Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

Beyond Cholesterol

Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237

Book ReviewAmbulatory Pediatric Care

Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,105

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,815

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,648

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626

Novel insights into the molecular mechanisms of the antiatherosclerotic properties of antioxidants: the alternatives to radical scavenging

Noguchi, N. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01114-0 · Cited by 32

Low Density Lipoprotein Receptor-related Protein Is Required for Macrophage-mediated Oxidation of Low Density Lipoprotein by 12/15-Lipoxygenase

Xu, W., Takahashi, Y., Sakashita, T., Iwasaki, T., Hattori, H., & Yoshimoto, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105093200 · Cited by 32

Physiological aspects of low-density lipoprotein oxidation

Thomas, M. J. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200006000-00011 · Cited by 32

Design and synthesis of 4-methoxyphenylacetic acid esters as 15-lipoxygenase inhibitors and SAR comparative studies of them

Sadeghian, H., Attaran, N., Jafari, Z., Saberi, M. R., Pordel, M., & Riazi, M. M. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.02.009 · Cited by 31

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

Assadieskandar, A., Amini, M., Salehi, M., Sadeghian, H., Alimardani, M., Sakhteman, A., Nadri, H., & Shafiee, A. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.09.050 · Cited by 31

Secreted phospholipase A2, lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics

Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., & Murakami, M. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4864-z · Cited by 31

Therapeutic implications of small interfering RNA in cardiovascular diseases

Raghunathan, S., & Patel, B. M. (2012) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2012.01051.x · Cited by 30

Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase

Sukhanov, S., Snarski, P., Vaughn, C., Lobelle‐Rich, P., Kim, C., Higashi, Y., Shai, S., & Delafontaine, P. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.024 · Cited by 30

Products of 12/15-Lipoxygenase Upregulate the Angiotensin II Receptor

Xu, Z., Yuan, H., Lanting, L. L., Li, S., Wang, M., Shanmugam, N., Kato, M. V., Adler, S. G., Reddy, M. A., & Natarajan, R. D. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007080939 · Cited by 30

Plasma 12‐ and 15‐Hydroxyeicosanoids are Predictors of Survival in Pulmonary Arterial Hypertension

Al‐Naamani, N., Sagliani, K. D., Dolnikowski, G. G., Warburton, R. R., Toksoz, D., Kayyali, U. S., Hill, N. S., Fanburg, B. L., Roberts, K. E., & Preston, I. R. (2016) · Pulmonary Circulation · doi:10.1086/686311 · Cited by 30

StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E‐deficient Mice

Ning, Y., Xu, L., Ren, S., Pandak, W. M., Chen, S., & Yin, L. (2009) · Lipids · doi:10.1007/s11745-009-3299-1 · Cited by 29

Fatty Acid Transduction of Nitric Oxide Signaling

Cole, M. P., & Freeman, B. Α. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00011-3 · Cited by 29

Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases

Coffey, M. J., Coles, B., & O’Donnell, V. B. (2001) · Free Radical Research · doi:10.1080/10715760100301471 · Cited by 29

Quest for Fire

Schultz, D. W., & Harrison, D. G. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1412 · Cited by 29

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies

Vyletelová, V., Nováková, M., & Pašková, Ľ. (2022) · Pharmaceuticals · doi:10.3390/ph15101278 · Cited by 30

SAR comparative studies on pyrimido[4,5-b][1,4] benzothiazine derivatives as 15-lipoxygenase inhibitors, using ab initio calculations

Bakavoli, M., Sadeghian, H., Tabatabaei, Z., Rezaei, E., Rahimizadeh, M., & Nikpour, M. (2008) · Journal of Molecular Modeling · doi:10.1007/s00894-008-0298-8 · Cited by 28

Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy

Qin, Q., Patil, K., Gronert, K., & Sharma, S. C. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.09.022 · Cited by 31

Amino Acid Differences in the Deduced 5-Lipoxygenase Sequence of CAST Atherosclerosis-Resistance Mice Confer Impaired Activity When Introduced Into the Human Ortholog

