Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

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HIF-1 and mechanisms of hypoxia sensing

Semenza, G. L. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00194-0 · Cited by 1,301

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214

HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia

Naranjo‐Suarez, S., Carlson, B. A., Tsuji, P. A., Yoo, M., Gladyshev, V. N., & Hatfield, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030470 · Cited by 32

Iron and oxygen sensing: a tale of 2 interacting elements?

Simpson, R. J., & McKie, A. T. (2014) · Metallomics · doi:10.1039/c4mt00225c · Cited by 32

Iron deficiency induces autophagy and activates Nrf2 signal through modulating p62/SQSTM

Inoue, H., Hanawa, N., Katsumata, S.-I., Katsumata-Tsuboi, R., Takahashi, N., & Uehara, M. (2017) · Biomedical Research · doi:10.2220/biomedres.38.343 · Cited by 32

The efficacy and safety of roxadustat for anemia in patients with chronic kidney disease: a meta-analysis

Zheng, Q., Yang, H., Fu, X., Huang, Y., Wei, R., Wang, Y., Liu, Y., & Liu, W. J. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa110 · Cited by 34

Role of dietary iron revisited: in metabolism, ferroptosis and pathophysiology of cancer.

Pandrangi, S. L., Chittineedi, P., Chikati, R., Lingareddy, J. R., Nagoor, M., & Ponnada, S. K. (2022) · PubMed · Cited by 34

HFE Mutations Modulate the Effect of Iron on Serum Hepcidin-25 in Chronic Hemodialysis Patients

Valenti, L. V. C., Girelli, D., Valenti, G., Castagna, A., Como, G., Campostrini, N., Rametta, R., Dongiovanni, P., Messa, P., & Fargion, S. R. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01370209 · Cited by 32

Pulmonary Arterial Hypertension: Iron Matters

Ramakrishnan, L., Pedersen, S. L., Toe, Q. K., Quinlan, G. J., & Wort, S. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00641 · Cited by 31

Targeting iron-metabolism:a potential therapeutic strategy for pulmonary fibrosis

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Hypoxia Inducible Factor-2a Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats

Davis, M. R., Shawron, K., Rendina-Ruedy, E., Peterson, S., Lucas, E. A., Smith, B. J., & Clarke, S. L. (2011) · Journal of Nutrition · doi:10.3945/jn.111.144105 · Cited by 30

Genetic study of the hepcidin gene (HAMP) promoter and functional analysis of the c.-582A > G variant

Parajes, S., González‐Quintela, A., Franco, J. C., Quinteiro, C., Domínguez, F., & Loidi, L. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-110 · Cited by 32

The relationship between systemic iron homeostasis and erythropoiesis

Rishi, G., & Subramaniam, V. N. (2017) · Bioscience Reports · doi:10.1042/bsr20170195 · Cited by 35

Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)?

da Silva, I. S., Rausch, V., Seitz, H. K., & Mueller, S. (2017) · Cancers · doi:10.3390/cancers9110145 · Cited by 31

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways

Luhachack, L. G., Visvikis, O., Wollenberg, A. C., Lacy‐Hulbert, A., Stuart, L. M., & Irazoqui, J. E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002798 · Cited by 33

Impact of bacterial infections on erythropoiesis

de Souza, L. V., Hoffmann, A., & Weiß, G. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1841636 · Cited by 30

Iron Homeostasis andTrypanosoma bruceiAssociated Immunopathogenicity Development: A Battle/Quest for Iron

Stijlemans, B., Beschin, A., Magez, S., Ginderachter, J. A. V., & BAETSELIER, P. D. (2015) · BioMed Research International · doi:10.1155/2015/819389 · Cited by 30

A Zebrafish Model for VHL and Hypoxia Signaling

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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders

Camaschella, C., & Silvestri, L. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.130 · Cited by 28

Mechanisms and Regulation of Intestinal Iron Transport

Collins, J. F., Flores, S. R., Wang, X., & Anderson, G. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00060-8 · Cited by 30

