Cited by 2,299Cancer Cells and MetastasisTGF-β signaling in diseasesCell Adhesion Molecules Research

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Biomarkers for epithelial-mesenchymal transitions

Open access

Zeisberg, Michael, Neilson, Eric G.·2009·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). Published reports from the literature typically rely on ad hoc criteria for determining EMT events; consequently, there is some uncertainty as to whether the same process occurs under different experimental conditions. As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci36183

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839
Fibroblasts in cancer
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Self-citation
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Complex networks orchestrate epithelial–mesenchymal transitions
Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,947
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
Yang, J., & Weinberg, R. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,079
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715
Self-citation
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605

Flagged first, then by citations

Show all 124 references

Research works printed but not linked: 8

Kalluri, 2003, J. Clin. Invest., 112, 1776, 10.1172/JCI200320530 · DOI
Xue, 2003, Cancer Res., 63, 3386
Colwell, 2005, Adv. Biochem. Eng. Biotechnol., 93, 83
Sommers, 1989, Cancer Res., 49, 4258
Wernert, 2001, Anticancer Res., 21, 2259
Higgins, 2007, J. Clin. Invest., 117, 3810
Bates, 2005, J. Clin. Invest., 115, 339, 10.1172/JCI200523183 · DOI
Gabbiani, 1981, Am. J. Pathol., 104, 206

Sorted by citations

Items 401–500 of 1,004

RETRACTED ARTICLE: Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling
Lin, J., Lin, W., Ye, Y., Wang, L., Chen, X., Zang, S., & Huang, A. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0603-4 · Cited by 73
“Knockdown or knockout of Kindlin-2 caused a reduction in the expression of the mesenchymal markers N-cadherin, Vimentin and Snail [40] in LM3 and MHCC97H cells, while ectopic Kindlin-2 expression increased the levels of these Fig.”
BackgroundInfluential
Retracted
3D collagen fibrillar microstructure guides pancreatic cancer cell phenotype and serves as a critical design parameter for phenotypic models of EMT
Puls, T. J., Tan, X., Whittington, C. F., & Voytik‐Harbin, S. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188870 · Cited by 73
Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling
Wang, Y., Lan, W., Xu, M., Song, J., Mao, J., Li, C., Du, X., Jiang, Y., Li, E., Zhang, R., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03509-x · Cited by 73
Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology
Mutsaers, H. A. M., Caetano-Pinto, P., Seegers, A. E. M., Dankers, A. C. A., van den Broek, P. H. H., Wetzels, J. F. M., van den Brand, J. A. J. G., van den Heuvel, L. P., Hoenderop, J. G. J., Wilmer, M. J. G., et al. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.07.020 · Cited by 77
“3H), in concordance with transitioning epithelial cells being resistant to apoptosis (Zeisberg and Neilson, 2009).”
MicroRNAs and Drug Resistance in Prostate Cancers
Li, F., & Mahato, R. I. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500099g · Cited by 72
Stabilization of Snail through AKT/GSK-3β signaling pathway is required for TNF-α-induced epithelial–mesenchymal transition in prostate cancer PC3 cells
Wang, H., Fang, R., Wang, X., Zhang, F., Chen, D., Zhou, B., Wang, H., Cai, S., & Du, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.05.046 · Cited by 73
Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis
Bao, Y.-N., Cao, X., Luo, D., Sun, R., Peng, L.-X., Wang, L., Yan, Y., Zheng, L.-S., Xie, P., Cao, Y., et al. (2014) · Cell Cycle · doi:10.4161/cc.28921 · Cited by 73
“Given the increased expression of mesenchymal markers and loss of epithelial markers, the EMT endows cancer cells with enhanced migratory and invasive capabilities.(31,32) In our study, we observed that uPAR suppression in highly metastatic NPC cells (S18 and 5-8F) results in upregulation of the epithelial marker E-ca…”
Background
The Histone Methyltransferase EZH2 Mediates Tumor Progression on the Chick Chorioallantoic Membrane Assay, a Novel Model of Head and Neck Squamous Cell Carcinoma
Liu, M., Scanlon, C. S., Banerjee, R., Russo, N., Inglehart, R. C., Willis, A. L., Weiss, S. J., & D’Silva, N. J. (2013) · Translational Oncology · doi:10.1593/tlo.13175 · Cited by 71
“EMT is a process by which nonmotile cells lose contact with neighboring cells and become more motile [37].”
