Cited by 2,299Cancer Cells and MetastasisTGF-β signaling in diseasesCell Adhesion Molecules Research

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Biomarkers for epithelial-mesenchymal transitions

Open access

Zeisberg, Michael, Neilson, Eric G.·2009·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). Published reports from the literature typically rely on ad hoc criteria for determining EMT events; consequently, there is some uncertainty as to whether the same process occurs under different experimental conditions. As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci36183

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839
Fibroblasts in cancer
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Self-citation
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Complex networks orchestrate epithelial–mesenchymal transitions
Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,947
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
Yang, J., & Weinberg, R. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,079
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715
Self-citation
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605

Flagged first, then by citations

Show all 124 references

Research works printed but not linked: 8

Kalluri, 2003, J. Clin. Invest., 112, 1776, 10.1172/JCI200320530 · DOI
Xue, 2003, Cancer Res., 63, 3386
Colwell, 2005, Adv. Biochem. Eng. Biotechnol., 93, 83
Sommers, 1989, Cancer Res., 49, 4258
Wernert, 2001, Anticancer Res., 21, 2259
Higgins, 2007, J. Clin. Invest., 117, 3810
Bates, 2005, J. Clin. Invest., 115, 339, 10.1172/JCI200523183 · DOI
Gabbiani, 1981, Am. J. Pathol., 104, 206

Sorted by citations

Items 601–700 of 1,004

Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
Wu, S., Luo, Z., Yu, P. Y., Xie, H., & He, Y. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0215 · Cited by 53
miR-26a-5p suppresses tumor metastasis by regulating EMT and is associated with prognosis in HCC
Chang, L., Li, K., & Guo, T. (2016) · Clinical & Translational Oncology · doi:10.1007/s12094-016-1582-1 · Cited by 52
The inhibition of lung cancer cell migration by AhR-regulated autophagy
Tsai, C.-H., Li, C.-H., Cheng, Y., Lee, C., Liao, P.-L., Lin, C., Huang, S.-H., & Kang, J. (2017) · Scientific Reports · doi:10.1038/srep41927 · Cited by 50
“These changes in cell morphology and function are accompanied by vimentin and snail protein expression 14,15 .”
Epithelial-to-mesenchymal transition in gallbladder cancer: from clinical evidence to cellular regulatory networks
Xu, S., Zhan, M., & Wang, J. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.69 · Cited by 52
lncRNA SNHG1 negatively regulates miRNA‑101‑3p to enhance the expression of ROCK1 and promote cell�proliferation, migration and invasion in osteosarcoma
Deng, R., Zhang, J., & Chen, J.-T. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4039 · Cited by 53
“Type 3 EMT occurs in epithelial carcinoma cells, generating secondary tumor nodules by transforming these cells to metastatic tumor cells that migrate to metastatic sites (40).”
Background
Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
Bailey, P. C., & Martin, S. S. (2019) · Cells · doi:10.3390/cells8060553 · Cited by 53
“There can be as many as six different clonal cell lines within just one tumor [123].”
Background
RETRACTED ARTICLE: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2
Li, J., Yang, R., Dong, Y., Chen, M., Wang, Y., & Wang, G. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1046-x · Cited by 50
Retracted
Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?
Kholodenko, I. V., Kurbatov, L. K., Kholodenko, R. V., Manukyan, G. V., & Yarygin, K. N. (2019) · Cells · doi:10.3390/cells8101127 · Cited by 54
“Importantly, both cadherins (-2 and -11) are involved in the epithelial-to-mesenchymal transition [70].”
Background
Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion
Prolo, L. M., Li, A., Owen, S. F., Parker, J. J., Foshay, K. M., Nitta, R. T., Morgens, D. W., Bolin, S., Wilson, C., Leonel, J. C. M. V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50160-w · Cited by 50
Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs
Shen, K., Hung, J., Liao, Y.-C., Tsai, S., Wu, M., & Chen, P.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093080 · Cited by 53
“The process of EMT is associated with the downregulation of epithelial markers such as E-cadherin, and the upregulation of mesenchymal markers such as vimentin [15].”
