Cited by 459Parathyroid Disorders and TreatmentsAlkaline Phosphatase Research StudiesBone health and osteoporosis research

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Endocrine functions of bone in mineral metabolism regulation

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Quarles, L. Darryl·2008·Journal of Clinical Investigation

DOI 10.1172/jci36479PMC PMC2586800

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Abstract

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Block, G. A., Klassen, P., Lazarus, J. M., Ofsthun, N. J., Lowrie, E. G., & Chertow, G. M. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000133041.27682.a2 · Cited by 2,684
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho
Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Baum, M. G., Schiavi, S. C., Hu, M. C., Moe, O. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,381
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199
Self-citation
Evolution of the Fgf and Fgfr gene families.
Itoh, N., & Ornitz, D. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.08.007 · Cited by 1,123
A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets
Francis, F., Hennig, S., Korn, B., Reinhardt, R., de Jong, P., Poustka, A. J., Lehrach, H. R., Rowe, P. S., Goulding, J. N., Summerfield, T. C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-130 · Cited by 1,095
The parathyroid is a target organ for FGF23 in rats
Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951
Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease
Gutiérrez, O. M., Isakova, T., Rhee, E. P., Shah, A., Holmes, J., Collerone, G., Diaeresis]ppner, H. J., & Wolf, M. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010052 · Cited by 920
Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia
Jonsson, K. B., Zahradnik, R. J., Larsson, T. E., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 904
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting
Riminucci, M., Collins, M. T., Fedarko, N. S., Cherman, N., Corsi, A., White, K. E., Waguespack, S. G., Gupta, A., Hannon, T. S., Econs, M. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18399 · Cited by 656
Fibroblast Growth Factor 23 Is a Counter-Regulatory Phosphaturic Hormone for Vitamin D
Liu, S., Tang, W., Zhou, J., Stubbs, J. R., Luo, Q., Pi, M., & Quarles, L. D. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005111185 · Cited by 641
Self-citation
βKlotho is required for metabolic activity of fibroblast growth factor 21
Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
Beck, L., Karaplis, A. C., Amizuka, N., Hewson, A. S., Ozawa, H., & Tenenhouse, H. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5372 · Cited by 607
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bonePreprint
Murshed, M., Harmey, D., Millán, J. L., McKee, M. D., & Karsenty, G. (2005) · Genes & Development · doi:10.1101/gad.1276205 · Cited by 599
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Chen, C.-D., Podvin, S., Gillespie, E., Leeman, S. E., & Abraham, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709805104 · Cited by 563
Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain
Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553
Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members
Goetz, R. M., Beenken, A., Ibrahimi, O. A., Kalinina, J., Olsen, S. K., Eliseenkova, A. V., Xu, C.-F., Neubert, T. A., Zhang, F., Linhardt, R. J., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 550
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.
Sitara, D., Razzaque, M., Hesse, M., Yoganathan, S., Taguchi, T., Erben, R., Jüppner, H., & Lanske, B. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.09.007 · Cited by 528
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
Lorenz‐Depiereux, B., Bastepe, M., Benet‐Pagès, A., Amyere, M., Wagenstaller, J., Mueller-Barth, U., Badenhoop, K. W. J., Kaiser, S., Rittmaster, R. S., Shlossberg, A. H., et al. (2006) · Nature Genetics · doi:10.1038/ng1868 · Cited by 524
Fibroblast Growth Factor-23 Relationship to Dietary Phosphate and Renal Phosphate Handling in Healthy Young Men
Ferrari, S. L., Bonjour, J.-P., & Rizzoli, R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1039 · Cited by 518
Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX
Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505
Self-citation
Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System
Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 501
Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis
Larsson, T. E., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, Ö., Tenenhouse, H. S., Jüppner, H., & Jonsson, K. B. (2004) · Endocrinology · doi:10.1210/en.2003-1768 · Cited by 497
Pathogenic role of Fgf23 in Hyp mice
Liu, S., Zhou, J., Tang, W., Jiang, X., Rowe, D. W., & Quarles, L. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2006 · Cited by 494
Self-citation
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
Ichikawa, S., Imel, E. A., Kreiter, M. L., Yu, X., Mackenzie, D. S., Sorenson, A. H., Goetz, R. M., Mohammadi, M., White, K. E., & Econs, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31330 · Cited by 491
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.