Background
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis
Lee, K., Gjorevski, N., Boghaert, E., Radisky, D. C., & Nelson, C. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.159 · Cited by 73
“with mammary branching, we used the 3D organotypic model to characterize the expression levels of genes within the EMT proteome (Kalluri and Neilson, 2003; Zeisberg and Neilson, 2009) during branching morphogenesis.”
Method
MiR-363-3p inhibits the epithelial-to-mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4
Hu, F., Min, J., Cao, X., Liu, L., Ge, Z., Hu, J., & Li, X. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.055 · Cited by 75
“Assessment of the EMT in cell lines has been reported based on the analysis of changes in the expression of molecular markers, including E-cadherin, ZO-1, vimentin, and bcatenin [20,21].”
Background
Kidney Spheroids Recapitulate Tubular Organoids Leading to Enhanced Tubulogenic Potency of Human Kidney-Derived Cells
Buzhor, E., Harari-Steinberg, O., Omer, D., Metsuyanim, S., Jacob-Hirsch, J., Noiman, T., Dotan, Z., Goldstein, R. S., & Dekel, B. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0595 · Cited by 72
The epithelial–mesenchymal transition (EMT) is regulated by oncoviruses in cancer
Xue, C., Bode, A. M., Dong, Z., & Cao, Y. (2016) · The FASEB Journal · doi:10.1096/fj.201600388r · Cited by 73
Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells
Shah, P. P., Lockwood, W. W., Saurabh, K., Kurlawala, Z., Shannon, S. P., Waigel, S. J., Zacharias, W., & Beverly, L. J. (2014) · Oncogene · doi:10.1038/onc.2014.97 · Cited by 72
“Several transcription factors are known to be involved in the regulation of EMT including Snail, Slug, Twist, and ZEB1/2 which simultaneously induce the expression of genes required for mesenchymal phenotype and repress the expression of genes required for maintaining epithelial phenotype such as E-cadherin (11).”
BackgroundInfluential
Epigenetics of Progression of Chronic Kidney Disease: Fact or Fantasy?
Wing, M. R., Ramezani, A., Gill, H. S., Devaney, J. M., & Raj, D. S. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.05.008 · Cited by 72
Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract
Morris, H., & Machesky, L. M. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.658 · Cited by 72
“In 2008, three types of EMT were defined at a meeting of experts at Cold Spring Harbor Laboratory (Kalluri and Weinberg, 2009; Zeisberg and Neilson, 2009).”
Background
Overexpression of integrin-linked kinase correlates with malignant phenotype in non-small cell lung cancer and promotes lung cancer cell invasion and migration via regulating epithelial–mesenchymal transition (EMT)-related genes
Chen, D., Zhang, Y., Zhang, X., Li, J., Han, B., Liu, S., Wang, L., Yuan, L., Mao, S., & Wang, X. (2012) · Acta Histochemica · doi:10.1016/j.acthis.2012.05.004 · Cited by 72
“At the molecular level, EMT is characterized by the combined loss of epithelial cell junction proteins (e.g., E-cadherin) and the gain of mesenchymal markers, such as vimentin and fibronectin (Zeisberg and Neilson, 2009).”
Background
Mechanism-based inhibition of cancer metastasis with (−)-epigallocatechin gallate
Takahashi, A., Watanabe, T., Mondal, A., Suzuki, K., Kurusu, M., Li, Z., Yamazaki, T., Fujiki, H., & Suganuma, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.094 · Cited by 72
BTB/POZ domain-containing protein 7: Epithelial-mesenchymal transition promoter and prognostic biomarker of hepatocellular carcinoma
Tao, Y., Huang, J.-L., Zeng, S., Zhang, S., Fan, X., Wang, Z., Yang, H., Yuan, X., Wang, P., Wu, F., et al. (2013) · Hepatology · doi:10.1002/hep.26268 · Cited by 72
“In HCC, E-cadherin, fibronectin, and Twist1 are intensively involved in various steps of metastasis, such as loss of cell-cell/cell-ECM adhesion, invasion of ECM, and angiogenesis.(21) Here, we show that knockdown of BTBD7, which acted as an upstream activator of EMT, induced E-cadherin expression, but restrained fibr…”
Background
Seed, soil, and beyond: The basic biology of brain metastasis
Rostomily, R., & Ramakrishna, R. (2013) · Surgical Neurology International · doi:10.4103/2152-7806.111303 · Cited by 71
“These changes are required for intravasation, - the cellular egress through the microvascular endothelium into the blood stream.[5,38,63,67,78,83-85,97]”
Background
The relationship between platinum drug resistance and epithelial–mesenchymal transition
Brozović, A. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1912-7 · Cited by 72
The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells
Kiweler, N., Brill, B., Wirth, M., Breuksch, I., Laguna, T., Dietrich, C., Strand, S., Schneider, G., Groner, B., Butter, F., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2229-5 · Cited by 72
Sweet and Sour: The Impact of Differential Glycosylation in Cancer Cells Undergoing Epithelial–Mesenchymal Transition
Freire‐de‐Lima, L. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00059 · Cited by 71
“Although EMT, by definition, results in the formation of migratory mesenchymal cells, each subtype represents a specific biological event (93).”