Kühn, H., Anton, M., Gerth, C., & Habenicht, A. J. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000074167.01184.48 · Cited by 27

The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs)

Alaaeddine, R. A., Elzahhar, P. A., AlZaim, I., Abou-Kheir, W. G., Belal, A. S. F., & EL‐Yazbi, A. F. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200820173853 · Cited by 26

Arachidonic acid metabolism and inflammatory biomarkers associated with exposure to polycyclic aromatic hydrocarbons

Lin, Y., Lu, X., Qiu, X., Yin, F., Faull, K. F., Tseng, C., Zhang, J. J., Fiehn, O., Zhu, T., Araujo, J. A., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113498 · Cited by 26

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation

Singh, N. K., Kundumani‐Sridharan, V., & Rao, G. N. (2011) · Blood · doi:10.1182/blood-2011-04-347468 · Cited by 26

Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase

Takahashi, Y., Zhu, H., Xu, W., Murakami, T., Iwasaki, T., Hattori, H., & Yoshimoto, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.182 · Cited by 26

Oxidative stress impairs endocytosis of the scavenger receptor class A

Aguilar-Gaytán, R., & Mas‐Oliva, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00796-4 · Cited by 27

Δ9-Tetrahydrocannabinol and Its Major Metabolite Δ9-Tetrahydrocannabinol-11-oic Acid as 15-Lipoxygenase Inhibitors

Takeda, S., Jiang, R., Aramaki, H., Imoto, M., Toda, A., Eyanagi, R., Amamoto, T., Yamamoto, I., & Watanabe, K. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22354 · Cited by 25

Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture

Seo, D. W., Choi, H., Lee, S. P., & Kuver, R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00013.2004 · Cited by 25

A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p

Rich, S. S., Bowden, D. W., Haffner, S. M., Norris, J. M., Saad, M. F., Mitchell, B. D., Rotter, J. I., Langefeld, C. D., Hedrick, C. C., Wagenknecht, L. E., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.290 · Cited by 25

15-Lipoxygenase-1 in the Vasculature

Mochizuki, N., & Kwon, Y. (2008) · Circulation Research · doi:10.1161/circresaha.107.170191 · Cited by 25

The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation

Krönke, G., Uderhardt, S., Katzenbeisser, J., & Schett, G. A. (2009) · Autoimmunity · doi:10.1080/08916930902832488 · Cited by 24

Mouse models of atherosclerosis: explaining critical roles of lipid metabolism and inflammation

Mukhopadhyay, R. (2013) · Journal of Applied Genetics · doi:10.1007/s13353-013-0134-4 · Cited by 24

Monocyte 15-Lipoxygenase Gene Expression Requires ERK1/2 MAPK Activity

Bhattacharjee, A., Mulya, A., Pal, S., Roy, B., Feldman, G. M., & Cathcart, M. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000514 · Cited by 24

Inflammatory mediators involved in the progression of the metabolic syndrome

Ma, K., Jin, X., Liang, X., Zhao, Q. D., & Zhang, X. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2291 · Cited by 24

Antiatherogenic role of high-density lipoproteins: insights from genetically engineered-mice

Escolá‐Gil, J. C. (2006) · Frontiers in bioscience · doi:10.2741/1887 · Cited by 24

Natural products: potential therapeutic agents for atherosclerosis

Cheng, X.-B., Zhao, C., Jin, Z., Hu, J., ZHANG, Z., & ZHANG, C. (2022) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(22)60219-x · Cited by 23

Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase

Yoshida, H., Sasaki, K., Hirowatari, Y., Kurosawa, H., Sato, N., Furutani, N., & Tada, N. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.03.018 · Cited by 23

Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping

Zoia, L., Perazzini, R., Crestini, C., & Argyropoulos, D. S. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.02.046 · Cited by 23

Inhibition of 12‐ and 15‐lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I‐Tiao‐Gung (Glycine tomentella)

Chen, T., Shiao, M., & Pan, B. S. (2005) · Lipids · doi:10.1007/s11745-005-1482-1 · Cited by 23

Production of added-value poultry meat: enrichment with n-3 polyunsaturated fatty acids

Al-Khalaifah, H. S. (2015) · World s Poultry Science Journal · doi:10.1017/s004393391500032x · Cited by 22

Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies

Tsimikas, S., & Shaw, P. X. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10420 · Cited by 22

Can Inflammation-Resolution Provide Clues to Treat Patients According to Their Plaque Phenotype?