Benet-Pagès, A., Orlik, P., Strom, T., & Lorenz-Depiereux, B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi034 · Cited by 486
SLC34A3 Mutations in Patients with Hereditary Hypophosphatemic Rickets with Hypercalciuria Predict a Key Role for the Sodium-Phosphate Cotransporter NaPi-IIc in Maintaining Phosphate Homeostasis
Bergwitz, C., Roslin, N. M., Tieder, M., Loredo‐Osti, J., Bastepe, M., Abu-Zahra, H., Frappier, D., Burkett, K. M., Carpenter, T. O., Anderson, D., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/499409 · Cited by 485
Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells
Krajisnik, T., Björklund, P., Marsell, R., Ljunggren, Ö., Åkerström, G., Jonsson, K. B., Westin, G., & Larsson, T. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0267 · Cited by 473
Circulating FGF-23 Is Regulated by 1α,25-Dihydroxyvitamin D3 and Phosphorus in Vivo
Saitô, H., Maeda, A., Ohtomo, S., Hirata, M., Kusano, K., Kato, S., Ogata, E., Segawa, H., Miyamoto, K., & Fukushima, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408903200 · Cited by 468
Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins
Fisher, L. W., & Fedarko, N. S. (2003) · Connective Tissue Research · doi:10.1080/03008200390152061 · Cited by 467
Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation.
Ma, Y. L., Cain, R. L., Halladay, D. L., Yang, X., Zeng, Q., Miles, R. R., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2001) · Endocrinology · doi:10.1210/endo.142.9.8356 · Cited by 428
Dietary and Serum Phosphorus Regulate Fibroblast Growth Factor 23 Expression and 1,25-Dihydroxyvitamin D Metabolism in Mice
Perwad, F., Azam, N., Zhang, M. Y. H., Yamashita, T., Tenenhouse, H. S., & Portale, A. A. (2005) · Endocrinology · doi:10.1210/en.2005-0777 · Cited by 424
Functional evolutionary history of the mouse Fgf gene family
Itoh, N., & Ornitz, D. M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21388 · Cited by 416
How Fibroblast Growth Factor 23 Works
Liu, S., & Quarles, L. D. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010068 · Cited by 415
Self-citation
Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1α,25-Dihydroxyvitamin D3 Production
Saitô, H., Kusano, K., Kinosaki, M., Ito, H., Hirata, M., Segawa, H., Miyamoto, K., & Fukushima, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207872200 · Cited by 412
α-Klotho as a Regulator of Calcium Homeostasis
Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., et al. (2007) · Science · doi:10.1126/science.1135901 · Cited by 390
Hypophosphatemia: an evidence-based approach to its clinical consequences and management
Amanzadeh, J., & Reilly, R. F. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0124 · Cited by 387
Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism
Shimada, T., Yamazaki, Y., Takahashi, M., Hasegawa, H., Urakawa, I., Oshima, T., Ono, K., Kakitani, M., Tomizuka, K., Fujita, T., et al. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00474.2004 · Cited by 359
Serum FGF23 Levels in Normal and Disordered Phosphorus Homeostasis
Weber, T. J., Liu, S., Indridason, Ó. S., & Quarles, L. D. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.7.1227 · Cited by 353
Self-citation
Immunohistochemical Localization of Klotho Protein in Brain, Kidney, and Reproductive Organs of Mice
Li, S.-A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M., & Takei, K. (2004) · Cell Structure and Function · doi:10.1247/csf.29.91 · Cited by 351
Premature aging‐like phenotype in fibroblast growth factor 23 null mice is a vitamin D‐mediated process
Razzaque, M. S., Sitara, D., Taguchi, T., St‐Arnaud, R., & Lanske, B. (2006) · The FASEB Journal · doi:10.1096/fj.05-5432fje · Cited by 345
βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c
Suzuki, M., Uehara, Y., Motomura-Matsuzaka, K., Oki, J., Koyama, Y., Kimura, M., Asada, M., Komi-Kuramochi, A., Oka, S., & Toru, T. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0313 · Cited by 345
FGF-23 Inhibits Renal Tubular Phosphate Transport and Is a PHEX Substrate
Bowe, A. E., Finnegan, R., de Beur, S. M. J., Cho, J., Levine, M. A., Kumar, R., & Schiavi, S. C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5084 · Cited by 339
