The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans
Open accessAbstract
Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high risk for bacterial sepsis remains an important clinical challenge. Recent studies have shown that antibiotics can alter microbial diversity in the intestine. Here, we characterized these effects using 16s rDNA pyrosequencing and demonstrated that antibiotic treatment of mice enabled exogenously administered VRE to efficiently and nearly completely displace the normal microbiota of the small and large intestine. In the clinical setting, we found that intestinal domination by VRE preceded bloodstream infection in patients undergoing allogeneic hematopoietic stem cell transplantation. Our results demonstrate that antibiotics perturb the normal commensal microbiota and set the stage for intestinal domination by bacteria associated with hospital-acquired infections. Thus, high-throughput DNA sequencing of the intestinal microbiota could identify patients at high risk of developing bacterial sepsis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [13]
In the citing paper
“Gram− commensals can be depleted by vancomycin, which is a Gram+-targeting drug [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“VRE colonizes the intestine following antibiotic treatment, prior to spreading to the bloodstream, and thus, represents a major threat for hospitalized patients [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“The taxonomic composition of the gut microbiota changes throughout the gastrointestinal tract, according to nutrient availability, mucus structure, pH and oxygen availability [1–6].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Flagged first, then by citations
Research works printed but not linked: 2
- Abreu, 2003, J Endotoxin Res., 9, 322, 10.1177/09680519030090050901 · DOI
- Rakoff-Nahoum, 2006, Curr Top Microbiol Immunol., 308, 1
Cited by
Sorted by citations
Items 901–945 of 945
Vaitkute, G., Panić, G., Alber, D., Faizura-Yeop, I., Cloutman-Green, E., Swann, J., Veys, P. A., Standing, J. F., Klein, N. J., & Bajaj‐Elliott, M. (2022) · Figshare · doi:10.6084/m9.figshare.20056032
Ma, Y., Peng, X., Zhang, J., Zhu, Y., Huang, R., Li, G., Wu, Y., Zhou, C., You, J., Fang, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752420
Duggar, M., Sun, Y., Leardini, D., Jia, Q., Muratore, E., Dallas, R. H., Ferrolino, J. A. A., Cherian, A., Cesaro, S., Faraci, M., et al. (2026) · medRxiv · doi:10.64898/2026.01.20.26344466
Function of Gut Microbiota in Longevity as a Futuristic Approach of Personalised Nutrition
Malik, S., Bharali, R., Barbhuyan, H. S. A., Bora, J., Lata, S., & Madan, A. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-4382-2.ch010 · Cited by 1
Current Management of Serious Infections due to Vancomycin-resistant Enterococci
Gomez-Villegas, S. I., Wh, M., & Arias, C. A. D. (2026) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2025.12.004
Mei, L.-N., Shen, J.-S., Duan, Y., Shi, Z.-Q., Peng, H., & Luo, X. (2026) · Natural Products and Bioprospecting · doi:10.1007/s13659-025-00584-x
Bacterial and Atypical Infections in Critically Ill Cancer Patients
la Hoz, A. D., & Cortés, J. A. (2026) · Springer eBooks · doi:10.1007/978-3-319-74698-2_123-2
Vijayakumar, K., Kannan, S., & Balakrishnan, J. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04829-2
Insights into the interaction of Enterococcus faecalis with host cells
Nunez, N. (2017) · theses.fr (ABES) · doi:10.70675/8636c8afzcac0z4f40za0ffz5a6d9da835c0
Ishnaiwer, M. M. (2022) · theses.fr (ABES) · doi:10.70675/61486caezc3ecz4191z953bz60a90b36660b · Cited by 2
Yang, S., Wei, M., Chen, H., Hu, Y., Luo, Z., Tingjian.Cao, Nie, X., & Qiu, Y. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1786780
Paduszynska, M. A., Shchuka, A., & Greber, K. E. (2026) · Antibiotics · doi:10.3390/antibiotics15050439
Diet-derived microbial metabolites modulate stress-responsive gene expression in germ-free zebrafish
Capistrano, J. D. R., Ketheeswaranathan, B., Horn, M., Tran, P. N. G., Ball, T., Chirmade, S., Vancuren, S. J., Ma, D. W. L., Walton, K., Allen‐Vercoe, E., et al. (2026) · Gut Microbiome · doi:10.64898/2026.05.04.722778
Vasil, E., Papanicolas, L. E., Miller, S. J., Shoubridge, A. P., Taylor, S., & Rogers, G. B. (2026) · Journal of Infection · doi:10.1016/j.jinf.2026.106774
Wolf, S., Zeltner, N., Henze, N., Enssle, J. C., Kempf, V. A. J., Kessel, J. M., Vehreschild, M. J. G. T., Steffen, B., Oellerich, T., Serve, H. L., et al. (2026) · Infection · doi:10.1007/s15010-026-02836-5
Chuang, Y., Collman, R. G., Ruan, S., Chien, Y., Huang, Y.-J., Hsu, C.-C., Jann-Tay, W., Zou, H.-B., & Chang, S. (2026) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-026-00871-6
Su, H., Xu, T., Hu, W., Wang, H., Pei, Z., & Lu, W. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-026-05071-0
Su, X., Xiang, Y., Zhao, H., Li, O., Zhang, L., & Guo, B. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1839030
Mills, E. G., Evans, K. M., Dorazio, A. J., Squires, K. M., Sundermann, A. J., Stellfox, M. E., Culyba, M. J., Shields, R. K., & Tyne, D. V. (2026) · Microbial Genomics · doi:10.1099/mgen.0.001778