Background
Chemical Factory‐Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer
Tang, Z., Wu, S., Zhao, P., Wang, H., Ni, D., Li, H., Jiang, X., Wu, Y., Meng, Y. F., Yao, Z., et al. (2022) · Advanced Science · doi:10.1002/advs.202201232 · Cited by 51
IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT).
Ji, X., Li, J., Xu, L., Wang, W., Luo, M., Luo, S., Ma, L., Li, K., Gong, S., He, L., et al. (2013) · Europe PMC (PubMed Central) · Cited by 51
Mutant p53 expression in fallopian tube epithelium drives cell migration
Quartuccio, S. M., Karthikeyan, S., Eddie, S. L., Lantvit, D. D., hAinmhire, E. Ó., Modi, D., Wei, J., & Burdette, J. E. (2015) · International Journal of Cancer · doi:10.1002/ijc.29528 · Cited by 51
Role of fucosyltransferase IV in epithelial–mesenchymal transition in breast cancer cells
Yang, X., Liu, S., & Yan, Q. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.241 · Cited by 53
“recognized as a hallmark of embryogenesis in the early 1980.(1,2) EMT is also a key event in the tumor-invasion process and has been implicated in increased cell invasion”
Background
MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway
LIN, Z.-H., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L., ZHANG, B., Zhu, W., & Ye, Q. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2455 · Cited by 49
Role of Epithelial–Mesenchymal Transition in Repair of the Lacrimal Gland after Experimentally Induced Injury
You, S., Avidan, O., Tariq, A., Ahluwalia, I. P., Stark, P. C., Kublin, C. L., & Zoukhri, D. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7893 · Cited by 49
“Snai1 appears to be the master regulator of EMT, although several other factors such as Snai2 (SLUG), ZEB1 ( EF1), ZEB2 (SIP1), and TWIST are also known to induce or contribute to EMT.1,2,4,5 Repression of Snai1 expression is usually sufficient to induce E-cadherin expression and the cells acquire an epithelial phenot…”
BackgroundInfluential
Functional Cooperation of RKTG with p53 in Tumorigenesis and Epithelial–Mesenchymal Transition
Jiang, Y., Xie, X., Li, Z., Wang, Z., Zhang, Y., Ling, Z., Pan, Y., Wang, Z., & Chen, Y. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4077 · Cited by 51
“This process involves the acquisition of mesenchymal markers, such as vimentin and fibronectin, together with loss of epithelial cell adhesion molecules such as E-cadherin (16).”
Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer
Ferguson, R. D., Gallagher, E. J., Cohen, D., Tobin‐Hess, A., Alikhani, N., Novosyadlyy, R., Haddad, N., Yakar, S., & LeRoith, D. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0333 · Cited by 51
“Vimentin belongs to the intermediate filament (IF) family of proteins and has recently been shown to be an important marker of the EMT in epithelial cells that normally express only cytokeratin-type IFs (Zeisberg & Neilson 2009, Satelli & Li 2011).”
Background
Activation of pancreatic stellate cells involves an EMT-like process
TIAN, L., Lu, Z., Cai, B., Zhao, L., QIAN, D., Xu, Q., Wu, P., Zhu, Y., Zhang, J., Du, Q., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3282 · Cited by 51
“Type 2 EMT is characterized by conversion from endothelial or epithelial cells into fibroblasts, which are responsible for tissue inflammation and fibrosis, such as that seen in PDAC (27,28).”
