The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
Open accessAbstract
Atherosclerosis may be viewed as an inflammatory disease process that includes early oxidative modification of LDLs, leading to foam cell formation. This "oxidation hypothesis" has gained general acceptance in recent years, and evidence for the role of lipoxygenases in initiation of, or participation in, the oxidative process is accumulating. However, the relative contribution of macrophage-expressed lipoxygenases to atherogenesis in vivo remains unknown. Here, we provide in vivo evidence for the role of 12/15-lipoxygenase in atherogenesis and demonstrate diminished plasma IgG autoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mice crossbred with atherosclerosis-prone apo E-deficient mice (apo E-/-/L-12LO-/-). In chow-fed 15-week-old apo E-/-/L-12LO-/- mice, the extent of lesions in whole-aorta en face preparations (198 +/- 60 microm2) was strongly reduced (P < 0.001, n = 12) when compared with 12/15-lipoxygenase-expressing controls (apo E-/-/L-12LO+/+), which showed areas of lipid deposition (15,700 +/- 2,688 microm2) in the lesser curvature of the aortic arch, branch points, and in the abdominal aorta. These results were observed despite cholesterol, triglyceride, and lipoprotein levels that were similar to those in apo E-deficient mice. Evidence for reduced lesion development was observed even at 1 year of age in apo E-/-/L-12LO-/- mice. The combined data indicate a role for 12/15-lipoxygenase in the pathogenesis of atherosclerosis and suggest that inhibition of this enzyme may decrease disease progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several lipoxygenases have been related to inflammation and cardiovascular disease, in particular, 5-lipoxygenase and 12/15-lipoxygenase (203, 597, 636).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [203]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Self-citationPlump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,105
Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877
Self-citationOxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,815
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,648
Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Peters, 1998, Natl Vital Stat Rep, 47, 2
- Parthasarathy, 1986, Atherosclerosis, 6, 505
Cited by
Sorted by citations
Items 401–500 of 528
Papel de los antioxidantes en la prevención de la enfermedad cardiovascular
Páramo, A. J., Orbe, M. A. J., & Rodríguez, J. A. (2001) · Medicina Clínica · doi:10.1016/s0025-7753(01)71926-4 · Cited by 13
Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing
Wang, T., Wang, Y., Zhang, X., Xu, W., Jin, K., Pang, Y., Wu, Y., Luo, J., Xu, R., Jiao, L., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101888 · Cited by 12
Thomas, C. P., Tyrrell, V. J., Burston, J. J., Johnson, S. R. C., Aldrovandi, M., Álvarez-Jarreta, J., Inglis, R., Leonard, A., Fice, L., Costales, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2502640122 · Cited by 13
Genetics of atherosclerosis: The search for genes acting at the level of the vessel wall
Colinayo, V. V., Shi, W., Araujo, J. A., & Lusis, A. J. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0076-2 · Cited by 12
12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis
Chen, J. W., Chen, S., Wu, X. R., Shu, X. Y., Tang, S. Y., Yuan, H., Li, Y. R., Quan, J. W., Feng, S., Zhang, R., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01297-0 · Cited by 11
Cytokine-Dependent Expression Regulation of ALOX15
Kühn, H., Gehring, T., Schroter, A., & Heydeck, D. (2016) · Journal of Cytokine Biology · doi:10.4172/2576-3881.1000106 · Cited by 11
Zhu, P., Jian, W., & Blair, I. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.035 · Cited by 11
Sobre los genes paraoxonasa-1 y SR-B1, y su importancia en la aterosclerosis
Rodríguez‐Esparragón, F., Trujillo, Y. H., Macías-Reyes, A., Ortega, E. H., Medina, A., & Pérez, J. C. R. (2006) · Revista Española de Cardiología · doi:10.1157/13084643 · Cited by 10
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease
Zhao, L., Großer, T., Fries, S., Kadakia, L., Wang, H., Zhao, J. C., & Falotico, R. (2006) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2.4.649 · Cited by 10
Modified Low-Density Lipoproteins and High-Density Lipoproteins
Koller, E., Volf, I., Gurvitz, A., & Koller, F. (2006) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000093225 · Cited by 10
Ferroptosis: A potential target of macrophages in plaque vulnerability
Li, Y., Ma, J., Wang, C.-C., Zhou, J., Sun, Y., Wei, X., & Zhao, Z. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0722 · Cited by 9
Li, Z., He, T., Du, K., Xing, Y., Yan, Y., Chen, Z., Zhang, H., & Shen, Y. (2012) · Europe PMC (PubMed Central) · Cited by 9
BOTPPI, a new Wittig salt for the synthesis of 12-(S)-hydroxy-eicosatetraenoic acid [12-(S)-HETE]
Christiansen, M. A., & Andrus, M. B. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.06.052 · Cited by 9
Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1
Cao, C., Zhao, J., Doughty, E., Migliorini, M. M., Strickland, D. K., Kann, M. G., & Zhang, L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645796 · Cited by 9
Kawakami, Y., Otsuki, A., Mori, Y., Kanzaki, K., Suzuki-Yamamoto, T., Fang, D. Z., Ito, H., & Takahashi, Y. (2019) · Molecules · doi:10.3390/molecules24020304 · Cited by 9
Gonen, A., Choi, S., Miu, P., Agatisa-Boyle, C., Acks, D., Taylor, A. M., McNamara, C. A., Tsimikas, S., Witztum, J. L., & Miller, Y. I. (2018) · Journal of Lipid Research · doi:10.1194/jlr.d090852 · Cited by 9
Self-citationKotla, S., Singh, N. K., Kirchhofer, D., & Rao, G. N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.804344 · Cited by 8
Sadeghian, H., Seyedi, S. M., Attaran, N., Jabbari, A., & Jafari, Z. (2010) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2010.495717 · Cited by 8
Attie, A. (2001) · Circulation Research · doi:10.1161/res.89.2.102 · Cited by 8
Akram, M. A., Khodja, A., Dalibalta, S., & Majdalawieh, A. F. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673348217241119063941 · Cited by 8
Effect of Lipoxygenase Oxidation on Surface Deposition of Unsaturated Fatty Acids
Tayeb, A. H., Hubbe, M. A., Zhang, Y., & Rojas, O. J. (2017) · Langmuir · doi:10.1021/acs.langmuir.7b00908 · Cited by 7
Prostaglandins and Other Lipid Mediators in Reproductive Medicine
Funk, C. D., Song, W., & FitzGerald, G. A. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00006-1 · Cited by 7
Self-citationYan, Y., He, T., Shen, Y., Chen, X., Diao, B., Li, Z., Liu, Q., & Xing, Y.-Q. (2012) · Europe PMC (PubMed Central) · doi:10.3980/j.issn.2222-3959.2012.05.04 · Cited by 7
Tang, L., Ding, T., & Praticò, D. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.038 · Cited by 7
Studies of Lipoxygenases in the Epithelium of Cultured Bovine Cornea Using an Air Interface Model
Liminga, M., & Oliw, E. H. (2000) · Experimental Eye Research · doi:10.1006/exer.2000.0852 · Cited by 7
Elkhatib, M. A. W., Gerges, S. H., Isse, F. A., & El‐Kadi, A. O. S. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0037 · Cited by 6
Mori, Y., Kawakami, Y., Kanzaki, K., Otsuki, A., Kimura, Y., Kanji, H., Tanaka, R., Tsukayama, I., Hojo, N., Suzuki-Yamamoto, T., et al. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa062 · Cited by 6
HPLC method for determination of lipoxygenase positional specific products
Hoffman, P., Rauová, D., Bezáková, L., Obložinský, M., & Mikuš, P. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.05.041 · Cited by 6
Sequence Determinants For The Positional Specificity Of Lipoxygenases
Schwarz, K., Anton, M., & Kühn, H. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0193-0_9 · Cited by 6
Ex-vivo regulation of endotoxin-induced tissue factor in whole blood by eicosanoids
Eilertsen, K., Olsen, J. O., & Østerud, B. (2003) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200301000-00008 · Cited by 6
Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes
Emanuelli, T., Augusti, P. R., & Roehrs, M. (2017) · Wiley eBooks · doi:10.1002/9781119158042.ch16 · Cited by 6
