Cited by 69Ocular Oncology and TreatmentsCancer-related Molecular PathwaysRetinal Development and Disorders

Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma

Open access
Sachdeva, Uma M., O’Brien, Joan M.·2012·Journal of Clinical Investigation

Abstract

Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, the challenge facing molecular biologists and clinical oncologists is how to integrate this vast body of molecular knowledge into the development of targeted therapies for treatment of retinoblastoma. We propose that a more thorough genetic understanding of retinoblastoma would inform targeted treatment decisions and could improve outcomes and quality of life in children affected by this disease.

Integrity signals

Registry

Crossref · 10.1172/jci57114

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 129 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Sachdeva, U. M., & O’Brien, J. M.
Affiliations
University of Pennsylvania (US)
Corresponding author
O’Brien, Joan M.
Venue
Journal of Clinical Investigation
Published
2012-02-01
Volume
122
Issue
2
Pages
425-434
ISSN
0021-9738 (ISSN-L)
OpenAlex
W1978465109
Cited by
67
References
129
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 7 · 2012: 2
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wayne and Gladys Valley Foundation
  • That Man May See
  • National Institutes of Health (00001, EY02162)
  • U.S. Public Health Service (HHSN260220700001C)
  • National Eye Institute (R01EY013812, EY02162, P30EY002162, EY13812)
Topics
  • Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords
retinoblastoma, retinoblastoma protein, retinoblastoma gene, RB1, tumor suppressor, targeted therapy, biallelic inactivation, cell cycle regulation, DNA replication, terminal differentiation
MeSH terms
Animals, Cell Cycle, Disease Models, Animal, Humans, Mutation, Retinoblastoma, Genetic Therapy, Retinoblastoma Protein, Genes, Retinoblastoma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review