Cited by 944Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Open access

Vaisar, Tomas, Pennathur, Subramaniam, Green, Pattie S., Gharib, Sina A., Hoofnagle, Andrew N., Cheung, Marian C., Byun, Jaeman, Vuletic, Simona, Kassim, Sean, Singh, Pragya, Chea, Helen, Knopp, Robert H., Brunzell, John, Geary, Randolph, Chait, Alan, Zhao, Xue-Qiao, Elkon, Keith, Marcovina, Santica, Ridker, Paul, Oram, John F., Heinecke, Jay W.·2007·Journal of Clinical Investigation

DOI 10.1172/jci26206PMC PMC1804352

Open this paper in CoChat — free account Open PDF

Abstract

HDL lowers the risk for atherosclerotic cardiovascular disease by promoting cholesterol efflux from macrophage foam cells. However, other antiatherosclerotic properties of HDL are poorly understood. To test the hypothesis that the lipoprotein carries proteins that might have novel cardioprotective activities, we used shotgun proteomics to investigate the composition of HDL isolated from healthy subjects and subjects with coronary artery disease (CAD). Unexpectedly, our analytical strategy identified multiple complement-regulatory proteins and a diverse array of distinct serpins with serine-type endopeptidase inhibitor activity. Many acute-phase response proteins were also detected, supporting the proposal that HDL is of central importance in inflammation. Mass spectrometry and biochemical analyses demonstrated that HDL3 from subjects with CAD was selectively enriched in apoE, raising the possibility that HDL carries a unique cargo of proteins in humans with clinically significant cardiovascular disease. Collectively, our observations suggest that HDL plays previously unsuspected roles in regulating the complement system and protecting tissue from proteolysis and that the protein cargo of HDL contributes to its antiinflammatory and antiatherogenic properties.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci26206

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A statistical model for identifying proteins by tandem mass spectrometry.
Nesvizhskii, A., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,902
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,534
Direct analysis of protein complexes using mass spectrometry
Link, A. J., Eng, J. K., Schieltz, D. M., Carmack, E., Mize, G. J., Morris, D. R., Garvik, B. M., & Yates, J. R. (1999) · Nature Biotechnology · doi:10.1038/10890 · Cited by 2,218
Identifying biological themes within lists of genes with EASE
Hosack, D. A., Dennis, G., Sherman, B. T., Lane, H. C., & Lempicki, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r70 · Cited by 1,961
Deaths: preliminary data for 2003.
Hoyert, D. L., Kung, H.-C., & Smith, B. L. (2005) · PubMed · Cited by 1,649
Effect of Statin Therapy on C-Reactive Protein Levels
Albert, M. A., Danielson, E., Rifai, N., Ridker, P. M., & for the PRINCE Investigators (2001) · JAMA · doi:10.1001/jama.286.1.64 · Cited by 1,644
Self-citation
High-Density Lipoprotein — The Clinical Implications of Recent Studies
Desforges, J. F., Gordon, D. J., & Rifkind, B. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911093211907 · Cited by 1,547
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
Braunwald, E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,426
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319

Show all 70 references

Research works printed but not linked: 4

Hoyert, 2005, Natl. Vital Stat. Rep., 53, 1
Gundry, 2007, J. Clin. Proteomics.
Davies, 1990, Circulation., 82(Suppl.), II38
Strunk, 1983, Immunology., 49, 169

