The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion
Open accessAbstract
The mechanisms underlying mucus-associated pathologies in cystic fibrosis (CF) remain obscure. However, recent studies indicate that CF transmembrane conductance regulator (CFTR) is required for bicarbonate (HCO3-) transport and that HCO3- is critical for normal mucus formation. We therefore investigated the role of HCO3- in mucus secretion using mouse small intestine segments ex vivo. Basal rates of mucus release in the presence or absence of HCO3- were similar. However, in the absence of HCO3-, mucus release stimulated by either PGE2 or 5-hydroxytryptamine (5-HT) was approximately half that stimulated by these molecules in the presence of HCO3-. Inhibition of HCO3- and fluid transport markedly reduced stimulated mucus release. However, neither absence of HCO3- nor inhibition of HCO3- transport affected fluid secretion rates, indicating that the effect of HCO3- removal on mucus release was not due to decreased fluid secretion. In a mouse model of CF (mice homozygous for the most common human CFTR mutation), intestinal mucus release was minimal when stimulated with either PGE2 or 5-HT in the presence or absence of HCO3-. These data suggest that normal mucus release requires concurrent HCO3- secretion and that the characteristically aggregated mucus observed in mucin-secreting organs in individuals with CF may be a consequence of defective HCO3- transport.
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Cited by
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,435
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Yang, S., & Yu, M. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s318327 · Cited by 325
Sontheimer-Phelps, A., Chou, D. B., Tovaglieri, A., Ferrante, T. C., Duckworth, T., Fadel, C., Frismantas, V., Sutherland, A. D., Jalili-Firoozinezhad, S., Kasendra, M., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.008 · Cited by 239
Metadata
- Authors
- Garcia, M. A. S., Yang, N., & Quinton, P. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2009-09-01
- Volume
- 119
- Issue
- 9
- Pages
- 2613-2622
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2142781849
- Cited by
- 287
- References
- 49
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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