Cited by 2,299Cancer Cells and MetastasisTGF-β signaling in diseasesCell Adhesion Molecules Research

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Biomarkers for epithelial-mesenchymal transitions

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Zeisberg, Michael, Neilson, Eric G.·2009·Journal of Clinical Investigation

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Abstract

Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). Published reports from the literature typically rely on ad hoc criteria for determining EMT events; consequently, there is some uncertainty as to whether the same process occurs under different experimental conditions. As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype.

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Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal Transitions
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Epithelial-mesenchymal transition in morphogenesis, cancer progression and angiogenesis
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BackgroundInfluential
Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells
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Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain
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Background
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Background

Authors: Zeisberg, M., & Neilson, E. G.
Affiliations: Beth Israel Deaconess Medical Center (US)
Vanderbilt University (US)
ORCID: Zeisberg, Michael
Neilson, Eric G.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2009-06-01
Volume: 119
Issue: 6
Pages: 1429-1437
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci36183
PMC: PMC2689132
OpenAlex: W1996118868
Cited by: 2,299
References: 124
Citations by year: 2026: 50 · 2025: 79 · 2024: 127 · 2023: 113 · 2022: 146 · 2021: 148 · 2020: 180 · 2019: 163 · 2018: 170 · 2017: 189 · 2016: 153 · 2015: 162 · 2014: 162 · 2013: 149 · 2012: 109
FWCI: 8.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R03DK081687, R01DK046282, DK46282, K08DK074558, DK-081687, DK074558)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: epithelial-mesenchymal transition, cellular plasticity, epithelial cells, endothelial cells, cell motility
MeSH terms: Animals, Cell Differentiation, Epithelial Cells, Fibroblasts, Humans, Neoplasms, Biomarkers, Mesenchymal Stem Cells

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Biomarkers for epithelial-mesenchymal transitions

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