The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
Open accessAbstract
The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulence-associated protein secretion system, enhanced the apoptosis of infected macrophages by diminishing secretion of mycobacterial superoxide dismutase. Deletion of secA2 markedly increased priming of antigen-specific CD8(+) T cells in vivo, and vaccination of mice and guinea pigs with a secA2 mutant significantly increased resistance to M. tuberculosis challenge compared with standard M. bovis bacille Calmette-Guérin vaccination. Our results define a mechanism for a key immune evasion strategy of M. tuberculosis and provide what we believe to be a novel approach for improving mycobacterial vaccines.
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Cites
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635213100 · Cited by 731
Self-citationApoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
Schaible, U. E., Winau, F., Sieling, P. A., Fischer, K., Collins, H. L., Hagens, K., Modlin, R. L., Brinkmann, V., & Kaufmann, S. H. E. (2003) · Nature Medicine · doi:10.1038/nm906 · Cited by 546
Apoptotic Vesicles Crossprime CD8 T Cells and Protect against Tuberculosis
Winau, F., Weber, S., Sad, S., de Diego, J., Hoops, S. L., Breiden, B., Sandhoff, K., Brinkmann, V., Kaufmann, S. H. E., & Schaible, U. E. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.001 · Cited by 395
Braunstein, M., Espinosa, B. J., Chan, J., Belisle, J. T., & R. Jacobs, W. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03438.x · Cited by 272
Self-citationKurtz, S., McKinnon, K. P., Runge, M. S., Ting, J. P.-Y., & Braunstein, M. (2006) · Infection and Immunity · doi:10.1128/iai.01022-06 · Cited by 114
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Cited by
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 622
Innate immunity in tuberculosis: host defense vs pathogen evasion
Liu, C. H., Liu, H., & Ge, B. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2017.88 · Cited by 532
Tuberculosis: What We Don’t Know Can, and Does, Hurt Us
Russell, D. G., Barry, C. E., & Flynn, J. L. (2010) · Science · doi:10.1126/science.1184784 · Cited by 489
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis
Behar, S. M., Martin, C. J., Booty, M. G., Nishimura, T., Zhao, X., Gan, H.-X., Divangahi, M., & Remold, H. G. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.3 · Cited by 447
Metadata
- Authors
- Hinchey, J., Lee, S., Jeon, B. Y., Basaraba, R. J., Venkataswamy, M. M., Chen, B., Chan, J., Braunstein, M., Orme, I. M., Derrick, S. C., Morris, S. L., Jacobs, W. R., & Porcelli, S. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-08-01
- Volume
- 117
- Issue
- 8
- Pages
- 2279-2288
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2094389347
- Cited by
- 290
- References
- 7
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. https://app.cochat.ai/papers/10.1172/jci31947
- The paper
- Hinchey, J., Lee, S., Jeon, B. Y., Basaraba, R. J., Venkataswamy, M. M., Chen, B., Chan, J., Braunstein, M., Orme, I. M., Derrick, S. C., Morris, S. L., Jacobs, W. R., & Porcelli, S. A. (2007). Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. Journal of Clinical Investigation. https://doi.org/10.1172/jci31947
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
