
- Huang, 2002, Curr. Opin. Investig. Drugs., 3, 295
- Elit, 2002, Curr. Opin. Investig. Drugs., 3, 1249
- Ogier-Denis, 2003, Biochim. Biophys. Acta., 1603, 113
Cited by
Sorted by citations
Items 901–1,000 of 1,003
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains
Ren, T., Takahashi, Y., Liu, X., Loughran, T. P., Sun, S.-C., Wang, H.-G., & Cheng, H. (2013) · Oncogene · doi:10.1038/onc.2013.552 · Cited by 58
The utility of chloroquine in cancer therapy
Zhang, Y., Liao, Z., Zhang, L., & Xiao, H. (2015) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1025731 · Cited by 58
Cancer Therapy Beyond Apoptosis: Autophagy and Anoikis as Mechanisms of Cell Death
Coates, J. M., Galante, J. M., & Bold, R. J. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.07.011 · Cited by 59
Wohlgemuth, S. E., Ramirez-Lee, Y., Tao, S., Monteiro, A. P. A., Ahmed, B. M. S., & Dahl, G. E. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10649 · Cited by 59
Drug rechanneling: A novel paradigm for cancer treatment
Kaushik, I., Ramachandran, S., Prasad, S., & Srivastava, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.011 · Cited by 60
The oncogenic potential of NANOG: An important cancer induction mediator
Najafzadeh, B., Asadzadeh, Z., azad, R. M., Mokhtarzadeh, A., Baghbanzadeh, A., Alemohammad, H., Shadbad, M. A., Vasefifar, P., Najafi, S., & Baradaran, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30063 · Cited by 58
Bialik, S., & Kimchi, A. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-1-4020-6554-5_9 · Cited by 58
Shafabakhsh, R., Arianfar, F., Vosough, M., Mirzaei, H. R., Mahjoubin‐Tehran, M., Khanbabaei, H., Kowsari, H., Shojaie, L., Azar, M. E. F., Hamblin, M. R., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-020-00272-7 · Cited by 57
Autophagy in Cancer Immunotherapy
Lei, Y., Zhang, E., Bai, L., & Li, Y. (2022) · Cells · doi:10.3390/cells11192996 · Cited by 59
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity
Li, J., Wang, Y., Luo, Y., Liu, Y., Yi, Y., Li, J., Pan, Y., Li, W., You, W., Hu, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35557-y · Cited by 63
XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation
Lin, F., Ghislat, G., Luo, S., Renna, M., Siddiqi, F. H., & Rubinsztein, D. C. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv052 · Cited by 57
Autophagy regulation in the development and treatment of breast cancer
Zhou, Y., Rucker, E. B., & Zhou, B. P. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv119 · Cited by 58
Singh, A. K., Bissoyi, A., Kashyap, M. P., Patra, P. K., & Rizvi, S. I. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9746-5 · Cited by 57
Huynh, T. Y. L., Zaręba, I., Baszanowska, W., Lewoniewska, S., & Palka, J. A. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03685-y · Cited by 59
Dröge, W., & Kinscherf, R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1953 · Cited by 58
Wu, N., Zheng, W., Zhou, Y., Tian, Y., Tang, M., Feng, X., Ashrafizadeh, M., Wang, Y. Z., Niu, X., Tambuwala, M. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102428 · Cited by 59
Yoo, B. H., Wu, X. Z., Li, Y., Haniff, M., Sasazuki, T., Shirasawa, S., Eskelinen, E., & Rosen, K. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046789 · Cited by 61
Self-citationBeclin1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines
Weng, J., Wang, C., Wang, Y., Tang, H., Liang, J., Liu, X., Huang, H., & Hou, J. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2014.06.020 · Cited by 56
Autophagy patterns and prognosis in uveal melanomas
Giatromanolaki, A. N., Charitoudis, G., Bechrakis, N. E., Kozobolis, V., Koukourakis, M. I., Foerster, M. H., & Sivridis, E. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.63 · Cited by 56
Role of autophagy in liver physiology and pathophysiology
Ding, W. (2010) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v1.i1.3 · Cited by 57
Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication
Niu, J., Yan, T., Guo, W., Wang, W., & Zhao, Z. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01232 · Cited by 57
Shah, S. Z. A., Zhao, D., Hussain, T., & Yang, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.004 · Cited by 55
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer
Cozzo, A. J., Coleman, M. F., Pearce, J. B., Pfeil, A. J., Etigunta, S. K., & Hursting, S. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590192 · Cited by 55
Drosophila as a model system to study autophagy
Zirin, J. D., & Perrimon, N. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0223-y · Cited by 56
Wu, M.-Y., Fu, J., Xu, J., O’Malley, B. W., & Wu, R. (2012) · Cell Research · doi:10.1038/cr.2012.44 · Cited by 55
Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro
ZHANG, X., Tang, X., Liu, H.-Q., Li, L., Hou, Q., & GAO, J. (2011) · Oncology Reports · doi:10.3892/or.2011.1599 · Cited by 55
Targeting Ca2+transport in cancer: close reality or long perspective?
