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Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans
Open accessAbstract
Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high risk for bacterial sepsis remains an important clinical challenge. Recent studies have shown that antibiotics can alter microbial diversity in the intestine. Here, we characterized these effects using 16s rDNA pyrosequencing and demonstrated that antibiotic treatment of mice enabled exogenously administered VRE to efficiently and nearly completely displace the normal microbiota of the small and large intestine. In the clinical setting, we found that intestinal domination by VRE preceded bloodstream infection in patients undergoing allogeneic hematopoietic stem cell transplantation. Our results demonstrate that antibiotics perturb the normal commensal microbiota and set the stage for intestinal domination by bacteria associated with hospital-acquired infections. Thus, high-throughput DNA sequencing of the intestinal microbiota could identify patients at high risk of developing bacterial sepsis.
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“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [13]
In the citing paper
“Gram− commensals can be depleted by vancomycin, which is a Gram+-targeting drug [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“VRE colonizes the intestine following antibiotic treatment, prior to spreading to the bloodstream, and thus, represents a major threat for hospitalized patients [83].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [83]
In the citing paper
“The taxonomic composition of the gut microbiota changes throughout the gastrointestinal tract, according to nutrient availability, mucus structure, pH and oxygen availability [1–6].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [3]
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Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
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Research works printed but not linked: 2
- Abreu, 2003, J Endotoxin Res., 9, 322, 10.1177/09680519030090050901 · DOI
- Rakoff-Nahoum, 2006, Curr Top Microbiol Immunol., 308, 1
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Rigottier‐Gois, L., Madec, C., Navickas, A., Matos, R. C., Akary, E., Mistou, M., & Serror, P. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu402 · Cited by 87
Lee, Y. J., Argüello, E., Jenq, R. R., Littmann, E. R., Kim, G. J., Miller, L., Ling, L., Figueroa, C. J., Robilotti, E. V., Perales, M., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix011 · Cited by 84
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Mamieva, Z. A., Poluektova, E. A., Свистушкин, В. М., Sobolev, V., Shifrin, O. S., Guarner, F., & Ivashkin, V. T. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i12.1204 · Cited by 87
Commensal gut flora and brain autoimmunity: a love or hate affair?
Berer, K., & Krishnamoorthy, G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0949-9 · Cited by 82
Impact of the gut microbiota on rodent models of human disease
Hansen, A. K., Hansen, C. H. F., Krych, Ł., & Nielsen, D. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17727 · Cited by 85
Zou, J., & Shankar, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136947 · Cited by 87
The gut microbiome and thromboembolism
Hasan, R. A., Koh, A. Y., & Zia, A. N. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.03.003 · Cited by 86
Rolling, T., Zhai, B., Gjonbalaj, M., Tosini, N. L., Yasuma-Mitobe, K., Fontana, E., Amoretti, L. A., Wright, R. J., Ponce, D. M., Perales, M., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00989-7 · Cited by 80
Self-citationRashidi, A., Ebadi, M., Rehman, T. U., Elhusseini, H., Kazadi, D., Halaweish, H., Khan, M. H., Hoeschen, A. L., Cao, Q., Luo, X., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.02366 · Cited by 84
Yu, L. C., Shih, Y.-A., Wu, L., Lin, Y., Kuo, W., Peng, W., Lu, K., Wei, S., Turner, J. R., & Ni, Y. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00070.2014 · Cited by 83
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 84
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Belkaid, Y., Bouladoux, N. J., & Hand, T. W. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.003 · Cited by 83
