PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2

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Requirement for NF-κB in osteoclast and B-cell development

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway

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Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis

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Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression

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Serum Calcium-decreasing Factor, Caldecrin, Inhibits Receptor Activator of NF-κB Ligand (RANKL)-mediated Ca2+ Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of Src Signaling Pathway

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TLT-1s, Alternative Transcripts of Triggering Receptor Expressed on Myeloid Cell-like Transcript-1 (TLT-1), Inhibits the Triggering Receptor Expressed on Myeloid Cell-2 (TREM-2)-mediated Signaling Pathway during Osteoclastogenesis*

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Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts

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Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12

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Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption

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Multifunctional Properties of RANKL/RANK in Cell Differentiation, Proliferation and Metastasis

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Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro

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The roles of Orai and Stim in bone health and disease

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Betulinic Acid Inhibits RANKL-Induced Osteoclastogenesis via Attenuating Akt, NF-κB, and PLCγ2-Ca2+ Signaling and Prevents Inflammatory Bone Loss

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Lymphocytes and the Dap12 Adaptor Are Key Regulators of Osteoclast Activation Associated with Gonadal Failure

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PLCγ2: where bone and immune cells find their common ground

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A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients

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Osteoclast Biology: Regulation of Formation and Function

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PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease

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Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish

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Thyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells

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Genetic effects of a titanium surface on osteoblasts: a meta-analysis.

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BCAP promotes osteoclast differentiation through regulation of the p38-dependent CREB signaling pathway

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Phospholipase Cγ1 (PLCγ1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/β-Catenin/CyclinD1 Pathway

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Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing

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Antiresorptive Activity ofBacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation

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ASP2-1, a polysaccharide from Acorus tatarinowii Schott, inhibits osteoclastogenesis via modulation of NFATc1 and attenuates LPS-induced bone loss in mice

Wang, J., Zhang, Y., Xu, X., Jin, W., Jing, C., Leng, X., Wang, M., Cao, J., Wang, H., & Sun, L. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.077 · Cited by 16

Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*

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Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1

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Ezrin silencing remodulates the expression of Phosphoinositide‐specific Phospholipase C enzymes in human osteosarcoma cell lines

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NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

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Glycyrrhizae Radix Inhibits Osteoclast Differentiation by Inhibiting c-Fos-Dependent NFATc1 Expression

Rho, T.-W., Lee, S. Y., Han, S., Kim, J. H., Lee, K., Kim, D.-S., Kwak, H. B., & Kim, Y.-K. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500185 · Cited by 16

Time-Dependent Response of Human Deciduous Tooth-Derived Dental Pulp Cells Treated with TheraCal LC: Functional Analysis of Gene Interactions Compared to MTA

Nam, O. H., Kim, J., Choi, S. C., & Kim, Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020531 · Cited by 14

VapB as a regulator of osteoclastogenesis via modulation of PLCγ2‐Ca 2+ ‐NFAT signaling

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β-Boswellic Acid Inhibits RANKL-Induced Osteoclast Differentiation and Function by Attenuating NF-κB and Btk-PLCγ2 Signaling Pathways

Park, G. D., Cheon, Y., Eun, S. Y., Lee, C. H., Lee, M. S., Kim, J., & Cho, H. J. (2021) · Molecules · doi:10.3390/molecules26092665 · Cited by 13

Aconitum pseudo-laeve var. erectum Inhibits Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclastogenesis via the c-Fos/nuclear Factor of Activated T-Cells, Cytoplasmic 1 Signaling Pathway and Prevents Lipopolysaccharide-Induced Bone Loss in Mice

Baek, J. S., Kim, J., Cheon, Y., Park, S., Ahn, S., Yoon, K., Oh, J., & Lee, M. S. (2014) · Molecules · doi:10.3390/molecules190811628 · Cited by 13

Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

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DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions

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SH3BP2 mutations potentiate osteoclastogenesis via PLCγ

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Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling

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Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages

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The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases

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Phospholipase Cγ2 Is Essential for Experimental Models of Epidermolysis Bullosa Acquisita

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Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice

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Ligustilide suppresses RANKL‐induced osteoclastogenesis and bone resorption via inhibition of RANK expression

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Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice

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Neutrophil Phospholipase Cγ2 Drives Autoantibody‐Induced Arthritis Through the Generation of the Inflammatory Microenvironment

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Spleen tyrosine kinase (SYK) inhibitor PRT062607 protects against ovariectomy-induced bone loss and breast cancer-induced bone destruction

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Osteoimmunology - Unleashing the concepts

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Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

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Targeted Inhibition of Phospholipase C γ2 Adaptor Function Blocks Osteoclastogenesis and Protects from Pathological Osteolysis

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Early estrogen‐induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression

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PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

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Multifunctional nanotherapeutics reprogramming the immunopathological landscape for rheumatoid arthritis therapy

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The Transmembrane Adaptor Protein, Linker for Activation of T cells (LAT), Regulates RANKL-Induced Osteoclast Differentiation

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Anti-Osteoporotic Effects of n-trans-Hibiscusamide and Its Derivative Alleviate Ovariectomy-Induced Bone Loss in Mice by Regulating RANKL-Induced Signaling

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Type I Phosphotidylinosotol 4-Phosphate 5-Kinase γ Regulates Osteoclasts in a Bifunctional Manner*

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Using Genetics in Periodontal Disease to Justify Implant Failure in Down Syndrome Patients

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Protein Kinase D Promotes in Vitro Osteoclast Differentiation and Fusion

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Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

Lee, D.-K., Jin, X., Choi, P.-R., Cui, Y. J., Che, X., Lee, S., Hur, K., Kim, H., & Choi, J. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01390-8 · Cited by 9

Stimuli and Relevant Signaling Cascades for NFATc1 in Bone Cell Homeostasis: Friend or Foe?

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A Shotgun Proteomic Platform for a Global Mapping of Lymphoblastoid Cells to Gain Insight into Nasu-Hakola Disease

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MIP-1δ Activates NFATc1 and Enhances Osteoclastogenesis: Involvement of Both PLCγ2 and NFκB Signaling

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PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications

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PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood

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A Porphyromonas gingivalis hypothetical protein controlled by the type I-C CRISPR-Cas system is a novel adhesin important in virulence

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Protaetia brevitarsis Extract Attenuates RANKL-Induced Osteoclastogenesis by Inhibiting the JNK/NF-κB/PLCγ2 Signaling Pathway

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Identification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of receptor activator of nuclear factor kappa B

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Osteoclasts-Key Players in Skeletal Health and Disease

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The Osteoclast

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Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge

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Mysteries in Ca2+ signaling during osteoclast differentiation

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Osteoclastos: mucho más que células remodeladoras del hueso

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Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice

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Integrated mRNA‐Seq and miRNA‐Seq analysis of PLCγ2‐overexpressing hepatocarcinoma cells and identification of the associated miRNA‐mRNA network

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Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain

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Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study

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Majewski, P. M. (2017) · ReIn UW (University of Warsaw) · Cited by 1

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Phosphoinositide-Specific Phospholipase C (PI-PLC)

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Osteoimmunology and Cancer - Clinical Implications

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The Effect of Lysenin on the Differentiation into Osteoclast Cells

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Cellular Players in Breast Cancer Bone Metastases

Faccio, R., Capietto, A.-H., Stewart, S. A., & Novack, D. V. (2013) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-013-9146-1

The role of the tumor suppressor PTEN in bone homeostasis

Arsenault, M. G. (2008) · eScholarship@McGill (McGill) · doi:10.82308/12655

Bone strength and architecture : pharmacological targeting of CaMKK2 as a method for enhancing bone quality.

Pritchard, Z. D. (2014) · doi:10.18297/etd/1156

Targeted Inhibition of Phospholipase C γ2 Adaptor Function Blocks Osteoclastogenesis and Protects from Pathological Osteolysis

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PLCγ2: where bone and immune cells find their common ground

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Research update for articles published in EJCI in 2012

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Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis

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