Fredman, G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00205 · Cited by 22

Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts

Belkner, J., Stender, H., Holzhütter, H., Holm, C., & Kühn, H. (2000) · Biochemical Journal · doi:10.1042/bj3520125 · Cited by 22

Iron-catalyzed lipid peroxidation in aortic cells in vitro: protective effect of extracellular magnesium

Kostellow, A. B., & Morrill, G. A. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.040 · Cited by 22

Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition

Trebus, F., Heydeck, D., Schimke, I., Gerth, C., & Kühn, H. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0452 · Cited by 22

Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions

Heydeck, D., Upston, J. M., Viita, H., Ylä‐Herttuala, S., & Stocker, R. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31597-2 · Cited by 22

The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

Heydeck, D., Reisch, F., Schäfer, M., Kakularam, K. R., Roigas, S., Stehling, S., Püschel, G. P., & Kühn, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.871585 · Cited by 24

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

Hinz, C., Aldrovandi, M., Uhlson, C. L., Marnett, L. J., Longhurst, H. J., Warner, T. D., Alam, S., Slatter, D. A., Lauder, S. N., Allen‐Redpath, K., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.700609 · Cited by 21

Screening for subclinical atherosclerosis by noninvasive methods in asymptomatic patients with risk factors

Castellon, X., & Богданова (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s40150 · Cited by 22

Quinoline-based imidazole-fused heterocycles as new inhibitors of 15-lipoxygenase

Dianat, S., Moghimi, S., Mahdavi, M. R., Nadri, H., Moradi, A., Firoozpour, L., Emami, S., Mouradzadegun, A., Shafiee, A., & Foroumadi, A. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1206087 · Cited by 21

Synthesis of Site-Specifically Labeled Arachidonic Acids as Mechanistic Probes for Prostaglandin H Synthase

Peng, S., McGinley, C. M., & van der Donk, W. A. (2004) · Organic Letters · doi:10.1021/ol0361711 · Cited by 21

Synthesis and Evaluation of a New Series of 3,5‐bis((5‐bromo‐6‐methyl‐2‐t‐aminopyrimidin‐4‐yl)thio)‐4H‐1,2,4‐triazol‐4‐amines and their Cyclized Products ‘Pyrimidinylthio Pyrimidotriazolothiadiazines’ as 15‐ Lipo‐Oxygenase Inhibitors

Asghari, T., Bakavoli, M., Rahimizadeh, M., Eshghi, H., Saberi, S., Karimian, A., Hadizadeh, F., & Ghandadi, M. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12375 · Cited by 20

Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism

Nikpour, M., Mousavian, M., Davoodnejad, M., Alimardani, M., & Sadeghian, H. (2013) · Medicinal Chemistry Research · doi:10.1007/s00044-013-0506-7 · Cited by 20

Design, synthesis and SAR studies of 4-allyoxyaniline amides as potent 15-lipoxygensae inhibitors

Seyedi, S. M., Jafari, Z., Attaran, N., Sadeghian, H., Saberi, M. R., & Riazi, M. M. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.12.065 · Cited by 20

Modulation of Lipid and Protein Mediators of Inflammation by Cytosolic Phospholipase A2α during Experimental Sepsis

Uozumi, N., Kita, Y., & Shimizu, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3558 · Cited by 20

A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis

Zhao, T., Wang, D., Cheranov, S. Y., Karpurapu, M., Chava, K. R., Kundumani‐Sridharan, V., Johnson, D. A., Penn, J. S., & Rao, G. N. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800388-jlr200 · Cited by 20

Lipoprotein Oxidation Mediated by J774 Murine Macrophages Is Inhibited by Individual Red Wine Polyphenols but Not by Ethanol