Prevarskaya, N. B., Skryma, R. N., & Шуба, Я. М. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.741594 · Cited by 61
Autophagy: a potential therapeutic target in lung diseases
Nakahira, K., & Choi, A. M. K. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00072.2013 · Cited by 57
Liu, C., DeRoo, E., Stecyk, C., Wolsey, M., Szuchnicki, M., & Hagos, E. G. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0373-6 · Cited by 55
Salah, F. S., Ebbinghaus, M., Muley, V. Y., Zhou, Z., Al-Saadi, K. R., Pacyna-Gengelbach, M., O’Sullivan, G. A., Betz, H., König, R., Wang, Z.-Q., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.93 · Cited by 56
Cell-cycle involvement in autophagy and apoptosis in yeast
Azzopardi, M., Farrugia, G., & Balzan, R. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.006 · Cited by 58
Fang, L.-M., Li, B., Guan, J.-J., Xu, H., Shen, G., Gao, Q., & Qin, Z. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.25 · Cited by 55
Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation
Zhang, N., Yang, X. P., Yuan, F., Zhang, L., Wang, Y., Wang, L., Mao, Z., Luo, J., Zhang, H., Zhu, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.006 · Cited by 56
Zhuang, H., Wu, F., Wei, W., Dang, Y., Yang, B., Ma, X., Han, F., & Li, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1446-z · Cited by 56
Delaney, J. R., Patel, C. B., Bapat, J., Jones, C. M., Zapatero, M. R., Ortell, K. K., Tanios, R., Haghighiabyaneh, M., Axelrod, J. L., DeStefano, J., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008558 · Cited by 57
Alvero, A. B., Montagna, M. K., Chen, R., Kim, K. H., Kyungjin, K., Visintin, I., Fu, H., Brown, D., & Mor, G. (2009) · Cancer · doi:10.1002/cncr.24397 · Cited by 55
Regulation of class III (Vps34) PI3Ks
Yan, Y., & Backer, J. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350239 · Cited by 57
Pimentel, J. M., Zhou, J. Y., & Wu, G. S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217285 · Cited by 55
Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M. S., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004409 · Cited by 57
Apoptosis regulation by autophagy gene 5
Yousefi, S., & Simon, H. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.06.005 · Cited by 55
Xu, F., Fang, Y., Yan, L., Xu, L., Zhang, S., Cao, Y. H., Li, X., Zhang, X., Xie, J., Jiang, G., et al. (2017) · Scientific Reports · doi:10.1038/srep45385 · Cited by 54
Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds
Vidoni, C., Ferraresi, A., Secomandi, E., Vallino, L., Dhanasekaran, D. N., & Isidoro, C. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.04.006 · Cited by 54
Core autophagy genes and human diseases
Zhao, Y. G., & Zhang, H. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.08.003 · Cited by 55
Li, P., Shi, M., Maique, J., Shaffer, J., Yan, S. X., Moe, O. W., & Hu, M. C. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00504.2019 · Cited by 54
HIF-1a regulates hypoxia-induced autophagy via translocation of ANKRD37 in colon cancer
Deng, M., Zhang, W., Yuan, L., Tan, J., & Chen, Z. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112175 · Cited by 55
Dysfunction of chaperone-mediated autophagy in human diseases
Liao, Z., Wang, B., Liu, W., Xu, Q., Hou, L., Song, J., Guo, Q., & Li, N. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-04006-z · Cited by 56
Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance
Wang, X., Lee, J., & Xie, C. (2022) · Cancers · doi:10.3390/cancers14020381 · Cited by 53
Impact of Complex Apoptotic Signaling Pathways on Cancer Cell Sensitivity to Therapy
Kim, R., Kin, T., & Beck, W. T. (2024) · Cancers · doi:10.3390/cancers16050984 · Cited by 56
