Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Mutation and cancer: statistical study of retinoblastoma

Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Stereological Principles for Morphometry in Electron Microscopic Cytology

Weibel, E. R. (1969) · International review of cytology · doi:10.1016/s0074-7696(08)61637-x · Cited by 1,932

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,303

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

Petiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

Carreira, R., Lee, Y., Ghochani, M., Gustafsson, Å. B., & Gottlieb, R. A. (2010) · Autophagy · doi:10.4161/auto.6.4.11553 · Cited by 131

Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling

Henry, W. S., Laszewski, T., Tsang, T., de Beça, F. F., Beck, A. H., McAllister, S. S., & Toker, A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-2400 · Cited by 127

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

Lim, S. M., Hanif, E. A. M., & Chin, S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00570-z · Cited by 138

Autophagy in health and disease: From molecular mechanisms to therapeutic target

Lu, G. X., Wang, Y., Shi, Y. P., Zhang, Z., Huang, C., He, W., Wang, C., & Shen, H. (2022) · MedComm · doi:10.1002/mco2.150 · Cited by 135

Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice

Li, Y., Lei, Z., Ritzel, R. M., He, J., Li, H., Choi, H., Lipinski, M. M., & Wu, J. (2022) · Theranostics · doi:10.7150/thno.72713 · Cited by 131

Ceramide induced mitophagy and tumor suppression

Dany, M., & Öğretmen, B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.12.039 · Cited by 130

Lectin of Concanavalin A as an anti-hepatoma therapeutic agent

Lei, H.-Y., & Chang, C. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-10 · Cited by 128

Endothelial Nitric-oxide Synthase Antisense (NOS3AS) Gene Encodes an Autophagy-related Protein (APG9-like2) Highly Expressed in Trophoblast

Yamada, T., Carson, A. R., Caniggia, I., Umebayashi, K., Yoshimori, T., Nakabayashi, K., & Scherer, S. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413957200 · Cited by 133

Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence

Peralta, E. R., Martin, B. C., & Edinger, A. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.111633 · Cited by 132

EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

Colella, B., Faienza, F., & Bartolomeo, S. D. (2019) · Cancers · doi:10.3390/cancers11030312 · Cited by 128

Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

Zhou, S., Zhao, L., Kuang, M., Zhang, B., Liang, Z., Yi, T., Wei, Y., & Zhao, X. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.02.017 · Cited by 125

High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer

Zhao, H., Yang, M., Zhao, J., Wang, J., Zhang, Y., & Zhang, Q. (2013) · Medical Oncology · doi:10.1007/s12032-013-0475-1 · Cited by 123

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. H., & Batra, S. K. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.02.003 · Cited by 127

SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors

Sun, Q., Xing, X., Wang, H., Wan, K., Fan, R., Liu, C., Wang, Y., Wu, W., Wang, Y., & Wang, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115586 · Cited by 125

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

Hamurcu, Z., Delibaşı, N., Geçene, S., Şener, E. F., Dönmez‐Altuntaş, H., Özkul, Y., Canatan, H., & Özpolat, B. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2557-5 · Cited by 125

Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy

Moretti, L., Yang, E. S.-H., Kim, K. W., & Lu, J. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.05.001 · Cited by 124

Apoptosis and autophagy: Targeting autophagy signalling in cancer cells –‘trick or treats’?

Corcelle–Termeau, E., Puustinen, P., & Jäättelä, M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07332.x · Cited by 124

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

Wu, L., Zhang, Y., Zhang, C., Cui, X., Zhai, S., Liu, Y., Li, C., Zhu, H., Qu, G., Jiang, G., et al. (2014) · ACS Nano · doi:10.1021/nn500376w · Cited by 121

Autophagy in the Lung

Ryter, S. W., & Choi, A. M. K. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-101js · Cited by 122

Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells

Sun, K., Deng, W.-J., Zhang, S., Cai, N., Jiao, S., Song, J., & Wei, L. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-35 · Cited by 123

