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Novel Immune-Related Ferroptosis Signature in Esophageal Cancer: An Informatics Exploration of Biological Processes Related to the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 Regulatory Network

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Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

Doehring, A., Antoniades, C. A., Channon, K. M., Tegeder, I., & Lötsch, J. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.04.007 · Cited by 27 · see citing works

AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle‐aged European‐Americans

Neumann, S. A., Tingley, W. G., Conklin, B. R., Shrader, C. J., Peet, E., Muldoon, M. F., Jennings, J. R., Ferrell, R. E., & Manuck, S. B. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00802.x · Cited by 25 · see citing works

Genetic variability of pain perception and treatment—clinical pharmacological implications

Lötsch, J. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1012-9 · Cited by 24 · see citing works

GCH1 in early‐onset Parkinson's disease

Cobb, S. A., Wider, C. W., Ross, O. A., Mata, I. F., Adler, C. H., Rajput, A. H., Rajput, A. H., Wu, R., Hauser, R. A., Josephs, K. A., et al. (2009) · Movement Disorders · doi:10.1002/mds.22729 · Cited by 21 · see citing works

Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population

Yan, J., Zhang, L., Xu, Y., Wang, X., Wang, C., & Wang, D. W. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.114 · Cited by 20 · see citing works

Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice

d’Uscio, L. V., Smith, L. A., & Katušić, Z. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00588.2011 · Cited by 20 · see citing works

Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19

Villaume, W. A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110842 · Cited by 18 · see citing works

Genetics of NO Deficiency

Leineweber, K., Moosmang, S., & Paulson, D. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.06.013 · Cited by 18 · see citing works

Genetics of ischemic stroke functional outcome

Carnwath, T., Demel, S. L., & Prestigiacomo, C. J. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12263-x · Cited by 17 · see citing works

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

Adlam, D., Herring, N., Douglas, G., de Bono, J. P., Li, D., Danson, E., Tatham, A. L., Lu, C.-J., Jennings, K. A., Cragg, S. J., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs005 · Cited by 17 · see citing works

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury

Chuaiphichai, S., Chu, S. M., Carnicer, R., Kelly, M., Bendall, J. K., Simon, J. N., Douglas, G., Crabtree, M. J., Casadei, B., & Channon, K. M. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00562.2022 · Cited by 16 · see citing works

Endothelial, Sympathetic, and Cardiac Function in Inherited (6 R )- l -Erythro-5,6,7,8-Tetrahydro- l -Biopterin Deficiency

Mayahi, L., Mason, L., Bleasdale-Barr, K., Donald, A. E., Trender‐Gerhard, I., Sweeney, M. G., Davis, M. B., Wood, N. W., Mathias, C. J., Watson, L. P. E., et al. (2010) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.957605 · Cited by 16 · see citing works

Oxidative stress induces BH4 deficiency in male, but not female, SHR

Gillis, E. E., Brinson, K. N., Rafikova, O., Chen, W., Musall, J. B., Harrison, D. G., & Sullivan, J. C. (2018) · Bioscience Reports · doi:10.1042/bsr20180111 · Cited by 16 · see citing works

The regulation of vascular tetrahydrobiopterin bioavailability

Starr, A., Hussein, D. A., & Nandi, M. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.08.002 · Cited by 16 · see citing works

Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects

Sadahiro, R., Suzuki, A., Matsumoto, Y., Shibuya, N., Enokido, M., Kamata, M., Goto, K., & Otani, K. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.040 · Cited by 15 · see citing works

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Wołkow, P. P., Kosiniak-Kamysz, W., Osmenda, G., Wilk, G., Bujak-Giżycka, B., Ignacak, A., Kanitkar, M., Waluś‐Miarka, M., Harrison, D. G., Korbut, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108587 · Cited by 14 · see citing works

Human Heart Rate

Zhang, K., Deacon, D. C., Rao, F., Schork, A. J., Fung, M. M., Waalen, J., Schork, N. J., Nievergelt, C. M., Chi, N. C., & O’Connor, D. T. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.025 · Cited by 13 · see citing works

A machine‐learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes

Kringel, D., Lippmann, C., Parnham, M. J., Kalso, E. A., Ultsch, A., & Lötsch, J. (2018) · European Journal of Pain · doi:10.1002/ejp.1270 · Cited by 14 · see citing works

Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats

Yue, G., Zhuo, S., Meng, X., Zhang, Z., Gao, Y., & Luo, Y. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/565784 · Cited by 13 · see citing works

GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder

Kishi, T., Ichinose, H., Yoshimura, R., Fukuo, Y., Kitajima, T., Inada, T., Kunugi, H., Kato, T., Yoshikawa, T., Ujike, H., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.004 · Cited by 13 · see citing works

Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats

Baotić, I., Weihrauch, D., Procknow, J. D., Vasquez-Vivar, J., Ge, Z., Sudhakaran, S., Warltier, D. C., & Kersten, J. R. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000778 · Cited by 12 · see citing works

Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

Tu, Y., Ding, H., Wang, X., Xu, Y., Zhang, L., Huang, C.-X., & Wang, D. W. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.68 · Cited by 12 · see citing works

Principles of Functional Genomic Analysis

Jackson, S. A., Patel, I. R., LeClerc, J. E., Cebula, T. A., Mammel, M. K., Kotewicz, M. L., Mukherjee, A. K., Mahata, S. K., Flores, J. R., Mahata, M., et al. (2008) · CRC Press eBooks · doi:10.3109/9781420067064-6 · Cited by 10 · see citing works

Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients

Fukuda, S., Horiguchi, M., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Ichinose, H., & Watanabe, Y. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.11.016 · Cited by 10 · see citing works

Parkinson’s disease-associated genetic variants synergistically shape brain networksPreprint

Chen, Z., Wu, B., Li, G., Zhou, L., Zhang, L., & Liu, J. (2022) · medRxiv · doi:10.1101/2022.12.25.22283938 · Cited by 10 · see citing works

GTP Cyclohydrolase Regulation

Ichinose, H., Homma, D., Sumi‐Ichinose, C., Nomura, T., & Kondo, K. (2013) · Advances in pharmacology · doi:10.1016/b978-0-12-411512-5.00003-8 · Cited by 8 · see citing works

Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury

Meng, C., Liang, X., Li, Q., Chen, G., Liu, H., & Li, K. (2013) · Neurological Sciences · doi:10.1007/s10072-013-1353-5 · Cited by 8 · see citing works

Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and Type 2 diabetic macrovascular disease in the Chinese population

Liao, Y.-F., Zeng, T., Chen, L., Li, Y., Yu, F., Hu, L., & Yue, L. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.04.003 · Cited by 8 · see citing works

Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia

Romero, J. H., Costa, G. M. F., Rocha, L. P. C., de Siqueira, S., Moreira, P. R., & Almeida‐Leite, C. M. (2021) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2021.106880 · Cited by 7 · see citing works

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance

Yasuda, Y., Hashimoto, R., Ohi, K., Yamamori, H., Fujimoto, M., Umeda‐Yano, S., Fujino, H., Fukunaga, M., Horiguchi, M., Takeda, M., et al. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.019 · Cited by 7 · see citing works

Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward

Xia, W., Zhang, M., Liu, C., Wang, S., Xu, A., Xia, Z., Pang, L., & Cai, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122594 · Cited by 6 · see citing works

Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity

Wang, L., Li, Y., & Zhou, S. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.02.007 · Cited by 6 · see citing works

Chiropractic care for hypertension: Review of the literature and study of biological and genetic bases.

Sullivan, S. G., Paolacci, S., Kiani, A. K., & Bertelli, M. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i13-s.10524 · Cited by 5 · see citing works

GTP cyclohydrolase 1 gene 3′-UTR C+243T variant predicts worsening outcome in patients with first-onset ischemic stroke

Tang, L. F. P., Zhang, L., Ding, H., Tu, W., & 严江涛 (2010) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-010-0642-y · Cited by 4 · see citing works

Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain

Kringel, D., Kaunisto, M. A., Lippmann, C., Kalso, E. A., & Lötsch, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01008 · Cited by 5 · see citing works

Complex Trait Genetics

Rao, F., Zhang, L., & O’Connor, D. T. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.080 · Cited by 4 · see citing works

Research highlights from the literature

Jordan, J. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0320-5 · Cited by 4 · see citing works