Rifici, V. A., Schneider, S. H., & Khachadurian, A. K. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2532 · Cited by 20

A Short Catalytic Enantioselective Synthesis of the Proinflammatory Eicosanoid 12(R)-Hydroxy- 5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid (12(R)-HETE)

Han, X., & Corey, E. J. (2000) · Organic Letters · doi:10.1021/ol0062392 · Cited by 20

Expression of Arachidonate 12-Lipoxygenase in Rat Tissues: A Possible Role in Glucagon Secretion

Kawajiri, H., Zhuang, D., Qiao, N., Yoshimoto, T., Yamamoto, M., Iseki, S., & Hamaguchi, K. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004801011 · Cited by 20

Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease

Lázaro, A. M. P., Blanco‐Colio, L. M., Peláez, J. A. F., & Tuñón, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132835 · Cited by 19

Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1and AT2receptors

Abdel‐Rahman, E. M., Abadir, P. M., & Siragy, H. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90699.2008 · Cited by 19

Aldosterone up‐regulates 12‐ and 15‐lipoxygenase expression and LDL oxidation in human vascular smooth muscle cells

Limor, R., Kaplan, M., Sharon, O., Knoll, E., Naidich, M., Weisinger, G., Keidar, S., & Stern, N. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22352 · Cited by 19

Lipoxygenase Products Regulate Nitric Oxide and Inducible Nitric Oxide Synthase Production in Interleukin-1.BETA. Stimulated Vascular Smooth Muscle Cells.

Hashimoto, T., Kihara, M., Yokoyama, K., Fujita, T., Kobayashi, S., Matsushita, K., Tamura, K., Hirawa, N., Toya, Y., & Umemura, S. (2003) · Hypertension Research · doi:10.1291/hypres.26.177 · Cited by 19

Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice

Olkowicz, M., Karaś, A., Berkowicz, P., Kaczara, P., Jasztal, A., Kuryłowicz, Z., Fedak, F. A., Rosales-Solano, H., Roy, K. S., Kij, A., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107478 · Cited by 18

Traditional Chinese Medication Tongxinluo Attenuates Lipidosis in Ox-LDL-Stimulated Macrophages by Enhancing Beclin-1-Induced Autophagy

Chen, Y., Yu, F., Zhang, Y., Li, M., Di, M., Chen, W., Liu, X., Zhang, Y., & Zhang, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.673366 · Cited by 18

A defect in the activities of Δ6 and Δ5 desaturases and pro-resolution bioactive lipids in the pathobiology of non-alcoholic fatty liver disease

Das, U. N. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i11.176 · Cited by 18

Association of polymorphisms in the ALOX15B gene with coronary artery disease

Wüst, S., Horn, T. L., Marti-Jaun, J., Kühn, H., & Hersberger, M. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.12.013 · Cited by 18

Viral Vector-Mediated 12/15-Lipoxygenase Overexpression in Vascular Smooth Muscle Cells Enhances Inflammatory Gene Expression and Migration

Dwarakanath, R. S., Sahar, S., Lanting, L. L., Wang, N., Stemerman, M. B., Natarajan, R. D., & Reddy, M. A. (2007) · Journal of Vascular Research · doi:10.1159/000109966 · Cited by 18

Cannabidiol-2',6'-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro

Takeda, S., Hirayama, A., Urata, S., Mano, N., Fukagawa, K., Imamura, M., Irii, A., Kitajima, S., Masuyama, T., Nomiyama, M., et al. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1252 · Cited by 18

New mouse models for lipoprotein metabolism and atherosclerosis

de Winther, M. P. J., & Hofker, M. H. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00011 · Cited by 18

Oxidative Stress in Cardiovascular Disease

Aviram, M., & Rosenblat, M. (2003) · Oxidative stress and disease · doi:10.1201/9780203912874.ch25 · Cited by 18

TP or Not TP: Primary Mediators in a Close Runoff?