Sorted by citations

Items 801–900 of 944

Inflammatory proteins on HDL: what are we measuring?
O’Brien, K. D. (2007) · Translational research · doi:10.1016/j.trsl.2007.04.007 · Cited by 2
“Therefore, why are these results intriguing? They are of interest in light of previous work implicating GPI-PLD in inflammatory processes (3-8), as well as more recent studies identifying a variety of inflammatory modifications of HDL (9-13).”
BackgroundMethodResultInfluential
Lipids in Gestational Diabetes: Abnormalities and Significance
Knopp, R. H., Chan, E. W., Zhu, X., Paramsothy, P., & Bonet, B. (2010) · Springer eBooks · doi:10.1007/978-1-84882-120-0_11 · Cited by 2
Self-citation
Genetic Disorders of HDL Metabolism
Lilley, J. S., Linton, M. F., & Fazio, S. (2015) · Contemporary Endocrinology · doi:10.1007/978-1-60761-424-1_12 · Cited by 2
High‐Density Lipoproteins‐Associated Proteins and Subspecies Related to Arterial Stiffness in Young Adults with Type 2 Diabetes Mellitus
Zhu, X., SHAH, A. S., Swertfeger, D. K., Li, H., Ren, S., Melchior, J., Gordon, S. M., Davidson, W. S., & Lu, L. J. (2018) · Complexity · doi:10.1155/2018/7514709 · Cited by 2
Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis
Moneta, G. L. (2011) · Yearbook of Vascular Surgery · doi:10.1016/j.yvas.2011.07.044 · Cited by 2
High-density lipoproteins
Blanchard, V., & Francis, G. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824048-9.00017-1 · Cited by 2
A practical approach to lipid management in the elderly
Viljoen, A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0014-8 · Cited by 2
“Around 60 protein types are associated with HDL and about 12 with LDL ( 10 , 11).”
INFLAMMATORY MARKERS AS NOVEL PREDICTORS OF CARDIOVASCULAR DISEASE
Welsh, P. I. (2008) · Enlighten: Theses (The University of Glasgow) · Cited by 2
Apolipoprotein M – Studies of Structure and Function
Ahnström, J. (2009) · Lund University Publications (Lund University) · Cited by 2
Chromatography of Membrane Proteins and Lipoproteins
Zolla, L., & D’Alessandro, A. (2011) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1607.pub2 · Cited by 2
Low HDL and High HDL Syndromes
Yamashita, S., & Matsuzawa, Y. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04000-9 · Cited by 2
High-Density Lipoproteins and Inflammatory Diseases: Full Circle Ahead
Genest, G., & Genest, J. J. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2019.302364 · Cited by 2
Genetics of High‐Density Lipoproteins
Genest, J. J., Dastani, Z., Engert, J. C., & Marcil, M. (2007) · Wiley eBooks · doi:10.1002/9783527625178.ch19 · Cited by 2
The role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
آقاسی زاده, م., غیور مبرهن, م., کاظمی, ط., آوان, ا., & میری مقدم, ا. (2020) · مجله علمی دانشگاه علوم پزشکی بیرجند · doi:10.32592/jbirjandunivmedsci.2020.27.2.100 · Cited by 1
SAA4: An Underdog Within the Serum Amyloid a Superfamily?
Malle, E., Madreiter‐Sokolowski, C. T., & Windpassinger, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093907 · Cited by 1
The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice
Tomoo, K., Zhang, Y., Portalatin, A. Z. D., & Henderson, G. C. (2026) · Obesity · doi:10.1002/oby.70214 · Cited by 1
From nanoparticle-protein to nanoparticle-complement interactions
Moghimi, S. M., Haroon, H., & Simberg, D. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103101 · Cited by 1
Overview of Current Proteomic Approaches for Discovery of Vascular Biomarkers of Atherosclerosis
Antonio, L., Zinellu, E., & Marile, F. (2012) · InTech eBooks · doi:10.5772/30879 · Cited by 1
“…isolation (Banfi et al., 2009; Davidson et al., 2009; Green et al., 2008; Heller et al., 2005, 2007; Hortin et al., 2006; Karlsson et al., 2005a, 2005b; Khovidhunkit et al., 2004; Mancone et al., 2007; Mazur et al., 2010; Rezaee et al., 2006; Vaisar et al., 2007, 2010; Alwaili et al, 2011).”
BackgroundMethodInfluential
Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation
Moore, N. H., Costa, L. G., Shaffer, S. A., Goodlett, D. R., & Guizzetti, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.0022-3042.2008.05836.x · Cited by 1
Bases moleculares de las propiedades antiaterogénicas de las lipoproteínas de alta densidad
Calvo, C. (2008) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(08)72596-8 · Cited by 1
CETP Inhibitors: Will They Live up to Their Promise?
Cheung, V., & Hegele, R. A. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0206-0 · Cited by 1
“Very low levels of a very wide range of protein types can determine key attributes of HDL such as anti-inflammatory effects [11].”
Background
Systems Biology and Personalized Prevention
Siest, G. (2009) · Personalized Medicine · doi:10.2217/pme.09.2 · Cited by 1
When good cholesterol turns bad: The evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein
Oram, J. F., & Heinecke, J. W. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0028-8 · Cited by 1
Self-citation
HDL: More Than Just Cholesterol
Meilina, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i3.123 · Cited by 1
High-density lipoprotein cholesterol as a predictor of clinical outcomes in patients achieving low-density lipoprotein cholesterol targets with statins after percutaneous coronary intervention
Toth, P. P. (2012) · Yearbook of Endocrinology · doi:10.1016/j.yend.2012.05.050 · Cited by 1
Cholesteryl Ester Transfer Protein Inhibitors – Future Soon to be REVEALed
Huggins, C., Charolidi, N., & COCKERILL, G. W. (2015) · European Cardiology Review · doi:10.15420/ecr.2015.10.01.64 · Cited by 1
Complement C3 as a potential NAFLD predictor in an Egyptian cohort with diabetes and/or obesity
Ragab, H. M., Maksoud, N. A. E., Amin, M. A., & Elaziz, W. A. (2022) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-022-00133-9 · Cited by 1
“Recently, it has also been identified in lipoprotein particles, such as high-density lipoprotein and chylomicron [17].”
Background
Bioprospecting of Fungi to Produce Protease and Amylase
Anguraj, A., Michael, H. S. R., Sivaraman, R. K., Thayumanavan, T., & Rathinasamy, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-4113-7_8 · Cited by 1
Nuclear Magnetic Resonance Analysis Implicates Sex-Specific Dysregulation of the Blood Lipids in Alzheimer’s Disease: A Retrospective Health-Controlled Study
Li, Y., Yu, X., Ma, Z., Liu, Q., Li, M., Tian, X., Li, B., Zhang, R., Gu, P., Bai, F., et al. (2024) · Psychiatry Investigation · doi:10.30773/pi.2024.0164 · Cited by 1
“38,39 The brain makes HDL-like particles, but these particles have not been fully characterized.”
Network Analysis in Translational Research
Zhang, M., Deng, J., Tan, L., Chen, Y., & Lu, L. J. (2012) · Translational bioinformatics · doi:10.1007/978-94-007-5149-1_15 · Cited by 1
Basics in Lipoprotein Metabolism
Yassine, H. N., Tappin, K., & Sethi, M. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-11161-2_1 · Cited by 1
Las lipoproteínas de alta densidad: protectoras vasculares contra la aterosclerosis
Gutiérrez, Y. P., Gutiérrez, A. P., León, A. R., & Alvarez, C. (2013) · CorSalud · Cited by 1
A Closer Look at Cardioprotective Function of HDL: Revise the HDL – Cholesterol Hypothesis?
Meiliana, A., & Wijaya, A. (2014) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v6i1.40 · Cited by 1
Newer Therapeutic Strategies to Alter High-Density Lipoprotein Level and Function
Bosch, N. A., & Frishman, W. H. (2013) · Cardiology in Review · doi:10.1097/crd.0b013e31829cac29 · Cited by 1
Isotopic Tracers for the Measurement of Metabolic Flux Rates
Beysen, C., Angel, T. E., Hellerstein, M. K., & Turner, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-11748-1_9 · Cited by 2
Lipoproteins
Libby, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28786-9.00005-0 · Cited by 1
Atherosclerosis II : HDL Elevation
Ali, A., Hunt, J. A., & Sinclair, P. J. (2010) · Wiley eBooks · doi:10.1002/0471266949.bmc193 · Cited by 1
Distribution of apolipoprotein ai-containing lipoprotein subclasses in plasma of normolipidemic subjects.
Atmeh, R. F., Kasasbeh, A. Z., & Odeh, M. R. A. (1970) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2407 · Cited by 1
“These large particles may represent apoA-I complexes with LDL (Ogasawara et al., 2008), proteins (Vézina, 1988; Vaisar et al., 2007), or albumin (Atmeh et al., 2009).”
BackgroundInfluential
Disorders of high‐density lipoprotein biogenesis
Krimbou, L., Ruel, I. L., Dastani, Z., Al‐Rasadi, K., Hassan, H. H., Iatan, I., Marcil, M., & Genest, J. J. (2008) · Annals of Medicine · doi:10.1080/07853890701689637 · Cited by 1
“Indeed, comparative genomics (58) and HDL proteomics (59,60) have allowed the identification of many novel proteins involved in HDL physiology.”
Background
Plasma levels of matrix metalloproteinase-9 in a normal population - a psychoneuroendocrinological approach
Garvin, P. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
High-density lipoproteins and cardiovascular disease: the plots thicken
Choudhury, R. P., & Ruparelia, N. (2012) · Heart · doi:10.1136/heartjnl-2012-302533 · Cited by 1
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
Pettersson, C. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Modification of HDL structure and function in individuals with diabetes and the haptoglobin 2-2 genotype
Levy, A. P. (2009) · Clinical Lipidology · doi:10.2217/17584299.4.1.5 · Cited by 1
Proteômica e funcionalidade das subfrações de lipoproteína de densidade alta (HDL) e aterosclerose subclínica no diabetes mellitus tipo 1
Toyoshima, M. T. K. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-11012022-135720 · Cited by 1
Heterogeneity
Kontush, A., & Chapman, M. J. (2011) · doi:10.1002/9781118158678.ch2 · Cited by 1
Current World Literature
(2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328312bffc · Cited by 1
Proteomics: a tool to investigate of composition and function of HDL in hyperlipidemia
da Silva, A. R. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2022.tde-26082022-123137 · Cited by 1
HDL particles and infection-related death: when size matters
Calabresi, L., & Norata, G. D. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad043 · Cited by 1
Dyslipidaemia and Diabetes
Viljoen, A., Handhle, A., & Wierzbicki, A. S. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch48 · Cited by 1
Complement Factor H and Pro-Resolving Mediators Synergistically Enhance Plaque Stability in Peripheral Arterial DiseasePreprint
Nissilä, E., Syed, S., Uvarov, P., Lokki, A. I., Laivuori, M., Chernyaeva, L., Roininen, E., Vataja, E., Tuhkala, A., Keskitalo, S., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6828685/v1 · Cited by 1
Humoral response towards high density lipoprotein : a new mechanism for atherogenesis
Batuca, J. R. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation
Levkau, B. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0168-9_7
“Again, this appears to be S1P receptor subtype specific, as S1P 1 and S1P 3 strengthen the formation of endothelial cell junctions [43–45], while S1P 2 weakens them [46, 47 ].”
Background
HDL Infusion Therapy
Brewer, H. B. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1059-2_22
“HDL has also been shown to protect LDL from oxidation [37, 38], increase NO levels [39, 40], and transport a number of potentially important biologically active molecules [ 41 ].”
Background
Lipoproteína de alta densidade (HDL) isolada de portadores de diabete melito tipo 2 com controle glicêmico inadequado favorece o acúmulo de colesterol em macrófagos
Pereira, P. H. G. R. (2009) · doi:10.11606/d.5.2009.tde-08032010-102308
Sphingosine 1‐Phosphate (S1P) Signaling in Cardiovascular Physiology and Disease
Levkau, B. (2013) · Wiley eBooks · doi:10.1002/9781118531426.ch14
The role of phospholipid transfer protein and cholesteryl ester transfer protein in reverse cholesterol transport
Vikstedt, R. (2009) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)
Reconstituted, Plasma‐Derived High‐Density Lipoprotein
Lerch, P. (2012) · Wiley eBooks · doi:10.1002/9781118356807.ch19
Proteomic analysis of plasma apolipoproteins in relation to atherosclerosis
Zinellu, E. (2012) · UnissResearch (Università degli Studi di Sassari)
Effects of corticosteroid treatment on high-density lipoprotein distribution and function
Cakan, Y. (2014) · The Sydney eScholarship Repository (The University of Sydney)
Overview of Intersection of Genomics of Cardiometabolic Disease and Other Disease States, Such as Eye Health (Macular Degeneration)
McKay, G. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799961-6.00012-3
When good cholesterol turns bad: The evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein
Oram, J. F., & Heinecke, J. W. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0055-y
Self-citation
Systemic Inflammation and the Dynamics of HDL Cholesterol–Associated Residual Cardiovascular Risk
Rosenson, R. S. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0167-2
“In pro-inflammatory states, the qualities of HDL particles change as they are enriched in acute phase proteins [13].”
Background
Complement therapy in dry age-related macular degeneration
Punjabi, O. S., & Kaiser, P. K. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.08.001
HDL – Hope Dies Last?
Tietge, U. J. F. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000164
Is Low HDL Cholesterol a Marker or a Mediator of Cardiovascular Disease
Yassine, H. N. (2015) · Springer eBooks · doi:10.1007/978-3-319-11161-2_5
Inibição do estresse do retículo endoplasmático restaura o conteúdo de ABCA-1 e o efluxo de colesterol em macrófagos tratados com albumina modificada por glicação avançada
Castilho, G. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2012.tde-02102012-100748
Modulation of cardiovascular risk factors and inflammation in rheumatic diseases
van Eijk, I. C. (2011) · Pure Amsterdam UMC
The emerging role of HDL in glucose
Rye, K., Duffy, S. J., Barter, P. J., & Kingwell, B. A. (2012)
Differentielle Analyse des HDL-Proteoms mittels Massenspektrometrie
Zellbiologie, M., & Beisiegel†, U. (2010)
High density lipoproteins are significantly reduced in early stages of untreated type 2 diabetes mellitus
Garg, S., Kar, R., & Madhu, S. (2015) · International Journal of Clinical Biochemistry and Research
Treinamento físico aeróbio em camundongos selvagens e transgênicos para CETP não altera a remoção de colesterol celular e a expressão de genes envolvidos no fluxo de lípides em macrófagos e arco aórtico