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Wu, H., Wei, H., Zhang, D., Sehgal, S. A., Zhang, D., Wang, X., Qin, Y., Liu, L., & Chen, Q. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101661 · Cited by 30

Novel insights into alcoholic liver disease: Iron overload, iron sensing and hemolysis

Mueller, S., Chen, C., Mueller, J. H., & Wang, S. (2022) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2021-0056 · Cited by 30

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

Lee, P. L., Hsu, M., Welser-Alves, J. V., & Peng, H. (2012) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.12.005 · Cited by 31

Systemic inflammation up-regulates serum hepcidin in exacerbations and stabile chronic obstructive pulmonary disease

Tandara, L., Grubišić, T. Ž., Gudelj, I., Jurišić, Z., Tandara, M., Gugo, K., Mladinov, S., & Salamunić, I. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.07.010 · Cited by 30

Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases

Padalko, V., Posnik, F., & Adamczyk, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189950 · Cited by 32

Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease

Larson, D. S., & Coyne, D. W. (2013) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2013.01.001 · Cited by 27

Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia

Bart, N., Curtis, M. K., Cheng, H., Hungerford, S. L., McLaren, R., Petousi, N., Dorrington, K. L., & Robbins, P. A. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00032.2016 · Cited by 30

Mechanisms of transcription factor acetylation and consequences in hearts

Thiagarajan, D., Vedantham, S., Ananthakrishnan, R., Schmidt, A. M., & Ramasamy, R. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.011 · Cited by 29

Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells

Bajbouj, K., Shafarin, J., Abdalla, M. Y., Ahmad, I. M., & Hamad, M. A. (2017) · Tumor Biology · doi:10.1177/1010428317726184 · Cited by 29

A Hypoxia-Inducible Factor Stabilizer Improves Hematopoiesis and Iron Metabolism Early after Administration to Treat Anemia in Hemodialysis Patients

Ogawa, C., Tsuchiya, K., Tomosugi, N., & Maeda, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197153 · Cited by 29

Anemia in Heart Failure: Association of Hepcidin Levels to Iron Deficiency in Stable Outpatients

Weber, C. S., Neto, L. B. D. S., Goldraich, L. A., Biolo, A., & Clausell, N. (2012) · Acta Haematologica · doi:10.1159/000342110 · Cited by 28

Live high, train low – influence on resting and post‐exercise hepcidin levels

Govus, A. D., Peeling, P., Abbiss, C. R., Lawler, N. G., Swinkels, D. W., Laarakkers, C. M., Thompson, K., Peiffer, J. J., Gore, C. J., & Garvican‐Lewis, L. A. (2016) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12685 · Cited by 28

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

Lalwani, A., Warren, J. A., Liuwantara, D., Hawthorne, W. J., O’Connell, P. J., Gonzalez, F. J., Stokes, R., Chen, J. H., Laybutt, D. R., Craig, M. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.086 · Cited by 27

Biomarkers of iron metabolism in chronic kidney disease

Głogowski, T., Wojtaszek, E., & Małyszko, J. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02663-z · Cited by 33

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression

Foka, P., Dimitriadis, A., Kyratzopoulou, E., Giannimaras, D. A., Sarno, S., Simos, G., Georgopoulou, U., & Mamalaki, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1621-4 · Cited by 27

TIME COURSE OF IRON METABOLISM IN CRITICALLY ILL PATIENTS

Piagnerelli, M., COTTON, F. J., Herpain, A., Rapotec, A., Chatti, R., Gulbis, B., & Vincent, J.-L. (2013) · Acta Clinica Belgica · doi:10.2143/acb.68.1.2062715 · Cited by 27

Gastrins, iron homeostasis and colorectal cancer

Kovac, S., Anderson, G. J., & Baldwin, G. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.02.007 · Cited by 28

FBXL5 modulates HIF-1α transcriptional activity by degradation of CITED2

Machado-Oliveira, G., Guerreiro, E. M., Matias, A. C., Facucho-Oliveira, J., Pacheco-Leyva, I., & Bragança, J. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.04.012 · Cited by 27