Background
Periodontal pathogens promote epithelial-mesenchymal transition in oral squamous carcinoma cells in vitro
Abdulkareem, A. A., Shelton, R. M., Landini, G., Cooper, P. R., & Milward, M. R. (2017) · Cell Adhesion & Migration · doi:10.1080/19336918.2017.1322253 · Cited by 71
“major criteria including downregulation of adhesion molecules, increased migratory ability, and expression of new mesenchymal markers.(42) Transcription of E-cadherin, the central protein of adherens junctions involved”
Background
Fibroblast growth factor 2 induces proliferation and fibrosis via SNAI1-mediated activation of CDK2 and ZEB1 in corneal endothelium
Lee, J. G., Jung, E. E., & Heur, M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000295 · Cited by 71
“Moreover, there is also increased expression of 1 (COL1A1) and 2 (COL1A2) chains of type I collagen (21, 22), and this is also observed in CECs (12, 16, 23).”
Background
Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis
Chen, Y., Sahoo, S., Brien, R., Jung, S., Humphries, B. A., Lee, W., Cheng, Y.-H., Zhang, Z., Luker, K. E., Wicha, M. S., et al. (2019) · The Analyst · doi:10.1039/c9an01358j · Cited by 71
Epithelial–mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart
Meglio, F. D., Castaldo, C., Nurzyńska, D., Romano, V., Miraglia, R., Bancone, C., Langella, G., Vosa, C., & Montagnani, S. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.05.013 · Cited by 71
“In accordance with recently published criteria for EMT in vitro [36], changes suggestive of this process were observed: cell/cell junction dissociation, polygonal to spindle-like shape modification, motility acquisition, and epithelial and/or mesenchymal marker expression.”
Background
Pathology of mixed Müllerian tumours
D′Angelo, E., & Prat, J. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.05.010 · Cited by 71
Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation
Chen, Y., Legan, S. K., Mahan, A., Thornton, J., Xu, H., & Schwarz, M. A. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-1 · Cited by 71
“While this cell population has some of the hallmark characteristics of a cell undergoing TGFb induced EMT, increased nuclear/cytoplasmic volume, changes in nuclear shape [34], loss of cobblestone appearance [27], active ruffling of b-catenin, elevation of rho kinase activity [25,35] and actin cytoskeleton dynamics con…”
Background
Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model
Banyard, J., Chung, I., Wilson, A. M., Vetter, G., Béchec, A. L., Bielenberg, D. R., & Zetter, B. R. (2013) · Scientific Reports · doi:10.1038/srep03151 · Cited by 71
Potential role of periodontal pathogens in compromising epithelial barrier function by inducing epithelial‐mesenchymal transition
Abdulkareem, A. A., Shelton, R. M., Landini, G., Cooper, P. R., & Milward, M. R. (2018) · Journal of Periodontal Research · doi:10.1111/jre.12546 · Cited by 73
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
Sagredo, A. I., Sagredo, E. A., Pola-Véliz, V., Echeverría, C., Andaur, R., Michea, L., Stutzin, A., Simón, F., Marcelain, K., & Armisén, R. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27371 · Cited by 71
“Furthermore, Snail1 regulates other important TFs to maintain mesenchymal phenotypes, such as Zeb1, Twist, and Slug (Lamouille, Xu, & Derynck, 2014; Zeisberg & Neilson, 2009).”
Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?
Mottais, A., Riberi, L., Falco, A., Soccal, S., Gohy, S. T., & Rose, V. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512412 · Cited by 75
“Three different types of EMT have been described depending on the biological or pathophysiological context [15,16].”
