Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 877

The DOI matches its Crossref record.

Going both ways: Immune regulation via CD1d-dependent NKT cells

Open access
Godfrey, Dale I., Kronenberg, Mitchell·2004·Journal of Clinical Investigation
DOI 10.1172/jci200423594
Open this paper in CoChat — free account

Abstract

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. In stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen-presenting molecule CD1d, and they recognize glycolipid antigens rather than peptides. Moreover, they can either up- or downregulate immune responses by promoting the secretion of Th1, Th2, or immune regulatory cytokines. This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci200423594

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 124

  1. 10.1038/nri1309 · DOI · Paper page
  2. 10.1016/S0167-5699(00)01735-7 · DOI · Paper page
  3. Kronenberg, 2002, Nat. Rev. Immunol., 2, 557, 10.1038/nri854 · DOI · Paper page
  4. 10.1084/jem.180.3.1171 · DOI · Paper page
  5. 10.1084/jem.178.1.1 · DOI · Paper page
  6. 10.1084/jem.188.8.1521 · DOI · Paper page
  7. 10.1016/S0952-7915(02)00329-1 · DOI
  8. 10.1002/(SICI)1521-4141(199911)29:11<3768::AID-IMMU3768>3.0.CO;2-G · DOI · Paper page
  9. 10.1084/jem.192.5.741 · DOI · Paper page
  10. Eberl, 1999, J. Immunol., 162, 6410, 10.4049/jimmunol.162.11.6410 · DOI · Paper page
  11. 10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F · doi:10.1002/(sici)1521-4141(199908)29:08<2406::aid-immu2406>3.0.co;2-f
  12. 10.1084/jem.20011786 · DOI · Paper page
  13. Prussin, 1997, J. Immunol., 159, 5862, 10.4049/jimmunol.159.12.5862 · DOI
  14. Exley, 2002, J. Immunol., 168, 1519, 10.4049/jimmunol.168.4.1519 · doi:10.4049/jimmunol.168.4.1519
  15. Kenna, 2003, J. Immunol., 171, 1775, 10.4049/jimmunol.171.4.1775 · DOI · Paper page
  16. 10.1016/S0952-7915(00)00243-0 · doi:10.1016/s0952-7915(00)00243-0
  17. 10.2174/0929867043456115 · DOI
  18. 10.1111/j.1600-065X.1999.tb01304.x · DOI
  19. Sidobre, 2002, J. Immunol., 169, 1340, 10.4049/jimmunol.169.3.1340 · DOI
  20. Hammond, 2001, J. Immunol., 167, 1164, 10.4049/jimmunol.167.3.1164 · DOI
  21. 10.1084/jem.191.11.1895 · DOI · Paper page
  22. 10.1084/jem.20030446 · DOI · Paper page
  23. 10.1016/S1074-7613(03)00052-9 · DOI · Paper page
  24. 10.1126/science.283.5399.225 · doi:10.1126/science.283.5399.225
  25. 10.1074/jbc.M308089200 · DOI
  26. Ortaldo, 2004, J. Immunol., 172, 943, 10.4049/jimmunol.172.2.943 · DOI
  27. 10.1038/82698 · DOI · Paper page
  28. 10.1038/nri1028 · DOI · Paper page
  29. 10.1073/pnas.1332805100 · DOI
  30. 10.1084/jem.20030630 · DOI · Paper page
  31. Crowe, 2003, J. Immunol., 171, 4020, 10.4049/jimmunol.171.8.4020 · DOI · Paper page
  32. 10.1084/jem.20011908 · DOI · Paper page
  33. Wang, 2001, J. Leukoc. Biol., 69, 741, 10.1189/jlb.69.5.741 · DOI