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
Masuyama, R., Stockmans, I., Torrekens, S., Looveren, R. V., Maes, C., Carmeliet, P., Bouillon, R., & Carmeliet, G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29463 · Cited by 332
Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders
Bai, X., Miao, D., Li, J., Goltzman, D., & Karaplis, A. C. (2004) · Endocrinology · doi:10.1210/en.2004-0233 · Cited by 329
Mutations that Cause Osteoglophonic Dysplasia Define Novel Roles for FGFR1 in Bone Elongation
White, K. E., Cabral, J. M., Davis, S. I., Fishburn, T., Evans, W., Ichikawa, S., Fields, J., Yu, X., Shaw, N. J., McLellan, N., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/427956 · Cited by 328
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1
Shiraki-Iida, T., Aizawa, H., Matsumura, Y., Sekine, S., Iida, A., Anazawa, H., Nagai, R., Kuro‐o, M., & Nabeshima, Y.-I. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00127-6 · Cited by 313
Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
Berndt, T. J., Craig, T. A., Bowe, A. E., Vassiliadis, J., Reczek, D., Finnegan, R., de Beur, S. M. J., Schiavi, S. C., & Kumar, R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18563 · Cited by 292
Liver-specific Activities of FGF19 Require Klotho beta
Lin, B. C., Wang, M., Blackmore, C. A., & Desnoyers, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704244200 · Cited by 288
Role of Hyperphosphatemia and 1,25-Dihydroxyvitamin D in Vascular Calcification and Mortality in Fibroblastic Growth Factor 23 Null Mice
Stubbs, J. R., Liu, S., Tang, W., Zhou, J., Wang, Y., Yao, X., & Quarles, L. D. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006121385 · Cited by 275
Self-citation
The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency
Bai, X., Miao, D., Goltzman, D., & Karaplis, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210490200 · Cited by 274
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Corut, A., Şenyiğit, A., İşerı̇, S. A. U., Altın, S., Özçelik, U., Çalışır, H. C., Yıldırım, Z., Göçmen, A., & Tolun, A. (2006) · The American Journal of Human Genetics · doi:10.1086/508263 · Cited by 270
MEPE has the properties of an osteoblastic phosphatonin and minhibin
Rowe, P. S., Kumagai, Y., Gutierrez, G., Garrett, I. R., Blacher, R. W., Rosen, D., Cundy, J., Navvab, S., Chen, D., Drezner, M. K., et al. (2003) · Bone · doi:10.1016/j.bone.2003.10.005 · Cited by 268
Self-citation
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Wang, H., Yoshiko, Y., Yamamoto, R., Minamizaki, T., Kozai, K., Tanne, K., Aubin, J. E., & Maeda, N. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080220 · Cited by 263
FGF23 is processed by proprotein convertases but not by PHEX
Benet‐Pagès, A., Lorenz‐Depiereux, B., Zischka, H., White, K. E., Econs, M. J., & Strom, T. M. (2004) · Bone · doi:10.1016/j.bone.2004.04.002 · Cited by 258
Dual Functional Roles of Dentin Matrix Protein 1
Narayanan, K., Ramachandran, A., Hao, J. J., He, G., Park, K. W., Cho, M., & George, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212700200 · Cited by 243
Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
Nishida, Y., Taketani, Y., Yamanaka-Okumura, H., Imamura, F., Taniguchi, A., Sato, T., Shuto, E., Nashiki, K., Arai, H., Yamamoto, H., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5002000 · Cited by 243
Alpha-Klotho as a regulator of calcium homeostasis
Tsuji, Y. (2008) · Kyoto University Research Information Repository (Kyoto University) · Cited by 241
Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in HomozygousklothoMutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene
Yoshida, T., Fujimori, T., & Nabeshima, Y. (2002) · Endocrinology · doi:10.1210/endo.143.2.8657 · Cited by 240
A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism
Brownstein, C. A., Adler, F., Nelson-Williams, C. J., Iijima, J., Li, P., Imura, A., Nabeshima, Y., Reyes‐Múgica, M., Carpenter, T. O., & Lifton, R. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712361105 · Cited by 239
Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.