Background
Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
Yu, G., Jing, Y., Kou, X., Ye, F., Gao, L., Fan, Q., Yang, Y., Zhao, Q., Li, R., Wu, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073312 · Cited by 70
“Hep3B cells cultured in presence of LX-2 CM underwent EMT, in which process polarized epithelial cells are converted into motile cells with loss of the epithelial phenotypes (degradation of Ecadherin/β-catenin complex), acquirement of mesenchymal phenotypes (upregulation of N-cadherin and Vimentin) and increase of spe…”
Background
Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication
Zhou, D. F., Tan, R. J., Zhou, L., Li, Y., & Liu, Y. (2013) · Scientific Reports · doi:10.1038/srep01878 · Cited by 70
Cell Signals Influencing Hepatic Fibrosis
Cong, M., Iwaisako, K., Jiang, C., & Kisseleva, T. (2012) · International Journal of Hepatology · doi:10.1155/2012/158547 · Cited by 74
Granzyme B Deficiency Protects against Angiotensin II–Induced Cardiac Fibrosis
Shen, Y., Cheng, F., Sharma, M., Merkulova, Y., Raithatha, S. A., Parkinson, L. G., Zhao, H., Westendorf, K., Bohunek, L., Bozin, T., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.010 · Cited by 72
Interaction between Wnt/β-catenin pathway and microRNAs regulates epithelial-mesenchymal transition in gastric cancer (Review)
Wu, C., Zhuang, Y., Jiang, S., Liu, S., Zhou, J., Wu, J., Teng, Y., Xia, B., Wang, R., & Zou, X. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3480 · Cited by 70
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1
Hahn, J. M., McFarland, K. L., Combs, K. A., & Supp, D. M. (2016) · Burns & Trauma · doi:10.1186/s41038-016-0055-7 · Cited by 73
“VIM, an intermediate filament gene, and CDH11, which encodes a component of adherens junctions, are both considered markers of mesenchymal cells that are increased during EMT [10, 19, 20, 48].”
BackgroundInfluential
Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
Cheng, K., & Hao, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122000 · Cited by 70
“accompanied by increased expression of vimentin, which bestows a motile phenotype on cancer cells through changes in cellular architecture and cell-matrix interactions [10,11].”
Background
From the Cover: l-Carnitine via PPARγ- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate
Chou, H., Wen, L.-L., Chang, C.-C., Lin, C., Lu, J., & Juan, S. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx183 · Cited by 71
MCT1 regulates aggressive and metabolic phenotypes in bladder cancer
Zhang, G., Zhang, Y., Dong, D., Wang, F., Ma, X., Guan, F., & Sun, L. (2018) · Journal of Cancer · doi:10.7150/jca.25257 · Cited by 70
“MCT1: Monocarboxylate transporter isoform 1 BCa: Bladder cancer NMI: Non-muscle invasive MI: Muscle invasive EMT: Epithelial-mesenchymal transition CAFs: Cancer-associated fibroblasts AHQDU: Affiliated Hospital of Qingdao University TCGA: The Cancer Genome Atlas IHC: Immunohistochemical qRT-PCR: Quantitative real-time…”
BackgroundInfluential
RETRACTED ARTICLE: PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612
Yang, X., Qu, S., Wang, L. Q., Zhang, H., Yang, Z.-X., Wang, J., Dai, B., Tao, K., Shang, R., Liu, Z., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0416-8 · Cited by 69
Retracted
Inflammatory and Fibrinolytic System in Acute Respiratory Distress Syndrome
Gouda, M. M., Shaikh, S. B., & Bhandary, Y. P. (2018) · Lung · doi:10.1007/s00408-018-0150-6 · Cited by 68
Unjamming and collective migration in MCF10A breast cancer cell lines
Kim, J. H., Pegoraro, A. F., Das, A., Koehler, S. A., Ujwary, S. A., Lan, B., Mitchel, J. A., Atia, L., He, S., Wang, K., et al. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.188 · Cited by 65
“N-cadherin was again detected highest in 10A.14–3-3ζ cells, and was weakly detected in other carcinoma cells (Supplementary Figure S6c).”
BackgroundInfluential
Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’?
