Cited by 945Gut microbiota and healthAntibiotic Resistance in BacteriaClostridium difficile and Clostridium perfringens research

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Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

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Ubeda, Carles, Taur, Ying, Jenq, Robert R., Equinda, Michele J., Son, Tammy, Samstein, Miriam, Viale, Agnes, Socci, Nicholas D., van den Brink, Marcel R.M., Kamboj, Mini, Pamer, Eric G.·2010·Journal of Clinical Investigation

DOI 10.1172/jci43918PMC PMC2993598

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Abstract

Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high risk for bacterial sepsis remains an important clinical challenge. Recent studies have shown that antibiotics can alter microbial diversity in the intestine. Here, we characterized these effects using 16s rDNA pyrosequencing and demonstrated that antibiotic treatment of mice enabled exogenously administered VRE to efficiently and nearly completely displace the normal microbiota of the small and large intestine. In the clinical setting, we found that intestinal domination by VRE preceded bloodstream infection in patients undergoing allogeneic hematopoietic stem cell transplantation. Our results demonstrate that antibiotics perturb the normal commensal microbiota and set the stage for intestinal domination by bacteria associated with hospital-acquired infections. Thus, high-throughput DNA sequencing of the intestinal microbiota could identify patients at high risk of developing bacterial sepsis.

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Self-citation

Authors: Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., & Pamer, E. G.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Taur, Ying
Jenq, Robert R.
Son, Tammy
Viale, Agnes
Socci, Nicholas D.
Kamboj, Mini
Pamer, Eric G.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2010-12-01
Volume: 120
Issue: 12
Pages: 4332-4341
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci43918
PMC: PMC2993598
OpenAlex: W1979573684
Cited by: 943
References: 51
Citations by year: 2026: 52 · 2025: 48 · 2024: 55 · 2023: 58 · 2022: 94 · 2021: 72 · 2020: 76 · 2019: 90 · 2018: 64 · 2017: 66 · 2016: 56 · 2015: 49 · 2014: 44 · 2013: 51 · 2012: 46
FWCI: 15.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research Institute
National Institutes of Health (4r37ai039031-21, CA023766)
National Cancer Institute (P01CA023766, R01CA107096, P30CA008748)
National Institute of General Medical Sciences (T32GM007739)
National Institute of Allergy and Infectious Diseases (R37-AI039031, R01AI080455, K23AI083880, R01AI042135)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: vancomycin-resistant enterococci, antibiotic-induced dysbiosis, gut microbiota, bacterial sepsis, bloodstream infection, allogeneic hematopoietic stem cell transplantation, nosocomial infections, sepsis risk prediction
MeSH terms: Animals, Anti-Bacterial Agents, Base Sequence, Cross Infection, DNA, Bacterial, DNA, Ribosomal, Humans, Intestines, Mice, Inbred C57BL, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus, Hematopoietic Stem Cell Transplantation, Vancomycin Resistance, Mice, Metagenome

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Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

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