The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Telomeres, stem cells, senescence, and cancer
Open accessAbstract
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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Creation of human tumour cells with defined genetic elements
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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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Cited by
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188
p53 ubiquitination: Mdm2 and beyond
Brooks, C. L., & Gu, W. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.020 · Cited by 924
Senescence and immortalization: Role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 610
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela, I., Cadiñanos, J., Pendás, A. M., Gutiérrez-Fernández, A., Folgueras, A. R., Sánchez, L. M., Zhou, Z., Rodríguez, F. J., Stewart, C. L., Vega, J. A., et al. (2005) · Nature · doi:10.1038/nature04019 · Cited by 466
Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448
Metadata
- Authors
- Sharpless, N. E., & DePinho, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-01-15
- Volume
- 113
- Issue
- 2
- Pages
- 160-168
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2093837468
- Cited by
- 473
- References
- 51
- FWCI
- 28.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
