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Cited by 1,295

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

Open access
Barber, A J, Lieth, E, Khin, S A, Antonetti, D A, Buchanan, A G, Gardner, T W·1998·Journal of Clinical Investigation
DOI 10.1172/jci2425
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Abstract

This study determined whether retinal degeneration during diabetes includes retinal neural cell apoptosis. Image analysis of retinal sections from streptozotocin (STZ) diabetic rats after 7.5 months of STZ diabetes identified 22% and 14% reductions in the thickness of the inner plexiform and inner nuclear layers, respectively (P < 0. 001). The number of surviving ganglion cells was also reduced by 10% compared to controls (P < 0.001). In situ end labeling of DNA terminal dUTP nick end labeling (TUNEL) identified a 10-fold increase in the frequency of retinal apoptosis in whole-mounted rat retinas after 1, 3, 6, and 12 months of diabetes (P < 0.001, P < 0. 001, P < 0.01, and P < 0.01, respectively). Most TUNEL-positive cells were not associated with blood vessels and did not colocalize with the endothelial cell-specific antigen, von Willebrand factor. Insulin implants significantly reduced the number of TUNEL-positive cells (P < 0.05). The number of TUNEL-positive cells was also increased in retinas from humans with diabetes. These data indicate that retinal neural cell death occurs early in diabetes. This is the first quantitative report of an increase in neural cell apoptosis in the retina during diabetes, and indicates that neurodegeneration is an important component of diabetic retinopathy.

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Metadata

Authors
Barber, A. J., Lieth, E., Khin, S. A., Antonetti, D. A., Buchanan, A. G., & Gardner, T. W.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1998-08-15
Volume
102
Issue
4
Pages
783-791
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci2425
OpenAlex
W1993968665
Cited by
1,295
References
39
FWCI
11.99
Type
journal article
Language
en
Open access
bronze

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