Role of intestinal microbiota in transplantation outcomes
Taur, Y., Jenq, R. R., Úbeda, C., van den Brink, M. R. M., & Pamer, E. G. (2015) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2015.10.013 · Cited by 79
Self-citationSanMiguel, A. J., Meisel, J. S., Horwinski, J., Zheng, Q., & Grice, E. A. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00774-17 · Cited by 86
O’Mahony, S. M., Neufeld, K. M., Waworuntu, R. V., Pusceddu, M. M., Manurung, S., Murphy, K., Strain, C., Laguna, M. C., Peterson, V. L., Stanton, C., et al. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14514 · Cited by 82
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Bongers, G., Pacer, M. E., Geraldino, T. H., Chen, L., He, Z., Hashimoto, D., Furtado, G. C., Ochando, J., Kelley, K. A., Clemente, J. C., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131587 · Cited by 79
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Guan, Z., Jia, J., Zhang, C., Sun, T., Zhang, W., Yuan, W., Leng, H., & Song, C. (2020) · Clinical Science · doi:10.1042/cs20201224 · Cited by 81
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Trifilio, S. M., Pi, J., & Mehta, J. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2012.10.030 · Cited by 78
Hendrickx, A. P. A., Top, J., Bayjanov, J. R., Kemperman, H., Rogers, M. R. C., Paganelli, F. L., Bonten, M. J. M., & Willems, R. J. L. (2015) · mBio · doi:10.1128/mbio.01346-15 · Cited by 78
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Carrasco, P., Pérez‐Cobas, A. E., van de Pol, C., Baixeras, J., Moyá, A., & Latorre, A. (2014) · PubMed · doi:10.2436/20.1501.01.212 · Cited by 77
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Kinnebrew, M. A., Lee, Y. J., Jenq, R. R., Lipuma, L., Littmann, E. R., Gobourne, A., No, D. J., van den Brink, M. R. M., Pamer, E. G., & Taur, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090158 · Cited by 77
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Barnes, A. M. T., Dale, J. L., Chen, Y., Manias, D. A., Greenwood‐Quaintance, K. E., Karau, M. J., Kashyap, P., Patel, R., Wells, C. L., & Dunny, G. M. (2016) · Virulence · doi:10.1080/21505594.2016.1208890 · Cited by 81
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Archambaud, C., Derré‐Bobillot, A., Lapaque, N., Rigottier‐Gois, L., & Serror, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-45441-3 · Cited by 78
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Qiu, W., Liu, T., Liu, X., Chen, H., Luo, S., Chen, Q., Magnuson, J. T., Zheng, C., Xu, E. G., & Schlenk, D. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c08712 · Cited by 75
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Biagi, E., Zama, D., Rampelli, S., Turroni, S., Brigidi, P., Consolandi, C., Severgnini, M., Picotti, E., Gasperini, P., Merli, P., et al. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0494-7 · Cited by 75
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Livanos, A. E., Snider, E. J., Whittier, S., Chong, D. H., Wang, T. C., Abrams, J. A., & Freedberg, D. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200322 · Cited by 71
Liu, L., Liu, Z., Li, H., Cao, Z., Li, W., Song, Z., Li, X., Lu, A., Lu, C., & Liu, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00012 · Cited by 68
Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome
Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y. H., Henden, A. S., et al. (2017) · Blood · doi:10.1182/blood-2016-08-732628 · Cited by 69
McKenney, P. T., Yan, J., Vaubourgeix, J., Becattini, S., Lampen, N., Motzer, A., Larson, P. J., Dannaoui, D., Fujisawa, S., Xavier, J. B., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.008 · Cited by 73
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Canfield, G. S., Chatterjee, A., Espinosa, J., Mangalea, M. R., Sheriff, E. K., Keidan, M., McBride, S. W., McCollister, B. D., Hang, H. C., & Duerkop, B. A. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00143-21 · Cited by 65
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Bucci, V., Bradde, S., Biroli, G., & Xavier, J. B. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002497 · Cited by 63
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You, J. S., Yong, J. H., Kim, G. H., Moon, S., Nam, K. T., Ryu, J. H., Yoon, M. Y., & Yoon, S. S. (2019) · Microbiome · doi:10.1186/s40168-019-0746-y · Cited by 69