BackgroundInfluential
Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis
Zhang, N., Liu, Y., Wang, Y., Zhao, M., Tu, L., & Luo, F. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s129305 · Cited by 51
Cancer Stem Cells and Metastasis
Nandy, S., & Lakshmanaswamy, R. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.07.007 · Cited by 50
Downregulation of miR‐3127‐5p promotes epithelial‐mesenchymal transition via FZD4 regulation of Wnt/β‐catenin signaling in non‐small‐cell lung cancer
Yang, Y., Sun, Y., Wu, Y., Tang, D., Ding, X., Xu, W., Su, B., & Gao, W. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22805 · Cited by 51
“During EMT, cells are characterized by decreased expression of the epithelial marker E-cadherin and increased expressions of the mesenchymal markers N-cadherin and Vimentin.(7) Cancer cells that acquire stromal”
BackgroundInfluential
Lonicera japonica Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice: Molecular Mechanisms of Action
Miao, H., Zhang, Y., Huang, Z., Lü, B., & Ji, L. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500174 · Cited by 51
Interaction of transforming growth factor‐β‐Smads/microRNA‐362‐3p/CD82 mediated by M2 macrophages promotes the process of epithelial‐mesenchymal transition in hepatocellular carcinoma cells
Zhang, Q., Huang, F., Yao, Y., Wang, J., Wei, J., Wu, Q., Xiang, S., & Xu, L. (2019) · Cancer Science · doi:10.1111/cas.14101 · Cited by 52
c‐Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment
Ding, Y., Hao, K., Li, Z., Ma, R., Zhou, Y. L., Zhou, Z., Wei, M., Liao, Y., Dai, Y., Yang, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29317 · Cited by 52
“…of epithelial cells to motile mesenchymal cells is a process known as epithelial–mesenchymal transition (EMT), and there are now many biomarkers, including cell surface proteins, cytoskeletal markers, and transcription factors for EMT (Feng, Zhao, Lu, Wang, & Chen, 2017; Zeisberg & Neilson, 2009).”
Background
Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
Walens, A., Lin, J., Damrauer, J. S., McKinney, B. J., Lupo, R., Newcomb, R., Fox, D. B., Mabe, N. W., Gresham, J. S., Sheng, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18730-z · Cited by 52
Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse
Yamben, I. F., Rachel, R. A., Shatadal, S., Copeland, N. G., Jenkins, N. A., Warming, S., & Griep, A. E. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.09.027 · Cited by 50
“The Apical Marker, ZO-1, is Gradually Lost From Epithelial Cells of the ScribLeCre Lenses Another hallmark of EMT is the loss of the apically-restricted tight junction protein, ZO-1 (Zeisberg and Neilson, 2009).”
Background
Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells
Chen, Y., Chuang, T.-Y., Liu, C., Liu, C.-W., Lai, T.-C., Lai, T.-C., & Chen, Y. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00373-z · Cited by 52
ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1
Li, F.-N., Zhang, Q., Li, O., Liu, S., Yang, Z., Pan, L., Zhao, C., Gong, W., Shu, Y., & Dong, P. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57623 · Cited by 50
“Especially, E-cadherin to N-cadherin switch in cancer cells relates to cancer progression[10].”
Background
lncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia
Zhang, Q., Wang, Z., Cheng, X., & Wu, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1988373 · Cited by 50
“EMT is necessary for cell migration and invasion, and it is characterized by the low-expressed key epithelial markers (E-cadherin) and high-expressed mesenchymal markers (β-catenin and vimentin) [32,33], among which the E-cadherin expression is negatively connected with the cell EMT, while both Vimentin and N-cadherin…”
Background
SOX5 promotes epithelial–mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma
Wang, D., Han, S., Wang, X., Peng, R., & Li, X. (2015) · Medical Oncology · doi:10.1007/s12032-014-0461-2 · Cited by 50
USP22 promotes tumor progression and induces epithelial–mesenchymal transition in lung adenocarcinoma
Hu, J., Yang, D., Zhang, H., Liu, W., Zhao, Y., Lu, H., Meng, Q., Pang, H., Chen, X., Liu, Y., et al. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.02.019 · Cited by 50
Chronic Exposure to Nanoparticulate TiO2 Causes Renal Fibrosis Involving Activation of the Wnt Pathway in Mouse Kidney
Hong, F., Hong, J., Wang, L., Zhou, Y., Liu, D., Xu, B., Yu, X., & Sheng, L. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5034834 · Cited by 50
FSP1-specific SMAD2 knockout in renal tubular, endothelial, and interstitial cells reduces fibrosis and epithelial-to-mesenchymal transition in murine STZ-induced diabetic nephropathy
Loeffler, I., Liebisch, M., Allert, S., Kunisch, E., Kinne, R. W., & Wolf, G. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2754-1 · Cited by 51
“**P = 0.01 is expressed in themouse from embryonic day 8.5 and is associated with cells of mesenchymal origin or of fibroblastic phenotype (Luo et al. 2015; Strutz et al. 1995; Zeisberg and Neilson 2009).”
