The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model
Open accessAbstract
Fibroblasts are ubiquitous cells that demonstrate remarkable diversity. However, their origin and pathways of differentiation remain poorly defined. Here, we show that connective tissue growth factor (CTGF; also known as CCN2) is sufficient to induce human bone marrow mesenchymal stem/stromal cells (MSCs) to differentiate into fibroblasts. CTGF-stimulated MSCs lost their surface mesenchymal epitopes, expressed broad fibroblastic hallmarks, and increasingly synthesized collagen type I and tenacin-C. After fibroblastic commitment, the ability of MSCs to differentiate into nonfibroblastic lineages - including osteoblasts, chondrocytes, and adipocytes - was diminished. To address inherent heterogeneity in MSC culture, we established 18 single MSC-derived clones by limiting dilution. CTGF-treated MSCs were alpha-SMA-, differentiating into alpha-SMA+ myofibroblasts only when stimulated subsequently with TGF-beta1, suggestive of stepwise processes of fibroblast commitment, fibrogenesis, and pathological fibrosis. In rats, in vivo microencapsulated delivery of CTGF prompted postnatal connective tissue to undergo fibrogenesis rather than ectopic mineralization. The knowledge that fibroblasts have a mesenchymal origin may enrich our understanding of organ fibrosis, cancer stroma, ectopic mineralization, scarring, and regeneration.
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Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401
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Tracy, L. E., Minasian, R. A., & Caterson, E. J. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0561 · Cited by 1,008
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Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Lo, A., Wang, L.-C. S., Scholler, J., Monslow, J., Avery, D., Newick, K., O'Brien, S., Evans, R. A., Bajor, D. J., Clendenin, C., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3041 · Cited by 498
Wei, J., Melichian, D., Komura, K., Hinchcliff, M., Lam, A. P., Lafyatis, R., Gottardi, C. J., MacDougald, O. A., & Varga, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30312 · Cited by 214
Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus
Zhang, Z.-Z., Chen, Y.-R., Wang, S.-J., Zhao, F., Wang, X.-G., Yang, F., Shi, J.-J., Ge, Z.-G., Ding, W.-Y., Yang, Y.-C., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0750 · Cited by 121
Lee, M.-O., Jung, K. B., Jo, S.-J., Hyun, S.-A., Moon, K.-S., Seo, J.-W., Kim, S.-H., & Son, M.-Y. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0139-6 · Cited by 72
Ohara, Y., Chew, S. H., Misawa, N., Wang, S., Somiya, D., Nakamura, K., Kajiyama, H., Kikkawa, F., Tsuyuki, Y., Jiang, L., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24892 · Cited by 44
Metadata
- Authors
- Lee, C. H., Shah, B., Moioli, E. K., & Mao, J. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-09-01
- Volume
- 120
- Issue
- 9
- Pages
- 3340-3349
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4235484022
- Cited by
- 289
- References
- 5
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