Govatati, S., Pichavaram, P., Mani, A. M., Kumar, R., Sharma, D., Dienel, A., Meena, S., Puchowicz, M. A., Park, E. A., & Rao, G. N. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102163 · Cited by 5
Heydeck, D., Ufer, C., Kakularam, K. R., Rothe, M., Liehr, T., Poulain, P., & Kühn, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054815 · Cited by 5
Oxidative Stress in Vascular Disease
Gorenne, I., & Bennett, M. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_10 · Cited by 5
Tsimikas, S. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29553-4_2 · Cited by 5
Marbach-Breitrück, E., Kutzner, L., Rothe, M., Gurke, R., Schreiber, Y., Reddanna, P., Schebb, N. H., Stehling, S., Wieler, L. H., Heydeck, D., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7751 · Cited by 5
Abuja, P. M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02273-1 · Cited by 5
Antioxidants and atherosclerotic cardiovascular disease: unresolved issues
Tribble, D. L. (2001) · Coronary Artery Disease · doi:10.1097/00019501-200111000-00003 · Cited by 5
Zhao, T., Chen, X., Yu, H., Du, J., Wang, D., Wang, C., Meng, Q., Sun, H., Liu, K., & Wu, J. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220601102629 · Cited by 4
Zhuravlev, A. V., Cruz, A., Aksenov, V., Golovanov, A., Lluch, J. M., Kühn, H., González‐Lafont, À., & Ivanov, I. (2023) · Molecules · doi:10.3390/molecules28145418 · Cited by 4
Role of Poultry Research in Increasing Consumption of PUFA in Humans
Al-Khalaifah, H. S., & Al-Nasser, A. Y. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85099 · Cited by 4
Heydeck, D., Kakularam, K. R., Łabuz, D., Machelska, H., Rohwer, N., Weylandt, K. H., & Kühn, H. (2023) · Inflammation Research · doi:10.1007/s00011-023-01770-8 · Cited by 5
Yu, R. C., & Navab, M. (2007) · Future Cardiology · doi:10.2217/14796678.3.3.309 · Cited by 4
Lipoprotein Oxidation and Modification
Miller, Y. I., & Tsimikas, S. (2009) · Elsevier eBooks · doi:10.1016/b978-141605469-6.50012-3 · Cited by 4
Xu, W., Takahashi, Y., Iwasaki, T., Hattori, H., & Yoshimoto, T. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9194-2_38 · Cited by 4
General Concepts about Oxidative Stress
Landmesser, U., & Drexler, H. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29553-4_1 · Cited by 4
Lipoxygenases at the heart of atherosclerosis susceptibility
Hofker, M. H. (2004) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201231 · Cited by 4
Hsi, L. C., Kamitani, H., Cornicelli, J. A., & Eling, T. E. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0263 · Cited by 4
Cohen, R. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137187.16206.79 · Cited by 4
Reisch, F., Schäfer, M., Łabuz, D., Machelska, H., Stehling, S., Püschel, G. P., Rothe, M., Heydeck, D., & Kühn, H. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00756-0 · Cited by 3
Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis
Costa, D. O., Hughes, S. T. O., Jenkins, R. L., Figueras, A. C., Protty, M. B., Tyrrell, V. J., Hajeyah, A. A., Jones, G. W., Burston, J. J., Morgan, B., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101093 · Cited by 3
Genetics of Atherosclerotic Cardiovascular Disease
Qasim, A., & Reilly, M. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00061-6 · Cited by 4
Matsunaga, T., Hara, A., & Komoda, T. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-382171-3.10011-7 · Cited by 3
Cardiovascular DiseaseMouse Models of Atherosclerosis
MAEDA, N., CGIVENS, R., & LReddick, R. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50070-4 · Cited by 3
Platelets and their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis
Stanley, R. G., Tucker, K. L., Barrett, N. E., & Gibbins, J. M. (2011) · Wiley eBooks · doi:10.1002/9780470940297.ch1 · Cited by 3
Sources of Vascular Oxidative Stress
Heinecke, J. W. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_2 · Cited by 3
Ethnopharmacology, phytochemistry and biological activities of malian medicinal plants
Togola, A. (2008) · NORA - Norwegian Open Research Archives · Cited by 3
Chatterjee, S., Hossain, U., & Sil, P. C. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_19 · Cited by 2