Influential
Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis
Liu, M., Liu, L., Bai, M., Zhang, L., Ma, F., Yang, X., & Sun, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.130 · Cited by 50
ADAM9 mediates the interleukin-6-induced Epithelial–Mesenchymal transition and metastasis through ROS production in hepatoma cells
Dong, Y., Wu, Z., He, M., Chen, Y., Chen, Y., Shen, X., Zhao, X., Zhang, L., Yuan, B., & Zeng, Z. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.02.010 · Cited by 51
Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity
Risom, T., Wang, X., Liang, J. B., Zhang, X., Pelz, C., Campbell, L. G., Eng, J., Chin, K., Farrington, C. C., Narla, G., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126390 · Cited by 48
Cancer‑associated fibroblasts induce epithelial‑mesenchymal transition through secreted cytokines in endometrial cancer cells
Wang, X., Zhang, W., Sun, X., Lin, Y., & Chen, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.8000 · Cited by 52
“There is increasing evidence indicating that EMT is stimulated by signals from the tumor microenvironment, including a variety of growth factors and cytokines (8,9).”
Influential
Multiple types of data are required to identify the mechanisms influencing the spatial expansion of melanoma cell colonies
Treloar, K. K., Simpson, M. J., Haridas, P., Manton, K. J., Leavesley, D. I., McElwain, D. L. S., & Baker, R. E. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-137 · Cited by 51
“To confirm the presence of cell motility and cell–to–cell adhesion proteins in the cell colony, we used immunofluorescence to examine the expression of E–cadherin, N–cadherin and vimentin [3,47,52,53].”
Method
RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo
Wang, W., Cheng, J., Qin, J., Voruganti, S., Nag, S. A., Fan, J., Gao, Q., & Zhang, R. (2014) · Oncotarget · doi:10.18632/oncotarget.2598 · Cited by 49
Mesenchymal stem cells in non-small cell lung cancer—Different from others? Insights from comparative molecular and functional analyses
Gottschling, S., Granzow, M., Kuner, R., Jauch, A. S., Herpel, E., Xu, E. C., Muley, T., Schnabel, P. A., Herth, F. J. F., & Meister, M. A. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2012.12.015 · Cited by 53
Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition
Muir, A. B., Dods, K. K., Noah, Y., Toltzis, S., Chandramouleeswaran, P. M., Lee, A., Benitez, A., Bedenbaugh, A., Falk, G. W., Wells, R. G., et al. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.026 · Cited by 49
“marker analysis alone, and must demonstrate acquisition of functional characteristics of activated myofibroblasts, including migration, contraction, and collagen deposition [8,21].”
Background
Syndecan-1 Overexpression Is Associated With Nonluminal Subtypes and Poor Prognosis in Advanced Breast Cancer
Nguyen, T. L. L., Grizzle, W. E., Zhang, K., Hameed, O., Siegal, G. P., & Wei, S. (2013) · American Journal of Clinical Pathology · doi:10.1309/ajcpz1d8calhdxcj · Cited by 49
A Signal Transduction Pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma
Qu, X., Shen, L., Zheng, Y., Cui, Y., Liu, F., Liu, J., & Liu, J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.281 · Cited by 49
DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma
Venza, M., Visalli, M., Catalano, T., Biondo, C., Beninati, C., Teti, D. V., & Venza, I. (2016) · Oncology Reports · doi:10.3892/or.2016.4618 · Cited by 49
Curcumin attenuates cyclosporine A-induced renal fibrosis by inhibiting hypermethylation of the klotho promoter
Hu, Y., Mou, L., Yang, F., Tu, H., & Lin, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5601 · Cited by 49
Elevation of MiR-9–3p suppresses the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via down-regulating FN1, ITGB1 and ITGAV
Ding, Y., Pan, Y., Liu, S., Jiang, F., & Jiao, J. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1323585 · Cited by 49
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells
Sun, D., Shen, W., Zhang, F., Fan, H., Xu, C., Li, L., Tan, J., Miao, Y., Zhang, H., Yang, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.062 · Cited by 49
Molecular targets and pathways involved in liver metastasis of colorectal cancer
Weidle, U. H., Birzele, F., & Krüger, A. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9732-3 · Cited by 51
JAM3 functions as a novel tumor suppressor and is inactivated by DNA methylation in colorectal cancer
Zhou, D., Tang, W., Zhang, Y., & An, H. (2019) · Cancer Management and Research · doi:10.2147/cmar.s189937 · Cited by 48
“EMT, which is known as the first step required for the complex process of metastasis, is critical for polarized epithelial cells to obtain enhanced invasion and migration abilities.(29,30) EMT is often observed in primary tumor at the cancer invasion front.”