Autophagy in Prostate Cancer and Androgen Suppression Therapy
Ziparo, E., Petrungaro, S., Marini, E. S., Starace, D., Conti, S., Facchiano, A., Filippini, A., & Giampietri, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612090 · Cited by 53
Huang, J.-J., Zhu, Y.-J., Lin, T.-Y., Jiang, W.-Q., Huang, H.-Q., & Li, Z. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.12.014 · Cited by 53
Engelmann, D., Meier, C., Alla, V., & Pützer, B. M. (2014) · Oncogene · doi:10.1038/onc.2014.365 · Cited by 53
MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation
Kufe (2009) · International Journal of Oncology · doi:10.3892/ijo_00000300 · Cited by 54
Roles of Autophagy Induced by Natural Compounds in Prostate Cancer
Naponelli, V., Modernelli, A., Bettuzzi, S., & Rizzi, F. (2015) · BioMed Research International · doi:10.1155/2015/121826 · Cited by 53
Roesly, H. B., Khan, M. R., Chen, H. D. R., Hill, K. A., Narendran, N. H., Watts, G. S., Chen, X. L., & Dvorak, K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00340.2011 · Cited by 53
Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms
Papoudou‐Bai, A., Hatzimichael, E. C., Barbouti, A., & Kanavaros, P. (2016) · Clinical and Experimental Medicine · doi:10.1007/s10238-016-0436-z · Cited by 53
Oh, S., & Roh, C. (2017) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2017.60.3.241 · Cited by 53
14-3-3τ Regulates Beclin 1 and Is Required for Autophagy
Wang, B., Ling, S., & Lin, W.-C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010409 · Cited by 55
Torrence, M. E., & Manning, B. D. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050329 · Cited by 55
Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma
Khan, I., Baig, M. H., Mahfooz, S., Rahim, M., Karaçam, B., Elbasan, E. B., Ulasov, I. V., Dong, J.-J., & Hatiboğlu, M. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031318 · Cited by 54
Autophagy is active in normal colon mucosa
Groulx, J., Khalfaoui, T., Benoit, Y. D., Bernatchez, G., Carrier, J. C., Basora, N., & Beaulieu, J. (2012) · Autophagy · doi:10.4161/auto.19738 · Cited by 55
Downregulation of Beclin1 and Impairment of Autophagy in a Small Population of Colorectal Cancer
Chen, Z., Li, Y., Zhang, C., Yi, H., Wu, C., Wang, J., Liu, Y., Tan, J., & Wen, J. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2732-8 · Cited by 54
Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications
Corazzari, M., Fimia, G. M., Lovat, P. E., & Piacentini, M. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.07.001 · Cited by 56
Colunga, A., Laing, J. M., & Aurelian, L. (2009) · Gene Therapy · doi:10.1038/gt.2009.126 · Cited by 53
Rajas, F., Labrune, P., & Mithieux, G. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.03.002 · Cited by 58
Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy
Launay, N., Aguado, C., Fourcade, S., Ruíz, M., Grau, L., Riera, J., Guilera, C., Girós, M., Ferrer, I., Knecht, E., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1378-8 · Cited by 55
Li, D., Wang, J., Hou, J., Fu, J.-H., Liu, J., & Lin, R. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1275-x · Cited by 52
Aydınlık, Ş., Erkısa, M., Cevatemre, B., Sarımahmut, M., Dere, E., Arı, F., & Ulukaya, E. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.11.013 · Cited by 52
Akkoç, Y., & Gözüaçık, D. (2018) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2018.150318 · Cited by 52
Deng, Z., Li, X., Ramírez, M. B., Purtell, K., Choi, I., Lu, J., Yu, Q., & Yue, Z. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020215118 · Cited by 52
Autophagy: from basic science to clinical application
Limbergen, J. V., Stevens, C., Nimmo, E., Wilson, D., & Satsangi, J. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.20 · Cited by 53
