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Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans
Open accessAbstract
Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high risk for bacterial sepsis remains an important clinical challenge. Recent studies have shown that antibiotics can alter microbial diversity in the intestine. Here, we characterized these effects using 16s rDNA pyrosequencing and demonstrated that antibiotic treatment of mice enabled exogenously administered VRE to efficiently and nearly completely displace the normal microbiota of the small and large intestine. In the clinical setting, we found that intestinal domination by VRE preceded bloodstream infection in patients undergoing allogeneic hematopoietic stem cell transplantation. Our results demonstrate that antibiotics perturb the normal commensal microbiota and set the stage for intestinal domination by bacteria associated with hospital-acquired infections. Thus, high-throughput DNA sequencing of the intestinal microbiota could identify patients at high risk of developing bacterial sepsis.
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“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [13]
In the citing paper
“Gram− commensals can be depleted by vancomycin, which is a Gram+-targeting drug [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“VRE colonizes the intestine following antibiotic treatment, prior to spreading to the bloodstream, and thus, represents a major threat for hospitalized patients [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“The taxonomic composition of the gut microbiota changes throughout the gastrointestinal tract, according to nutrient availability, mucus structure, pH and oxygen availability [1–6].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [3]
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Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Flagged first, then by citations
Research works printed but not linked: 2
- Abreu, 2003, J Endotoxin Res., 9, 322, 10.1177/09680519030090050901 · DOI
- Rakoff-Nahoum, 2006, Curr Top Microbiol Immunol., 308, 1
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Items 401–500 of 945
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Kalfopoulou, E., & Hüebner, J. (2020) · Cells · doi:10.3390/cells9112397 · Cited by 37
Hourigan, D., Stefanovic, E., Hill, C., & Ross, R. P. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03243-2 · Cited by 37
A Review of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models
Hansen, A. K., Krych, Ł., Nielsen, D. S., & Hansen, C. H. F. (2015) · ILAR Journal · doi:10.1093/ilar/ilv010 · Cited by 34
Perturbation of the Human Microbiome as a Contributor to Inflammatory Bowel Disease
Missaghi, B., Barkema, H. W., Madsen, K., & Ghosh, S. K. (2014) · Pathogens · doi:10.3390/pathogens3030510 · Cited by 35
Andersen, H. M., Connolly, N., Bangar, H., Staat, M. A., Mortensen, J. E., DeBurger, B., & Haslam, D. B. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.02638-15 · Cited by 34
Shimizu, K., Seiki, I., Goto, Y., & Murata, T. (2021) · Antibiotics · doi:10.3390/antibiotics10020180 · Cited by 35
Ермоленко, Е. И., GROMOVA, L., BORSCHEV, Y., VOEIKOVA, A., Karaseva, A. B., Ермоленко, К. Д., Груздков, А. А., & Suvorov, A. N. (2013) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.32.41 · Cited by 34
Sorini, C., & Falcone, M. (2013) · Europe PMC (PubMed Central) · Cited by 33
Harley, I. T. W., Giles, D. A., Pfluger, P. T., Burgess, S. L., Walters, S., Hembree, J., Raver, C., Rewerts, C. L., Downey, J., Flick, L. M., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.004 · Cited by 35
Ziegler, M. J., Han, J., Landsburg, D. J., Pegues, D. A., Reesey, E., Gilmar, C., Gorman, T., Bink, K., Moore, A., & Kelly, B. J. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz252 · Cited by 33
