Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Mutation and cancer: statistical study of retinoblastoma

Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Stereological Principles for Morphometry in Electron Microscopic Cytology

Weibel, E. R. (1969) · International review of cytology · doi:10.1016/s0074-7696(08)61637-x · Cited by 1,932

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,303

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

Petiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168

Autophagy in colorectal cancer: An important switch from physiology to pathology

Burada, F. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i11.271 · Cited by 171

Autophagy in Protein and Organelle TurnoverPreprint

Mizushima, N. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.011023 · Cited by 170

Autophagy as a modulator and target in prostate cancer

Farrow, J. M., Yang, J. C., & Evans, C. P. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.196 · Cited by 167

Obesity, insulin resistance, NASH and hepatocellular carcinoma

Yu, J. Q., Shen, J., Sun, T., Zhang, X., & Wong, N. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.07.003 · Cited by 164

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

Li, X., He, L., Che, K. H., Funderburk, S. F., Pan, L., Pan, N., Zhang, M., Yue, Z., & Zhao, Y. (2012) · Nature Communications · doi:10.1038/ncomms1648 · Cited by 167

Targeting cancer by binding iron: Dissecting cellular signaling pathways

Lui, G. Y. L., Kovačević, Ž., Richardson, V., Merlot, A. M., Kalinowski, D. S., & Richardson, D. R. (2015) · Oncotarget · doi:10.18632/oncotarget.4349 · Cited by 165

Killing a cancer: what are the alternatives?

Kreuzaler, P. A., & Watson, C. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3264 · Cited by 164

Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment

Song, Y., Zhang, S., Guo, X., Sun, K., Han, Z., Li, R., Zhao, Q., Deng, W.-J., Xie, X., zhang, J.-W., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.07.021 · Cited by 162

Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11

Sinha, S. C., Colbert, C. L., Becker, N., Wei, Y., & Levine, B. (2008) · Autophagy · doi:10.4161/auto.6803 · Cited by 166

Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells

Kim, Y., Oh, S., Yun, H. S., Oh, S., & Kim, S. H. (2010) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2010.02859.x · Cited by 161

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

McEwan, D. G., & Đikić, I. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.12.006 · Cited by 168

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

Rodríguez, D. A., Rojas‐Rivera, D., & Hetz, C. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.012 · Cited by 164

Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABAAReceptors in Caenorhabditis elegans

Rowland, A. M., Richmond, J. E., Olsen, J. G., Hall, D. H., & Bamber, B. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2279-05.2006 · Cited by 159

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

Koukourakis, M. I., Giatromanolaki, A. N., Sivridis, E., Pitiakoudis, M. S., Gatter, K. C., & Harris, A. L. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605904 · Cited by 168

Chapter 2 Methods for Monitoring Autophagy Using GFP‐LC3 Transgenic Mice

Mizushima, N. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03602-1 · Cited by 161

A mosquito salivary protein promotes flavivirus transmission by activation of autophagy

Sun, P., Nie, K., Zhu, Y., Liu, Y., Wu, P., Liu, Z., Du, S., Fan, H., Chen, C., Zhang, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14115-z · Cited by 163

Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells

Chen, Y., Yang, L., Feng, C., & Wen, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.018 · Cited by 161

Autophagy limits activation of the inflammasomes

Takahama, M., Akira, S., & Saitoh, T. (2017) · Immunological Reviews · doi:10.1111/imr.12613 · Cited by 163

MIR181Aregulates starvation- and rapamycin-induced autophagy through targeting ofATG5

Tekirdağ, K. A., Korkmaz, G., Öztürk, D. G., Agami, R., & Gözüaçık, D. (2013) · Autophagy · doi:10.4161/auto.23117 · Cited by 161

Human immunodeficiency virus type-1 infection inhibits autophagy

Zhou, D., & Spector, S. A. (2008) · AIDS · doi:10.1097/qad.0b013e3282f4a836 · Cited by 157

Diet, Autophagy, and Cancer: A Review

Singletary, K. W., & Milner, J. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2917 · Cited by 160

The role of autophagy in hepatocellular carcinoma: friend or foe

Liu, L., Liao, J., He, X., & Li, P. (2017) · Oncotarget · doi:10.18632/oncotarget.17202 · Cited by 158

New Insights into the Mechanisms of Macroautophagy in Mammalian Cells

Eskelinen, E. (2008) · International review of cytology · doi:10.1016/s1937-6448(07)66005-5 · Cited by 161

Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection

Niu, H., Xiong, Q., Yamamoto, A., Hayashi, M., & Rikihisa, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218674109 · Cited by 161

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

Kim, M. S., Jeong, E. G., Ahn, C. H., Kim, S. S., Lee, S. H., & Yoo, N. J. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.11.013 · Cited by 166

Autophagy—A double‐edged sword in oncology

Apel, A., Zentgraf, H., Büchler, M. W., & Herr, I. (2009) · International Journal of Cancer · doi:10.1002/ijc.24500 · Cited by 162

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity

Cicchini, M., Chakrabarti, R., Kongara, S., Price, S. M., Nahar, R., Lozy, F., Zhong, H., Vázquez, A., Kang, Y., & Karantza, V. (2014) · Autophagy · doi:10.4161/auto.34398 · Cited by 159

TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation

Chuang, S.-Y., Yang, C.-H., Chou, C.-C., Chiang, Y.-P., Chuang, T., & Hsu, L.-C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306556110 · Cited by 153

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

Park, J. M., Huang, S., Wu, T., Foster, N. R., & Sinicrope, F. A. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.22954 · Cited by 157

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 154

The role of autophagy induced by tumor microenvironment in different cells and stages of cancer

Yang, X. F., Yu, D., Yan, F., Jing, Y., Han, Z., Sun, K., Liang, L., Hou, J., & Wei, L. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0005-2 · Cited by 155

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

Qin, W., Li, C., Zheng, W., Guo, Q., Zhang, Y., Kang, M., Zhang, B., Yang, B., Li, B., Yang, H., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5674 · Cited by 159

Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization

Pérez-Hernández, M., Arias, A., Martínez‐García, D., Pérez‐Tomás, R., Quesada, R., & Soto‐Cerrato, V. (2019) · Cancers · doi:10.3390/cancers11101599 · Cited by 158

Autophagy protects the retina from light-induced degeneration

Chen, Y., Sawada, O., Kohno, H., Le, Y.-Z., Subauste, C., Maeda, T., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439935 · Cited by 152

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

Haspel, J., Shaik, R. S., Ifedigbo, E., Nakahira, K., Dolinay, T., Englert, J. A., & Choi, A. M. K. (2011) · Autophagy · doi:10.4161/auto.7.6.15100 · Cited by 152

BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

Kim, Y., Kim, Y.-S., Kim, D., Lee, J. S., Song, J. H., Kim, H., Cho, D., Jeong, S., Jin, D., Jang, S. J., et al. (2013) · Autophagy · doi:10.4161/auto.26308 · Cited by 154

Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

Carew, J. S., Espitia, C. M., Esquivel, J., Mahalingam, D., Kelly, K. R., Reddy, G., Giles, F. J., & Nawrocki, S. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.151324 · Cited by 153

Autophagy as a target for cancer therapy: new developments

Nawrocki, S. T., Carew, & Kelly, K. (2012) · Cancer Management and Research · doi:10.2147/cmar.s26133 · Cited by 156

Autophagy: More Than a Nonselective Pathway

Reggiori, F., Komatsu, M., Finley, K. D., & Simonsen, A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/219625 · Cited by 161

Autophagy Signaling and the Cogwheels of Cancer

Botti, J., Djavaheri‐Mergny, M., Pilatte, Y., & Codogno, P. (2006) · Autophagy · doi:10.4161/auto.2.2.2458 · Cited by 154

Programmed Cell Death Pathways and Current Antitumor Targets

Tan, M., Ooi, J. P., Ismail, N. I., Moad, A. I. H., & Muhammad, T. S. T. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9895-1 · Cited by 156

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

He, C., Wei, Y., Sun, K., Li, B., Dong, X., Zou, Z., Liu, Y., Kinch, L. N., Khan, S., Sinha, S. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.035 · Cited by 161

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1

Li, H., Wang, P., Sun, Q., Ding, W.-X., Yin, X.-M., Sobol, R. W., Stolz, D. B., Yu, J., & Zhang, L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4475 · Cited by 150

Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells

Ganesan, A. K., Ho, H., Bodemann, B. O., Petersen, S., Aruri, J., Koshy, S., Richardson, Z., Le, L. Q., Krasieva, T. B., Roth, M. G., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000298 · Cited by 152

Autophagy in kidney disease and aging: lessons from rodent models

Lenoir, O., Tharaux, P., & Huber, T. B. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.014 · Cited by 156

Autophagy in Kidney Disease

Choi, M. E. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034658 · Cited by 152

Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

Iwamaru, A., Kondo, Y., Iwado, E., Aoki, H., Fujiwara, K., Yokoyama, T., Mills, G. B., & Kondo, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209992 · Cited by 149

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y., Levine, B., & Kritzer, J. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b01698 · Cited by 148

TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

Seillier, M., Peuget, S., Gayet, O., Gauthier, C., N’guessan, P., Monte, M., Carrier, A., Iovanna, J., & Dusetti, N. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.30 · Cited by 152

Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment

Tsai, K. K. C., Chuang, E. Y.-Y., Little, J. B., & Yuan, Z.-M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0703 · Cited by 145

Autophagy supports genomic stability by degrading retrotransposon RNA

Guo, H., Chitiprolu, M., GAGNON, D. R., Meng, L., Perez‐Iratxeta, C., Lagace, D. C., & Gibbings, D. (2014) · Nature Communications · doi:10.1038/ncomms6276 · Cited by 154

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T., & He, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.032 · Cited by 144

Autophagy and the degradation of mitochondria

Goldman, S. J., Taylor, R., Zhang, Y., & Jin, S. V. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.01.005 · Cited by 147

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

Desai, S., Liu, Z., Yao, J., Patel, N., Chen, J., Wu, Y., Ahn, E.-Y. E., Fodstad, Ø., & Tan, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422071 · Cited by 149

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143

The cell biology of autophagy in metazoans: a developing story

Meléndez, A., & Neufeld, T. P. (2008) · Development · doi:10.1242/dev.016105 · Cited by 145

Mitochondrial Autophagy Promotes Cellular Injury in Nephropathic Cystinosis

Sansanwal, P., Yen, B. T. S., Gahl, W. A., Ma, Y., Ying, L., Wong, L. C., & Sarwal, M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009040383 · Cited by 144

The cellular decision between apoptosis and autophagy

Fan, Y., & Zong, W. (2012) · 癌症：英文版 · doi:10.5732/cjc.012.10106 · Cited by 142

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

Huang, X., Bai, H., Chen, L., Li, B., & Lu, Y. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2010.03.051 · Cited by 145

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

Wang, Y., Lin, Y., Qiao, Z., An, H., Qiao, S., Wang, L., Rajapaksha, R. P. Y. J., & Wang, H. (2015) · Advanced Materials · doi:10.1002/adma.201405926 · Cited by 141

Autophagy Roles in the Modulation of DNA Repair Pathways

Gomes, L., Menck, C. F. M., & Leandro, G. D. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112351 · Cited by 147

SCD1, autophagy and cancer: implications for therapy

Ascenzi, F., Vitis, C. D., Maugeri‐Saccà, M., Napoli, C., Ciliberto, G., & Mancini, R. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02067-6 · Cited by 143

Conversation between apoptosis and autophagy: “Is it your turn or mine?”

Giansanti, V., Torriglia, A., & Scovassi, A. I. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0589-x · Cited by 147

Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions

Miracco, C., Cevenini, G., Franchi, A., Luzi, P., Cosci, E., Mourmouras, V., Monciatti, I., Mannucci, S., Biagioli, M., Toscano, M., et al. (2010) · Human Pathology · doi:10.1016/j.humpath.2009.09.004 · Cited by 139

Autophagy: Emerging roles in lipid homeostasis and metabolic control

Christian, P., Sacco, J., & Adeli, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.009 · Cited by 139

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

Sheng, Z., Ma, L., Sun, J. E., Zhu, L. J., & Green, M. R. (2011) · Blood · doi:10.1182/blood-2010-12-322537 · Cited by 139

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

Kumar, D., Shankar, S., & Srivastava, R. K. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-171 · Cited by 141

VPS34 complexes from a structural perspective

Ohashi, Y., Tremel, S., & Williams, R. L. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r089490 · Cited by 147

Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations

Towers, C. G., Wodetzki, D., & Thorburn, A. M. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201909033 · Cited by 142

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Buqué, A., Bloy, N., Perez-Lanzón, M., Iribarren, K., Humeau, J., Pol, J. G., Levesque, S., Mondragon, L., Yamazaki, T., Sato, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17644-0 · Cited by 138

Role of Autophagy in Breast Cancer

Karantza, V., & White, E. (2007) · Autophagy · doi:10.4161/auto.4867 · Cited by 141

Autophagy modulation for cancer therapy

Yang, Z. J., Chee, C. E., Huang, S., & Sinicrope, F. A. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14663 · Cited by 140

Autophagy and Tumorigenesis

Roy, S., & Debnath, J. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0213-0 · Cited by 146

PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression

Luo, T., Fu, J., Xu, A., Su, B., Ren, Y., Li, N., Zhu, J., Zhao, X., Dai, R., Cao, J., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1034405 · Cited by 139

Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma

Jl, L., Chen, F.-F., Lung, J., Lo, C.-H., Lee, F., Lu, Y.-C., & Hung, C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.355 · Cited by 139

An IFN-γ–stimulated ATF6–C/EBP-β–signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy

Gade, P., Ramachandran, G., Maachani, U. B., Rizzo, M. A., Okada, T., Prywes, R., Cross, A. S., Mori, K., & Kalvakolanu, D. V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119273109 · Cited by 137

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

Panda, P. K., Mukhopadhyay, S., Das, D. N., Sinha, N., Naik, P. P., & Bhutia, S. K. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.013 · Cited by 141

TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradation

Wu, H., Lu, X.-X., Wang, J., Yang, T., Li, X., He, X., Li, Y., Ye, W.-L., Wu, Y., Gan, W.-J., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1586250 · Cited by 139

Autophagy and Cancer Metabolism

Goldsmith, J., Levine, B., & Debnath, J. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00002-9 · Cited by 139

Recent advances in targeting autophagy in cancer

Jain, V., Singh, M. P., & Amaravadi, R. K. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.003 · Cited by 142

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

Son, Y., Wang, X., Hitron, J. A., Zhang, Z., Cheng, S., Budhraja, A., Ding, S., Lee, J., & Shi, X. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.06.024 · Cited by 136

Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death

Kanno, H., Ozawa, H., Sekiguchi, A., & Itoi, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.009 · Cited by 135

XIAP inhibits autophagy via XIAP‐Mdm2‐p53 signalling

Huang, X., Wu, Z., Mei, Y., & Wu, M. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.133 · Cited by 138

Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches

Zhang, J. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.003 · Cited by 141

Autophagy and Non-Alcoholic Fatty Liver Disease

Lavallard, V., & Gual, P. (2014) · BioMed Research International · doi:10.1155/2014/120179 · Cited by 138

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

Goussetis, D. J., Gounaris, E. G., Wu, E. J., Vakana, E., Sharma, B., Bogyo, M. S., Altman, J. K., & Platanias, L. C. (2012) · Blood · doi:10.1182/blood-2012-01-402578 · Cited by 144

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2 -Associated Hereditary Breast Cancer

Huo, Y., Cai, H., Teplova, I., Bowman-Colin, C., Chen, G., Price, S. M., Barnard, N., Ganesan, S., Karantza, V., White, E., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0011 · Cited by 135

Molecular targets of celastrol in cancer: Recent trends and advancements

Kashyap, D., Sharma, A. K., Tuli, H. S., Sak, K., Mukherjee, T. K., & Bishayee, A. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.05.019 · Cited by 132

Triterpenes FromGanoderma LucidumInduce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)

Thyagarajan‐Sahu, A., Jedinak, A., Nguyen, H. V., Terry, C. L., Baldridge, L. A., Jiang, J., & Slíva, D. (2010) · Nutrition and Cancer · doi:10.1080/01635580903532390 · Cited by 131

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer

Ichimura, Y., & Komatsu, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00210 · Cited by 132

Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Cocco, S., Leone, A., Roca, M. S., Lombardi, R., Piezzo, M., Caputo, R., Ciardiello, C., Costantini, S., Bruzzese, F., Sisalli, M. J., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03462-z · Cited by 132

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

Zhang, J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i34.4281 · Cited by 130

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

Lee, S., Kim, H.-P., Jin, Y., Choi, A. M. K., & Ryter, S. W. (2011) · Autophagy · doi:10.4161/auto.7.8.15598 · Cited by 130

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Tang, H., Sebti, S., Titone, R., Zhou, Y., Isidoro, C., Ross, T. S., Hibshoosh, H. H., Xiao, G., Packer, M., Xie, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.01.008 · Cited by 131

Autophagy - An Emerging Anti-Aging Mechanism?

Hansen, M. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-006 · Cited by 131

The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells

Gao, P., Bauvy, C., Souquère, S., Tonelli, G., Liu, L., Zhu, Y., Qiao, Z., Bakula, D., Proikas‐Cezanne, T., Pierron, G., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118125 · Cited by 132

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

Young, J. E., Martinez, R. A., & Spada, A. R. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806088200 · Cited by 132

The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone

Yazdankhah, M., Vecchioli, S. F., Tonchev, A. B., Stoykova, A., & Cecconi, F. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.358 · Cited by 133

Increased autophagy blocks HER2-mediated breast tumorigenesis

Vega-Rubín-de-Celis, S., Zou, Z., Fernández, Á. F., Ci, B., Kim, M., Xiao, G., Xie, Y., & Levine, B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717800115 · Cited by 131

Single-Cell RNA Transcriptome Helps Define the Limbal/Corneal Epithelial Stem/Early Transit Amplifying Cells and How Autophagy Affects This Population

Kaplan, N., Wang, J., Wray, B. D., Patel, P. A., Yang, W., Peng, H., & Lavker, R. M. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27656 · Cited by 128

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

The role of Beclin 1 interacting proteins and Beclin 1 post-translational modification in autophagy regulation.

Baerga, R., Kalkum, M., & Jin, C. (2007) · Cancer Research

New Insights Into Beclin-1: Evolution and Pan-Malignancy Inhibitor Activity

Wechman, S. L., Pradhan, A. K., DeSalle, R., Das, S. K., Emdad, L., Sarkar, D., & Fisher, P. B. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.11.002 · Cited by 24

Ambra1 is a novel autophagy tumour suppressor gene

Fuoco, C. (2010) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/fuoco-claudia_phd2010