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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
Open accessAbstract
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously generated pancreas epithelium-specific TGF-β receptor type II (Tgfbr2) knockout mice in the context of Kras activation (mice referred to herein as Kras+Tgfbr2KO mice) and found that they developed aggressive PDAC that recapitulated the histological manifestations of the human disease. The mouse PDAC tissue showed strong expression of connective tissue growth factor (Ctgf), a profibrotic and tumor-promoting factor, especially in the tumor-stromal border area, suggesting an active tumor-stromal interaction. Here we show that the PDAC cells in Kras+Tgfbr2KO mice secreted much higher levels of several Cxc chemokines compared with mouse pancreatic intraepithelial neoplasia cells, which are preinvasive. The Cxc chemokines induced Ctgf expression in the pancreatic stromal fibroblasts, not in the PDAC cells themselves. Subcutaneous grafting studies revealed that the fibroblasts enhanced growth of PDAC cell allografts, which was attenuated by Cxcr2 inhibition. Moreover, treating the Kras+Tgfbr2KO mice with the CXCR2 inhibitor reduced tumor progression. The decreased tumor progression correlated with reduced Ctgf expression and angiogenesis and increased overall survival. Taken together, our data indicate that tumor-stromal interactions via a Cxcr2-dependent chemokine and Ctgf axis can regulate PDAC progression. Further, our results suggest that inhibiting tumor-stromal interactions might be a promising therapeutic strategy for PDAC.
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“Notably, data from various mouse models indicate that disrupting the CXCR1/2–MDSC axis in tumours is therapeutically efficacious across a wide variety of solid cancers166–172.”
From The current state of the art and future trends in RAS-targeted cancer therapies (2022) · cites this paper as [169]
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“Moreover, the important role of CXCR2 in pancreatic adenocarcinoma models (Ijichi et al., 2011) and of S100A8/9 in colorectal cancer (Ichikawa et al., 2011) suggest that the relevance of targeting the CXCL1/2–S100A8/9 axis may extend beyond breast cancer.”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Ijichi et al., 2011
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Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citationAnalysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,927
Research works printed but not linked: 5
- Rozenblum, 1997, Cancer Res., 57, 1731
- Venkatasubbarao, 2000, Anticancer Res., 20, 43
- Fujioka, 2003, Clin Cancer Res., 9, 346
- Shier, 1999, Anticancer Res., 19, 4969
- Weidner, 1995, Am J Pathol., 147, 9
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Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639
Tumor angiogenesis: causes, consequences, challenges and opportunities
Lugano, R., Ramachandran, M., & Dimberg, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03351-7 · Cited by 2,149
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P. G., Manova-Todorova, K., Leversha, M., Hogg, N., Seshan, V. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.042 · Cited by 1,085
Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.007 · Cited by 1,158
The roles of TGFβ in the tumour microenvironment
Pickup, M. W., Novitskiy, S. V., & Moses, H. L. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3603 · Cited by 936
Self-citationSteele, C. W., Karim, S. A., Leach, J. D. G., Bailey, P. J., Upstill‐Goddard, R., Rishi, L., Foth, M., Bryson, S., McDaid, K., Wilson, Z., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.014 · Cited by 857
Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment
Kim, J., & Bae, J. (2016) · Mediators of Inflammation · doi:10.1155/2016/6058147 · Cited by 820
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Ha, H., Debnath, B., & Neamati, N. (2017) · Theranostics · doi:10.7150/thno.15625 · Cited by 805
Neutrophils in cancer: heterogeneous and multifaceted
Hedrick, C. C., & Malanchi, I. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00571-6 · Cited by 795
Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies
Adamska, A., Domenichini, A., & Falasca, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071338 · Cited by 632
Laklai, H., Miroshnikova, Y. A., Pickup, M. W., Collisson, E. A., Kim, G., Barrett, A., Hill, R. C., Lakins, J. N., Schlaepfer, D. D., Mouw, J. K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4082 · Cited by 614
Self-citationPancreatic cancer: from state-of-the-art treatments to promising novel therapies
Garrido‐Laguna, I., & Hidalgo, M. M. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.53 · Cited by 576
Platelets guide the formation of early metastatic niches
Labelle, M., Begum, S., & Hynes, R. O. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411082111 · Cited by 555
The current state of the art and future trends in RAS-targeted cancer therapies
Punekar, S. R., Velcheti, V., Neel, B. G., & Wong, K.-K. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00671-9 · Cited by 549
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Principe, D. R., Doll, J. A., Bauer, J. I., Jung, B., Munshi, H. G., Bartholin, L., Pasche, B., Lee, C., & Grippo, P. J. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt369 · Cited by 537
Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S. K., & DuBois, R. N. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.009 · Cited by 477
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
Apte, M. V., Wilson, J. S., Lugea, A., & Pandol, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.11.037 · Cited by 461
Gemcitabine resistance in pancreatic ductal adenocarcinoma
Binenbaum, Y., Na’ara, S., & Gil, Z. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.10.002 · Cited by 418
Mace, T. A., Ameen, Z., Collins, A., Wojcik, S. E., Mair, M., Young, G. S., Fuchs, J. R., Eubank, T. D., Frankel, W. L., Bekaii‐Saab, T., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4601 · Cited by 427
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook, C. J., & Lyssiotis, C. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.006 · Cited by 403
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Jamieson, T., Clarke, M., Steele, C. W., Samuel, M. S., Neumann, J., Jung, A., Huels, D., Olson, M. F., Das, S., Nibbs, R. J. B., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61067 · Cited by 391
Wang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
Cheng, Y., Ma, X., Wei, Y.-Q., & Wei, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.005 · Cited by 352
Binenbaum, Y., Fridman, E., Yaari, Z. A., Milman, N., Schroeder, A., David, G. B., Shlomi, T., & Gil, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0124 · Cited by 344
Lee, Y. S., Choi, I., Ning, Y., Kim, N., Khatchadourian, V., Yang, D., Chung, H. K., Choi, D., LaBonte, M. J., Ladner, R. D., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.177 · Cited by 293
Neutrophils in innate and adaptive immunity
Jaillon, S., Galdiero, M. R., Prete, D. D., Cassatella, M. A., Garlanda, C., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0374-8 · Cited by 295
Angiogenesis in pancreatic cancer: current research status and clinical implications
Li, S., Xu, H., Wu, C., Wang, W.-Q., Jin, W., Gao, H.-L., Li, H., Zhang, S.-R., Xu, J.-Z., Qi, Z.-H., et al. (2018) · Angiogenesis · doi:10.1007/s10456-018-9645-2 · Cited by 287
Cancer Inflammation and CytokinesPreprint
Galdiero, M. R., Marone, G., & Mantovani, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028662 · Cited by 274
El-Kenawi, A., & El‐Remessy, A. B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12344 · Cited by 261
Neeße, A., Frese, K. K., Bapiro, T. E., Nakagawa, T., Sternlicht, M. D., Seeley, T. W., Pilarsky, C. P., Jodrell, D. I., Spong, S. M., & Tuveson, D. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300415110 · Cited by 251
Chao, T., Furth, E. E., & Vonderheide, R. H. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0188 · Cited by 252
Heparanase: From basic research to therapeutic applications in cancer and inflammation
Vlodavsky, I., Singh, P., Boyango, I., Gutter-Kapon, L., Elkin, M., Sanderson, R. D., & Ilan, N. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.10.001 · Cited by 244
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236
CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target