Pires, J., Kraemer, J. G., Kuenzli, E., Kasraian, S., Tinguely, R., Hatz, C., Endimiani, A., & Hilty, M. (2018) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2018.10.012 · Cited by 33
Jin, M., Chen, J., Zhao, X., Hu, G., Wang, H.-L., Liu, Z., & Chen, W.-H. (2022) · Microbiology spectrum · doi:10.1128/spectrum.01271-22 · Cited by 27
Zhao, L., Zhang, X., Zuo, T., & Yu, J. Q. (2017) · Engineering · doi:10.1016/j.eng.2017.01.012 · Cited by 35
Di Caro, V., Alcamo, A. M., Cummings, J. L., Clark, R. S. B., Novak, E. A., Mollen, K. P., Morowitz, M. J., & Aneja, R. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224838 · Cited by 32
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Galloway-Peña, J., Jenq, R. R., & Shelburne, S. A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3173 · Cited by 32
Self-citationTransferable vancomycin resistance in clade B commensal-type Enterococcus faecium
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Zhang, M., Zhao, J., Deng, J., Duan, Z., Zhu, C., & Fan, D. (2019) · Food & Function · doi:10.1039/c9fo00242a · Cited by 32
Alhajjar, N., Chatterjee, A., Spencer, B. L., Burcham, L. R., Willett, J. L. E., Dunny, G. M., Duerkop, B. A., & Doran, K. S. (2020) · Infection and Immunity · doi:10.1128/iai.00270-20 · Cited by 33
Tan, L., Zhang, C., Liu, F., Chen, P., Wei, X., Li, H., Gao, Y., Xu, Y., & Zheng, X. (2021) · Journal of Environmental Management · doi:10.1016/j.jenvman.2021.113709 · Cited by 35
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Babady, N. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.dmih2-0003-2015 · Cited by 35
Laffin, M., Millan, B., & Madsen, K. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1278105 · Cited by 31
Fujiya, Y., Harada, T., Sugawara, Y., Akeda, Y., Yasuda, M., Masumi, A., Hayashi, J., Tanimura, N., Tsujimoto, Y., Shibata, W., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94213-5 · Cited by 31
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Timsit, J., Ling, L., de Montmollin, É., Bracht, H., Morris, A. C., Bus, L. D., Falcone, M., Harris, P. N. A., Machado, F. R., Paiva, J.-A., et al. (2025) · Intensive Care Medicine · doi:10.1007/s00134-025-08063-0 · Cited by 39
Gontjes, K. J., Gibson, K. E., Lansing, B. J., Mantey, J., Jones, K. M., Cassone, M., Wang, J., Mills, J. P., Mody, L., & Patel, P. K. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.44959 · Cited by 26
Guo, Z., Chen, J., Zeng, Y., Wang, Z., Yao, M. C., Tomlinson, S., Chen, B., Yuan, G., & He, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.785287 · Cited by 29
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Topka, G., Bloch, S., Nejman-Faleńczyk, B., Grabski, M., Jurczak-Kurek, A., Górniak, M., Dydecka, A., Necel, A., Węgrzyn, G., & Węgrzyn, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176345 · Cited by 30
Gonçalves-Pereira, J., Fernandes, J., Duarte, A. R., & Fernandes, S. M. (2022) · Antibiotics · doi:10.3390/antibiotics11121839 · Cited by 30
Banla, I. L., Kommineni, S., Hayward, M., Rodrigues, M., Palmer, K. L., Salzman, N. H., & Kristich, C. J. (2017) · Infection and Immunity · doi:10.1128/iai.00381-17 · Cited by 28
Jimeno, R., Brailey, P. M., & Barral, P. (2018) · Journal of Visualized Experiments · doi:10.3791/58481 · Cited by 29
Hall, C. L., Lytle, B. L., Jensen, D. R., Hoff, J. S., Peterson, F. C., Volkman, B. F., & Kristich, C. J. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.019 · Cited by 28
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Haddad, L. E., Hanson, B., Arias, C. A., Ghantoji, S. S., Harb, C. P., Stibich, M., & Chemaly, R. F. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab001 · Cited by 26