Praticò, D., Cheng, Y., & FitzGerald, G. A. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.7.1695 · Cited by 18

Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets

Doucet, M. S., Jougleux, J., Poirier, S. J., Cormier, M., Léger, J. L., Surette, M. E., Pichaud, N., Touaibia, M., & Boudreau, L. H. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.113480 · Cited by 17

No association of two functional polymorphisms in human ALOX15 with myocardial infarction

Hersberger, M., Müller‐Nurasyid, M., Marti-Jaun, J., Heid, I. M., Coassin, S., Young, T. F., Waechter, V., Hengstenberg, C., Meisinger, C., Peters, A., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.017 · Cited by 17

Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury

Deliri, H., Meller, N., Kadakkal, A., Malhotra, R., Brewster, J. A., Doran, A. C., Pei, H., Oldham, S. N., Skaflen, M. D., Garmey, J. C., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.212068 · Cited by 17

Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1

Rai, G., Joshi, N., Perry, S., Yasgar, A., Schultz, L., Jung, J. E., Liu, Y., Terasaki, Y., Diaz, G., Kenyon, V. A., et al. (2014) · Europe PMC (PubMed Central) · Cited by 17

The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B–dependent expression of interleukin-8

Cheranov, S. Y., Wang, D., Kundumani‐Sridharan, V., Karpurapu, M., Zhang, Q., Chava, K. R., & Rao, G. N. (2009) · Blood · doi:10.1182/blood-2008-10-183210 · Cited by 17

N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action

Golovanov, A., Zhuravlev, A. V., Cruz, A., Aksenov, V., Шафиуллина, Р. Р., Kakularam, K. R., Lluch, J. M., Kühn, H., González‐Lafont, À., & Ivanov, I. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01563 · Cited by 16

Seeking Novel Targets for Improving In Vivo Macrophage-Specific Reverse Cholesterol Transport: Translating Basic Science into New Therapies for the Prevention and Treatment of Atherosclerosis

Julve, J., Llaverías, G., Blanco‐Vaca, F., & Escolá‐Gil, J. C. (2011) · Current Vascular Pharmacology · doi:10.2174/157016111794519264 · Cited by 16

LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression

Éder, K., Guan, H., Sung, H. Y., Francis, S., Crossman, D. C., & Kiss‐Toth, E. (2008) · Immunology Letters · doi:10.1016/j.imlet.2007.12.011 · Cited by 16

Group IIA secretory phospholipase A2 is a unique 12/15-lipoxygenase-regulated gene in cytokine-stimulated rat fibroblastic 3Y1 cells

Kuwata, H., Yamamoto, S., Takekura, A., Murakami, M., & Kudo, I. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.07.002 · Cited by 16

Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity

Kawakami, Y., Hosokawa, T., Morinaka, T., Irino, S., Hirano, S., Kobayashi, H., Yoshioka, A., Suzuki-Yamamoto, T., Yokoro, M., Kimoto, M., et al. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.10.011 · Cited by 16

Pathophysiology of Lipoprotein Oxidation

Jairam, V., Uchida, K., & Narayanaswami, V. (2012) · InTech eBooks · doi:10.5772/50622 · Cited by 15

New Aspects of Gene-Silencing for the Treatment of Cardiovascular Diseases

Koenig, O., Walker, T., Perle, N., Zech, A., Neumann, B., Schlensak, C., Wendel, H.-P., & Nolte, A. (2013) · Pharmaceuticals · doi:10.3390/ph6070881 · Cited by 15

Lipoxygenase-mediated peroxidation of model plant extractives

Tayeb, A. H., Sadeghifar, H., Hubbe, M. A., & Rojas, O. J. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.04.041 · Cited by 15

Absence of an effect of vitamin E on protein and lipid radical formation during lipoperoxidation of LDL by lipoxygenase

Ganini, D., & Mason, R. P. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.031 · Cited by 15

Heterogeneity of Macrophages in Atherosclerosis

Stremmel, C., Stark, K., & Schulz, C. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1692665 · Cited by 16

Effects of antioxidants against atherosclerosis

Niki, E., & Noguchi, N. (2002) · Springer eBooks · doi:10.1007/978-1-4615-1087-1_3 · Cited by 15

