The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Inflammation in diabetic retinopathy
Open accessAbstract
Diabetes causes a number of metabolic and physiologic abnormalities in the retina, but which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is less clear. Many of the molecular and physiologic abnormalities that have been found to develop in the retina in diabetes are consistent with inflammation. Moreover, a number of anti-inflammatory therapies have been found to significantly inhibit development of different aspects of DR in animal models. Herein, we review the inflammatory mediators and their relationship to early and late DR, and discuss the potential of anti-inflammatory approaches to inhibit development of different stages of the retinopathy. We focus primarily on information derived from in vivo studies, supplementing with information from in vitro studies were important.
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Renal and retinal effects of enalapril and losartan in type 1 diabetes
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Para-Inflammation in the Aging Retina
Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · cited 1×
“Aging or hypertension in the absence of diabetes increase expression of proinflammatory molecules in the retina (Silva et al., 2007; Xu et al., 2009), yet these conditions do not cause a diabetic-like retinopathy.”
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Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function
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Cited by
Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Duh, E. J., Sun, J. K., & Stitt, A. W. (2017) · JCI Insight · doi:10.1172/jci.insight.93751 · Cited by 1,057
Role of Inflammation in Diabetic Retinopathy
Rübsam, A., Parikh, S., & Fort, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040942 · Cited by 750
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
Jun, J.-I., & Lau, L. F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3599 · Cited by 568
Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives
Simó, R., & Hernández, C. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.005 · Cited by 490
The pathology associated with diabetic retinopathy
Lechner, J., O'Leary, O. E., & Stitt, A. W. (2017) · Vision Research · doi:10.1016/j.visres.2017.04.003 · Cited by 474
Metadata
- Authors
- Tang, J., & Kern, T. S.
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 30
- Issue
- 5
- Pages
- 343-358
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2047640394
- Cited by
- 1,116
- References
- 8
- FWCI
- 35.75
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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