Hafner, C., van Oers, J. V., Vogt, T., Landthaler, M., Stoehr, R., Blaszyk, H., Hofstaedter, F., Zwarthoff, E., & Hartmann, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28163 · Cited by 217
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216
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Yamashita, T., Konishi, M., Miyake, A., Inui, K., & Itoh, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202527200 · Cited by 215
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Yu, X., Ibrahimi, O. A., Goetz, R. M., Zhang, F., Davis, S. I., Garringer, H. J., Linhardt, R. J., Ornitz, D. M., Mohammadi, M., & White, K. E. (2005) · Endocrinology · doi:10.1210/en.2005-0670 · Cited by 213
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Bennett, E., Hassan, H., & Clausen, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17006 · Cited by 211
Parathyroid Hormone Regulates Fibroblast Growth Factor-23 in a Mouse Model of Primary Hyperparathyroidism
Kawata, T., Imanishi, Y., Kobayashi, K., Miki, T., Arnold, A., Inaba, M., & Nishizawà, Y. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070783 · Cited by 208
Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice
Hesse, M., Fröhlich, L. F., Zeitz, U., Lanske, B., & Erben, R. G. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.10.003 · Cited by 198
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Yamazaki, Y., Tamada, T., Kasai, N., Urakawa, I., Aono, Y., Hasegawa, H., Fujita, T., Kuroki, R., Yamashita, T., Fukumoto, S., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080417 · Cited by 195
Genetic Evidence of Serum Phosphate-Independent Functions of FGF-23 on Bone
Sitara, D., Kim, S., Razzaque, M. S., Bergwitz, C., Taguchi, T., Schüler, C., Erben, R. G., & Lanske, B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000154 · Cited by 184
Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
Yuan, B., Takaiwa, M., Clemens, T. L., Feng, J. Q., Kumar, R., Rowe, P. S., Xie, Y., & Drezner, M. K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32702 · Cited by 178
Expression of SIBLINGs and Their Partner MMPs in Salivary Glands
Ogbureke, K. U. E., & Fisher, L. W. (2004) · Journal of Dental Research · doi:10.1177/154405910408300902 · Cited by 174
Degradation of MEPE, DMP1, and release of SIBLING ASARM-Peptides (Minhibins): ASARM-Peptide(s) are directly responsible for defective mineralization in HYP
Martin, A., David, V., Laurence, J. S., Schwarz, P. M., Lafer, E. M., Hedge, A.-M., & Rowe, P. S. N. (2008) · Endocrinology · doi:10.1210/en.2007-1205 · Cited by 173
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Carpenter, T. O., Ellis, B. K., Insogna, K. L., Philbrick, W. M., Sterpka, J., & Shimkets, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0357 · Cited by 158
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Mori, S., Wu, C., Yamaji, S., Saegusa, J., Shi, B., Ma, Z., Kuwabara, Y., Lam, K. S., Isseroff, R. R., Takada, Y. K., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801213200 · Cited by 154
Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf-23-Null Animals
Sitara, D., Razzaque, M. S., St‐Arnaud, R., Huang, W. Y., Taguchi, T., Erben, R. G., & Lanske, B. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060329 · Cited by 153
Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis).
