The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation
Open accessAbstract
Many microRNAs (miRNAs), posttranscriptional regulators of numerous cellular processes and developmental events, are downregulated in tumors. However, their role in tumorigenesis remains largely unknown. In this work, we examined the role of the muscle-specific miRNAs miR-1 and miR-206 in human rhabdomyosarcoma (RMS), a soft tissue sarcoma thought to arise from skeletal muscle progenitors. We have shown that miR-1 was barely detectable in primary RMS of both the embryonal and alveolar subtypes and that both miR-1 and miR-206 failed to be induced in RMS cell lines upon serum deprivation. Moreover, reexpression of miR-206 in RMS cells promoted myogenic differentiation and blocked tumor growth in xenografted mice by switching the global mRNA expression profile to one that resembled mature muscle. Finally, we showed that the product of the MET proto-oncogene, the Met tyrosine-kinase receptor, which is overexpressed in RMS and has been implicated in RMS pathogenesis, was downregulated in murine satellite cells by miR-206 at the onset of normal myogenesis. Thus, failure of posttranscriptional modulation may underlie Met overexpression in RMS and other types of cancer. We propose that tissue-specific miRNAs such as miR-1 and miR-206, given their ability to modulate hundreds of transcripts and to act as nontoxic differentiating agents, may override the genomic heterogeneity of solid tumors and ultimately hold greater therapeutic potential than single gene-directed drugs.
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2 retracted
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MicroRNA expression profiles classify human cancers
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novak, J., & Bienertova-Vasku, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 478
MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.012 · Cited by 449
Control of metastatic progression by microRNA regulatory networks
Pencheva, N., & Tavazoie, S. F. (2013) · Nature Cell Biology · doi:10.1038/ncb2769 · Cited by 295
Metadata
- Authors
- Taulli, R., Bersani, F., Foglizzo, V., Linari, A., Vigna, E., Ladanyi, M., Tuschl, T., & Ponzetto, C.
- Venue
- Journal of Clinical Investigation
- Published
- 2009-07-20
- Volume
- 119
- Issue
- 8
- Pages
- 2366-78
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2004775268
- Cited by
- 260
- References
- 51
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Taulli, R., Bersani, F., Foglizzo, V., Linari, A., Vigna, E., Ladanyi, M., Tuschl, T., & Ponzetto, C. (2009). The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. Journal of Clinical Investigation. https://doi.org/10.1172/jci38075
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