Background
Insight into the role of DPP-4 in fibrotic wound healing
Zhang, K., Liu, S., Jia, Y., Zou, M., Teng, Y., Chen, Z.-H., Li, Y., Guo, D., Wu, J., Yuan, Z., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113143 · Cited by 50
In vitro modeling of endometriosis and endometriotic microenvironment – Challenges and recent advances
Gołąbek-Grenda, A., & Olejnik, A. M. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110375 · Cited by 53
A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL
Weng, Y., Wang, H., Wu, D., Xu, S., Chen, X., Huang, J., Feng, Y., Li, L., & Wang, Z. (2022) · Cell Research · doi:10.1038/s41422-022-00687-x · Cited by 52
Epithelial-mesenchymal transitions in bronchopulmonary dysplasia of newborn rats
Yang, H., Fu, J., Xue, X., Li, Y., Lin, Q., Hou, A., Jin, L., & Xing, Y. (2014) · Pediatric Pulmonology · doi:10.1002/ppul.22969 · Cited by 48
“SPC and E-cadherin are epithelial cell markers, while a-SMA and N-CAD are mesenchymal cell markers.(34) Using immunoblot analysis, we found that on Days 14 and 21, the protein and mRNA expression levels of SPC in the lung tissues from BPD model group were significantly higher than those in the control group, indicatin…”
Background
Nanobiotechnology for the capture and manipulation of circulating tumor cells
Hughes, A. D., & King, M. R. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.168 · Cited by 48
Low-dose radiation-induced epithelial-mesenchymal transition through NF-κB in cervical cancer cells
YAN, S., Wang, Y., Yang, Q., Li, X., Kong, X., Zhang, N., Yuan, C., Yang, N., & Kong, B. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1852 · Cited by 48
Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis
Matuszak, E. A., & Kyprianou, N. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.32 · Cited by 48
Increased DNA methyltransferase activity and DNA methylation following epidermal growth factor stimulation in ovarian cancer cells
Samudio‐Ruiz, S. L., & Hudson, L. G. (2012) · Epigenetics · doi:10.4161/epi.7.3.19273 · Cited by 48
Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory pathways?
Burdick, M. M., Henson, K. A., Delgadillo, L. F., Choi, Y. E., Goetz, D. J., Tees, D. F. J., & Benencia, F. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00103 · Cited by 49
Protumorigenic actions of S100A2 involve regulation of PI3/Akt signaling and functional interaction with Smad3
Naz, S., Bashir, M., Ranganathan, P., Bodapati, P., Santosh, V., & Kondaiah, P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt287 · Cited by 48
The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells
Fu, J., KE, X., Tan, S., Liu, T., Wang, S., Ma, J., & Lu, H. (2015) · Oncology Reports · doi:10.3892/or.2015.4394 · Cited by 49
Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail
Feng, J.-T., Junhua, C., Li, J., Zhao, R., Zhu, C., Wang, Z., Xie, J., & Tang, W. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1112486 · Cited by 48
Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
Jeon, M. J., Kim, W. G., Lim, S., Choi, H.-J., Sim, S., Kim, T. Y., Shong, Y. K., & Kim, W. B. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.005 · Cited by 50
Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial–mesenchymal transition-like process in lung cancer cells
Shao, K., Chen, Z. Y., Gautam, S., Deng, N. H., Zhou, Y. L., & Wu, X. (2015) · Glycobiology · doi:10.1093/glycob/cwv089 · Cited by 48
TRPC1-STIM1 activation modulates transforming growth factor β-induced epithelial-to-mesenchymal transition
Schaar, A., Sukumaran, P., Sun, Y., Dhasarathy, A., & Singh, B. B. (2016) · Oncotarget · doi:10.18632/oncotarget.12895 · Cited by 48
Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT)
Martínez-Ramírez, A. S., Díaz‐Muñoz, M., Butanda-Ochoa, A., & Vázquez‐Cuevas, F. G. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9550-3 · Cited by 48
The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial–Mesenchymal Transition
Cao, Z., Sun, B., Zhao, X., Zhang, Y., Gu, Q., Liang, X., Dong, X., & Zhao, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030500 · Cited by 48
“During EMT, the expression of epithelial markers such as E-cadherin are downregulated and the expression of mesenchymal markers such as Vimentin is upregulated [22,30].”