Fisher, S. E., Black, G. C. M., Lloyd, S. E., Hatchwell, E., WRONG, O. M., Thakker, R. V., & Craig, I. (1994) · PubMed · Cited by 146
Pathogenic role of Fgf23 in Dmp1 -null mice
Liu, S., Zhou, J., Tang, W., Menard, R., Feng, J. Q., & Quarles, L. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90201.2008 · Cited by 144
Self-citation
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Segawa, H., Yamanaka, S., Ohno, Y., Onitsuka, A., Shiozawa, K., Aranami, F., Furutani, J., Tomoe, Y., Ito, M., Kuwahata, M., et al. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00248.2006 · Cited by 144
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Liu, S., Vierthaler, L., Tang, W., Zhou, J., & Quarles, L. D. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007121301 · Cited by 143
Self-citation
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Feild, J. A., Zhang, L., Brun, K. A., Brooks, D. P., & Edwards, R. M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0666 · Cited by 143
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Topaz, O., Indelman, M., Chefetz, I., Geiger, D., Metzker, A., Altschuler, Y., Choder, M., Bercovich, D., Uitto, J., Bergman, R., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/508069 · Cited by 136
Fibroblast Growth Factor-23 Mutants Causing Familial Tumoral Calcinosis Are Differentially Processed
Larsson, T. E., Davis, S. I., Garringer, H. J., Mooney, S. D., Draman, M. S., Cullen, M. J., & White, K. E. (2005) · Endocrinology · doi:10.1210/en.2005-0431 · Cited by 134
Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
Lu, Y., Ye, L., Yu, S., Zhang, S., Xie, Y., McKee, M. D., Li, Y. C., Kong, J., Eick, J. D., Dallas, S. L., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.001 · Cited by 129
Dentin Matrix Protein 1 Initiates Hydroxyapatite Formation In Vitro
He, G., Dahl, T., Veis, A., & George, A. (2003) · Connective Tissue Research · doi:10.1080/03008200390181726 · Cited by 127
Intrinsic mineralization defect inHyp mouse osteoblasts
Xiao, Z., Crenshaw, M. A., Guo, R., Nesbitt, T., Drezner, M. K., & Quarles, L. D. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.4.e700 · Cited by 114
Self-citation
Role of 1,25-Dihydroxyvitamin D3 on Intestinal Phosphate Absorption in Rats with a Normal Vitamin D Supply
Rizzoli, R., Fleisch, H. A., & Bonjour, J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108815 · Cited by 112
Differential effects ofNpt2agene ablation and X-linkedHypmutation on renal expression of Npt2c
Tenenhouse, H. S., Martel, J., Gauthier, C., Segawa, H., & Miyamoto, K. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00252.2003 · Cited by 110
Cloning and Sequencing of Human PEX from a Bone cDNA Library: Evidence for Its Developmental Stage-Specific Regulation in Osteoblasts
Guo, R., & Quarles, L. D. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.7.1009 · Cited by 108
Self-citation
Genetic Transmission of Tumoral Calcinosis: Autosomal Dominant with Variable Clinical Expressivity*
Lyles, K. W., Burkes, E. J., Ellis, G. J., LUCAS, K. J., Dolan, E. A., & Drezner, M. K. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1093 · Cited by 105
Partial Rescue of theHypPhenotype by Osteoblast-TargetedPHEX(Phosphate-Regulating Gene with Homologies to Endopeptidases on the X Chromosome) Expression
Bai, X., Miao, D., Panda, D., Grady, S., McKee, M. D., Goltzman, D., & Karaplis, A. C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0113 · Cited by 100
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein
Campos, M., COUTURE, C., Hirata, I. Y., Juliano, M. A., Loisel, T. P., Crine, P., Juliano, L., Boileau, G., & Carmona, A. K. (2003) · Biochemical Journal · doi:10.1042/bj20030287 · Cited by 98
Ontogeny of Phex/PHEX Protein Expression in Mouse Embryo and Subcellular Localization in Osteoblasts
Thompson, D., Sabbagh, Y., Tenenhouse, H. S., Roche, P. C., Drezner, M. K., Salisbury, J. L., Grande, J. P., Poeschla, E. M., & Kumar, R. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.311 · Cited by 97
Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23
Marsell, R., Krajisnik, T., Göransson, H., Ohlsson, C., Ljunggren, Ö., Larsson, T. E., & Jonsson, K. B. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm672 · Cited by 94
Phosphorylated acidic serine–aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
Liu, S., Rowe, P. S., Vierthaler, L., Zhou, J., & Quarles, L. D. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07059 · Cited by 92
Self-citation
Overexpression of Phex in Osteoblasts Fails to Rescue the Hyp Mouse Phenotype
Liu, S., Guo, R., Tu, Q., & Quarles, L. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107707200 · Cited by 91
Self-citation
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Chihara, Y., Rakugi, H., Ishikawa, K., Ikushima, M., Maekawa, Y., Ohta, J., Kida, I., & Ogihara, T. (2006) · Endocrinology · doi:10.1210/en.2005-1529 · Cited by 90
Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts
Tummalapalli, C. M., Heath, B. J., & Tyagi, S. C. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010315)80:4 · Cited by 88
Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
Liu, S., Tang, W., Zhou, J., Vierthaler, L., & Quarles, L. D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00396.2007 · Cited by 86
Self-citation
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Guo, R., Liu, S., Spurney, R. F., & Quarles, L. D. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.4.e837 · Cited by 81
Self-citation
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Mori, K., Yahata, K., Mukoyama, M., Suganami, T., Makino, H., Nagae, T., Masuzaki, H., Ogawa, Y., Sugawara, A., Nabeshima, Y.-I., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3864 · Cited by 65
Overexpression of Human PHEX Under the Human β-Actin Promoter Does Not Fully Rescue the Hyp Mouse Phenotype
Erben, R. G., Mayer, D., Weber, K., Jonsson, K. B., Jüppner, H., & Lanske, B. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050212 · Cited by 60
Tumor producing fibroblast growth factor 23 localized by two-staged venous sampling
van Boekel, G., Ruinemans‐Koerts, J., Joosten, F. B. M., Dijkhuizen, P. A., van Sorge, A., & de Boer, H. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0779 · Cited by 60
Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin
Rowe, P. S., Matsumoto, N., Jo, O. D., Shih, R. N. J., Oconnor, J., Roudier, M. P., Bain, S., Liu, S., Harrison, J. S., & Yanagawa, N. (2006) · Bone · doi:10.1016/j.bone.2006.04.012 · Cited by 59
FGF23 is elevated in Gambian children with rickets
Prentice, A., Ceesay, M., Nigdikar, S., Allen, S. J., & Pettifor, J. M. (2007) · Bone · doi:10.1016/j.bone.2007.11.014 · Cited by 57
An interpretation of acute changes in plasma45Ca following parathyroid hormone administration to thyroparathyroidectomized rats
Talmage, R. V., Doppelt, S. H., & Fondren, F. B. (1977) · Calcified Tissue International · doi:10.1007/bf02010351 · Cited by 51
Skeletal changes in epidermal nevus syndrome: Does focal bone disease harbor clues concerning pathogenesis?
Heike, C. L., Cunningham, M. L., Steiner, R. D., Wenkert, D., Hornung, R. L., Gruss, J. S., Gannon, F. H., McAlister, W. H., Mumm, S. R., & Whyte, M. P. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30915 · Cited by 50
Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration
Brown, E. M., Watson, E. J., Thatcher, J. G., Koletsky, R. J., Dawson-Hughes, B. F., Posillico, J. T., & Shoback, D. (1987) · Metabolism · doi:10.1016/0026-0495(87)90060-6 · Cited by 23
Role of Circulating Fibroblast Growth Factor 23 in the Development of Secondary Hyperparathyroidism
Kazama, J. J., Gejyo, F., Shigematsu, T., & Fukagawa, M. (2005) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2005.00291.x · Cited by 19
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
李, 順. (2005) · Okayama University Scientific Achievement Repository (Okayama University) · Cited by 17
Parathyroid Hormone Stimulates Phosphate Efflux through an Apparently Adenosine 3′,5′-Monophosphate-Independent Process in Rat Parotid Cell Aggregates
Shiraki, M., Gee, M. V., Baum, B. J., & Roth, G. S. (1986) · Endocrinology · doi:10.1210/endo-118-5-2009 · Cited by 13

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Research works printed but not linked: 4

Ben-Dov, 2007, J. Clin. Invest., 117, 4003
Yuan, 2008, J. Clin. Invest., 118, 722
Xiao, 1998, Am. J. Physiol., 275, E700
Fisher, 1994, Hum. Mol. Genet., 3, 2053

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Authors: Quarles, L. D.
Affiliations: University of Kansas Medical Center (US)
Corresponding author: Quarles, L. Darryl
ORCID: Quarles, L. Darryl
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2008-12-01
Volume: 118
Issue: 12
Pages: 3820-3828
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci36479
PMC: PMC2586800
OpenAlex: W2165433745
Cited by: 459
References: 117
Citations by year: 2026: 7 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 19 · 2019: 37 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 19 · 2014: 28 · 2013: 26 · 2012: 65
FWCI: 5.74
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045955, R01-AR-45955, R56AR045955)
Topics: Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: bone endocrine function, mineral metabolism, calcium homeostasis, phosphate homeostasis, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, bone mineralization, hyperphosphatemia, skeletal mass
MeSH terms: Fibroblast Growth Factor-23, Animals, Bone and Bones, Calcitriol, Calcium, Energy Metabolism, Fibroblast Growth Factors, Homeostasis, Humans, Phosphates, Bone Density, Hyperphosphatemia

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Endocrine functions of bone in mineral metabolism regulation

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