Avelar, G. M., Dambuza, I. M., Ricci, L., Yuecel, R., Mackenzie, K. S., Childers, D. S., Bain, J. M., Pradhan, A., Larcombe, D. E., Netea, M. G., et al. (2022) · The Cell Surface · doi:10.1016/j.tcsw.2022.100084 · Cited by 25
Waldetoft, K. W., Sundius, S. A., Kuske, R., & Brown, S. P. (2022) · mBio · doi:10.1128/mbio.01349-22 · Cited by 27
de Resende, M. C. C., Caierão, J., Prates, J. G., Narvaez, G. A., Dias, C. A. G., & d’Azevedo, P. A. (2014) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.4126 · Cited by 28
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Zhou, B., Dong, C., Zhao, B., Lin, K., Tian, Y., Zhang, R., Zhu, L., Xu, H., & Yang, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1015130 · Cited by 28
McMahon, S., Sahasrabhojane, P. V., Kim, J., Franklin, S., Chang, C., Jenq, R. R., Hillhouse, A., Shelburne, S. A., & Galloway-Peña, J. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00415-23 · Cited by 29
Self-citationBacterial community structure in intertidal sediments of Fildes Peninsula, maritime Antarctica
Wang, L., Liu, X., Yu, S., Shi, X., Wang, X., & Zhang, X. (2016) · Polar Biology · doi:10.1007/s00300-016-1958-2 · Cited by 27
Scher, J. U., Sczesnak, A., Longman, R., Segata, N., Úbeda, C., Bielski, C. M., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202.028 · Cited by 27
Self-citationThe unforeseen intracellular lifestyle of Enterococcus faecalis in hepatocytes
Nunez, N., Derré‐Bobillot, A., Trainel, N., Lakisic, G., Lecomte, A., Mercier‐Nomé, F., Cassard, A., Bierne, H., Serror, P., & Archambaud, C. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2058851 · Cited by 26
Song, Q., Wang, X., Wu, X., Kang, T. H., Qin, H., Zhao, D., Jenq, R. R., van den Brink, M. R. M., Riggs, A. D., Martin, P. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21133-3 · Cited by 26
Self-citationHorton, L. E., Haste, N. M., & Taplitz, R. A. (2018) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-018-0435-0 · Cited by 26
Adaptation of Candida albicans During Gastrointestinal Tract Colonization
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Li, N., Yu, H., Liu, H., Wang, Y., Zhou, J., Ma, X., Wang, Z., Sun, C., & Qiao, S. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0341-x · Cited by 27
Hornuß, D., Göpel, S., Walker, S. V., Tobys, D., Häcker, G. A., Seifert, H., Higgins, P. G., Xanthopoulou, K., Gladstone, B. P., Cattaneo, C., et al. (2024) · Infection · doi:10.1007/s15010-024-02249-2 · Cited by 27
Antibiotics and the post-genome revolution
Amini, S., & Tavazoie, S. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.07.017 · Cited by 25
Intestinal microbiome changes and stem cell transplantation: Lessons learned
Taur, Y. (2016) · Virulence · doi:10.1080/21505594.2016.1250982 · Cited by 25
Self-citationGut microbiota: a new player in regulating immune- and chemo-therapy efficacy
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Rashidi, A., Ebadi, M., Rehman, T. U., Elhusseini, H., Kazadi, D., Halaweish, H., Khan, M. H., Hoeschen, A. L., Cao, Q., Luo, X., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2327442 · Cited by 24
Frickmann, H., Wiemer, D. F., Frey, C., Hagen, R. M., Hinz, R., Podbielski, A., Köller, T., & Warnke, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162129 · Cited by 24
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Rashidi, A., & Weisdorf, D. J. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.011 · Cited by 24
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Su, F., Luo, Y., Yu, J., Shi, J., Zhao, Y., Yan, M., Huang, H., & Tan, Y. (2021) · European journal of medical research · doi:10.1186/s40001-021-00508-8 · Cited by 24
Ho, K. J., Xiong, L., Hubert, N., Nadimpalli, A., Wun, K., Chang, E. B., & Kibbe, M. R. (2015) · Physiological Reports · doi:10.14814/phy2.12627 · Cited by 24