Iron Deficiency and Anemia Associated with Infectious and Inflammatory Diseases

Hoffmann, A., de Souza, L. V., & Weiß, G. (2022) · Nutrition and health · doi:10.1007/978-3-031-14521-6_17 · Cited by 29

The mechanism of hypoxia-inducible factor-1α enhancing the transcriptional activity of transferrin ferroportin 1 and regulating the Nrf2/HO-1 pathway in ferroptosis after cerebral ischemic injury

Yao, H., Tian, J., Cheng, S., Dou, H., & Zhu, Y. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.025 · Cited by 26

HIF-independent oxygen sensing via KDM6A regulates ferroptosis

Minikes, A. M., Liu, P., Wang, H., Hu, J., Alwaseem, H., Li, Y., & Jiang, X. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.07.001 · Cited by 30

β Cell and Autophagy: What Do We Know?

Mohammadi‐Motlagh, H., Sadeghalvad, M., Yavari, N., Primavera, R., Soltani, S., Chetty, S. S., Ganguly, A., Regmi, S., Fløyel, T., Kaur, S., et al. (2023) · Biomolecules · doi:10.3390/biom13040649 · Cited by 27

Hepcidin Regulation in Wild‐Type and Hfe Knockout Mice in Response to Alcohol Consumption: Evidence for an Alcohol‐Induced Hypoxic Response

Heritage, M. L., Murphy, T. L., Bridle, K. R., Anderson, G. J., Crawford, D. H., & Fletcher, L. M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00969.x · Cited by 27

A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

Casanovas, G., Banerji, A., D’Alessio, F., Muckenthaler, M. U., & Legewie, S. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003421 · Cited by 26

Genetic diversities of MT-ND1 and MT-ND2 genes are associated with high-altitude adaptation in yak

Shi, Y., Hu, Y., Wang, J., Elzo, M. A., Yang, X., & Lai, S. (2017) · Mitochondrial DNA Part A · doi:10.1080/24701394.2017.1307976 · Cited by 26

Circulating factors are involved in hypoxia-induced hepcidin suppression

Ravasi, G., Pelucchi, S., Greni, F., Mariani, R., Giuliano, A., Parati, G., Silvestri, L., & Piperno, A. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.06.006 · Cited by 25

Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax

Neves, J. V., Caldas, C., Ramos, M. F., & Rodrigues, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153940 · Cited by 25

Reduction of hepatic fibrosis by overexpression of von Hippel–Lindau protein in experimental models of chronic liver disease

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Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice

Nakai, T., Iwamura, Y., Kato, K., Hirano, I., Matsumoto, Y., Tomioka, Y., Yamamoto, M. P., & Suzuki, N. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009798 · Cited by 25

Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase

Starzyński, R. R., Canonne‐Hergaux, F., Willemetz, A., Gralak, M. A., Woliński, J., Styś, A., Olszak, J., & Lipiński, P. (2009) · Biochemical Journal · doi:10.1042/bj20082137 · Cited by 25

GDF15 Is Related to Anemia and Hepcidin in Kidney Allograft Recipients

Małyszko, J., Koc‐Żórawska, E., Małyszko, J. S., Głowińska, I., Myśliwiec, M., & Macdougall, I. C. (2013) · Nephron Clinical Practice · doi:10.1159/000351810 · Cited by 24

Effects of Pregnancy and Lactation on Iron Metabolism in Rats

Gao, G., Liu, S.-Y., Wang, H., Zhang, T.-W., Yu, P., Duan, X., Zhao, S.-E., & Chang, Y.-Z. (2015) · BioMed Research International · doi:10.1155/2015/105325 · Cited by 26

Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders

Wang, C., Fang, Z., Zhu, Z., Liu, J., & Chen, H. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.05.002 · Cited by 25

Serum prohepcidin reflects the degree of liver function impairment in liver cirrhosis

Jaroszewicz, J., Rogalska, M., & Flisiak, R. (2008) · Biomarkers · doi:10.1080/13547500802033391 · Cited by 25

Iron endowment at birth: maternal iron status and other influences

Viteri, F. E. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00449.x · Cited by 26

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice

Chiabrando, D., Fiorito, V., Marro, S., Silengo, L., Altruda, F., & Tolosano, E. (2013) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2012.08.002 · Cited by 24

The Pathology of Comparative Animal Models of Human Haemochromatosis

Klopfleisch, R., & Olias, P. (2012) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2012.09.001 · Cited by 26

Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation

Jain, M. R., Joharapurkar, A. A., PATEL, V. G., Kshirsagar, S. G., Sutariya, B., Patel, M. S., Patel, H., & Patel, P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.023 · Cited by 25

Iron Mining for Erythropoiesis

Correnti, M., Gammella, E., Cairo, G., & Recalcati, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105341 · Cited by 30

Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease

Koury, M. J., Agarwal, R., Chertow, G. M., Eckardt, K., Fishbane, S. N., Ganz, T., Haase, V. H., Hanudel, M. R., Parfrey, P. S., Pérgola, P. E., et al. (2022) · American Journal of Hematology · doi:10.1002/ajh.26644 · Cited by 24

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94

Baek, J. H., Reiter, C. E. N., Manalo, D. J., Buehler, P. W., Hider, R. C., & Alayash, A. I. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.04.010 · Cited by 24

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

Walmsley, S. R., Chilvers, E. R., & Whyte, M. K. B. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2632 · Cited by 24

Prohepcidin binds to the HAMP promoter and autoregulates its own expression

Pandur, E., Sipos, K., Grama, L., Nagy, J., Poór, V. S., Sétáló, G., Miseta, A., & Fekete, Z. (2013) · Biochemical Journal · doi:10.1042/bj20121466 · Cited by 24

Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?

Yousaf, F., & Spinowitz, B. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0629-6 · Cited by 23

Safe and Effective Treatment for Anemic Patients With Chronic Kidney Disease: An Updated Systematic Review and Meta-Analysis on Roxadustat

Tang, M., Zhu, C., Yan, T., Zhou, Y., Lv, Q., & Chuan, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.658079 · Cited by 25

Future alternative therapies for β-thalassemia

Rivella, S., & Rachmilewitz, E. A. (2009) · Expert Review of Hematology · doi:10.1586/ehm.09.56 · Cited by 23

Molecular Mechanisms of Intestinal Iron Transport

Collins, J. F., & Anderson, G. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00071-3 · Cited by 22

Reduced phenotypic expression in genetic hemochromatosis with time: Role of exposure to non-genetic modifiers

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Signaling pathways regulating hepcidin

Rishi, G., & Subramaniam, V. N. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.003 · Cited by 23

Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis

Hoffbrand, A. V., Hershko, C., & Camaschella, C. (2010) · Wiley eBooks · doi:10.1002/9781444323160.ch3 · Cited by 23

The HIF-1α–C/EBPα Axis

Janardhan, H. P. (2008) · Science Signaling · doi:10.1126/scisignal.143jc2 · Cited by 23

Hepcidin and its role in inflammatory bowel disease.

Dudkowiak, R., Neubauer, K., & Poniewierka, E. (2013) · PubMed · Cited by 22

The manganese superoxide dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells

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ER Stress and Iron Homeostasis: A New Frontier for the UPR

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Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice

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Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

Luo, Q., Wang, D., Yu, M., & Zhu, L. (2011) · IUBMB Life · doi:10.1002/iub.419 · Cited by 22

Metabolic adjustments during starvation in Daphnia pulex

Klumpen, E., Hoffschröer, N., Schwalb, A., Gigengack, U., Koch, M., Paul, R. J., & Zeis, B. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110591 · Cited by 21

Iron biology

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Hematologic Aspects of Kidney Disease

Brugnara, C., & Eckardt, K. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6193-9.10056-9 · Cited by 21

Approaches to the treatment of anaemia in patients with chronic heart failure

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Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolism

Ting, K. K. Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1403915 · Cited by 20

The role of roxadustat in chronic kidney disease patients complicated with anemia

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Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice

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Metabolism in Immune Cell Differentiation and Function

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Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway

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