Pathological Variations in 3′‐Untranslated Regions of Human Genes

Pal, J. K., Chatterjee, S., & Rao, S. J. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022450.pub2 · Cited by 4 · see citing works

A consensus single-cell transcriptomic atlas of dermal fibroblast heterogeneityPreprint

Ascensión, A. M., & Izeta, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611379 · Cited by 4 · see citing works

The Role of GCH1 Deficiency and Tetrahydrobiopterin in Mental Health

Williams, G. E., Hausman-Cohen, S., Sotos, M., Gutierrez, E., Bilich, C., Mueller, F. W., & Jagshi, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168030 · Cited by 3 · see citing works

Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review)

Kang, C., Li, X., & Wei, X. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5625 · Cited by 3 · see citing works

Nucleotide Variants of the BH4 Biosynthesis Pathway Gene GCH1 and the Risk of Orofacial Clefts

Hozyasz, K. K., Mostowska, A., Wójcicki, P., Lasota, A., Zadurska, M., Dunin‐Wilczyńska, I., & Jagodziński, P. P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9342-8 · Cited by 2 · see citing works

GCH1 haplotypes and cardiovascular risk in HIV

Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T., & Gupta, S. K. (2019) · AIDS · doi:10.1097/qad.0000000000002263 · Cited by 1 · see citing works

Does Chronic Pain Affect Heart Function?

Goldaniga, G., & Allegri, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-28008-6_41 · Cited by 1 · see citing works

25-OH Vitamin D and ADMA in Relation to C1 Metabolism in Children with Congenital Heart Defects and Their Mothers

Alsayed, R. (2014)

Evaluation of pharmacological properties of Danshen compounds by computational and biochemical approaches

Zhou, Z. (2016) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27581778

Genetics of HIV-associated sensory neuropathy in black Southern Africans

Hendry, L. M. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

Human Genomics in Hypertension

Shih, P.-A. B., O’Connor, D., & Mahata, S. K. (2008) · CRC Press eBooks · doi:10.3109/9781420067064-11

General Discussion and Future Perspectives

Cassarini, C. (2019) · CRC Press eBooks · doi:10.1201/9780429448300-7

In silico, in vitro, in vivo and in populo: Regulatory genetics of single nucleotide polymorphisms in the phenylethanolamine N-methyltransferase promoter

Flores, R., & Lorenzo, J. C. (2009)

Research highlights from the literature

Jordan, J. (2007) · Clinical Autonomic Research · doi:10.1007/s10286-007-0434-z

Does Chronic Pain Affect Heart Function?

Goldaniga, G., & Allegri, M. (2020) · Springer eBooks · doi:10.1007/978-3-319-90305-7_41-1

Pathological Variations in 3′‐untranslated Regions of Human Genes

Pal, J. K., Chatterjee, S., & Berwal, S. K. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022450

Genetic and environmental determinants of blood pressure

Man, T. (2022) · doi:10.33612/diss.255261014

Catecholamines and Catecholamine Receptors in Cardiovascular Behavioral Medicine

Peterson, C. T., Ziegler, M. G., & Mills, P. J. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_37

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

Doehring, A., Antoniades, C. A., Channon, K. M., Tegeder, I., & Lötsch, J. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.04.007 · Cited by 27 · see citing works

Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects

Sadahiro, R., Suzuki, A., Matsumoto, Y., Shibuya, N., Enokido, M., Kamata, M., Goto, K., & Otani, K. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.040 · Cited by 15 · see citing works

Research highlights from the literature

Jordan, J. (2007) · Clinical Autonomic Research · doi:10.1007/s10286-007-0434-z

GTP cyclohydrolase 1 gene 3′-UTR C+243T variant predicts worsening outcome in patients with first-onset ischemic stroke

Tang, L. F. P., Zhang, L., Ding, H., Tu, W., & 严江涛 (2010) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-010-0642-y · Cited by 4 · see citing works

Genetic variation in GCH1, encoding GTP cyclohydrolase 1, regulates vascular biopterin synthesis: effects on eNOS coupling, NO bioavailability and superoxide generation in human vessels

Antoniades, C. A., Guzik, T. J., Shirodaria, C. C., Van-Assche, T., Pillai, R. S., Lötsch, J., Tousoulis, D., Stefanadis, C., Tegeder, I., & Channon, K. M. (2008) · European Heart Journal