Gopalsamy, S. N., Woodworth, M. H., Wang, T. L., Carpentieri, C., Mehta, N., Friedman‐Moraco, R., Mehta, A. K., Larsen, C. P., & Kraft, C. S. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.08.015 · Cited by 26
Bastard, Q. L., Chapelet, G., Birgand, G., Hillmann, B., Javaudin, F., Hayatgheib, N., Bourigault, C., Bémer, P., de Decker, L., Batard, É., et al. (2020) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-020-00773-y · Cited by 24
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Tan, R., Hui, D., Li, J., Zhong, X., Xiao-jia, W., Wen, D., Jun-ming, F., & Li, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.583668 · Cited by 23
Lee, J.-J., Yong, D., Suk, K. T., Kim, D. J., Woo, H., Lee, S. S., & Kim, B. S. (2021) · Microorganisms · doi:10.3390/microorganisms9020352 · Cited by 23
Zhu, Y., Liu, Y., Wu, C.-Y., Li, H., Du, H., Yu, H., Huang, C., Chen, Y., Wang, W., Zhu, Q., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002767 · Cited by 23
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Iannetta, A. A., Minton, N. E., Uitenbroek, A. A., Little, J. L., Stanton, C. R., Kristich, C. J., & Hicks, L. M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00635 · Cited by 21
Margolis, E. B., Marón, G. M., Sun, Y., Dallas, R. H., Allison, K., Ferrolino, J. A. A., Ross, H. S., Davis, A., Jia, Q., Turner, P., et al. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad190 · Cited by 24
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Tyne, D. V., & Gilmore, M. S. (2017) · mBio · doi:10.1128/mbio.00066-17 · Cited by 23
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Torres, A., Menéndez, R., & Wunderink, R. G. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00033-6 · Cited by 25
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Schlüter, J., Djuković, A., Taylor, B. P., Yan, J., Duan, C., Hussey, G. A., Liao, C., Sharma, S., Fontana, E., Amoretti, L. A., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.05.027 · Cited by 24
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Nunez, N., Derré‐Bobillot, A., Gaubert, S., Herry, J., Deschamps, J., Yu, W., Baranek, T., Si‐Tahar, M., Briandet, R., Serror, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20206-6 · Cited by 22
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Madani, W. A. M., Ramos, Y., Cubillos‐Ruiz, J. R., & Morales, D. K. (2024) · FEMS Microbes · doi:10.1093/femsmc/xtae027 · Cited by 21
Willett, J. L. E., & Dunny, G. M. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00081-23 · Cited by 22
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Citron, D. M., Tyrrell, K. L., Dale, S. E., Chesnel, L., & Goldstein, E. J. C. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02531-15 · Cited by 22
Messina, J. A., Tan, C. Y., Ren, Y., Hill, L., Bush, A. T., Lew, M., Andermann, T. M., Peled, J. U., Gomes, A. L. C., van den Brink, M. R. M., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab1043 · Cited by 21
Microarray patches for managing infections at a global scale
Anjani, Q. K., Sabri, A. H. B., Hutton, A. R. J., Cárcamo-Martínez, Á., Wardoyo, L. A. H., Mansoor, A. Z., & Donnelly, R. F. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.038 · Cited by 23
Li, S., Xu, K., Cheng, Y., Chen, L., Yi, A., Xiao, Z., Zhao, X., Chen, M., Tian, Y., Wei, M., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1188455 · Cited by 24
Bosnjak, M., Karpe, A. V., Van, T. T. H., Kotsanas, D., Jenkin, G., Costello, S. P., Johanesen, P., Moore, R. J., Beale, D. J., Srikhanta, Y. N., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43671-8 · Cited by 22
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Schreiber, K., Karrison, T. G., Wolf, S. P., Kiyotani, K., Steiner, M., Littmann, E. R., Pamer, E. G., Kammertoens, T., Schreiber, H. W., & Leisegang, M. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0567 · Cited by 21