Autophagy paradox and ceramide

Jiang, W., & Öğretmen, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.005 · Cited by 123

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

Jutten, B., & Rouschop, K. M. A. (2013) · Cell Cycle · doi:10.4161/cc.27518 · Cited by 121

Metallomics insights into the programmed cell death induced by metal-based anticancer compounds

Tan, C., Lu, Y., Ji, L., & Mao, Z. (2014) · Metallomics · doi:10.1039/c3mt00225j · Cited by 125

Autophagy in tumour cell death

Macintosh, R. L., & Ryan, K. M. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.006 · Cited by 122

SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

Lv, Y., Zhang, W., Zhao, J., Sun, B., Qi, Y., Ji, H., Chen, C., Zhang, J., Sheng, J., Wang, T., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00495-6 · Cited by 122

Senescent Keratinocytes Die by Autophagic Programmed Cell Death

Gosselin, K., Deruy, E., Martien, S., Vercamer, C., Bouali, F., Dujardin, T., Slomianny, C., Houel-Renault, L., Chelli, F., De Launoit, Y., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080332 · Cited by 119

Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis

Tian, Y., Kuo, C.-F., Sir, D., Wang, L., Govindarajan, S., Petrovic, L. M., & Ou, J.-H. J. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.201 · Cited by 122

Oxidative Stress in Cancer Therapy: Friend or Enemy?

Azmanova, M., & Pitto‐Barry, A. (2022) · ChemBioChem · doi:10.1002/cbic.202100641 · Cited by 123

The Vacuolar Transporter Chaperone (VTC) Complex Is Required for Microautophagy

Uttenweiler, A., Schwarz, H., Neumann, H., & Mayer, A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0664 · Cited by 122

Intersections between Regulated Cell Death and Autophagy

Napoletano, F., Baron, O., Vandenabeele, P., Mollereau, B., & Fanto, M. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.12.007 · Cited by 120

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

Ladoire, S., Enot, D., Senovilla, L., Ghiringhelli, F., Poirier-Colame, V., Chaba, K., Semeraro, M., Chaix, M., Penault-Llorca, F., Arnould, L., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1154244 · Cited by 117

The RB-E2F1 Pathway Regulates Autophagy

Jiang, H., Martín, V., Gomez‐Manzano, C., Johnson, D. G., Alonso, M. M., White, E. J., Xu, J., McDonnell, T. J., Shinojima, N., & Fueyo-Margareto, J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1604 · Cited by 122

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

Hennig, P., Fenini, G., Filippo, M. D., Karakaya, T., & Beer, H. (2021) · Biomedicines · doi:10.3390/biomedicines9070707 · Cited by 121

Autophagy and Hallmarks of Cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N. G., Feng, H., Hu, B., & Cheng, S. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018027913 · Cited by 120

Targeting Autophagy in Breast Cancer

Cocco, S., Leone, A., Piezzo, M., Caputo, R., Lauro, V. D., Rella, F. D., Fusco, G., Capozzi, M., Gioia, G. D., Budillon, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217836 · Cited by 120

DJ-1 Protects Dopaminergic Neurons against Rotenone-Induced Apoptosis by Enhancing ERK-Dependent Mitophagy

Gao, H., Yang, W., Qi, Z., Lu, L., Duan, C., Zhao, C., & Yang, H. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.06.034 · Cited by 117

The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets

Cui, J., Gong, Z., & Shen, H. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.02.003 · Cited by 116

Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

Fujimoto, K., Hanson, P. T., Tran, H. D., Ford, E. L., Han, Z., Johnson, J. D., Schmidt, R. E., Green, K. G., Wice, B. M., & Polonsky, K. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041616 · Cited by 116

Molecular Pathways: Autophagy in Cancer—A Matter of Timing and Context

Cicchini, M., Karantza, V., & Xia, B. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2438 · Cited by 118

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

Ke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020300 · Cited by 117

p62/SQSTM1 synergizes with autophagy for tumor growth in vivoPreprint

Wei, H., Wang, C., Croce, C. M., & Guan, J. (2014) · Genes & Development · doi:10.1101/gad.237354.113 · Cited by 120

Macroautophagy versus mitochondrial autophagy: a question of fate?

