Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma
Open accessAbstract
Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, the challenge facing molecular biologists and clinical oncologists is how to integrate this vast body of molecular knowledge into the development of targeted therapies for treatment of retinoblastoma. We propose that a more thorough genetic understanding of retinoblastoma would inform targeted treatment decisions and could improve outcomes and quality of life in children affected by this disease.
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Rb phosphorylation on Ser780 by cyclin-dependent kinases inactivates Rb, leading to release of E2F transcription factors and promoting E2F-mediated transcription of genes necessary for cell cycle progression.
“Rb phosphorylation on Ser780 by cyclin-dependent kinases (CDKs) inactivates Rb, leading to the release of E2F transcription factors, and promotes E2F-mediated transcription of genes necessary for cell cycle progression [35].”
From Inhibition of fatty acid synthase enhances therapeutic efficacy and delays acquired resistance to BRAF-targeted therapy in colorectal cancer (2026) · cites this paper as [35]
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Data from The Retinoblastoma Tumor Suppressor Modulates DNA Repair and Radioresponsiveness
Thangavel, C., Boopathi, E., Ciment, S., Liu, Y., Neill, R. O., Sharma, A. D., McMahon, S. B., Mellert, H. S., Addya, S., Ertel, A., et al. (2023) · doi:10.1158/1078-0432.c.6524742.v1
Pomalidomide enhanced gemcitabine and nab-paclitaxel on pancreatic cancer both in vitro and in vivo
斉藤, 庸. (n.d.) · Institutional Repositories DataBase (IRDB)
- Authors
- Sachdeva, U. M., & O’Brien, J. M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- O’Brien, Joan M.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-02-01
- Volume
- 122
- Issue
- 2
- Pages
- 425-434
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3266776
- OpenAlex
- W1978465109
- Cited by
- 67
- References
- 129
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 7 · 2012: 2
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wayne and Gladys Valley Foundation
- That Man May See
- National Institutes of Health (00001, EY02162)
- U.S. Public Health Service (HHSN260220700001C)
- National Eye Institute (R01EY013812, EY02162, P30EY002162, EY13812)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinoblastoma, retinoblastoma protein, retinoblastoma gene, RB1, tumor suppressor, targeted therapy, biallelic inactivation, cell cycle regulation, DNA replication, terminal differentiation
- MeSH terms
- Animals, Cell Cycle, Disease Models, Animal, Humans, Mutation, Retinoblastoma, Genetic Therapy, Retinoblastoma Protein, Genes, Retinoblastoma
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