Brimson, J. M., Prasanth, M. I., Malar, D. S., Thitilertdecha, P., Kabra, A., Tencomnao, T., & Prasansuklab, A. (2021) · Pharmaceuticals · doi:10.3390/ph14100982 · Cited by 53
Gungor, M. Z., Uysal, M., & Şentürk, Ş. (2022) · Cancers · doi:10.3390/cancers14040940 · Cited by 53
Therapeutic strategies targeting AMPK-dependent autophagy in cancer cells
Yuan, W., Fang, W., Zhang, R., Lyu, H., Xiao, S., Guo, D. S., Ali, D. W., Michalak, M., Chen, X., Zhou, C., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119537 · Cited by 53
Chen, S., Han, Q., Wang, X., Yang, M., Zhang, Z., Li, P., Chen, A., Hu, C., & Li, S. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.380 · Cited by 51
Beclin 1 expression is an independent prognostic factor for gastric carcinomas
Yu, M., Gou, W., Zhao, S., Xiao, L.-J., Mao, X., Xing, Y., Takahashi, H., Takano, Y., & Zheng, H. (2013) · Tumor Biology · doi:10.1007/s13277-013-0648-8 · Cited by 51
Targeting autophagy in skin diseases
Yu, T., Zuber, J., & Li, J. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1225-3 · Cited by 51
Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors
Eekels, J. J. M., Sagnier, S., Geerts, D., Jeeninga, R. E., Biard‐Piechaczyk, M., & Berkhout, B. (2012) · Virology Journal · doi:10.1186/1743-422x-9-69 · Cited by 55
Arsov, I., Li, X., Matthews, G., Coradin, J. H., Hartmann, B., Simon, A. K., Sealfon, S. C., & Yue, Z. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.59 · Cited by 53
Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome
Šumarac-Dumanović, M., Apostolović, M., Janjetović, K., Jeremić, D., Popadic, D. M., Ljubić, A., Micić, J., Stamenković, J., Tubic, A., Stevanović, D., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.009 · Cited by 52
Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma
Djavaheri‐Mergny, M., Giuriato, S., Tschan, M. P., & Humbert, M. (2019) · Cells · doi:10.3390/cells8020103 · Cited by 52
Tumor-intrinsic determinants of immunogenic cell death modalities
Workenhe, S. T., Pol, J. G., & Kroemer, G. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1893466 · Cited by 52
Mammalian Target of Rapamycin Signaling and Autophagy: Roles in Lymphangioleiomyomatosis Therapy
Yu, J. J., Parkhitko, A. A., & Henske, E. P. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-104js · Cited by 51
Self-citationAutophagy Regulates Keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors
Kongara, S., Kravchuk, O., Teplova, I., Lozy, F., Schulte, J., Moore, D. F., Barnard, N., Neumann, C. A., White, E., & Karantza, V. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0494 · Cited by 53
Choi, J. H., Cho, Y., Ko, Y. H., Hong, S. U., Park, J. H., & Lee, M. A. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/179586 · Cited by 50
Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation
Guo, X., Dong, Y., Yin, S., Zhao, C., Huo, Y., Fan, L., & Hu, H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.349 · Cited by 51
Chen, N., Eritja, N., Lock, R., & Debnath, J. (2013) · Oncogene · doi:10.1038/onc.2012.277 · Cited by 50
Targeting Androgen Receptor Leads to Suppression of Prostate Cancer via Induction of Autophagy
Jiang, Q., Yeh, S., Wang, X., Xu, D., Zhang, Q., Wen, X., Xia, S., & Chang, C. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.06.004 · Cited by 50
Seiwert, N., Neitzel, C., Stroh, S., Frisan, T., Audebert, M., Toulany, M., Kaina, B., & Fahrer, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.418 · Cited by 54
Denisenko, T. V., Pivnyuk, A. D., & Zhivotovsky, B. (2018) · Cancers · doi:10.3390/cancers10050148 · Cited by 51
Autophagy as a mechanism for anti-angiogenic therapy resistance