Visal, T. H., den Hollander, P., Cristofanilli, M., & Mani, S. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01768-9 · Cited by 72
SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody–Drug Conjugate, Shows Antitumor Activity in Uterine and Ovarian Carcinosarcoma with HER2/Neu Expression
Menderes, G., Bonazzoli, E., Bellone, S., Black, J., Predolini, F., Pettinella, F., Masserdotti, A., Zammataro, L. A., Altwerger, G. H., Buza, N., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2862 · Cited by 70
Selective trapping of single mammalian breast cancer cells by insulator-based dielectrophoresis
Bhattacharya, S., Chao, T., Ariyasinghe, N., Ruiz, Y. W., Lake, D. F., Ros, R., & Ros, A. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7598-2 · Cited by 69
“The transition from an epithelial to a mesenchymal phenotype is accompanied by changes in expression levels of various proteins [51].”
BackgroundInfluential
PTK 7 Is a Transforming Gene and Prognostic Marker for Breast Cancer and Nodal Metastasis Involvement
Gärtner, S., Gunesch, A., Knyazeva, T., Wolf, P., Högel, B., EIERMANN, W., Ullrich, A., Knyazev, P. G., & Ataseven, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084472 · Cited by 69
“Interestingly, GAS6, the ligand for RTK AXL, is also coexpressed with PTK7 (Data not shown) [25–31].”
Background
Akt and β-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line
Yi, G., Liu, Y., Xiang, W., Wang, H., Chen, Z., Xie, S., & Qi, S. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.05.054 · Cited by 69
“Epithelial-to-mesenchymal transition (EMT) is a process initially observed in embryonic development in which cells lose epithelial characteristics and gain mesenchymal properties to increase motility and invasion, and this process is also important in tumor progression and metastasis [14].”
Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin
Chen, L., Mai, W., Chen, M., Hu, J., Zhuo, Z., Lei, X., Deng, L., Liu, J., Yao, N., Huang, M., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.009 · Cited by 69
Role of Oral Bacteria in the Development of Oral Squamous Cell Carcinoma
Li, Q., Hu, Y., Zhou, X., Liu, S., Han, Q., & Cheng, L. (2020) · Cancers · doi:10.3390/cancers12102797 · Cited by 71
“According to several studies, EMT is linked to all four of these steps [87,88]( Figure 3).”
Background
Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells
Cheng, W.-H., Kao, S.-Y., Chen, C., Yuliani, F. S., Lin, L., Lin, C., & Chen, B.-C. (2022) · Respiratory Research · doi:10.1186/s12931-022-02285-2 · Cited by 68
“Fibroblast-like mesenchymal cells can express FN, collagens, and α-smooth muscle actin (α-SMA) as EMT markers [15, 16].”
Background
New Insights into the Role of Podoplanin in Epithelial–Mesenchymal Transition
Renart, J., Carrasco-Ramírez, P., Fernández‐Muñoz, B., Martín-Villar, E., Montero-Montero, L., Yurrita, M. M., & Quintanilla, M. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.01.009 · Cited by 72
Tumor-stromal interactions with direct cell contacts enhance motility of non-small cell lung cancer cells through the hedgehog signaling pathway.
Choe, C., Shin, Y.-S., Kim, S.-H., Jeon, M.-J., Choi, S., Lee, J., & Kim, J. (2013) · PubMed · Cited by 68
TGF‐β1 and FGF2 Stimulate the Epithelial–Mesenchymal Transition of HERS Cells Through a MEK‐Dependent Mechanism
Chen, J., Chen, G., Yan, Z., Guo, Y., Yu, M., Feng, L., Jiang, Z., Guo, W., & Tian, W. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24610 · Cited by 68
“EMT is a process by which epithelial cells convert to mesenchymal cells (Zeisberg and Neilson, 2009).”
Background
Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation
Kim, H., Park, J., Cho, Y.-S., Cho, C., Kim, J., Shin, H., Chung, D. H., Kim, S. J., & Chun, Y. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.002 · Cited by 69
Snail regulated by PKC/GSK-3β pathway is crucial for EGF-induced epithelial-mesenchymal transition (EMT) of cancer cells
Liu, Z.-C., Chen, X.-H., Song, H.-X., Wang, H., Zhang, G., Wang, H., Chen, D., Fang, R., Liu, H., Cai, S., et al. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1953-2 · Cited by 68
Epithelial-to-Mesenchymal Transition in Renal Neoplasms
He, H., & Magi‐Galluzzi, C. (2014) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000018 · Cited by 68
Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells
Chen, Y., Fan, Y., Guo, D.-Y., Xu, B., Shi, X.-Y., Li, J.-T., & Duan, L.-F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110413 · Cited by 63
Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
Ortmann, B. M. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2023-000154 · Cited by 67
Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value
Fabisiewicz, A., Szostakowska-Rodzoś, M., Zaczek, A. J., & Grzybowska, E. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051671 · Cited by 67
“It is a multistage process associated with dynamic changes in morphology, cytoskeleton and adhesion, including the loss of apicobasal polarity and delocalization of tight junction and adherens junction proteins, such as E-cadherin and ZO-1 [43,44].”
