The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress
Open accessAbstract
In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangiectasia (MacTel), in which, despite the absence of large-scale leakage or hemorrhage, abnormal neovascularization (NV) is associated with local neuronal dysfunction. We describe here a retinal phenotype in mice with dysfunctional receptors for VLDL (Vldlr-/- mice) that closely resembles human retinal diseases in which abnormal intra- and subretinal NV is associated with photoreceptor cell death. Such cell death was evidenced by decreased cone and, to a lesser extent, rod opsin expression and abnormal electroretinograms. Cell death in the region of intraretinal vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved retinal function, despite the continued presence of abnormal intra- and subretinal vessels. What we believe to be novel, Müller cell-based, virally mediated delivery of neurotrophic compounds specifically to sites of NV was also neuroprotective. These observations demonstrate that neuronal loss secondary to NV can be prevented by the use of simple antioxidant dietary measures or cell-based delivery of neurotrophic factors, even when the underlying vascular phenotype is not altered.
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“Stress (GFAP promoter) or hypoxia-driven GFAP promoters (HRSE-6xHRE-GfaABC1D) have been generated that might be safer for cells that are sensitive to continuous overexpressed artificial gene vectors [96,97,99,100,102].”
From Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays (2020) · cites this paper as [100]
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Issa, P. C., Gillies, M. C., Chew, E. Y., Bird, A. C., Heeren, T. F. C., Pető, T., Holz, F. G., & Scholl, H. P. N. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.11.002 · Cited by 396
Self-citationRetinal vasculature development in health and disease
Selvam, S., Kumar, T., & Fruttiger, M. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.001 · Cited by 363
Targeted deletion of Vegfa in adult mice induces vision loss
Kurihara, T., Westenskow, P. D., Bravo, S., Aguilar, E., & Friedlander, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65157 · Cited by 331
Self-citationA Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data
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Neurons Limit Angiogenesis by Titrating VEGF in Retina
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Metadata
- Authors
- Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G., & Friedlander, M.
- Affiliations
- Scripps Research Institute (US)
- University of Michigan (US)
- Hadassah Medical Center (IL)
- Moorfields Eye Hospital (GB)
- Corresponding author
- Friedlander, Martin
- Venue
- Journal of Clinical Investigation
- Published
- 2009-03-02
- Volume
- 119
- Issue
- 3
- Pages
- 611-623
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2648679
- OpenAlex
- W1999304307
- Cited by
- 127
- References
- 57
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 15 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California Institute for Regenerative Medicine
- V. Kann Rasmussen Foundation
- National Institutes of Health
- National Eye Institute (R01EY011254)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- neovascularization, oxidative stress, photoreceptor degeneration, retinal angiomatous proliferation, macular telangiectasia, VLDL receptor, antioxidant supplementation, neurotrophic factor delivery, Müller cells, viral gene delivery, retinal function, cone opsin, rod opsin, electroretinogram
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Electroretinography, Mice, Inbred C57BL, Nerve Growth Factors, Receptors, LDL, Retina, Retinitis Pigmentosa, Rhodopsin, Lipid Peroxidation, Retinal Neovascularization, Gene Expression, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Gene Transfer Techniques, Mice, Knockout, Oxidative Stress, Angiogenesis Inhibitors, Gene Expression Profiling, Vascular Endothelial Growth Factor A, Mice, Aptamers, Nucleotide, Retinal Pigment Epithelium, Opsins
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