  34. Wang, 1997, J. Immunol., 158, 2150, 10.4049/jimmunol.158.5.2150 · DOI
  35. 10.1084/jem.190.9.1215 · DOI · Paper page
  36. Sonoda, 2001, J. Immunol., 166, 42, 10.4049/jimmunol.166.1.42 · DOI · Paper page
  37. Nakamura, 2003, J. Immunol., 171, 1266, 10.4049/jimmunol.171.3.1266 · DOI
  38. 10.1073/pnas.1834479100 · DOI · Paper page
  39. Azuma, 2003, Cancer Res., 63, 4516
  40. Sonoda, 2002, J. Immunol., 168, 2028, 10.4049/jimmunol.168.4.2028 · DOI
  41. 10.1073/pnas.041608298 · doi:10.1073/pnas.041608298
  42. Higuchi, 2002, J. Immunol., 169, 5564, 10.4049/jimmunol.169.10.5564 · doi:10.4049/jimmunol.169.10.5564
  43. 10.1172/JCI8922 · DOI
  44. 10.1084/jem.189.7.1073 · doi:10.1084/jem.189.7.1073
  45. Lan, 2001, J. Immunol., 167, 2087, 10.4049/jimmunol.167.4.2087 · doi:10.4049/jimmunol.167.4.2087
  46. 10.1073/pnas.97.2.740 · DOI · Paper page
  47. 10.1034/j.1399-0039.2002.590501.x · DOI
  48. 10.1016/j.coi.2003.09.014 · DOI
  49. 10.2337/diabetes.46.4.572 · DOI
  50. 10.1084/jem.187.7.1047 · DOI · Paper page
  51. 10.1084/jem.188.10.1831 · DOI · Paper page
  52. 10.1093/intimm/13.7.887 · DOI
  53. 10.1038/nm0901-1052 · DOI · Paper page
  54. 10.1002/eji.1830261226 · DOI · Paper page
  55. 10.1084/jem.194.3.313 · DOI · Paper page
  56. 10.1038/nm0901-1057 · DOI · Paper page
  57. 10.1073/pnas.251531798 · DOI · Paper page
  58. 10.1016/S1074-7613(02)00473-9 · DOI · Paper page
  59. 10.1038/34419 · DOI · Paper page
  60. Kukreja, 2002, J. Clin. Invest., 109, 131, 10.1172/JCI0213605 · DOI · Paper page
  61. 10.2337/diacare.25.10.1818 · DOI
  62. Lee, 2002, J. Clin. Invest., 110, 793, 10.1172/JCI0215832 · DOI · Paper page
  63. 10.1046/j.1440-1711.2004.01238.x · DOI
  64. 10.1002/eji.200323885 · DOI
  65. 10.1084/jem.194.12.1789 · DOI · Paper page
  66. 10.1084/jem.194.12.1801 · DOI · Paper page
  67. Pal, 2001, J. Immunol., 166, 662, 10.4049/jimmunol.166.1.662 · DOI
  68. 10.1038/35097097 · DOI · Paper page
  69. 10.1002/art.11489 · DOI
  70. Stanic, 2003, J. Immunol., 171, 4539, 10.4049/jimmunol.171.9.4539 · DOI
  71. 10.1002/1521-4141(200106)31:6<1720::AID-IMMU1720>3.0.CO;2-U · DOI · Paper page
  72. Carnaud, 1999, J. Immunol., 163, 4647, 10.4049/jimmunol.163.9.4647 · DOI · Paper page
  73. Mars, 2002, J. Immunol., 168, 6007, 10.4049/jimmunol.168.12.6007 · DOI
  74. 10.1093/intimm/dxg029 · DOI
  75. 10.1084/jem.177.1.155 · DOI
  76. Mieza, 1996, J. Immunol., 156, 4035, 10.4049/jimmunol.156.10.4035 · DOI · Paper page
  77. Yang, 2003, J. Immunol., 171, 2142, 10.4049/jimmunol.171.4.2142 · DOI
  78. 10.1002/eji.200324099 · DOI
  79. Chan, 2001, J. Immunol., 167, 2985, 10.4049/jimmunol.167.5.2985 · DOI
  80. Yang, 2003, J. Immunol., 171, 4439, 10.4049/jimmunol.171.8.4439 · DOI
  81. Zeng, 2003, J. Clin. Invest., 112, 1211, 10.1172/JCI200317165 · doi:10.1172/jci200317165
  82. Zeng, 2000, J. Immunol., 164, 5000, 10.4049/jimmunol.164.10.5000 · DOI
  83. 10.1053/gast.2000.9114 · DOI · Paper page
