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Cited by 795

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

IL-1 mediates TNF-induced osteoclastogenesis

Open access
Wei, Shi, Kitaura, Hideki, Zhou, Ping, Ross, F. Patrick, Teitelbaum, Steven L.·2005·Journal of Clinical Investigation
DOI 10.1172/jci200523394
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Abstract

TNF-induced receptor activator NF-kappaB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. We found that this process was abolished by IL-1 receptor antagonist (IL-1Ra) or in stromal cells derived from type I IL-1 receptor-deficient (IL-1RI-deficient) mice. Reflecting sequential signaling of the cytokines TNF and IL-1, TNF induces stromal cell expression of IL-1 and IL-1RI. These data suggest that TNF regulates RANKL expression via IL-1, and, therefore, IL-1 plays a role in TNF-induced periarticular osteolysis. Consistent with this posture, TNF-stimulated osteoclastogenesis in cultures consisting of WT marrow macrophages and stromal cells exposed to IL-1Ra or in cocultures established with IL-1RI-deficient stromal cells was reduced approximately 50%. The same magnitude of osteoclast inhibition occurred in IL-1RI-deficient mice following TNF administration in vivo. Like TNF, IL-1 directly targeted osteoclast precursors and promoted the osteoclast phenotype in a TNF-independent manner in the presence of permissive levels of RANKL. IL-1 is able to induce RANKL expression by stromal cells and directly stimulate osteoclast precursor differentiation under the aegis of p38 MAPK. Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors.

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Research works printed but not linked: 21

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Metadata

Authors
Wei, S., Kitaura, H., Zhou, P., Ross, F. P., & Teitelbaum, S. L.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2005-01-20
Volume
115
Issue
2
Pages
282-290
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci200523394
OpenAlex
W1981803131
Cited by
795
References
6
FWCI
17.52
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: IL-1 mediates TNF-induced osteoclastogenesis. https://app.cochat.ai/papers/10.1172/jci200523394
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Wei, S., Kitaura, H., Zhou, P., Ross, F. P., & Teitelbaum, S. L. (2005). IL-1 mediates TNF-induced osteoclastogenesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci200523394

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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