The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Altered macrophage differentiation and immune dysfunction in tumor development
Open accessAbstract
Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the accumulation and functional differentiation of myelomonocytic cells, most of which are macrophages, at the tumor site. An important side effect of the accumulation and functional differentiation of these cells is that they can induce lymphocyte dysfunction. A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.
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Cites
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Self-citationInterferons, immunity and cancer immunoediting
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Cited by
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Metadata
- Authors
- Sica, A., & Bronte, V.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-05-01
- Volume
- 117
- Issue
- 5
- Pages
- 1155-1166
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2039183048
- Cited by
- 1,238
- References
- 20
- FWCI
- 27.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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