Background
Therapeutic potential of pro-resolving mediators in diabetic kidney disease
Vartak, T., Godson, C., & Brennan, E. P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113965 · Cited by 68
EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332
Richter, P., Umbreit, C., Franz, M., Berndt, A., Grimm, S., Uecker, A., Böhmer, F. D., Kosmehl, H., & Berndt, A. (2010) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2010.00936.x · Cited by 67
Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss
Ueno, T., Kobayashi, N., Nakayama, M., Takashima, Y., Ohse, T., Pastan, I. H., Pippin, J. W., Shankland, S. J., Uesugi, N., Matsusaka, T., et al. (2013) · Kidney International · doi:10.1038/ki.2013.48 · Cited by 67
Enhanced Epithelial-Mesenchymal Transition-like Phenotype in N-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing
Terao, M., Ishikawa, A., Nakahara, S., Kimura, A., Kato, A., Moriwaki, K., Kamada, Y., Murota, H., Taniguchi, N., Katayama, I., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220376 · Cited by 67
Transition of Mesothelial Cell to Fibroblast in Peritoneal Dialysis: EMT, Stem Cell or Bystander?
Liu, Y., Dong, Z., Liu, Z., Zhu, J., Liu, F., & Chen, G. (2015) · Peritoneal Dialysis International · doi:10.3747/pdi.2014.00188 · Cited by 67
“EMT occurs when secondary epithelial cells switch into mesenchymal cells during tissue repair and fibrosis; Type 3 EMT occurs when epithelial carcinoma cells turn into migrating and invasive mesenchymal cells (35,36).”
Background
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells
Chen, Y.-C., Statt, S. N., Wu, R., Chang, H., Liao, J., Wang, C., Shyu, W., & Lee, C. (2016) · Scientific Reports · doi:10.1038/srep18815 · Cited by 69
Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: therapeutic approaches in cancer
Garg, M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.975794 · Cited by 66
“Three types of EMT program -- EMT type 1, EMT type 2 and EMT type 3 -- are known to be involved in three different processes of cell embryonic development, adult tissue injury repair and tissue invasion/metastasization of malignant epithelial cells, respectively [4,7].”
Background
An integrated microfluidic device for rapid and high-sensitivity analysis of circulating tumor cells
Jiang, J., Zhao, H., Shu, W., Tian, J., Huang, Y., Song, Y., Wang, R., Li, E., Slamon, D., Hou, D., et al. (2017) · Scientific Reports · doi:10.1038/srep42612 · Cited by 66
LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway
Tao, Y., Han, T., Zhang, T., Ma, C., & Sun, C. (2017) · Oncotarget · doi:10.18632/oncotarget.16850 · Cited by 66
Retracted
Crosstalk between Beta-Catenin and Snail in the Induction of Epithelial to Mesenchymal Transition in Hepatocarcinoma: Role of the ERK1/2 Pathway
Zucchini-Pascal, N., Peyre, L., & Rahmani, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020768 · Cited by 66
“The epithelial cytokeratin intermediate filaments are replaced by vimentin [15].”
Background
The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology
Burns, W. C., & Thomas, M. C. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001481 · Cited by 66
Wnt-Dependent T-Cell Factor-4 Controls Human Etravillous Trophoblast Motility
Meinhardt, G., Haider, S., Haslinger, P., Proestling, K., Fiala, C., Pollheimer, J., & Knöfler, M. (2014) · Endocrinology · doi:10.1210/en.2013-2042 · Cited by 66
“Hallmarks of EMT include down-regulation of genes involved in maintaining epithelial integrity, such as the tight junction proteins occludin and zona occludens-1 (ZO-1), or the adherens junction protein E-cadherin and up-regulation of promigratory/mesenchymal genes, for example, ITGA5, ITGB1, fibronectin, vimentin, se…”
Background
MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases
Zou, X., Liu, T. C., Gong, Z., Hu, C.-P., & Zhang, Z. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.12.003 · Cited by 67
Osthole inhibited TGFβ-induced epithelial–mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells
Feng, H., Lu, J., Wang, Y., Pei, L., & Chen, X. (2017) · Cell Adhesion & Migration · doi:10.1080/19336918.2016.1259058 · Cited by 65
High Vimentin Expression Predicts a Poor Prognosis and Progression in Colorectal Cancer: A Study with Meta-Analysis and TCGA Database
Du, L., Li, J., Lei, L., He, H., Chen, E., Dong, J., & Yang, J. (2018) · BioMed Research International · doi:10.1155/2018/6387810 · Cited by 66
“Vimentin is regarded as a sign of cell epithelial to mesenchymal conversion and seems to be one of the best indicators of EMT in tumorigenesis [7, 8].”