Chatterjee, A., Willett, J. L. E., Dunny, G. M., & Duerkop, B. A. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009204 · Cited by 68
Odenwald, M. A., Lin, H., Lehmann, C. J., Dylla, N. P., Cole, C. G., Mostad, J. D., Pappas, T. E., Ramaswamy, R., Moran, A., Hutchison, A. L., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01493-w · Cited by 69
Self-citationTemporal trends in prevalence of bacteria isolated from foals with sepsis: 1979–2010
Theelen, M. J. P., Wilson, W. D., Edman, J. M., Magdesian, K. G., & Kass, P. H. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12131 · Cited by 66
Sex Differences in Pulmonary Responses to Ozone in Mice. Role of the Microbiome
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Wang, Y., Leong, L. E. X., Keating, R. L., Kanno, T., Abell, G. C. J., Mobegi, F. M., Choo, J. M., Wesselingh, S. L., Mason, A. J., Burr, L. D., et al. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1534512 · Cited by 65
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Zaza, G., Gassa, A. D., Felis, G. E., Granata, S., Torriani, S., & Lupo, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178228 · Cited by 63
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Zhang, X., de Maat, V., Prieto, A. M. G., Prajsnar, T. K., Bayjanov, J. R., de Been, M., Rogers, M. R. C., Bonten, M. J. M., Mesnage, S., Willems, R. J. L., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-4299-9 · Cited by 59
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Hullahalli, K., Rodrigues, M., & Palmer, K. L. (2017) · eLife · doi:10.7554/elife.26664 · Cited by 60
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Lin, Y.-T., Liu, C., Yeh, Y., Chen, T., & Fung, C.-P. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit157 · Cited by 59
Werner, G., Klare, I., Fleige, C., Geringer, U., Witte, W., Just, H.-M., & Ziegler, R. (2012) · Antimicrobial Resistance and Infection Control · doi:10.1186/2047-2994-1-21 · Cited by 59
Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system
Guo, Y., Yang, X., Qi, Y., Shu, W., Liu, Y., Tang, S., Huang, R., & Tang, L. (2017) · Scientific Reports · doi:10.1038/srep43035 · Cited by 61
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Bellone, M., Brevi, A., & Huber, S. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-19 · Cited by 60
Fu, Y., Moscoso, D. I., Porter, J., Krishnareddy, S., Abrams, J. A., Seres, D. S., Chong, D. H., & Freedberg, D. E. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1682 · Cited by 59
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Wang, X., Wang, S., & Zhao, H. L. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-03781-y · Cited by 56
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Brown, J. A., Sanidad, K. Z., Lucotti, S., Lieber, C. M., Cox, R. M., Ananthanarayanan, A., Basu, S., Chen, J. B., Shan, M., Amir, M., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2105609 · Cited by 56
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Melo-Marques, I., Cardoso, S. M., & Empadinhas, N. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2396494 · Cited by 61
Djorić, D., & Kristich, C. J. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03984-14 · Cited by 56
Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia
Rashidi, A., Kaiser, T., Shields‐Cutler, R. R., Graiziger, C. T., Holtan, S. G., Rehman, T. U., Wasko, J. A., Weisdorf, D. J., Dunny, G. M., Khoruts, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42652-6 · Cited by 56
Ochi, T., Feng, Y., Kitamoto, S., Nagao‐Kitamoto, H., Kuffa, P., Atarashi, K., Honda, K., Teitelbaum, D. H., & Kamada, N. (2016) · Scientific Reports · doi:10.1038/srep27634 · Cited by 55
Exploring the microbiome in health and disease
Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 56
Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE)
AbdelKhalek, A., Abutaleb, N. S., Mohammad, H. T., & Seleem, M. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199710 · Cited by 55
Fiore, E., Tyne, D. V., & Gilmore, M. S. (2019) · ASM Press eBooks · doi:10.1128/9781683670131.ch24 · Cited by 60
Multidrug-resistant high-risk Enterococcus faecium clones: can we really define them?