  84. 10.1016/S1074-7613(02)00453-3 · DOI · Paper page
  85. 10.1006/clim.2001.5060 · DOI · Paper page
  86. 10.1053/gast.2002.36020 · DOI · Paper page
  87. 10.1016/S0952-7915(02)00316-3 · DOI · Paper page
  88. 10.1126/science.278.5343.1623 · DOI · Paper page
  89. 10.1126/science.278.5343.1626 · DOI · Paper page
  90. 10.1073/pnas.1630663100 · DOI
  91. 10.1182/blood.V99.4.1259 · DOI · Paper page
  92. 10.1084/jem.20031192 · DOI · Paper page
  93. 10.1084/jem.189.7.1121 · DOI · Paper page
  94. 10.1084/jem.20030324 · DOI · Paper page
  95. 10.1084/jem.191.4.661 · DOI · Paper page
  96. 10.1084/jem.20020092 · DOI · Paper page
  97. 10.1038/82771 · DOI · Paper page
  98. Ostrand-Rosenberg, 2002, J. Immunol., 169, 5796, 10.4049/jimmunol.169.10.5796 · DOI
  99. 10.1084/jem.20022227 · DOI · Paper page
  100. 10.1038/82782 · DOI · Paper page
  101. 10.1002/ijc.10678 · DOI
  102. Ali Tahir, 2001, J. Immunol., 167, 4046, 10.4049/jimmunol.167.7.4046 · DOI · Paper page
  103. 10.1084/jem.20021650 · DOI · Paper page
  104. Kawano, 1999, Cancer Res., 59, 5102
  105. 10.1054/bjoc.2001.1973 · DOI
  106. Metelitsa, 2001, J. Immunol., 167, 3114, 10.4049/jimmunol.167.6.3114 · DOI · Paper page
  107. Giaccone, 2002, Clin. Cancer Res., 8, 3702
  108. 10.1182/blood-2003-04-1155 · DOI · Paper page
  109. 10.1038/ni827 · DOI · Paper page
  110. 10.1128/JVI.76.9.4294-4303.2002 · DOI
  111. 10.1086/378503 · doi:10.1086/378503
  112. Grubor-Bauk, 2003, J. Immunol., 170, 1430, 10.4049/jimmunol.170.3.1430 · DOI · Paper page
  113. Roberts, 2004, J. Immunol., 172, 3454, 10.4049/jimmunol.172.6.3454 · DOI
  114. 10.1038/ni1002 · DOI · Paper page
  115. 10.1073/pnas.96.9.5141 · DOI · Paper page
  116. Mempel, 2002, J. Immunol., 168, 365, 10.4049/jimmunol.168.1.365 · DOI
  117. 10.1073/pnas.0403787101 · DOI · Paper page
  118. 10.1084/jem.189.3.553 · DOI · Paper page
  119. Lisbonne, 2003, J. Immunol., 171, 1637, 10.4049/jimmunol.171.4.1637 · DOI · Paper page
  120. 10.1038/nm851 · DOI · Paper page
  121. 10.1002/eji.200324303 · doi:10.1002/eji.200324303
  122. 10.1078/0171-2985-00284 · DOI
  123. 10.1084/jem.20021562 · DOI
  124. 10.1084/jem.20030997 · DOI · Paper page

Cited by

See all 877

Metadata

Authors
Godfrey, D. I., & Kronenberg, M.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2004-11-15
Volume
114
Issue
10
Pages
1379-1388
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci200423594
OpenAlex
W2026578316
Cited by
877
References
0
FWCI
21.46
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Going both ways: Immune regulation via CD1d-dependent NKT cells. https://app.cochat.ai/papers/10.1172/jci200423594
The paper
Godfrey, D. I., & Kronenberg, M. (2004). Going both ways: Immune regulation via CD1d-dependent NKT cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci200423594

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.