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
Roeder, S. S., Stefanska, A., Eng, D. G., Kaverina, N., Sunseri, M. W., McNicholas, B. A., Rabinovitch, P., Engel, F. B., Daniel, C., Amann, K., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00144.2015 · Cited by 62
Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer
Wang, Y.-P., Sun, N., Lü, C., Bei, Y.-B., Qian, R., & Hua, L. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3987 · Cited by 69
“The cadherin switch from E-cadherin to N-cadherin, which is expressed in mesenchymal cells, fibroblasts, cancer cells, and neural tissues has often been used to monitor the EMT progress during the embryonic development and cancer progression (31).”
Silencing of CEMIP suppresses Wnt/β-catenin/Snail signaling transduction and inhibits EMT program of colorectal cancer cells
Liang, G., Fang, X., Yang, Y., & Song, Y. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.11.002 · Cited by 65
Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition
Saliem, S. S., Bede, S. Y. H., Cooper, P. R., Abdulkareem, A. A., Milward, M. R., & Abdullah, B. H. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.09.001 · Cited by 75
“During EMT, expression of certain biomarkers is markedly changed (Table 1) and these are considered as the hallmarks of the EMT process [59,60].”
Background
New Insights into the Mechanism of Fibroblast to Myofibroblast Transformation and Associated Pathologies
Watsky, M. A., Weber, K. T., Sun, Y., & Postlethwaite, A. E. (2010) · International review of cytology · doi:10.1016/s1937-6448(10)82004-0 · Cited by 68
Estrogen receptors in breast and bone: from virtue of remodeling to vileness of metastasis
Bado, I., Gugala, Z., Fuqua, S. A. W., & Zhang, X. (2017) · Oncogene · doi:10.1038/onc.2017.94 · Cited by 65
Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas
Tsai, C., Huang, L., Tsai, W., Huang, S., Lee, J., & Hueng, D. (2018) · Oncotarget · doi:10.18632/oncotarget.24594 · Cited by 63
The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome
Redfern, A. D., Spalding, L. J., & Thompson, E. W. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9906-x · Cited by 64
Elastin is a key factor of tumor development in colorectal cancer
Li, J., Xu, X., Jiang, Y., Hansbro, N. G., Hansbro, P. M., Xu, J., & Liu, G. (2020) · BMC Cancer · doi:10.1186/s12885-020-6686-x · Cited by 67
“Full length immunoblots of α-SMA, VIM, E-cadherin and β-actin in Fig.”
MethodInfluential
Bladder cancer-derived exosomal KRT6B promotes invasion and metastasis by inducing EMT and regulating the immune microenvironment
Song, Q., Yu, H., Cheng, Y., Han, J., Li, K., Zhuang, J., Lv, Q., Yang, X. F., & Yang, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03508-2 · Cited by 65
“Currently, several genes have been proven to be biomarkers of the EMT process, including CDH1, CDH2, vimentin, MMP9, Twist, snail and TGF-β [19, 20].”