Background
Epithelial-Mesenchymal Transition Markers in Breast Cancer and Pathological Responseafter Neoadjuvant Chemotherapy
Elzamly, S., Badri, N., Padilla, O., Dwivedi, A. K., Alvarado, L. A., Hamilton, M., Diab, N., Rock, C. D., Elfar, A., Teleb, M., et al. (2018) · Breast Cancer Basic and Clinical Research · doi:10.1177/1178223418788074 · Cited by 49
Plumbagin induces ROS-mediated apoptosis and cell cycle arrest and inhibits EMT in human cervical carcinoma cells
Jaiswal, A., Sabarwal, A., Mishra, J. P. N., & Singh, R. P. (2018) · RSC Advances · doi:10.1039/c8ra05339a · Cited by 48
Unresolved Complexity in the Gene Regulatory Network Underlying EMT
Lavin, D. P., & Tiwari, V. K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00554 · Cited by 50
Long non-coding RNA (lncRNA) and epithelial-mesenchymal transition (EMT) in colorectal cancer: a systematic review
O’Brien, S. J., Bishop, C., Hallion, J. C., Fiechter, C. R., Scheurlen, K. M., Paas, M., Burton, J. F., & Galandiuk, S. (2020) · Cancer Biology & Therapy · doi:10.1080/15384047.2020.1794239 · Cited by 49
“Epithelial cells express a number of different cell surface markers, most notably E-cadherin, but also cytokeratins, occludins, and claudins among others.(8,9) These markers are significant factors in cell-cell adhesion and apical-basal cellular polarity.”
Background
Nodal promotes aggressive phenotype via Snail-mediated epithelial–mesenchymal transition in murine melanoma
Fang, R., Zhang, G., Guo, Q., Ning, F., Wang, H., Cai, S., & Du, J. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.014 · Cited by 45
Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development
Wu, K., Zeng, J., Zhou, J., Fan, J., Chen, Y., Wang, Z., Zhang, T., Wang, X., & He, D. (2012) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.02.001 · Cited by 47
Molecular Pathways Mediating Metastases to the Brain via Epithelial-to-Mesenchymal Transition: Genes, Proteins, and Functional Analysis.
Jeevan, D. S., Cooper, J., Braun, A., Murali, R., & Jhanwar‐Uniyal, M. (2016) · PubMed · Cited by 46
Epithelial–Mesenchymal Transition in Chronic Rhinosinusitis: Differences Revealed Between Epithelial Cells from Nasal Polyps and Inferior Turbinates
Könnecke, M., Assmann, M., Pries, R., Böscke, R., Bruchhage, K., Ungefroren, H., Klimek, L., & Wollenberg, B. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-016-0409-7 · Cited by 47
“Exp. progression (Zeisberg and Neilson 2009).”
Histone deacetylase inhibitors upregulate Snail via Smad2/3 phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells
Xu, W., Liu, H., Liu, Z., Wang, H., Zhang, F., Wang, H., Zhang, J., Chen, J., Huang, H., Tan, Y., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.068 · Cited by 47
Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition
Yang, J., Li, M., Chen, X.-O., Lian, Q., Wang, Q., Gao, F., Jin, S., & Zheng, S. (2019) · Respiratory Research · doi:10.1186/s12931-019-1158-z · Cited by 49
Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
Shetty, S. S., Sharma, M., Fonseca, F. P., Jayaram, P., Tanwar, A. S., Kabekkodu, S. P., Satyamoorthy, K., & Radhakrishnan, R. A. (2020) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2020.07.002 · Cited by 49
“Type III EMT exhibits change in the phenotype ith the upregulation of EMT associated genes to promote tissue nvasion and metastasis of cancer cells [10].”