Zhang, W., Wang, H., Sun, M., Deng, X., Wu, X., Ma, Y., Li, M., Shuoa, S. M., You, Q., & Miao, L. (2020) · 癌症：英文版 · doi:10.1002/cac2.12010 · Cited by 239
Sun, X., He, X., Zhang, Y., Hosaka, K., Andersson, P., Wu, J., Wu, J., Xu, J., Du, Q., Hui, X., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-322744 · Cited by 240
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01355-1 · Cited by 214
Modeling Pancreatic Cancer with Organoids
Baker, L. A., Tiriac, H., Clevers, H. C., & Tuveson, D. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.03.004 · Cited by 227
Regulation and modulation of antitumor immunity in pancreatic cancer
Leinwand, J., & Miller, G. (2020) · Nature Immunology · doi:10.1038/s41590-020-0761-y · Cited by 207
The immune network in pancreatic cancer development and progression
Wörmann, S. M., Diakopoulos, K. N., Lesina, M., & Algül, H. (2013) · Oncogene · doi:10.1038/onc.2013.257 · Cited by 206
Heßmann, E., Patzak, M. S., Klein, L., Chen, N., Kari, V., Ramu, I., Bapiro, T. E., Frese, K. K., Gopinathan, A., Richards, F. M., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-311954 · Cited by 205
Tumor stroma as targets for cancer therapy
Zhang, J., & Liu, J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.10.003 · Cited by 196
Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis
Ueha, S., Shand, F. H. W., & Matsushima, K. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00071 · Cited by 196
Genetically engineered mouse models of pancreatic adenocarcinoma
Guerra, C. E., & Barbacid, M. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.02.002 · Cited by 179
Pancreatic cancer: Stroma and its current and emerging targeted therapies
Kota, J., Hancock, J., Kwon, J. J., & Korc, M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.12.035 · Cited by 177
What We Have Learned About Pancreatic Cancer From Mouse Models
Pérez-Mancera, P. A., Guerra, C. E., Barbacid, M., & Tuveson, D. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.002 · Cited by 178
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Korbecki, J., Kupnicka, P., Chlubek, M., Gorący, J., Gutowska, I., & Baranowska‐Bosiacka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042168 · Cited by 173
Saintigny, P., Massarelli, E., Lin, S. H., Ahn, Y., Chen, Y., Goswami, S., Erez, B., O’Reilly, M. S., Liu, D., Lee, J. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0263 · Cited by 165
Liang, C., Shi, S., Meng, Q., Liang, D., Ji, S., Zhang, B., Qin, Y., Xu, J., Ni, Q., & Yu, X. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.255 · Cited by 166
Roles of neutrophils in cancer growth and progression
Galdiero, M. R., Varricchi, G., Loffredo, S., Mantovani, A., & Marone, G. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0717-292r · Cited by 157
Korbecki, J., Barczak, K., Gutowska, I., Chlubek, D., & Baranowska‐Bosiacka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020792 · Cited by 163
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Grabner, B., Schramek, D., Mueller, K. M., Moll, H. P., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7285 · Cited by 146
Genetically Engineered Mouse Models of Pancreatic Cancer
Westphalen, C. B., & Olive, K. P. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e31827ab4c4 · Cited by 140
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Schnittert, J., Bansal, R., & Prakash, J. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.01.001 · Cited by 145
Maris, P., Blomme, A., Palacios, A. P., Costanza, B., Bellahcène, A., Bianchi, E., Gofflot, S., Drion, P. V., Trombino, G. E., Valentin, E. D., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001871 · Cited by 134
Chronic pancreatitis: A path to pancreatic cancer
Pinho, A. V., Chantrill, L. A., & Rooman, I. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.015 · Cited by 138
Kenkel, J. A., Tseng, W. W., Davidson, M. G., Tolentino, L. L., Choi, O., Bhattacharya, N., Seeley, E. S., Winer, D. A., Reticker-Flynn, N. E., & Engleman, E. G. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2212 · Cited by 139
Lesina, M., Wörmann, S. M., Morton, J. P., Diakopoulos, K. N., Korneeva, O., Wimmer, M., Einwächter, H., Sperveslage, J., Demir, İ. E., Kehl, T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86477 · Cited by 134
Neutrophil dynamics in the tumor microenvironment
McFarlane, A. J., Fercoq, F., Coffelt, S. B., & Carlin, L. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143759 · Cited by 133
Pancreatic cancer and its stroma: A conspiracy theory
Xu, Z. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11216 · Cited by 127
Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes
Wang, T., Notta, F., Navab, R., Joseph, J., Ibrahimov, E., Xu, J., Zhu, C.-Q., Borgida, A., Gallinger, S., & Tsao, M.-S. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0192 · Cited by 123
Zhou, Z., Xia, G., Xiang, Z., Liu, M., Wei, Z., Yan, J., Chen, W., Zhu, J., Awasthi, N., Sun, X., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3567 · Cited by 125
Ion channels and transporters in tumour cell migration and invasion
Schwab, A., & Stock, C. M. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0102 · Cited by 121
Key role of pancreatic stellate cells in pancreatic cancer
Pothula, S. P., Xu, Z., Goldstein, D., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.035 · Cited by 123
Lv, M., Xu, Y., Tang, R., Ren, J., Shen, S., Chen, Y., Liu, B., Hou, Y., & Wang, T. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0448 · Cited by 117
Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target
Hartupee, C. D., Nagalo, B. M., Chabu, C. Y., Tesfay, M. Z., Coleman‐Barnett, J., West, J. T., & Moaven, O. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1287459 · Cited by 116
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.018 · Cited by 115
Liot, S., Balas, J., Aubert, A., Prigent, L., Mercier‐Gouy, P., Verrier, B., Bertolino, P., Hennino, A., Valcourt, U., & Lambert, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612271 · Cited by 121
Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression
Wilson, J. S., Pirola, R. C., & Apte, M. V. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00052 · Cited by 108
Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
Bonavita, E., Galdiero, M. R., Jaillon, S., & Mantovani, A. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.013 · Cited by 102
TGF-β and αvβ6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression
Hezel, A. F., Deshpande, V., Zimmerman, S. M., Contino, G., Alagesan, B., O’Dell, M. R., Rivera, L. B., Harper, J. W., Lonning, S. M., Brekken, R. A., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0634 · Cited by 99
Wei, Z.-W., Xia, G., Wu, Y., Chen, W., Xiang, Z., Schwarz, R. E., Brekken, R. A., Awasthi, N., He, Y.-L., & Zhang, C.-H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.01.033 · Cited by 95
Sano, M., Ijichi, H., Takahashi, R., Miyabayashi, K., Fujiwara, H., Yamada, T., Kato, H., Nakatsuka, T., Tanaka, Y., Tateishi, K., et al. (2019) · Oncogenesis · doi:10.1038/s41389-018-0117-8 · Cited by 97
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Jiang, B., Zhou, L., Lü, J., Wang, Y., Liu, C., You, L., & Guo, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.576399 · Cited by 104
Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches
Thyagarajan‐Sahu, A., Alshehri, M. S. A., Miller, K. L., Sherwin, C. M. T., Travers, J. B., & Sahu, R. P. (2019) · Cancers · doi:10.3390/cancers11111627 · Cited by 95
Meng, F., Li, W., Li, C., GAO, Z., Guo, K., & Song, S. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2794 · Cited by 89
Bijlsma, M. F., & van Laarhoven, H. W. M. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9541-1 · Cited by 84
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Lafaro, K. J., & Melstrom, L. G. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.09.009 · Cited by 87
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Hermano, E., Meirovitz, A., Meir, K. S., Nussbaum, G., Appelbaum, L., Peretz, T., & Elkin, M. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju332 · Cited by 81
Yan, H. H., Jiang, J. D., Pang, Y., Achyut, B. R., Lizardo, M. M., Liang, X., Hunter, K. W., Khanna, C., Hollander, C. M., & Li, Y. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-2282-t · Cited by 83
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Achyut, B. R., Bader, D. A., Robles, A. I., Wangsa, D., Harris, C. C., Ried, T., & Yang, H. H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003251 · Cited by 77