Grunnvåg, J. S., Hegstad, K., Ahator, S. D., & Lentz, C. S. (2026) · FEMS Microbes · doi:10.1093/femsmc/xtag038
Joo, M.-K., Tak, J., Ha, S., Yoon, K., Namgoong, J., & Kim, H. O. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1835588
Acute myeloid leukemia and gut microbiome: bidirectional effects and opportunities for intervention
Arora, K., Chowdhary, R., Shenoy, A., Kapadia, C., Paras, F., Vora, N., Arora, A., Chowdhary, R., Arora, A., Goyal, M., et al. (2026) · Annals of Hematology · doi:10.1007/s00277-026-07176-w
Ju, Y., Liu, K., Xiao, Y., Ma, G., Zhu, B., Wang, H. X., Hu, Z., Zhao, J., Zhang, L., Cui, K., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1848531
Fang, X., Yan, C., Li, R., Chen, Z., & Lu, J. (2026) · MicroBiome and One Health · doi:10.1016/j.micoh.2026.100004
Rath, A., & Schneider‐Brachert, W. (2026) · Infection · doi:10.1007/s15010-026-02890-z
Li, X., Xia, Y., Fan, J., Jiang, F., Li, L., Du, X., Wang, X., & Yu, G. (2026) · The Veterinary Journal · doi:10.1016/j.tvjl.2026.106808
Selbach, F., Mezochow, A. K., & Lee, J. R. (2026) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000001305
Lawal, O. U., Rubin, I. M. C., Castruita, J. A. S., Petersen, A. M., Mollerup, S., Pedersen, M. S., Camoez, M., Faria, N. A., Westh, H., Pinholt, M., et al. (2026) · Genome Medicine · doi:10.1186/s13073-026-01747-2
Zhao, Y., Chen, W., Chen, P., Chen, X., Ding, Y., & Han, Z. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1919715
Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances
Wang, Z., Wen, X., Yuan, S., Zhang, J., & Xu, D. (2026) · Biomedicines · doi:10.3390/biomedicines14091992
Zhou, J., Li, R., Zhang, M., Wu, Y., & Hu, R. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.02578-26
Beyond antibiotics: collateral damage to the gut microbiome during cancer therapy
Jin, T., Lv, Y., Jiang, S., & Jia, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1955949
Devito, A., Kimm-Drapeau, A. L., Higgins, W. J., Montecillo, M., Bernstein, M., Wright, S., Li, C., Bal, I., Dadhania, D. M., Selbach, F., et al. (2026) · Transplant Infectious Disease · doi:10.1111/tid.70323
Alvarez, D. A. N., Alvarez, M. V. N., Ferreira, A. S., Hirai, W. Y., Silva, N. L., Souza, L. D. A., Machado, L. D., Ciconelli, R. M., Feliciano, J. V. P., Colturato, I., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14102249
Streptococcal mutanobactin mediates interspecies competition with gram-positive bacteria
Isenberg, R. Y., Sackih, C. W., Abdulrahman, F. A., & Willett, J. L. E. (2026) · mBio · doi:10.1128/mbio.01623-26
Aldhaheri, K., Fung, J. S. T., Nishi, C., Lau, J. E., Mah, A., Wright, A. J., Stubbins, R. J., Charles, M., & Belga, S. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag627
Urakami, I., Fukushima, S., Tsuji, S., Gotoh, K., Iio, K., Mayura, I. P. B., & Hagiya, H. (2026) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2026.103103
Functionally declining microbiota in chronic disease: beyond taxonomic loss
Kim, H. S. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2748134
PASTA kinase dimerization in Enterococcus faecalis does not require the extracellular PASTA domains
Djorić, D., Puliyelil, M., Little, J. L., & Kristich, C. J. (2026) · Microbiology spectrum · doi:10.1128/spectrum.02211-26
Yu, X., Liu, S., Gutang, Q., Wang, Y., Yin, X., Li, Y., & Wang, X. (2026) · Water Research · doi:10.1016/j.watres.2026.127177
Hasegawa, M., Koizumi, Y., Das, N. K., Zhang, L., Lyssiotis, C. A., Shah, Y. M., Fukuda, S., Núñez, G., & Inohara, N. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.09.020
BindingDB (2022) · UC San Diego · doi:10.7270/q2fr019p
Metadata
- Authors
- Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., & Pamer, E. G.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2010-12-01
- Volume
- 120
- Issue
- 12
- Pages
- 4332-4341
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2993598
- OpenAlex
- W1979573684
- Cited by
- 943
- References
- 51
- Citations by year
- 2026: 52 · 2025: 48 · 2024: 55 · 2023: 58 · 2022: 94 · 2021: 72 · 2020: 76 · 2019: 90 · 2018: 64 · 2017: 66 · 2016: 56 · 2015: 49 · 2014: 44 · 2013: 51 · 2012: 46
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health (4r37ai039031-21, CA023766)
- National Cancer Institute (P01CA023766, R01CA107096, P30CA008748)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Allergy and Infectious Diseases (R37-AI039031, R01AI080455, K23AI083880, R01AI042135)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- vancomycin-resistant enterococci, antibiotic-induced dysbiosis, gut microbiota, bacterial sepsis, bloodstream infection, allogeneic hematopoietic stem cell transplantation, nosocomial infections, sepsis risk prediction
- MeSH terms
- Animals, Anti-Bacterial Agents, Base Sequence, Cross Infection, DNA, Bacterial, DNA, Ribosomal, Humans, Intestines, Mice, Inbred C57BL, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus, Hematopoietic Stem Cell Transplantation, Vancomycin Resistance, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