Chandra, A., Rick, J. W., Yagnik, G., & Aghi, M. K. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.031 · Cited by 54
Expressional and mutational analyses of ATG5 gene in prostate cancers
Kim, M. S., Song, S. Y., Lee, J. Y., Yoo, N. J., & Lee, S. H. (2011) · Apmis · doi:10.1111/j.1600-0463.2011.02812.x · Cited by 50
Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E
Cao, L., Xu, J., Lin, Y. H., Zhao, X., Liu, X., & Chi, Z. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.178 · Cited by 51
Identification of a lung cancer cell line deficient in atg7-dependent autophagy
Mandelbaum, J., Rollins, N., Shah, P., Bowman, D., Lee, J. Y., Tayber, O., Bernard, H., Leroy, P. J., Li, P., Koenig, E. M., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1056966 · Cited by 49
Miki, Y., Tanji, K., Mori, F., Utsumi, J., Sasaki, H., Kakita, A., Takahashi, H., & Wakabayashi, K. (2015) · Brain Pathology · doi:10.1111/bpa.12297 · Cited by 50
LITAF , a BCL 6 target gene, regulates autophagy in mature B‐cell lymphomas
Bértolo, C., Roa, S., Sagardoy, A., Mena‐Varas, M., Robles, E. F., Martínez‐Ferrandis, J. I., Sagaert, X., Tousseyn, T., Orta, A., Lossos, I. S., et al. (2013) · British Journal of Haematology · doi:10.1111/bjh.12440 · Cited by 50
Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation
Han, J., Hou, W., Lu, C., Goldstein, L. A., Stolz, D. B., Watkins, S. C., & Rabinowich, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.461350 · Cited by 49
Recent insights on the putative role of autophagy in autoimmune diseases
Gianchecchi, E., Delfino, D. V., & Fierabracci, A. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.10.007 · Cited by 50
Lőrincz, P., Lakatos, Z., Maruzs, T., Szatmári, Z., Kis, V., & Sass, M. (2014) · BioMed Research International · doi:10.1155/2014/851349 · Cited by 53
Zambrano, J. N., & Yeh, E. S. (2016) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s32791 · Cited by 50
Rosa, J. D. L., Weber, J., Friedrich, M., Li, Y., Rad, L., Ponstingl, H., Liang, Q., Fernández, S. B. D. Q., Noorani, I., Metzakopian, E., et al. (2017) · Nature Genetics · doi:10.1038/ng.3817 · Cited by 50
Metadata
- Authors
- Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., Cattoretti, G., & Levine, B.
- Affiliations
- Columbia University (US)
- Baylor College of Medicine (US)
- National Institute for Basic Biology (JP)
- Corresponding author
- Levine, Beth
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1809-1820
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297002
- OpenAlex
- W2115886998
- Cited by
- 2,311
- References
- 71
- Citations by year
- 2026: 46 · 2025: 55 · 2024: 75 · 2023: 85 · 2022: 110 · 2021: 142 · 2020: 122 · 2019: 125 · 2018: 123 · 2017: 122 · 2016: 125 · 2015: 144 · 2014: 154 · 2013: 179 · 2012: 130
- FWCI
- 21.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (5r01ai044157-03, CA16303)
- National Cancer Institute (R01 CA84254, R01CA016303, R01 CA16303, R01CA084254)
- National Institute of Allergy and Infectious Diseases (R01 AI44157)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- Beclin-1, autophagy, tumor suppression, haploinsufficiency, hepatitis B virus, precancerous lesions, cell proliferation, monoallelic deletion, carcinogenesis
- MeSH terms
- Beclin-1, Alleles, Animals, Autophagy, Cell Division, Cell Transformation, Neoplastic, Female, Genotype, Hepatitis B virus, Heterozygote, Male, Membrane Proteins, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Microscopy, Fluorescence, Models, Genetic, Mutation, Neoplasms, Proteins, Recombination, Genetic, Thymus Gland, Time Factors, Blotting, Southern, DNA Primers, Mice, Knockout, Cell Line, Tumor, Apoptosis Regulatory Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review