The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
Open accessAbstract
Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (BMSSCs). The mechanism involved in the impaired differentiation of BMSSCs is due, at least partially, to the overactivated TGF-beta/Smad2 signaling pathway and the upregulated expressions of p53 and p21 along with the downregulated expressions of Cdk2 and Cdc2, and ultimately increased replicative senescence. In addition, the overactivated TGF-beta/Smad2 signaling may result in the compromised Runx2/Cbfa1 expression in preosteoblasts. Furthermore, we demonstrate that caspase-3 inhibitor, a potential agent for clinical treatment of human diseases, caused accelerated bone loss in ovariectomized mice, which is also associated with the overactivated TGF-beta/Smad2 signaling in BMSSCs. This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-beta/Smad2 pathway and cell cycle progression.
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
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“Bisphosphonates and calcitonin, commonly used as therapeutic drugs for osteoporosis, can also inhibit apoptosis of osteocyte and osteoblast (18).”
BackgroundEstrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
Cenci, S., Weitzmann, M. N., Roggia, C., Namba, N., Novack, D., Woodring, J., & Pacifici, R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11066 · Cited by 705
High glucose-induced replicative senescence: point of no return and effect of telomerase
Blazer, S., Khankin, E., Segev, Y., Ofir, R., Yalon-Hacohen, M., Kra-Oz, Z., Gottfried, Y., Larisch, S., & Skorecki, K. L. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00818-5 · Cited by 113
Caspase 3 Deficiency Rescues Peripheral Nervous System Defect in Retinoblastoma Nullizygous Mice
Simpson, M. T. W., MacLaurin, J. G., Xu, D., Ferguson, K. L., Vanderluit, J. L., Davoli, M. A., Roy, S., Nicholson, D. W., Robertson, G. S., Park, D. S., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07089.2001 · Cited by 35
Cited by
Old, new and emerging functions of caspases
Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.216 · Cited by 1,267
Caspases in apoptosis and beyond
Li, J., & Yuan, J. (2008) · Oncogene · doi:10.1038/onc.2008.297 · Cited by 1,090
Sun, L., Akiyama, K., Zhang, H., Yamaza, T., Hou, Y., Zhao, S., Xu, T., Le, A., & Shi, S. (2009) · Stem Cells · doi:10.1002/stem.68 · Cited by 580
Self-citationMiura, M., Miura, Y., Padilla-Nash, H. M., Molinolo, A. A., Fu, B., Patel, V., Seo, B.-M., Sonoyama, W., Zheng, J. J., Baker, C. C., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0403 · Cited by 567
Self-citationOsteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue
Cardoso, L., Herman, B. C., Verborgt, O., Laudier, D., Majeska, R. J., & Schaffler, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081210 · Cited by 340
Metadata
- Authors
- Miura, M., Chen, X.-D., Allen, M. R., Bi, Y., Gronthos, S., Seo, B.-M., Lakhani, S., Flavell, R. A., Feng, X.-H., Robey, P. G., Young, M., & Shi, S.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-12-15
- Volume
- 114
- Issue
- 12
- Pages
- 1704-1713
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4231212060
- Cited by
- 262
- References
- 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miura, M., Chen, X.-D., Allen, M. R., Bi, Y., Gronthos, S., Seo, B.-M., Lakhani, S., Flavell, R. A., Feng, X.-H., Robey, P. G., Young, M., & Shi, S. (2004). A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci200420427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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