Background
AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial–mesenchymal transition of prostate cancer cells
Liu, Z.-C., Wang, H., Zhang, G., Liu, H., Chen, X.-H., Zhang, F., Chen, D., Cai, S., & Du, J. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.07.018 · Cited by 64
NetGestalt: integrating multidimensional omics data over biological networks
Shi, Z., Wang, J., & Zhang, B. (2013) · Nature Methods · doi:10.1038/nmeth.2517 · Cited by 62
A smac mimetic reduces TNF Related Apoptosis Inducing Ligand (TRAIL)‐induced invasion and metastasis of cholangiocarcinoma cells†
Fingas, C. D., Blechacz, B. R. A., Smoot, R. L., Guicciardi, M. E., Mott, J. L., Bronk, S. F., Werneburg, N. W., Sirica, A. E., & Gores, G. J. (2010) · Hepatology · doi:10.1002/hep.23729 · Cited by 64
Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition
Masszi, A., & Kapùs, A. (2010) · Cells Tissues Organs · doi:10.1159/000320180 · Cited by 67
Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis
Meyer, C., Liu, Y., Kaul, A., Peipe, I., & Dooley, S. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.204 · Cited by 64
The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions
Davidson, B., Holth, A., Hellesylt, E., Tan, T. Z., Huang, R. Y., Trope, C. G., Nesland, J. M., & Thiery, J. P. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.10.004 · Cited by 63
The TGF-β1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjögren’s Syndrome
Sisto, M., Lorusso, L., Ingravallo, G., Tamma, R., Ribatti, D., & Lisi, S. (2018) · Mediators of Inflammation · doi:10.1155/2018/1965935 · Cited by 63
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients
Liu, Y., Yan, X. S., Chen, J., Zhan, Q., Hua, Y., Xu, S., Li, Z., Wang, Z., Dong, Y., Zuo, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012228118 · Cited by 64
“Reduced CK expression in cancer cells is often associated with loss of epithelial signatures and epithelial-to-mesenchymal transition (EMT)—a process that has been implicated in the intravasation of CTCs into blood vessels (29).”
Background
BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma
Zhang, P., Dong, Z., Cai, J., Zhang, C., Shen, Z., Ke, A., Gao, D., Fan, J., & Shi, G. (2015) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632015572070 · Cited by 63
NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells
Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I., Kalt, R., Krieger, S., Vo, T. P. N., Madlener, S., Bauer, S., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.194 · Cited by 63
“S100A4 is a calcium-binding protein that interacts with intracellular target proteins (Mandinova et al, 1998) and is a marker for a mesenchymal phenotype and mesenchymal transition of epithelial cells, which encompasses cell mobility (Zeisberg and Neilson, 2009).”
Background
Fibrous Stroma Is Associated with Poorer Prognosis in Lung Squamous Cell Carcinoma Patients
Takahashi, Y., Ishii, G., Taira, T., Fujii, S., Yanagi, S., Hishida, T., Yoshida, J., Nishimura, M., Nomori, H., Nagai, K., et al. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318229189d · Cited by 69
Epithelial mesenchymal transition correlates with CD24+CD44+ and CD133+ cells in pancreatic cancer
Miao, Y. (2012) · Oncology Reports · doi:10.3892/or.2012.1681 · Cited by 63
“In addition to its role in development, tissue regeneration and fibrosis, EMT is considered a critical process in cancer progression (5-9).”
All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro
Cui, J., Gong, M., He, Y., Li, Q., He, T., & Bi, Y. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3235 · Cited by 63
Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis
Tennakoon, A. H., Izawa, T., Kuwamura, M., & Yamate, J. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm5010004 · Cited by 68
“Additionally, the expression of cytoskeletal markers, particularly α-SMA, vimentin, desmin, fibroblast specific protein-1 (FSP-1) and β-catenin, has been evaluated to characterize renal tubular epithelia undergoing type 2 EMT [5,34,35].”
Background

Authors: Zeisberg, M., & Neilson, E. G.
Affiliations: Beth Israel Deaconess Medical Center (US)
Vanderbilt University (US)
ORCID: Zeisberg, Michael
Neilson, Eric G.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2009-06-01
Volume: 119
Issue: 6
Pages: 1429-1437
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci36183
PMC: PMC2689132
OpenAlex: W1996118868
Cited by: 2,299
References: 124
Citations by year: 2026: 50 · 2025: 79 · 2024: 127 · 2023: 113 · 2022: 146 · 2021: 148 · 2020: 180 · 2019: 163 · 2018: 170 · 2017: 189 · 2016: 153 · 2015: 162 · 2014: 162 · 2013: 149 · 2012: 109
FWCI: 8.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R03DK081687, R01DK046282, DK46282, K08DK074558, DK-081687, DK074558)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: epithelial-mesenchymal transition, cellular plasticity, epithelial cells, endothelial cells, cell motility
MeSH terms: Animals, Cell Differentiation, Epithelial Cells, Fibroblasts, Humans, Neoplasms, Biomarkers, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biomarkers for epithelial-mesenchymal transitions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks