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Cited by 133

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Popov, Alexey, Abdullah, Zeinab, Wickenhauser, Claudia, Saric, Tomo, Driesen, Julia, Hanisch, Franz-Georg, Domann, Eugen, Raven, Emma Lloyd, Dehus, Oliver, Hermann, Corinna, Eggle, Daniela, Debey, Svenja, Chakraborty, Trinad, Krönke, Martin, Utermöhlen, Olaf, Schultze, Joachim L.·2006·Journal of Clinical Investigation
DOI 10.1172/jci28996
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Abstract

Control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. We show in human listeriosis that DCs expressing indoleamine 2,3-dioxygenase (IDO), together with macrophages, are major cellular components of suppurative granulomas in vivo. Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as Bartonella henselae. Reporting on our use of the clinically applied anti-TNF-alpha antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-alpha dependent. Repression of IDO therefore might result in exacerbation of granulomatous diseases observed during anti-TNF-alpha therapy. These findings place IDO(+) DCs not only at the intersection of innate and adaptive immunity but also at the forefront of bacterial containment in granulomatous infections.

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Research works printed but not linked: 4

  1. Paschen, 2000, Eur. J. Immunol., 30, 3447, 10.1002/1521-4141(2000012)30:12<3447::AID-IMMU3447>3.0.CO;2-M · DOI
  2. Perez, 2005, Histol. Histopathol., 20, 1165
  3. 10.1172/JCI200418991 · DOI
  4. Furst, 2006, Semin. Arthritis Rheum.

Cited by

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Metadata

Authors
Popov, A., Abdullah, Z., Wickenhauser, C., Saric, T., Driesen, J., Hanisch, F.-G., Domann, E., Raven, E. L., Dehus, O., Hermann, C., Eggle, D., Debey, S., Chakraborty, T., Krönke, M., Utermöhlen, O., & Schultze, J. L.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2006-12-01
Volume
116
Issue
12
Pages
3160-3170
ISSN
0021-9738
DOI
10.1172/jci28996
Cited by
133
References
81
Language
en

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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