Self-citationTacconelli, E., Autenrieth, I. B., & Peschel, A. (2017) · Science · doi:10.1126/science.aam6372 · Cited by 20
Cheng, L., Cao, Y., Liu, S., Lv, L., Zhang, J., Bao, J., Wang, G., & Xu, P. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002668 · Cited by 27
Rubin, I. M. C., Pedersen, M. S., Mollerup, S., Kaya, H., Petersen, A. M., Westh, H., & Pinholt, M. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa074 · Cited by 20
Zhang, N., Liu, J., Chen, Z., Chen, N., Gu, F., & He, Q. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.832915 · Cited by 21
Yan, M., He, Y.-H., Ruan, G., Xue, F., Zheng, B., & Lv, Y. (2022) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2022.07.001 · Cited by 21
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Lam, L. N., Wong, J. J., Chong, K. K. L., & Kline, K. A. (2020) · Infection and Immunity · doi:10.1128/iai.00058-20 · Cited by 18
Idriss, O. M. A., AlSudais, H., Alhumaidan, O. S., Altwaijry, H. D., Bakhsh, A., Almuhanna, Y., Alkudmani, Z. S., Al-Qarni, I., Alenazi, D., Aljasham, A. T., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111426 · Cited by 22
Gut microbiota recovery and immune response in ampicillin-treated mice
Castro-Mejía, J. L., Jakesevic, M., Fabricius, N. F., Krych, Ł., Nielsen, D. S., Kot, W., Bendtsen, K. M., Vogensen, F. K., Hansen, C. H. F., & Hansen, A. K. (2018) · Research in Veterinary Science · doi:10.1016/j.rvsc.2018.03.013 · Cited by 19
Pianko, M. J., & Golob, J. L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10033-7 · Cited by 20
Ramos, Y., Sansone, S., Hwang, S., Sandoval, T. A., Zhu, M., Zhang, G., Cubillos‐Ruiz, J. R., & Morales, D. K. (2022) · mBio · doi:10.1128/mbio.02294-22 · Cited by 19
Hong, J. H., & Woo, I. S. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216236 · Cited by 20
Nguyen, J. T., Jessri, M., Costa-da-Silva, A. C., Sharma, R., Mays, J. W., & Treister, N. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910411 · Cited by 22
Bacterial Foodborne Infections after Hematopoietic Cell Transplantation
Boyle, N. M., Podczervinski, S. T., Jordan, K. M., Stednick, Z. J., Butler‐Wu, S. M., McMillen, K. K., & Pergam, S. A. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.06.034 · Cited by 19
Gaca, A. O., & Gilmore, M. S. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1127482 · Cited by 20
Metadata
- Authors
- Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., & Pamer, E. G.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2010-12-01
- Volume
- 120
- Issue
- 12
- Pages
- 4332-4341
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2993598
- OpenAlex
- W1979573684
- Cited by
- 943
- References
- 51
- Citations by year
- 2026: 52 · 2025: 48 · 2024: 55 · 2023: 58 · 2022: 94 · 2021: 72 · 2020: 76 · 2019: 90 · 2018: 64 · 2017: 66 · 2016: 56 · 2015: 49 · 2014: 44 · 2013: 51 · 2012: 46
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health (4r37ai039031-21, CA023766)
- National Cancer Institute (P01CA023766, R01CA107096, P30CA008748)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Allergy and Infectious Diseases (R37-AI039031, R01AI080455, K23AI083880, R01AI042135)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- vancomycin-resistant enterococci, antibiotic-induced dysbiosis, gut microbiota, bacterial sepsis, bloodstream infection, allogeneic hematopoietic stem cell transplantation, nosocomial infections, sepsis risk prediction
- MeSH terms
- Animals, Anti-Bacterial Agents, Base Sequence, Cross Infection, DNA, Bacterial, DNA, Ribosomal, Humans, Intestines, Mice, Inbred C57BL, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus, Hematopoietic Stem Cell Transplantation, Vancomycin Resistance, Mice, Metagenome
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