Kundu, M., & Thompson, C. B. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401780 · Cited by 118

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

Riehle, C., Wende, A. R., Sena, S., Pires, K. M., Pereira, R. O., Zhu, Y., Bugger, H., Frank, D., Bevins, J., Chen, D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71171 · Cited by 114

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans

Ruck, A., Attonito, J., Garces, K. T., Nuñez, L., Palmisano, N. J., Rubel, Z., Bai, Z., Nguyen, K. C. Q., Sun, L., Grant, B. D., et al. (2011) · Autophagy · doi:10.4161/auto.7.4.14391 · Cited by 115

To be or not to be, the level of autophagy is the question: Dual roles of autophagy in the survival response to starvation

Kang, C., & Avery, L. (2008) · Autophagy · doi:10.4161/auto.5154 · Cited by 115

Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy

Ding, W., Ni, H., Gao, W., Chen, X., Kang, J. H., Stolz, D. B., Liu, J., & Yin, X. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1169 · Cited by 117

Targeting cancer cells through autophagy for anticancer therapy

Turcotte, S., & Giaccia, A. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.007 · Cited by 116

Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer.

Cao, Q.-H., Liu, F., Yang, Z. L., Fu, X., Yang, Z., Liu, Q., Wang, L., Wan, X., & Fan, X. (2016) · PubMed Central · Cited by 114

At a glance: A history of autophagy and cancer

Wen, X., & Klionsky, D. J. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.11.005 · Cited by 116

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders

Kaur, S., & Changotra, H. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.025 · Cited by 116

BECN1 is involved in the initiation of mitophagy

Choubey, V., Cagalinec, M., Liiv, J., Safiulina, D., Hickey, M. A., Kuum, M., Liiv, M., Anwar, T., Eskelinen, E., & Kaasik, A. (2014) · Autophagy · doi:10.4161/auto.28615 · Cited by 117

Amino acid management in cancer

Tsun, Z.-Y., & Possemato, R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.002 · Cited by 120

Targeting autophagy in cancer management – strategies and developments

Özpolat, B., & Benbrook, D. M. (2015) · Cancer Management and Research · doi:10.2147/cmar.s34859 · Cited by 116

Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer

Ladoire, S., Penault-Llorca, F. M., Senovilla, L., Dalban, C., Enot, D. P., Locher, C., Prada, N., Poirier-Colame, V., Chaba, K., Arnould, L., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1082022 · Cited by 116

Novel Insights into the Interplay between Apoptosis and Autophagy

Rikiishi, H. (2012) · International Journal of Cell Biology · doi:10.1155/2012/317645 · Cited by 117

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

Belaïd, A., Cerezo, M., Chargui, A., Corcelle–Termeau, E., Pédeutour, F., Giuliano, S., Ilié, M., Rubera, I., Tauc, M., Barale, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4142 · Cited by 119

A Role for Autophagic Protein Beclin 1 Early in Lymphocyte Development

Arsov, I., Adebayo, A., Kučerová-Levisohn, M., Haye, J. E., MacNeil, M. A., Papavasiliou, F. N., Yue, Z., & Ortiz, B. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002223 · Cited by 119

Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression

Guo, J., Wu, Y., Du, J., Yang, L., Chen, W., Gong, K., Dai, J., Miao, S., Jin, D., & Xi, S. (2018) · Oncogenesis · doi:10.1038/s41389-018-0054-6 · Cited by 115

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis

Dang, S., Xu, H., Xu, C., Cai, W., Li, Q., Cheng, Y., Jin, M., Wang, R., Peng, Y., Zhang, Y., et al. (2014) · Autophagy · doi:10.4161/auto.28771 · Cited by 115

