Genetics of Longevity and Aging

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Broken Limits to Life Expectancy

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

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Effects of Human Growth Hormone in Men over 60 Years Old

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p53 mutant mice that display early ageing-associated phenotypes

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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The Endocrine Regulation of Aging by Insulin-like Signals

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Genetic associations with human longevity at the APOE and ACE loci

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Dwarf mice and the ageing process

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A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

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DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

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Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

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Redox Regulation of Forkhead Proteins Through a <i>p66shc</i> -Dependent Signaling Pathway

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Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

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Evolution of ageing

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Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones

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Genetic analysis of ageing: role of oxidative damage and environmental stresses

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Modulation of mammalian life span by the short isoform of p53

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Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity

Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 576 · see citing works

Evolutionary medicine: from dwarf model systems to healthy centenarians?

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Aging and Genome Maintenance: Lessons from the Mouse?

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Premature Aging in Mice Deficient in DNA Repair and Transcription

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Cancer and ageing: rival demons?

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Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span

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Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

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Genetics of Aging

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Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

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FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

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High-quality life extension by the enzyme peptide methionine sulfoxide reductase

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A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

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Genetics and the Specificity of the Aging Process

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Life-long sustained mortality advantage of siblings of centenarians

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Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

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Deletion of Ku86 causes early onset of senescence in mice

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A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4

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Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)

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Fisher, Medawar, Hamilton and the Evolution of Aging

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Polymorphic Variants of Insulin-Like Growth Factor I (IGF-I) Receptor and Phosphoinositide 3-Kinase Genes Affect IGF-I Plasma Levels and Human Longevity: Cues for an Evolutionarily Conserved Mechanism of Life Span Control

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Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity

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Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

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Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

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Lessons from human progeroid syndromes

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Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

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Inheritance of human longevity in Iceland

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Evolution of lifespan in C. elegans

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Siblings of centenarians live longer

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Clinical Phenotype of Families with Longevity

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Familial Excess Longevity in Utah Genealogies

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Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease

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Genetics of Aging in the Fruit Fly,<i>Drosophila melanogaster</i>

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Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

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The effects of gene-environment interaction on the expression of longevity

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Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase

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Testing an ‘aging gene’ in long‐lived Drosophila strains: increased longevity depends on sex and genetic background

Spencer, C. C., Howell, C. E., Wright, A. R., & Promislow, D. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00044.x · Cited by 139 · see citing works

Assaying metabolic activity in ageing Caenorhabditis elegans

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Caloric Restriction: A Key to Understanding and Modulating Aging

Masoro, E. J. (2013) · Thammasat University Digital Collections · Cited by 110 · see citing works

The Oldest Human

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The paradox of the insulin/IGF-1 signaling pathway in longevity

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Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism

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Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

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The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900

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The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans

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The Sir2 protein family: A novel deacetylase for gene silencing and more

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Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

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Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

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Quantitative trait loci affecting natural variation in Drosophila longevity

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Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan

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Mouse Phenome Project: understanding human biology through mouse genetics and genomics

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SIR2 and aging – the exception that proves the rule

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Unique lipoprotein phenotype and genotype associated with exceptional longevity

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Caenorhabditis elegans—a paradigm for aging research: advantages and limitations

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Caloric restriction mimetics

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Molecular Mechanism of Maternal Rescue in the clk-1 Mutants of Caenorhabditis elegans

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Gene Expression and Regulation in the Extended Longevity Phenotypes of Drosophila

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Genes that shape the course of ageing

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Does Caloric Restriction in the Laboratory Simply Prevent Overfeeding and Return House Mice to Their Natural Level of Food Intake?

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Functional Genomics of Ageing

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Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

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Measuring biological age using omics data

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The redox stress hypothesis of aging

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Two faces of p53: aging and tumor suppression

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