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Steele, C. W., Jamieson, N. B., Evans, T. R. J., McKay, C. J., Sansom, O. J., Morton, J. P., & Carter, C. R. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.24 · Cited by 77
Bohrer, L. R., & Schwertfeger, K. L. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0275 · Cited by 74
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Desurmont, T., Skrypek, N., Duhamel, A., Jonckheere, N., Millet, G., Leteurtre, E., Gosset, P., Duchêne, B., Ramdane, N., Hebbar, M., et al. (2015) · Cancer Science · doi:10.1111/cas.12603 · Cited by 77
Fokas, E., O’Neill, E., Gordon-Weeks, A. N., Mukherjee, S., McKenna, W. G., & Muschel, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.12.001 · Cited by 75
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Awaji, M. I., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Sushil Kumar, K., Rachagani, S., Ly, Q. P., Jain, M., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902990r · Cited by 69
Zhang, Y., Davis, C., Ryan, J. C., Janney, C., & Peña, M. M. O. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9591-8 · Cited by 68
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Wells, J. E., Howlett, M., Cole, C., & Kees, U. R. (2014) · International Journal of Cancer · doi:10.1002/ijc.28972 · Cited by 66
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Charrier, A., & Brigstock, D. R. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.07.001 · Cited by 67
Yang, T., Deng, Z., Xu, L., Li, X., Tan, Y., Qian, Y., Lü, Y., Tian, L., Yao, W., & Wang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02235-8 · Cited by 62
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Self-citationLee, Y.-C., Gajdošik, M. Š., Josić, D., Clifton, J. G., Logothetis, C. J., Yu‐Lee, L., Gallick, G. E., Maity, S. N., & Lin, S.-H. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.039909 · Cited by 60
Sano, M., Takahashi, R., Ijichi, H., Ishigaki, K., Yamada, T., Miyabayashi, K., Kimura, G., Mizuno, S., Kato, H., Fujiwara, H., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-320608 · Cited by 56
Self-citation
Metadata
- Authors
- Ijichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Bierie, B., Tada, M., Mohri, D., Miyabayashi, K., Asaoka, Y., Maeda, S., Ikenoue, T., Tateishi, K., Wright, C. V. E., Koike, K., Omata, M., & Moses, H. L.
- Affiliations
- The University of Tokyo (JP)
- Vanderbilt University (US)
- Whitehead Institute for Biomedical Research (US)
- Chiba University (JP)
- Yokohama City University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Yamanashi Prefectural Central Hospital (JP)
- Corresponding author
- Ijichi, Hideaki
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2011-10-03
- Volume
- 121
- Issue
- 10
- Pages
- 4106-4117
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3195452
- OpenAlex
- W2014434319
- Cited by
- 256
- References
- 50
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 31 · 2020: 19 · 2019: 17 · 2018: 7 · 2017: 20 · 2016: 20 · 2015: 20 · 2014: 22 · 2013: 27 · 2012: 24
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Vanderbilt University
- Ministry of Education, Culture, Sports, Science and Technology
- Foundation for Promotion of Cancer Research
- National Institutes of Health
- U.S. Public Health Service (U54126505)
- Japan Society for the Promotion of Science (23591011, 22501004)
- National Cancer Institute (CA 085492, R01CA085492, CA102162, R01CA102162)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- pancreatic ductal adenocarcinoma, tumor-stroma interactions, connective tissue growth factor, CXCR2, CXCL chemokines, desmoplasia, TGFBR2, tumor angiogenesis, tumor growth, overall survival, pancreatic intraepithelial neoplasia
- MeSH terms
- Receptor, Transforming Growth Factor-beta Type II, Animals, Female, Humans, Mice, Inbred C57BL, Mice, Nude, Pancreatic Neoplasms, Signal Transduction, Gene Expression, Proto-Oncogene Proteins p21(ras), Stromal Cells, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Mice, Knockout, Chemokines, CXC, Carcinoma, Pancreatic Ductal, Receptors, Interleukin-8B, Mice, Connective Tissue Growth Factor, Tumor Microenvironment
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