High glucose induces autophagy in podocytes

Ma, T., Zhu, J., Chen, X., Zha, D., Singhal, P. C., & Ding, G. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.01.018 · Cited by 113

An emerging role of PARK2 in cancer

Xu, L., Lin, D., Yin, D., & Koeffler, H. P. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1107-0 · Cited by 114

Autophagy in inflammation, infection, neurodegeneration and cancer

Arroyo, D. S., Gaviglio, E. A., Ramos, J. M. P., Bussi, C., Rodriguez‐Galán, M. C., & Iribarren, P. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.11.001 · Cited by 114

Statin‐induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells

Parikh, A. R., Childress, C., Deitrick, K., Lin, Q., Rukstalis, D. B., & Yang, W. (2010) · The Prostate · doi:10.1002/pros.21131 · Cited by 114

Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal

Yu, S.-W., Baek, S., Brennan, R. T., Bradley, C. J., Park, S. K., Lee, Y. S., Jun, E. J., Lookingland, K. J., Kim, E. K., Lee, H., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0153 · Cited by 120

Autophagy as a basis for the health-promoting effects of vitamin D

Høyer-Hansen, M. H., Nordbrandt, S. P. S., & Jäättelä, M. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.005 · Cited by 116

Regulation of Beclin 1 in autophagy

Sun, Q., Fan, W., & Zhong, Q. (2009) · Autophagy · doi:10.4161/auto.5.5.8524 · Cited by 114

Selective Autophagy: Talking with the UPS

Park, C., & Cuervo, A. M. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9623-7 · Cited by 118

p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome

Ryan, K. M. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.10.020 · Cited by 114

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

Salem, A. F., Whitaker‐Menezes, D., Zhao, L., Martinez‐Outschoorn, U., Tanowitz, H. B., Zoubi, M. S. A., Howell, A., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2012) · Cell Cycle · doi:10.4161/cc.20920 · Cited by 113

Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor

Gawriluk, T. R., Ko, C. J., Hong, X., Christenson, L. K., & Rucker, E. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409323111 · Cited by 113

A perspective on the role of autophagy in cancer

Ariosa, A., Lahiri, V., Lei, Y., Yang, Y., Yin, Z., Zhang, Z., & Klionsky, D. J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166262 · Cited by 115

ER Stress Signaling and the BCL-2 Family of Proteins: From Adaptation to Irreversible Cellular Damage

Hetz, C. A. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1793 · Cited by 113

ANG II promotes autophagy in podocytes

Yadav, A., Vallabu, S., Arora, S., Tandon, P., Slahan, D., Teichberg, S., & Singhal, P. C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00424.2009 · Cited by 111

Autophagy, Prion Infection and their Mutual Interactions

Heiseke, A., Aguib, Y., & Schätzl, H. M. (2010) · Caister Academic Press eBooks · doi:10.21775/9781912530076.03 · Cited by 110

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis

Qiang, L., Sample, A., Shea, C. R., Soltani, K., Macleod, K. F., & He, Y. (2017) · Autophagy · doi:10.1080/15548627.2017.1380757 · Cited by 111

Inhibition of autophagy impairs tumor cell invasion in an organotypic model

Macintosh, R. L., Timpson, P., Thorburn, J., Anderson, K. I., Thorburn, A. M., & Ryan, K. M. (2012) · Cell Cycle · doi:10.4161/cc.20424 · Cited by 115

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.373 · Cited by 109

Autophagic pathways as new targets for cancer drug development

Liu, B., Cheng, Y., Liu, Q., Bao, J., & Yang, J. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.118 · Cited by 109

Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer

Won, K. Y., Kim, G. Y., Kim, Y. W., Song, J. Y., & Lim, S. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.07.006 · Cited by 109

Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes

Trincheri, N. F., Follo, C., Nicotra, G., Peracchio, C., Castino, R., & Isidoro, C. (2008) · Carcinogenesis · doi:10.1093/carcin/bgm271 · Cited by 109

p53-Dependent and p53-Independent Activation of Autophagy by ARF

Abida, W. M., & Gu, W. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2069 · Cited by 109

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Cassidy, L. D., Young, A. R. J., Young, C. N. J., Soilleux, E. J., Fielder, E., Weigand, B. M., Lagnado, A., Brais, R., Ktistakis, N. T., Wiggins, K. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14187-x · Cited by 108

Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila

Shravage, B. V., Hill, J. H., Powers, C. M., Wu, L. P., & Baehrecke, E. H. (2013) · Development · doi:10.1242/dev.089490 · Cited by 108

Fine Structure of the Autophagosome

Eskelinen, E. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_2 · Cited by 110

Autophagy: Supporting cellular and organismal homeostasis by self-eating

Eskelinen, E. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.03.010 · Cited by 110

Altered Ca2+ signaling in cancer cells: Proto-oncogenes and tumor suppressors targeting IP3 receptors

Akl, H., & Bultynck, G. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.12.001 · Cited by 110

The Role of Beclin 1-Dependent Autophagy in Cancer

Vega-Rubín-de-Celis, S. (2019) · Biology · doi:10.3390/biology9010004 · Cited by 109

Autophagy in ageing and ageing-associated diseases

He, L., Lu, J., & Yue, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.188 · Cited by 107

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

Huang, G.-M., Jiang, Q., Cai, C., Qu, M., & Shen, W. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.036 · Cited by 106

Regulation and function of mitophagy in development and cancer

Lu, H., Li, G., Liu, L., Feng, L., Wang, X., & Jin, H. (2013) · Autophagy · doi:10.4161/auto.26550 · Cited by 107

Autophagy and NF-κB: Fight for fate

Xiao, G. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.04.006 · Cited by 107

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy

Zeng, X., & Kinsella, T. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6163 · Cited by 94

Selective Inactivation of a Fas-associated Death Domain Protein (FADD)-dependent Apoptosis and Autophagy Pathway in Immortal Epithelial Cells

Thorburn, J., Moore, F., Rao, A., Barclay, W. W., Thomas, L. R., Grant, K., Cramer, S. D., & Thorburn, A. M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0906 · Cited by 107

mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells

Yang, X., Zhong, X., Tanyi, J. L., Shen, J., Xu, C., Gao, P., Zheng, T. M., DeMichele, A. M., & Zhang, L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.083 · Cited by 105

Induction of macroautophagy by exogenously introduced calcium

Gao, W., Ding, W., Stolz, D. B., & Yin, X. (2008) · Autophagy · doi:10.4161/auto.6360 · Cited by 106

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L. B., & Levine, B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020478118 · Cited by 104

Oncosuppressive Functions of Autophagy

Morselli, E., Galluzzi, L., Kepp, O., Mariño, G., Michaud, M., Vitale, I., Maiuri, M. C., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3478 · Cited by 112

T-cell death and cancer immune tolerance

Lu, B., & Finn, O. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402274 · Cited by 106

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

Nobukuni, T., Kozma, S. C., & Thomas, G. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.019 · Cited by 105

Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity

Furuya, D., Tsuji, N., Yagihashi, A., & Watanabe, N. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.02.023 · Cited by 105

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

The role of Beclin 1 interacting proteins and Beclin 1 post-translational modification in autophagy regulation.

Baerga, R., Kalkum, M., & Jin, C. (2007) · Cancer Research

New Insights Into Beclin-1: Evolution and Pan-Malignancy Inhibitor Activity

Wechman, S. L., Pradhan, A. K., DeSalle, R., Das, S. K., Emdad, L., Sarkar, D., & Fisher, P. B. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.11.002 · Cited by 24

Ambra1 is a novel autophagy tumour suppressor gene

Fuoco, C. (2010) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/fuoco-claudia_phd2010