Pinto, P. R. (2015) · doi:10.11606/d.5.2015.tde-23092015-110341
Análisis de la composición y de la función de las HDL, ¿un estudio para el clínico del futuro?
Aguilar-Salinas, C. A., & Melgarejo-Hernández, M. A. (2011) · Revista de Endocrinología y Nutrición
Cholesterol HDL — przyjaciel czy wróg? Cholesterol HDL — friend or foe?*
Banach, J., & Bydgoszcz (2013)
High-Density Lipoprotein Functions: Lessons from the Proteomic Approach
S, B. S. S. (2014) · Journal of Glycomics & Lipidomics · doi:10.4172/2153-0637.1000118
Functional activities of HDL particles in acute myocardial infarction : dissection of the roles of proteome vs. lipidome components
Rached, F. H. (2013)
Normal and abnormal lipid and lipoprotein metabolism There is a range of disorders of lipoprotein metabolism with varied biochemical changes, risk and manifestations depending on the cause.
Marais, A. D., & Marais, D. A. (2009)
2. Cholesterol and cognitive functioning in persons free from stroke and dementia
Crichton, G. E., Sullivan, K., & Elias, M. F. (2016) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-821-6_2
The Role of High-Density Lipoprotein Cholesterol in the Development of Atherosclerotic Cardiovascular Disease
Gandotra, P., & Miller, M. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1366-4.00013-5
HDL Apoprotein Mimetic Peptides as Antiinflammatory Molecules
Getz, G. S., & Reardon, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00004-5
Proteomics translational
Wölfler, M. M., Pecks, U., Bauerschlag, D., & Maass, N. (2010) · Der Gynäkologe · doi:10.1007/s00129-010-2535-3
Network Analysis and Applications in Pediatric Research
Li, H., Ren, Z., Ren, S., Guo, X., Zhu, X., & Lu, L. J. (2016) · Translational bioinformatics · doi:10.1007/978-981-10-1104-7_13
Lipoproteomics : Environmental and Genetic Factors Affecting High-Density Lipoprotein (HDL)
Ljunggren, S. (2016) · Linköping University medical dissertations · doi:10.3384/diss.diva-131643
Cell Biology/Signaling Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters Relevance to Antioxidative Function
Davidson, W. S., Silva, D., Lagor, W. R., Chapman, M. J., & Kontush, A. (2009)
Molecular Mechanisms of Hyperalphalipoproteinemia
Yamashita, S., Masuda, D., Ohama, T., & Koseki, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00001-x
HIGH-DENSITY LIPOPROTEINS AND APOLIPOPROTEIN A-I WITH AORTIC ENDOTHELIAL CELLS
Ohnsorg, P. M. (2011)
Disarray at the membrane
Theodorou (2018) · Research Publications (Maastricht University) · doi:10.26481/dis.20180119kt
Extremely low high-density-lipoprotein cholesterol due to an unusual non-inherited cause: a case report
Kwakernaak, A. J., Post, M. C., Pijlman, A. H., & Bosma, M. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2018-0501
Response to Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431–2437
Mathew, A. V., & Pennathur, S. (2019) · Diabetes Care · doi:10.2337/dci18-0053
“We used a standard, reliable, and reproducible KBr ultracentrifugation protocol previously published by our group (4,5) and therefore”
MethodResultSelf-citation
Aterosclerose subclínica medida pelo escore de cálcio coronariano e avaliação da HDL em pacientes com doença de Crohn
Rocha, B. D. C. L. (2019) · doi:10.11606/t.5.2019.tde-10122019-123825
Multiple actions of high-density lipoprotein
Florentin, M., Liberopoulos, E. N., Wierzbicki, A. S., & Mikhailidis, D. P. (2008) · Current Opinion in Internal Medicine · doi:10.1097/mci.0b013e32831550d9
Biologie Vasculaire
(2010) · Elsevier eBooks · doi:10.1016/b978-2-294-70917-3.50003-4
HDL Apoprotein Mimetic Peptides as Anti-Inflammatory Molecules
Getz, G. S., & Reardon, C. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407867-3.00009-3
Enriquecimento da HDL em apolipoproteína A-IV favorece sua funcionalidade na doença renal diabética
Santana, M. D. F. M. (2020) · doi:10.11606/d.5.2020.tde-10022021-101317
The Role of Liver X Receptors in Reverse Cholesterol Transport and Atherosclerosis
Breevoort, S. R. (2014) · doi:10.18130/v3925p
Innovative Lipid Biomarkers and Long-Term Outcomes
Anderson, J. L. C. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.192996734
Two-Time Scale Control of a High Speed Planar Parallel Manipulator With Structural Flexibility
Kang, B.-S., & Mills, J. K. (2002)
Altered Composition
(2011) · Wiley eBooks · doi:10.1002/9781118158678.ch8
Biologic Activities
Kontush, A., & Chapman, M. J. (2011) · Wiley eBooks · doi:10.1002/9781118158678.ch7
Chromatography of Membrane Proteins and Lipoproteins
Zolla, L., D’Alessandro, A., & Lana, A. (2016) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1607.pub3
Cardiovascular Proteomics
Vivanco, F., de la Cuesta, F., Barderas, M. G., Zubiri, I., & Álvarez‐Llamas, G. (2011) · doi:10.1002/9780470940297.ch14