Freitas, A. R., Pereira, A. P. D., Novais, C., & Peixe, L. M. S. V. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106227 · Cited by 56
Vehreschild, M. J. G. T., Weitershagen, D., Biehl, L. M., Tacke, D., Waldschmidt, D., Töx, U., Wisplinghoff, H., von Bergwelt‐Baildon, M., Cornely, O. A., & Vehreschild, J. J. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.02.022 · Cited by 54
Isaac, S., Flor‐Duro, A., Carruana, G., Puchades‐Carrasco, L., Quirant, A., López‐Nogueroles, M., Pineda‐Lucena, A., Garcia‐Garcerà, M., & Úbeda, C. (2022) · Nature Communications · doi:10.1038/s41467-022-35380-5 · Cited by 54
The Gut Microbiome in Sepsis: From Dysbiosis to Personalized Therapy
Piccioni, A., Spagnuolo, F., Candelli, M., Voza, A., Covino, M., Gasbarrini, A., & Franceschi, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13206082 · Cited by 59
Strzępa, A., Majewska‐Szczepanik, M., Lobo, F. M., Li, W., & Szczepanik, M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.052 · Cited by 55
Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria
Rangan, K. J., & Hang, H. C. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.08.005 · Cited by 55
Eshraghi, R. S., Deth, R. C., Mittal, R., Aranke, M., Kay, S.-I. S., Moshiree, B., & Eshraghi, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00256 · Cited by 58
Dubin, K. A., Mathur, D., McKenney, P. T., Taylor, B. P., Littmann, E. R., Peled, J. U., van den Brink, M. R. M., Taur, Y., Pamer, E. G., & Xavier, J. B. (2019) · Infection and Immunity · doi:10.1128/iai.00102-19 · Cited by 53
Self-citationMicrobiota Contribute to Obesity-Related Increases in the Pulmonary Response to Ozone
Tashiro, H., Cho, Y., Kasahara, D. I., Brand, J. D., Bry, L., Yeliseyev, V., Abu-Ali, G., Huttenhower, C., & Shore, S. A. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0144oc · Cited by 54
Rubio-García, E., Vergara, A., Aziz, F., Narváez, S., Cuesta, G., Hernández, M., Toapanta, D., Marco, F., Fernández, J., Soriano, À., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.01.004 · Cited by 52
Mu, S., Xiang, H., Wang, Y., Wei, W., Long, X., Han, Y., Kuang, Z., Yang, Y., Xu, F., Xue, M., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03943-z · Cited by 57
Pathogenesis and therapeutic opportunities of gut microbiome dysbiosis in critical illness
Cho, N. A., Strayer, K., Dobson, B., & McDonald, B. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2351478 · Cited by 60
Sadowska‐Klasa, A., Piekarska, A., Prejzner, W., Bieniaszewska, M., & Hellmann, A. R. (2017) · Annals of Hematology · doi:10.1007/s00277-017-3205-5 · Cited by 52
Lellek, H., Franke, G. C., Ruckert, C., Wolters, M., Wolschke, C., Christner, M., Büttner, H., Alawi, M., Kröger, N., & Rohde, H. (2015) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2015.09.005 · Cited by 51
Kelly, M. S., Ward, D. V., Severyn, C. J., Arshad, M., Heston, S. M., Jenkins, K. E. H., Martin, P., McGill, L., Stokhuyzen, A., Bhattarai, S. K., et al. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.07.019 · Cited by 51
In Vivo Antibacterial Activity of Acetazolamide
Abutaleb, N. S., Elkashif, A., Flaherty, D. P., & Seleem, M. N. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01715-20 · Cited by 51
Trubiano, J. A., Worth, L. J., Thursky, K., & Slavin, M. A. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12310 · Cited by 50
Microbial regulation of allergic responses to food
Feehley, T., Stefka, A. T., Cao, S. Z., & Nagler‐Anderson, C. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0337-5 · Cited by 50
Metadata
- Authors
- Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., & Pamer, E. G.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2010-12-01
- Volume
- 120
- Issue
- 12
- Pages
- 4332-4341
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2993598
- OpenAlex
- W1979573684
- Cited by
- 943
- References
- 51
- Citations by year
- 2026: 52 · 2025: 48 · 2024: 55 · 2023: 58 · 2022: 94 · 2021: 72 · 2020: 76 · 2019: 90 · 2018: 64 · 2017: 66 · 2016: 56 · 2015: 49 · 2014: 44 · 2013: 51 · 2012: 46
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health (4r37ai039031-21, CA023766)
- National Cancer Institute (P01CA023766, R01CA107096, P30CA008748)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Allergy and Infectious Diseases (R37-AI039031, R01AI080455, K23AI083880, R01AI042135)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- vancomycin-resistant enterococci, antibiotic-induced dysbiosis, gut microbiota, bacterial sepsis, bloodstream infection, allogeneic hematopoietic stem cell transplantation, nosocomial infections, sepsis risk prediction
- MeSH terms
- Animals, Anti-Bacterial Agents, Base Sequence, Cross Infection, DNA, Bacterial, DNA, Ribosomal, Humans, Intestines, Mice, Inbred C57BL, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus, Hematopoietic Stem Cell Transplantation, Vancomycin Resistance, Mice, Metagenome
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