Background
Putative stem cells and epithelial-mesenchymal transition revealed in sections of ovarian tumor in patients with serous ovarian carcinoma using immunohistochemistry for vimentin and pluripotency-related markers
Kenda-Suster, N., Smrkolj, Š., & Virant-Klun, I. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0306-7 · Cited by 30
“Several molecular mechanisms are involved in this process, like down-regulation of E-cadherin, cytokeratins, zona occludens 1 (ZO-1), claudins, occludin, laminin-1, entactin, mucin 1 (MUC-1), the microRNA 200 family, and acquisition of the transcription factors Snail 1, Snail 2, Twist, Zeb1 and Zeb2/SIP1 as well as N-…”
Background
CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression
Li, L., Liu, C., Amato, R. J., Chang, J. T., Du, G., & Li, W. (2014) · Oncotarget · doi:10.18632/oncotarget.2535 · Cited by 45
MicroRNA-10b Triggers the Epithelial–Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin
Zhang, L., Sun, J., Wang, B., Ren, J.-C., Su, W., & Zhang, T. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1505-6 · Cited by 46
“The EMT process will result in weakened adhesion ability and enhanced motility [25].”
Background
DLG5 in Cell Polarity Maintenance and Cancer Development
Liu, J., Li, J., Ren, Y. T., & Liu, P. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.8888 · Cited by 46
“ZO1, located on the plasma membrane surface at sites of the cell-cell junction [29], is a well-known organizer for tight junction and notable epithelial marker [30].”
Background
Transcriptional Networks in Epithelial-Mesenchymal Transition
Venkov, C. D., Plieth, D., Ni, T. T., Karmaker, A., Bian, A., George, A. L., & Neilson, E. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025354 · Cited by 47
“shared with control fibroblasts, which may reflect the unique transcriptional patterns of parental cells [1] or the axial variability in fibroblast subpopulations [63].”
BackgroundMethodSelf-citation
Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition
Boström, A.-K., Möller, C., Nilsson, E., Elfving, P., Axelson, H., & Johansson, M. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.06.019 · Cited by 46
ZNF281/ZBP-99: a new player in epithelial–mesenchymal transition, stemness, and cancer
Hahn, S., & Hermeking, H. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1160-3 · Cited by 47
“mal markers [31, 37].”
Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis
Xu, H., Zaidi, M., Struve, J. A., Jones, D. W., Krolikowski, J. G., Nandedkar, S. D., Lohr, N. L., Gadicherla, A. K., Pagel, P. S., Csuka, M. E., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00123.2010 · Cited by 47
Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo
Zheng, L., Fu, Y., Zhuang, L., Gai, R., Ma, J., Lou, J.-S., Zhu, H., He, Q., & Yang, B. Y. (2014) · International Journal of Cancer · doi:10.1002/ijc.28810 · Cited by 46
“4b).(23) As the most important marker for EMT, Ecadherin has been reported to be responsible for the susceptibility of cancer cells to several anticancer drugs.”
Background
Ascites-induced shift along epithelial-mesenchymal spectrum in ovarian cancer cells: enhancement of their invasive behavior partly dependant on αv integrins
Carduner, L., Leroy‐Dudal, J., Picot, C. R., Gallet, O., Carreiras, F., & Kellouche, S. (2014) · Clinical & Experimental Metastasis · doi:10.1007/s10585-014-9658-1 · Cited by 46
SNAIL transcription factor increases the motility and invasive capacity of prostate cancer cells
Osorio, L. A., FARFÁN, N. M., Castellón, E. A., & Contreras, H. R. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4585 · Cited by 46
“In addition, cells, which initiate EMT also increase their synthesis of cytoskeletal proteins, including vimentin (24).”
Background
Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?
Sohal, S. S. (2016) · Respiratory Research · doi:10.1186/s12931-016-0337-4 · Cited by 46
Huaier restrains proliferative and invasive potential of human hepatoma SKHEP-1 cells partially through decreased Lamin B1 and elevated NOV
Hu, Z., Yang, A., Su, G., Zhao, Y., Wang, Y., Chai, X., & Tu, P. (2016) · Scientific Reports · doi:10.1038/srep31298 · Cited by 46
A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics
Harner-Foreman, N., Vadakekolathu, J. N., Laversin, S. A., Mathieu, M. G., Reeder, S., Pockley, A. G., Rees, R. C., & Boocock, D. J. (2017) · Scientific Reports · doi:10.1038/srep40633 · Cited by 46
Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells
Mitrović, A., Fonović, U. P., & Kos, J. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.04.003 · Cited by 45
Oral cancer stem cells - properties and consequences
Rodini, C. O., Lopes, N. M., Lara, V. S., & Mackenzie, I. C. (2017) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2016-0665 · Cited by 46
The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition
Sharma, S., Goswami, R., & Rahaman, S. O. (2018) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-00565-w · Cited by 46
DNA methylation is associated with transcription of Snail and Slug genes
Chen, Y., Wang, K., Qian, C.-N., & Leach, R. E. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.034 · Cited by 46
“Defective EMTs or METs are often associated with failures in embryonic development and diseases [3].”
Background
Berberine Suppresses TPA-Induced Fibronectin Expression through the Inhibition of VEGF Secretion in Breast Cancer Cells
Kim, S., Oh, S. J., Lee, J., Han, J., Jeon, M., Jung, T., Lee, S. K., Bae, S. Y., Kim, J., Gil, W. H., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356591 · Cited by 45
Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells
Rodrigues‐Díez, R., Lavoz, C., Carvajal, G., Rayego‐Mateos, S., Rodrigues-Díez, R. R., Ortíz, A., Egido, J., Mezzano, S. A., & Ruiz‐Ortega, M. (2013) · Nephron Experimental Nephrology · doi:10.1159/000346575 · Cited by 45
Cessation of Epithelial Bmp Signaling Switches the Differentiation of Crown Epithelia to the Root Lineage in a β-Catenin-Dependent Manner
Yang, Z., Hai, B., Qin, L., Ti, X., Shangguan, L., Zhao, Y., Wiggins, L. L., Liu, Y., Feng, J. Q., Chang, J. Y., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00456-13 · Cited by 45
“Taken together, we detected all 5 types of markers for EMT (34) in AKO cells, including cell surface proteins (downregulation of E-cad and upregulation of N-cad), cytoskeletal markers (upregulation of Vim and relocation of -catenin), extracellular matrix (ECM) proteins (upregulation of Col1, Bsp, MMP2 and Postn), tran…”
Background
RANKL Promotes Migration and Invasion of Hepatocellular Carcinoma Cells via NF-κB-Mediated Epithelial-Mesenchymal Transition
Fang-Nan, S., Duan, M., Liu, L., Wang, Z., Shi, J.-Y., Yang, L., Zhou, J., Fan, J., Gao, Q., & Wang, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108507 · Cited by 45
“, vimentin and N-cadherin) [5,9].”

Authors: Zeisberg, M., & Neilson, E. G.
Affiliations: Beth Israel Deaconess Medical Center (US)
Vanderbilt University (US)
ORCID: Zeisberg, Michael
Neilson, Eric G.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2009-06-01
Volume: 119
Issue: 6
Pages: 1429-1437
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci36183
PMC: PMC2689132
OpenAlex: W1996118868
Cited by: 2,299
References: 124
Citations by year: 2026: 50 · 2025: 79 · 2024: 127 · 2023: 113 · 2022: 146 · 2021: 148 · 2020: 180 · 2019: 163 · 2018: 170 · 2017: 189 · 2016: 153 · 2015: 162 · 2014: 162 · 2013: 149 · 2012: 109
FWCI: 8.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R03DK081687, R01DK046282, DK46282, K08DK074558, DK-081687, DK074558)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: epithelial-mesenchymal transition, cellular plasticity, epithelial cells, endothelial cells, cell motility
MeSH terms: Animals, Cell Differentiation, Epithelial Cells, Fibroblasts, Humans, Neoplasms, Biomarkers, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biomarkers for epithelial-mesenchymal transitions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks