The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
Open accessAbstract
Ischemia/reperfusion (IR) injury in transplanted livers contributes to organ dysfunction and failure and is characterized in part by loss of NO bioavailability. Inhalation of NO is nontoxic and at high concentrations (80 ppm) inhibits IR injury in extrapulmonary tissues. In this prospective, blinded, placebo-controlled study, we evaluated the hypothesis that administration of inhaled NO (iNO; 80 ppm) to patients undergoing orthotopic liver transplantation inhibits hepatic IR injury, resulting in improved liver function. Patients were randomized to receive either placebo or iNO (n = 10 per group) during the operative period only. When results were adjusted for cold ischemia time and sex, iNO significantly decreased hospital length of stay, and evaluation of serum transaminases (alanine transaminase, aspartate aminotransferase) and coagulation times (prothrombin time, partial thromboplastin time) indicated that iNO improved the rate at which liver function was restored after transplantation. iNO did not significantly affect changes in inflammatory markers in liver tissue 1 hour after reperfusion but significantly lowered hepatocyte apoptosis. Evaluation of circulating NO metabolites indicated that the most likely candidate transducer of extrapulmonary effects of iNO was nitrite. In summary, this study supports the clinical use of iNO as an extrapulmonary therapeutic to improve organ function following transplantation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It is used in infants with primary pulmonary hypertension of the newborn to reduce pulmonary artery pressure.158”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [158]
Experimental — accuracy not yet measuredIn the citing paper
“A previous study from Lang et al demonstrated that inhaled NO therapy before liver transplanation significantly elevated tissue nitrite levels that were associated with cytoprotection [166].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [166]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
The role of oxidants and free radicals in reperfusion injury
Zweier, J. L., & Talukder, M. F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.025 · Cited by 743
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674
Self-citationThe emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609
Self-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518
Nitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462
Hepatic ischemia/reperfusion injury—a fresh look
Fondevila, C., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00008-x · Cited by 407
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400
Flagged first, then by citations
Research works printed but not linked: 1
- 10.1172/JCI200522493 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 224
Clinical use of inhaled nitric oxide: Local and systemic applications
Barnes, M., & Brisbois, E. J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.029 · Cited by 33
Liver graft preconditioning, preservation and reconditioning
Gilbo, N., Catalano, G., Salizzoni, M., & Romagnoli, R. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.06.031 · Cited by 32
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction
Rodriguez, C., Vitturi, D. A., He, J., Vandromme, M., Brandon, A., Hutchings, A., Rue, L. W., Kerby, J. D., & Patel, R. P. (2009) · Biochemical Journal · doi:10.1042/bj20090735 · Cited by 31
Self-citationFukazawa, K., & Pretto, E. A. (2010) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1007/s00534-010-0344-7 · Cited by 31
Use of a hanging-weight system for liver ischemic preconditioning in mice
Hart, M. L., Much, C. C., Köhler, D., Schittenhelm, J., Gorzolla, I. C., Stahl, G. L., & Eltzschig, H. K. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00083.2008 · Cited by 31
Theodoraki, K. A., Karmaniolou, I. I., Tympa, A., Tasoulis, M. K., Nastos, C., Vassiliou, I., Arkadopoulos, N. F., & Smyrniotis, V. E. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8235921 · Cited by 30
Measuring nitrate reductase activity from human and rodent tongues
Ahmed, K. A., Nichols, A., Honavar, J., Dransfield, M. T., Matalon, S., & Patel, R. P. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.04.001 · Cited by 30
Self-citationLiver protection strategies in liver transplantation
Jia, J., Li, J., Jiang, L., Lin, B.-Y., Wang, L., Su, R., Zhou, L., & Zheng, S. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60332-0 · Cited by 29
Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., et al. (2012) · Kidney International · doi:10.1038/ki.2012.116 · Cited by 28
Self-citationIs extracorporeal hypothermic machine perfusion of the liver better than the ‘good old icebox’?
Bae, C., Henry, S. D., & Guarrera, J. V. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328351083d · Cited by 28
Plasma methemoglobin as a potential biomarker of anemic stress in humans
Hare, G. M. T., Mu, A., Romaschin, A. D., Tsui, A. K. Y., Shehata, N., Beattie, W. S., & Mazer, C. D. (2012) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-011-9663-7 · Cited by 27
Nagai, K., Yagi, S., Afify, M., Bleilevens, C., Üemoto, S., & Tolba, R. H. (2012) · Transplantation · doi:10.1097/tp.0b013e318277e2d1 · Cited by 28
Srinivasan, P. K., Yagi, S., Doorschodt, B. M., Nagai, K., Afify, M., Üemoto, S., & Tolba, R. H. (2011) · Liver Transplantation · doi:10.1002/lt.22442 · Cited by 27
Tissue conservation for transplantation
Krezdorn, N., Tasigiorgos, S., Wo, L. M., Turk, M., Lopdrup, R. G., Kiwanuka, H., Win, T.-S., Bueno, E. M., & Pomahač, B. (2017) · Innovative Surgical Sciences · doi:10.1515/iss-2017-0010 · Cited by 29
Liang, Z., Chen, H., Gong, X., Shi, B., Lin, L., Tao, F.-Y., Wu, Q., Fang, M., Li, H., Lu, C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.745693 · Cited by 26
He, S., Rehman, H., Wright, G. L., & Zhong, Z. (2010) · Transplantation · doi:10.1097/tp.0b013e3181c99185 · Cited by 24
Liu, Q., Rehman, H., Krishnasamy, Y., Ramshesh, V. K., Theruvath, T. P., Chavin, K. D., Schnellmann, R. G., Lemasters, J. J., & Zhong, Z. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.012 · Cited by 25
Redox therapeutics in hepatic ischemia reperfusion injury
Patel, R. P., Lang, J. D., Smith, A. B., & Crawford, J. H. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i1.1 · Cited by 23
Self-citationSiriussawakul, A., Chen, L. I., & Lang, J. D. (2012) · Journal of Transplantation · doi:10.1155/2012/819382 · Cited by 23
Self-citationZhang, B., Liu, Q.-H., Zhou, C.-J., Hu, M., & Qian, H. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3762 · Cited by 23
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Lundberg, J. O., Weitzberg, E., Shiva, S., & Gladwin, M. T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_3 · Cited by 26
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke
Sienel, R. I., Mamrak, U., Biller, J., Roth, S., Zellner, A., Parakaw, T., Khambata, R. S., Liesz, A., Haffner, C., Ahluwalia, A., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02988-3 · Cited by 22
Effects of non-drug treatment on liver cells apoptosis during hepatic ischemia-reperfusion injury
Wang, P., Huang, X., Yang, M.-W., Fang, S.-Y., Hong, F., & Yang, S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119321 · Cited by 22
Liu, Q., Rehman, H., Krishnasamy, Y., Schnellmann, R. G., Lemasters, J. J., & Zhong, Z. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.017 · Cited by 22
Wadström, J., Ericzon, B., Halloran, P. F., Bechstein, W. O., Opelz, G., Serón, D., Grinyo, J. M., Loupy, A., Kuypers, D. R. J., Mariat, C., et al. (2017) · Transplantation · doi:10.1097/tp.0000000000001563 · Cited by 23
Preventing ischemic brain injury after sudden cardiac arrest using NO inhalation
Kida, K., & Ichinose, F. (2014) · Critical Care · doi:10.1186/cc13779 · Cited by 22
The multifaceted role of the renal microvasculature during acute kidney injury
Maringer, K. V., & Sims‐Lucas, S. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3231-2 · Cited by 21
Nitric Oxide in Post-cardiac Arrest Syndrome
Miyazaki, Y., & Ichinose, F. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000765 · Cited by 21
Dezfulian, C., Olsufka, M., Fly, D., Scruggs, S., Do, R., Maynard, C. C., Nichol, G., & Kim, F. (2017) · Resuscitation · doi:10.1016/j.resuscitation.2017.11.055 · Cited by 19
Haugaa, H., Gómez, H., Maberry, D. R., Holder, A. L., Ogundele, O., Quintero, A. M. B., Escobar, D. A., Tønnessen, T. I., Airgood, H., Dezfulian, C., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0903-z · Cited by 19
Goździk, W., Albert, J., Harbut, P., Zieliński, S., Ryniak, S., Lindwall, R., Dzięgiel, P., Podhorska‐Okołów, M., Kübler, A., & FROSTELL, C. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01908.x · Cited by 19
Novel Pharmacologic Strategies to Protect the Liver from Ischemia- Reperfusion Injury
Avila, M. A., Íñiguez, M., Dotor, J., Feijoó, E., Goñi, S., Prìeto, J., & Berasain, C. (2008) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489008783331643 · Cited by 18
Principles of Liver Preservation
Petrowsky, H., & Clavien, P. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-0268-8.00044-0 · Cited by 18
L-arginine in the ischemic phase protects against liver ischemia-reperfusion injury
Taha, M. O., Caricati‐Neto, A., Ferreira, R. M., Simões, M. D. J., Monteiro, H. P., & Fagundes, D. J. (2012) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502012000900005 · Cited by 18
Zhao, J., Hou, L., Dery, K. J., Yuan, X., Kim, K. H., Kupiec‐Weglinski, J. W., Hall, D. R., Thornley, C. J., Hobeika, M. J., Eltzschig, H. K., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001609 · Cited by 23
Abdel‐Salam, O. M. E., Sleem, A. A., & Shafee, N. (2010) · Inflammopharmacology · doi:10.1007/s10787-009-0027-7 · Cited by 17
Kim, S. M., Kim, S.-W., Jung, Y.-J., Min, S., Min, S., Kim, S. J., & Ha, J. (2013) · Surgery · doi:10.1016/j.surg.2013.10.005 · Cited by 17
Inhaled nitric oxide in adults with in-hospital cardiac arrest: A feasibility study
Patel, J., Schoenfeld, E. R., Hou, W., Singer, A. J., Rakowski, E., Ahmad, S., Patel, R., Parikh, P. B., & Smaldone, G. C. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.07.001 · Cited by 17
Self-citationValidation of two point-of-care tests against standard lab measures of NO in saliva and in serum
Modi, A. G., Morou-Bermúdez, E., Vergara, J. L., Patel, R. P., Nichols, A., & JOSHIPURA, K. J. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.01.009 · Cited by 16
Self-citationPotential role for age as a modulator of oral nitrate reductase activity
Ahmed, K. A., Kim, K., Ricart, K. C., Pol, W. V. D., Qi, X., Bamman, M. M., Behrens, C. E., Fisher, G., Boulton, M. E., Morrow, C. D., et al. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.12.001 · Cited by 18
Self-citationMechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
Webb, A., & Ahluwalia, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00017-4 · Cited by 15
Shi, Y., Rehman, H., Wright, G. L., & Zhong, Z. (2010) · Liver Transplantation · doi:10.1002/lt.22148 · Cited by 14
Brücken, A., Bleilevens, C., Berger, P., Nolte, K. W., Gaisa, N. T., Rossaint, R., Marx, G., Derwall, M., & Fries, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-25213-1 · Cited by 14
Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver
Björnsson, B. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1775 · Cited by 13
Ko, H.-S., Joo, S. H., Jo, J. H., Park, W. S., Jung, W. Y., Shin, J. H., & Ahn, H. J. (2017) · Transplantation Proceedings · doi:10.1016/j.transproceed.2017.03.054 · Cited by 13
Goździk, W., Zieliński, S., Zielińska, M., Ratajczak, K., Skrzypczak, P., Rodziewicz, S., Kübler, A., Löfström, K., Dzięgiel, P., Olbromski, M., et al. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632017751486 · Cited by 13
Transpulmonary Flux of S -Nitrosothiols and Pulmonary Vasodilation during Nitric Oxide Inhalation
Torok, J. A., Brahmajothi, M. V., Zhu, H., Tinch, B. T., Auten, R. L., & McMahon, T. J. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0439oc · Cited by 13
Nitric Oxide in Liver Ischemia–Reperfusion Injury
Fu, P., & Li, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00008-4 · Cited by 13
Guan, L., Liu, H., Fu, P., Li, Z., Li, P., Xie, L., Xin, M., Wang, Z., & Li, W. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1429835 · Cited by 12
Improving outcomes after cardiac arrest using NO inhalation
Ichinose, F. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.08.011 · Cited by 12
Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period
Magliocca, A., & Fries, M. (2021) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000820 · Cited by 10
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential
Dent, M. R., & DeMartino, A. W. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16274 · Cited by 11
Pecker, L. H., & Ackerman, H. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_7 · Cited by 10
Immunomodulation by a combination of nitric oxide and glucocorticoids in a human endotoxin model
Hållström, L., Berghäll, E., FROSTELL, C. G., Sollevi, A., & Soop, A. (2010) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2010.02297.x · Cited by 9
Vekemans, K., Monbaliu, D. R. L., Balligand, E., Heedfeld, V., Jochmans, I., Pirenne, J., & van Pelt, J. F. (2011) · Liver Transplantation · doi:10.1002/lt.22446 · Cited by 9
Role of nitric oxide in liver transplantation: Should it be routinely used?
Fukazawa, K., & Lang, J. D. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i34.1489 · Cited by 9
Self-citationTherapeutic Application of Nitric Oxide in Human Diseases
Namkoong, S., & Kim, Y. (2010) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2010.18.4.351 · Cited by 9
Subcellular Energetics and Metabolism: Potential Therapeutic Applications
Thiele, R. H. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001865 · Cited by 8
Emerging graft protective strategies in clinical liver transplantation
Nickkholgh, A., & Maluf, D. G. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1322901 · Cited by 8
Koraki, E., Mantzoros, I., Chatzakis, C., Gkiouliava, A., Cheva, A., Lavrentieva, A., Sifaki, F., Argiriadou, H., Κεσίσογλου, Ι., Galanos-Demiris, K., et al. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i11.1098 · Cited by 8
Nitrate reduction by salivary bacteria, glucose metabolism, and lifestyle
Morou-Bermúdez, E., Guo, K., Morales, J. M., Ricart, K. C., Patel, R. P., Clemente, J. C., & JOSHIPURA, K. J. (2025) · Journal of Oral Microbiology · doi:10.1080/20002297.2025.2489612 · Cited by 8
Self-citationWilson, E. A. H., Weinberg, D. L., & Patel, G. P. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006902 · Cited by 7
Lack of endothelial dysfunction in patients under tacrolimus after orthotopic liver transplantation
Rouyer, O., Talha, S., Marco, P. D., Ellero, B., Doutreleau, S., Diemunsch, P. A., Piquard, F., & Gény, B. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.01013.x · Cited by 7
Szabó, C. (2010) · Wiley eBooks · doi:10.1002/0471266949.bmc178 · Cited by 7
Inhaled nitric oxide prevents NSAID-induced renal impairment in pseudo-normovolaemic piglets
Junot, S., Keroack, S., del Castillo, J. R. E., Ayoub, J., Paquet, C., Bonnet‐Garin, J., & Troncy, É. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179475 · Cited by 7
Çekmez, F., Purtuloğlu, T., Aydemir, G., Aydınöz, S., Fidancı, K., Karaoğlu, A., Babacan, O., Canpolat, F. E., Çetınkaya, M., Tunç, T., et al. (2012) · Pediatric Surgery International · doi:10.1007/s00383-012-3181-8 · Cited by 6
No Signs of Inflammation during Knee Surgery with Ischemia: A Study Involving Inhaled Nitric Oxide
Hållström, L., FROSTELL, C. G., Herrlin, A., Lindroos, E., Lundberg, I. E., & Soop, A. (2014) · Mediators of Inflammation · doi:10.1155/2014/620281 · Cited by 5
Clinical Application of Inhaled Nitric Oxide
Maruyama, K., Zhang, E., & Maruyama, J. (2011) · KARGER eBooks · doi:10.1159/000321941 · Cited by 5
Pichugin, V. V., Seyfetdinov, I. R., Medvedev, A. P., & Domnin, S. E. (2019) · Medical Almanac · doi:10.21145/2499-9954-2019-1-81-87 · Cited by 5
Recent advances in the role of gasotransmitters in necroptosis
Hao, M.-Y., Li, K., Han, H.-S., Chu, T., Wang, Y., Si, W.-R., Jiang, Q., & Wu, D. (2025) · APOPTOSIS · doi:10.1007/s10495-024-02057-x · Cited by 4
Porschen, A., Srinivasan, P. K., Iwasaki, J., Afify, M., & Tolba, R. H. (2016) · European Surgical Research · doi:10.1159/000445682 · Cited by 4
Nitric oxide application for myocardial protection in coronary artery disease
Podoksenov, Y. K., Олегович, К. Н., & Аркадьевна, М. И. (2019) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology201902134 · Cited by 4
Tonelli, A. R., Aulak, K. S., Ahmed, M., Hausladen, A., AbuHalimeh, B. J., Casa, C. J., Rogers, S. C., Timm, D. D., Doctor, A., Gaston, B. M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221777 · Cited by 4
Donation: Where are our opportunities for expansion?
Guarrera, J. V. (2014) · Liver Transplantation · doi:10.1002/lt.24001 · Cited by 4
A novel in situ model of liver cold ischemia–reperfusion in rats
Li, R., Mi, Y., Tan, G., Zhang, W., Li, G., & Sun, X. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.05.042 · Cited by 4
Inhaled Nitric Oxide—Current Practice and Future Potential Uses and Development
Ichinose, F., & Zapol, W. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00025-9 · Cited by 4
Effects of GIT-27NO, a NO-donating compound, on hepatic ischemia/reperfusion injury
Mangano, K., Lanteri, R., Basile, M. S., Bellavia, N., Latino, R., Messina, D., Fagone, P., Colletti, G., Nania, R., Caltabiano, R., et al. (2019) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738419862736 · Cited by 4
D’Aragon, F., Selzner, M., Breau, R., Masse, M.-H., Lamontagne, F., Masse, M., Chassé, M., Carrier, F. M., Cardinal, H., Chaudhury, P. K., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-086777 · Cited by 3
Crawford, R. S., & Watkins, M. T. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5223-4.00006-8 · Cited by 3
Karnatovskaia, L. V., Matharu, J., Burger, C. D., & Keller, C. A. (2014) · Transplantation · doi:10.1097/tp.0000000000000364 · Cited by 3
Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury
Sawada, T., Inoue, K., Tanabe, D., Kawamoto, S., Tsuji, T., & Tashiro, S. (2016) · The Journal of Medical Investigation · doi:10.2152/jmi.63.262 · Cited by 3
Immunometabolic remodeling: new perspectives and strategies for liver transplantation
Wang, L., Sheng, X., Shi, G., Li, Y., Wang, D., Wang, W., Mi, C., Wang, S., Du, Y., & 杨含腾 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1776694 · Cited by 2
D’Aragon, F., Rousseau, W., Breau, R., Aminaei, D., Ichaï, C., Boyd, G. J., Burns, K. E. A., Cardinal, H., Carrier, F. M., Chassé, M., et al. (2023) · Transplantation Direct · doi:10.1097/txd.0000000000001519 · Cited by 2
Lyu, H., Yi, X., Zou, Y., Lu, P., Li, L., Liu, J., Chen, S., Wei, X., Yang, Y., & Yi, H. (2024) · Liver Research · doi:10.1016/j.livres.2024.09.005 · Cited by 2
Guo, K., JOSHIPURA, K. J., Ricart, K. C., Patel, R. P., Gower, B. A., Andriankaja, O. M., & Morou-Bermúdez, E. (2025) · Frontiers in Oral Health · doi:10.3389/froh.2025.1488286 · Cited by 3
Self-citationAirway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle, S. J., Freeman, A., Patel, R. P., Ambalavanan, N., & Lal, C. V. (2020) · Respiratory Research · doi:10.1186/s12931-020-01508-8 · Cited by 2
Self-citationMiranda, L. E. C., Tirapelli, L. F., Ramos, S. G., Capellini, V. K., Celotto, A. C., Carlotti, C. G., & Évora, P. R. B. (2012) · Experimental and Clinical Transplantation · doi:10.6002/ect.2011.0055 · Cited by 2
Shcherba, A. E., Коротков, С. В., Efimov, D., Minou, A. F., Lebedz, O. A., Karytka, A. A., Fedaruk, D., Сантоцкий, Е. О., Михайлович, Д. А., & Руммо, О. О. (2016) · Journal of Translational Medicine and Research · doi:10.21614/jtmr-21-2-82 · Cited by 2
Petrowsky, H., & Busuttil, R. W. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-0268-8.00075-0 · Cited by 2
Preventing Ischemic Brain Injury after Sudden Cardiac Arrest Using NO Inhalation
Kida, K., & Ichinose, F. (2014) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-03746-2_34 · Cited by 2
Cenci, S., Gaonkar, M. P., Villalobos, R., Medeiros, K. J., -, N. S., Nardini, R., Carroll, R. W., Bittner, E. A., Winkler, T., Yu, B., et al. (2026) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2026.04.029 · Cited by 1
Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension
Maruyama, J., Yokochi, A., Zhang, E., Sawada, H., & Maruyam, K. (2013) · InTech eBooks · doi:10.5772/55680 · Cited by 2
Inhaled Nitric Oxide Therapy for Extrapulmonary Inflammation
Crawford, J. H., Lang, J. D., & Patel, R. P. (2015) · Future Science OA · doi:10.4155/fso.15.34 · Cited by 1
Self-citationGoździk, W., & Goździk, A. (2012) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2012.32684 · Cited by 1
Acute Renal Failure in Kidney Transplant Recipients
Yadav, A., Singh, P., & McCauley, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44942-7.00046-7 · Cited by 1
Systemic organoprotection with inhaled nitric oxide (literature review)
Аркадьевна, М. И., Yavorovsky, A. G., Ma, V., Владимирович, Н. П., Khalikova, E. Y., Kozlova, D. S., Bayrashevskaya, A. V., Temirova, K., Демура, Т. А., & Николаевна, З. Е. (2024) · Messenger of Anesthesiology and Resuscitation · doi:10.24884/2078-5658-2024-21-4-104-114 · Cited by 1
The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury
Spagnolli, E., & Zapol, W. M. (2011) · Wiley eBooks · doi:10.1002/9781119975427.ch5 · Cited by 1
Bloch, K. D., Steinbicker, A. U., Lohmeyer, L. K., & Malhotra, R. K. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_12 · Cited by 1
Datta, G. (2014) · UCL Discovery (University College London)
The Influences of Nitric Oxide on Liver Ischemia-Reperfusion Injury
Stoltenberg, E., Alexander, A., Bradley, E., & Lang, J. D. (2012) · InTech eBooks · doi:10.5772/27998
Self-citation
Metadata
- Authors
- Lang, J. D., Teng, X., Chumley, P., Crawford, J. H., Isbell, T. S., Chacko, B. K., Liu, Y., Jhala, N., Crowe, D. R., Smith, A. B., Cross, R. C., Frenette, L., Kelley, E. E., Wilhite, D. W., Hall, C. R., Page, G. P., Fallon, M. B., Bynon, J. S., Eckhoff, D. E., & Patel, R. P.
- Affiliations
- University of Washington (US)
- University of Alabama at Birmingham (US)
- University of Pittsburgh (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2583-2591
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1950460
- OpenAlex
- W2016928245
- Cited by
- 224
- References
- 44
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 16 · 2016: 10 · 2015: 24 · 2014: 18 · 2013: 9 · 2012: 23
- FWCI
- 18.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- inhaled nitric oxide, orthotopic liver transplantation, ischemia-reperfusion injury, liver function recovery, nitric oxide bioavailability, hepatocyte apoptosis, nitrite, transaminases, coagulation, length of hospital stay, inflammatory markers
- MeSH terms
- Administration, Inhalation, Adult, Aged, Female, Humans, Length of Stay, Liver, Male, Middle Aged, Nitric Oxide, Reperfusion Injury, Liver Transplantation, Cell Death, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review