Effects of antioxidants against atherosclerosis

Niki, E., & Noguchi, N. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015911519713 · Cited by 15

Urinary cysteinyl leukotrienes in one-year follow-up of percutaneous transluminal angioplasty for peripheral arterial occlusive disease

Maga, P., Sanak, M., Rewerska, B., Maga, M., Jawień, J., Wachsmann, A., Rewerski, P., Szczeklik, W., & Celejewska‐Wójcik, N. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.04.013 · Cited by 14

Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy

Jang, I., Park, S., Cho, J. W., Yiğitkanlı, K., van Leyen, K., & Roth, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.11.017 · Cited by 14

Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis

Takahashi, Y., Otsuki, A., Mori, Y., Kawakami, Y., & Ito, H. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.03.105 · Cited by 14

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness

McCaskie, P. A., Beilby, J. P., Hung, J., Chapman, C., McQuillan, B., Powell, B. L., Thompson, P. L., & Palmer, L. J. (2008) · Human Genetics · doi:10.1007/s00439-008-0496-6 · Cited by 14

Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo

Lauder, S. N., Tyrrell, V. J., Allen‐Redpath, K., Aldrovandi, M., Gray, D., Collins, P. W., Jones, S. A., Taylor, P. R., & O’Donnell, V. B. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.10308.1 · Cited by 14

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-γ-dependent way

Jostarndt, K., Rubic, T., Kühn, H., Anthosen, M. W., Anděra, L., Gellert, N., Trottman, M., Weber, C., Johansen, B., Hrboticky, N., et al. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.041 · Cited by 14

Lipoxygenases in the Cardiovascular System

Kühn, H. (2004) · Circulation Research · doi:10.1161/01.res.0000134763.72053.50 · Cited by 14

Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties

Zhuravlev, A. V., Gavrilyuk, V., Chen, X., Aksenov, V., Kühn, H., & Ivanov, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212058 · Cited by 13

An integrated approach to simulating the vulnerable atherosclerotic plaque

Mirzaei, N. M., Weintraub, W., & Fok, P. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00174.2020 · Cited by 13

Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases

Gila-Díaz, A., Carrillo, G. H., Singh, P., & Ramiro‐Cortijo, D. (2021) · Antioxidants · doi:10.3390/antiox10060933 · Cited by 13

Concerning the Significance of Paraoxonase-1 and SR-B1 Genes in Atherosclerosis

Rodríguez‐Esparragón, F., Trujillo, Y. H., Macías-Reyes, A., Ortega, E. H., Medina, A., & Pérez, J. C. R. (2006) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60124-2 · Cited by 13

Do Atherosclerosis and Obesity-Associated Susceptibility to Cancer Share Causative Link to oxLDL and LOX-1?

Khaidakov, M., & Mehta, J. L. (2011) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-011-6330-8 · Cited by 13

Absence of 12/15-Lipoxygenase Expression Decreases Lipid Peroxidation and Atherogenesis in Apolipoprotein E–Deficient Mice

Cyrus, T., Praticò, D., Zhao, L., Witztum, J. L., Rader, D. J., Rokach, J., FitzGerald, G. A., & Funk, C. D. (2001) · Circulation · doi:10.1161/01.cir.103.18.2277 · Cited by 231

Critical Role of Macrophage 12/15-Lipoxygenase for Atherosclerosis in Apolipoprotein E–Deficient Mice

Harry, B. L., Funk, C. D., & Ley, K. F. (2014)

12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice

George, J., Afek, A. B., Shaish, A., Levkovitz, H., Bloom, N., Cyrus, T., Zhao, L., Funk, C. D., Sigal, E., & Harats, D. (2001) · Circulation · doi:10.1161/hc3901.095772 · Cited by 195

12/15-Lipoxygenase gene disruption and Vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway

Zhao, L., Praticò, D., Rader, D. J., & Funk, C. D. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.07.003 · Cited by 37

Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

Zhao, L., Cuff, C. A., Moss, E., Wille, U., Cyrus, T., Klein, E. A., Praticò, D., Rader, D. J., Hunter, C. A., Puré, E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205738200 · Cited by 102