Authors: Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., Chea, H., Knopp, R. H., Brunzell, J., Geary, R., Chait, A., Zhao, X.-Q., Elkon, K., Marcovina, S., Ridker, P., Oram, J. F., & Heinecke, J. W.
Affiliations: University of Washington (US)
Wake Forest University (US)
Harvard University (US)
Corresponding author: Heinecke, Jay W.
ORCID: Pennathur, Subramaniam
Gharib, Sina A.
Hoofnagle, Andrew N.
Kassim, Sean
Singh, Pragya
Brunzell, John
Chait, Alan
Elkon, Keith
Marcovina, Santica
Ridker, Paul
Heinecke, Jay W.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-03-01
Volume: 117
Issue: 3
Pages: 746-756
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci26206
PMC: PMC1804352
OpenAlex: W2083315579
Cited by: 942
References: 70
Citations by year: 2026: 16 · 2025: 20 · 2024: 19 · 2023: 25 · 2022: 36 · 2021: 28 · 2020: 35 · 2019: 36 · 2018: 45 · 2017: 31 · 2016: 51 · 2015: 69 · 2014: 58 · 2013: 81 · 2012: 79
FWCI: 79.98
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Washington (P30ES07033)
National Institutes of Health (P30ES07033, DK017047)
National Heart, Lung, and Blood Institute (HL086798, P01HL030086, HL-078527, K08HL074223, HL-57557, HL074223, R01HL086798, R01HL057557, R01HL078527)
National Institute of Diabetes and Digestive and Kidney Diseases (DK017047, DK 02456, P01DK002456, P30DK017047)
National Institute of Environmental Health Sciences (P30 ES-07033, P30ES007033)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: HDL cholesterol, HDL proteome, complement regulation, serpins, protease inhibition, anti-inflammatory activity, coronary artery disease, HDL3, apolipoprotein E, acute phase proteins, atherosclerosis, cardiovascular disease
MeSH terms: Amino Acid Sequence, Chromatography, Liquid, Complement Activation, Coronary Artery Disease, Humans, Inflammation, Lipoproteins, HDL, Microscopy, Electron, Scanning, Molecular Sequence Data, Peptide Hydrolases, Mass Spectrometry, Proteomics, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks