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Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress
Open accessAbstract
In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangiectasia (MacTel), in which, despite the absence of large-scale leakage or hemorrhage, abnormal neovascularization (NV) is associated with local neuronal dysfunction. We describe here a retinal phenotype in mice with dysfunctional receptors for VLDL (Vldlr-/- mice) that closely resembles human retinal diseases in which abnormal intra- and subretinal NV is associated with photoreceptor cell death. Such cell death was evidenced by decreased cone and, to a lesser extent, rod opsin expression and abnormal electroretinograms. Cell death in the region of intraretinal vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved retinal function, despite the continued presence of abnormal intra- and subretinal vessels. What we believe to be novel, Müller cell-based, virally mediated delivery of neurotrophic compounds specifically to sites of NV was also neuroprotective. These observations demonstrate that neuronal loss secondary to NV can be prevented by the use of simple antioxidant dietary measures or cell-based delivery of neurotrophic factors, even when the underlying vascular phenotype is not altered.
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“Stress (GFAP promoter) or hypoxia-driven GFAP promoters (HRSE-6xHRE-GfaABC1D) have been generated that might be safer for cells that are sensitive to continuous overexpressed artificial gene vectors [96,97,99,100,102].”
From Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays (2020) · cites this paper as [100]
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Citations
Cites
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261
The epidemiology of age-related macular degeneration
Klein, R., Peto, T., Bird, A., & Vannewkirk, M. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.069 · Cited by 932
Self-citationRETINAL ANGIOMATOUS PROLIFERATION IN AGE–RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2012) · Retina · doi:10.1097/iae.0b013e31823f9b3b · Cited by 660
RETINAL ANGIOMATOUS PROLIFERATION IN AGE-RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2001) · Retina · doi:10.1097/00006982-200110000-00003 · Cited by 658
Protein-bound acrolein: Potential markers for oxidative stress
Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4882 · Cited by 632
Involvement of oxidative stress in Alzheimer disease
Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1439 · Cited by 549
Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study.
Gass, J. D. M., & Blodi, B. A. (1993) · PubMed · Cited by 507
Idiopathic Macular Telangiectasia
Yannuzzi, L. A. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.4.450 · Cited by 473
Idiopathic Juxtafoveolar Retinal Telangiectasis
Gass, J. D. M., & Blodi, B. A. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31447-8 · Cited by 462
Antioxidants reduce cone cell death in a model of retinitis pigmentosa
Komeima, K., Rogers, B. S., Lu, L., & Campochiaro, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604056103 · Cited by 420
Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381
THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR HEALTH AND DISEASE
Adamis, A. P., & Shima, D. T. (2005) · Retina · doi:10.1097/00006982-200502000-00001 · Cited by 336
The role of VEGF in the regulation of physiological and pathological angiogenesis
Ferrara, N. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_15 · Cited by 322
Dorrell, M. I., Aguilar, E., & Friedlander, M. (2002) · PubMed · Cited by 318
Self-citationOxidative Damage in Huntington's Disease Pathogenesis
Browne, S. E., & Beal, M. F. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2061 · Cited by 313
Relationship between astrocytes, ganglion cells and vasculature of the retina
Stone, J., & Dreher, Z. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902550104 · Cited by 307
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa
Shen, J., Yang, X., Dong, A., Petters, R. M., Peng, Y., Wong, F., & Campochiaro, P. A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20346 · Cited by 300
The Role of Neurotrophins in Axonal Growth, Guidance, and Regeneration
Lykissas, M. G., Batistatou, A. K., Charalabopoulos, K., & Beris, A. E. (2007) · Current Neurovascular Research · doi:10.2174/156720207780637216 · Cited by 268
PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina
Fruttiger, M., Calver, A. R., Krueger, W. H., Mudhar, H. S., Michalovich, D., Takakura, N., Nishikawa, S. I., & Richardson, W. D. (1996) · Neuron · doi:10.1016/s0896-6273(00)80244-5 · Cited by 267
Frykman, P. K., Brown, M. S., Yamamoto, T., Goldstein, J. L., & Herz, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8453 · Cited by 256
Wang, J.-Y., Wen, L. L., Huang, Y.-N., Chen, Y.-T., & Ku, M.-C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778343109 · Cited by 250
Blood vessels change in the mesencephalon of patients with Parkinson's disease
Faucheux, B. A., Agid, Y., Hirsch, É. C., & Bonnet, A.-M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00641-8 · Cited by 218
Vascular permeability in ocular disease and the role of tight junctions
Erickson, K. K., Sundstrom, J. M., & Antonetti, D. A. (2007) · Angiogenesis · doi:10.1007/s10456-007-9067-z · Cited by 196
Kulkarni, A. C., Kuppusamy, P., & Parinandi, N. L. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1724 · Cited by 190
Vascular oxidative stress in Alzheimer disease
Zhu, X., Smith, M. A., Honda, K., Aliev, G., Moreira, P. I., Nunomura, A., Casadesús, G., Harris, P. L. R., Siedlak, S. L., & Perry, G. L. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.039 · Cited by 175
Calabrese, V., Ravagna, A., Colombrita, C., Scapagnini, G., Guagliano, E., Calvani, M., Butterfield, D. A., & Stella, A. M. G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20386 · Cited by 170
Ohno‐Matsui, K., Hirose, A., Yamamoto, S., Saikia, J., Okamoto, N., Gehlbach, P. L., Duh, E. J., Hackett, S. F., Chang, M., Bok, D., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64891-2 · Cited by 163
Vessels and Nerves: Marching to the Same Tune
Weinstein, B. M. (2005) · Cell · doi:10.1016/j.cell.2005.01.010 · Cited by 160
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis
Otani, A., Slike, B. M., Dorrell, M. I., Hood, J. D., Kinder, K., Ewalt, K. L., Cheresh, D. A., SCHIMMEL, P. R., & Friedlander, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012601899 · Cited by 156
Self-citationGasmi, M., Herzog, C. D., Brandon, E. P., Cunningham, J. J., Ramirez, G. A., Ketchum, E. T., & Bartus, R. T. (2006) · Molecular Therapy · doi:10.1038/sj.mt.6300010 · Cited by 153
Self-citationOxidative damage in age-related macular degeneration.
Shen, J., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R., & Campochiaro, P. A. (2007) · PubMed · doi:10.14670/hh-22.1301 · Cited by 152
MOUSE MODEL OF SUBRETINAL NEOVASCULARIZATION WITH CHOROIDAL ANASTOMOSIS
Heckenlively, J. R., Hawes, N. L., Friedlander, M., Nusinowitz, S., Hurd, R. E., Davisson, M. T., & Chang, B. (2003) · Retina · doi:10.1097/00006982-200308000-00012 · Cited by 151
Self-citationCombination angiostatic therapy completely inhibits ocular and tumor angiogenesis
Dorrell, M. I., Aguilar, E., Scheppke, L., Barnett, F. H., & Friedlander, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607542104 · Cited by 147
Self-citationBesnard, F., Brenner, M., Nakatani, Y., Chao, R., Purohit, H. J., & Freese, E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55145-0 · Cited by 146
Calabrese, V., Stella, A. G., Calvani, M., & Butterfield, D. A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.027 · Cited by 130
Liu, J., Head, E., Kuratsune, H., Cotman, C. W., & Ames, B. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1320.011 · Cited by 120
Hu, W., Jiang, A., Liang, J., Meng, H., Chang, B., Gao, H., & Qiao, X. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0870 · Cited by 117
Combination therapy for the treatment of ocular neovascularization
Bradley, J. M. B., Ju, M., & Robinson, G. S. (2007) · Angiogenesis · doi:10.1007/s10456-007-9069-x · Cited by 115
VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function
Tzima, E., Reader, J. S., Irani-Tehrani, M., Ewalt, K. L., Schwartz, M. A., & SCHIMMEL, P. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400431200 · Cited by 101
Chen, Y., Hu, Y., Lu, K., Flannery, J. G., & Ma, J.-X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611289200 · Cited by 92
Issa, P. C., Holz, F. G., & Scholl, H. P. N. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.03.079 · Cited by 91
Banin, E., Dorrell, M. I., Aguilar, E., Ritter, M. R., Aderman, C. M., Smith, A. C. H., Friedlander, J., & Friedlander, M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1096 · Cited by 89
Self-citationINTRAVITREAL BEVACIZUMAB (AVASTIN) FOR RETINAL ANGIOMATOUS PROLIFERATION
MEYERLE, C. B., Freund, K. B., Iturralde, D., Spaide, R. F., Sorenson, J. A., Slakter, J. S., Klancnik, J. M., Fisher, Y. L., Cooney, M. J., & Yannuzzi, L. A. (2007) · Retina · doi:10.1097/iae.0b013e318030ea80 · Cited by 88
Das, A., Puklin, J. E., Frank, R. N., & Zhang, N. L. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31792-0 · Cited by 67
Virmani, A., Gaetani, F., & BINIENDA, Z. K. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00024.x · Cited by 65
Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice
Li, C. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.6.795 · Cited by 61
Dorrell, M. I., Otani, A., Aguilar, E., Moreno, S. K., & Friedlander, M. (2004) · Blood · doi:10.1182/blood-2003-09-3012 · Cited by 54
Self-citationVirmani, A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1344.016 · Cited by 45
Liu, P. K. (2003) · Journal of Biomedical Science · doi:10.1007/bf02255992 · Cited by 44
Blood vessels and Parkinsonism
Barcia, C. (2004) · Frontiers in Bioscience · doi:10.2741/1145 · Cited by 41
Harada, C., Harada, T., Quah, H.-M. A., Namekata, K., Yoshida, K., Ohno, S., Tanaka, K., & Parada, L. F. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0826 · Cited by 36
Histopathologic Study of Presumed Parafoveal Telangiectasis
Gass, J. D. M. (2000) · Retina · doi:10.1097/00006982-200002000-00028 · Cited by 36
Chew, E. Y. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.4.573 · Cited by 17
Bakri, S. J., & Ekdawi, N. S. (2007) · Eye · doi:10.1038/sj.eye.6703041 · Cited by 9
Evaluating Retinal Function in the Mouse Retina with the Electroretinogram
(2006) · The MIT Press eBooks · doi:10.7551/mitpress/5557.003.0105 · Cited by 7
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Research works printed but not linked: 3
- Dorrell, 2002, Invest. Ophthalmol. Vis. Sci., 43, 3500
- Shen, 2007, Histol. Histopathol., 22, 1301
- Ferrara, 2005., EXS., 209
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Issa, P. C., Gillies, M. C., Chew, E. Y., Bird, A. C., Heeren, T. F. C., Pető, T., Holz, F. G., & Scholl, H. P. N. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.11.002 · Cited by 396
Self-citationRetinal vasculature development in health and disease
Selvam, S., Kumar, T., & Fruttiger, M. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.001 · Cited by 363
Targeted deletion of Vegfa in adult mice induces vision loss
Kurihara, T., Westenskow, P. D., Bravo, S., Aguilar, E., & Friedlander, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65157 · Cited by 331
Self-citationA Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data
Vinaixa, M., Samino, S., Saez, I., Duran, J., Guinovart, J., & Yanes, Ó. (2012) · Metabolites · doi:10.3390/metabo2040775 · Cited by 272
Neurons Limit Angiogenesis by Titrating VEGF in Retina
Okabe, K., Kobayashi, S., Yamada, T., Kurihara, T., Tai-Nagara, I., Miyamoto, T. K., Mukouyama, Y., Sato, T. N., Suda, T., Ema, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.025 · Cited by 313
Metadata
- Authors
- Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G., & Friedlander, M.
- Affiliations
- Scripps Research Institute (US)
- University of Michigan (US)
- Hadassah Medical Center (IL)
- Moorfields Eye Hospital (GB)
- Corresponding author
- Friedlander, Martin
- Venue
- Journal of Clinical Investigation
- Published
- 2009-03-02
- Volume
- 119
- Issue
- 3
- Pages
- 611-623
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2648679
- OpenAlex
- W1999304307
- Cited by
- 127
- References
- 57
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 15 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 15
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California Institute for Regenerative Medicine
- V. Kann Rasmussen Foundation
- National Institutes of Health
- National Eye Institute (R01EY011254)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- neovascularization, oxidative stress, photoreceptor degeneration, retinal angiomatous proliferation, macular telangiectasia, VLDL receptor, antioxidant supplementation, neurotrophic factor delivery, Müller cells, viral gene delivery, retinal function, cone opsin, rod opsin, electroretinogram
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Electroretinography, Mice, Inbred C57BL, Nerve Growth Factors, Receptors, LDL, Retina, Retinitis Pigmentosa, Rhodopsin, Lipid Peroxidation, Retinal Neovascularization, Gene Expression, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Gene Transfer Techniques, Mice, Knockout, Oxidative Stress, Angiogenesis Inhibitors, Gene Expression Profiling, Vascular Endothelial Growth Factor A, Mice, Aptamers, Nucleotide, Retinal Pigment Epithelium, Opsins
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