Aoyagi, R., Yamamoto, T. S., Furukawa, Y., & Arita, M. (2021) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c21-00274 · Cited by 2
Lipoprotein-Associated Phospholipase A2 and Other Lipid-Related Biomarkers in Cardiovascular Disease
Arnold, N., & Köenig, W. (2006) · Humana Press eBooks · doi:10.1007/978-1-59745-051-5_30 · Cited by 2
Prostaglandins and Other Lipid Mediators in Reproductive Medicine
Funk, C. D., Song, W., & FitzGerald, G. A. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00006-8 · Cited by 2
Self-citationFirth, C. A. (2006) · UC Research Repository (University of Canterbury) · doi:10.26021/6713 · Cited by 2
Monocytes and Macrophages in Atherosclerosis
Meng, S., Fang, P., Yang, X., & Wang, H. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch12 · Cited by 2
Lipid metabolism: 5-lipoxygenase, 12/15-lipoxygenase, and atherogenesis
Davidson, J., & Rotondo, D. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3280140237 · Cited by 2
Intracellular Activation and Induction of 12-lipoxygenase in Mouse Peritoneal Macrophages
Kawajiri, H., Makino, I., & Yoshimoto, T. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0193-0_25 · Cited by 2
Genetic determinants: is there an "atherosclerosis gene"?
Prager, G. W., & Binder, B. R. (2004) · PubMed · Cited by 2
Reactive Oxygen Species Signals Leading to Vascular Dysfunction and Atherosclerosis
Madamanchi, N. R., Vendrov, A. E., & Runge, M. S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369420-1.00056-1 · Cited by 2
McCall, M. R., & Frei, B. B. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4649-8_5 · Cited by 2
The Lipoxygenase System in the Vasculature and Hypertension
Stern, N., & Tuck, M. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-987-5_19 · Cited by 2
Chen, X., Strätker, S. M., Parvez, S., Vabulas, R. M., Bochert, A., Rothe, M., Holzhütter, H., Aparoy, P., & Kühn, H. (2026) · Communications Biology · doi:10.1038/s42003-026-10233-9 · Cited by 1
Lee, D. H., Kain, V., Wang, D., Rokosh, D. G., Prabhu, S. D., & Halade, G. V. (2023) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2023.100046 · Cited by 1
Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity
Ovezgeldiyev, D., Trefzer, V., Doolan, R., Moyat, M., Coakley, G., Wickramasinghe, L. C., Daunt, C., Volpe, B., Henkel, F. D. R., Serra, A., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20241620 · Cited by 1
Joven, J., Tous, M., & Rull, A. (2006) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(06)73680-4 · Cited by 1
Lipoxygenases and Cardiovascular Diseases
Laguna-Fernández, A., Petri, M. H., Thul, S., & Bäck, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27766-0_6 · Cited by 1
The Role of Noninvasive Imaging for Detection High Risk Patients with Subclinical Atherosclerosis
Hristová, K. (2016) · Archives of Clinical Hypertension · doi:10.17352/ach.000005 · Cited by 1
(2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.2.245 · Cited by 1
Etiopatogeneza miazdzycy: rola procesu zapalnego
Nowicka, G. (2005) · Żywienie Człowieka i Metabolizm · Cited by 1
Hattie, W. H. (1927) · PubMed Central · Cited by 1
Degenerated HDL and Its Clinical Implications
Honda, H., Matsunaga, T., & Komoda, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00003-3 · Cited by 1
Opportunities for the treatment of inflammation in cardiovascular disease
Crossman, D. C. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.11.1751 · Cited by 1
Discovery of a novel lipoxygenase pathway in skin.
Zhang, Y. (2005) · Europe PMC (PubMed Central) · Cited by 1
The Immune System in the Pathogenesis of Vascular Proliferative Disease
Laman, J. D., & Ludewig, B. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-001-0_6 · Cited by 1
Atherosclerosis: cell biology and lipoproteins
Abuja, P. M. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00017 · Cited by 1
Implication de LRP1 dans l’athérosclérose et la calcification vasculaire
Woldt, E. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Genes That Modify Susceptibility to Atherosclerosis: Targets for Drug Action
Knowles, J. W. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06214-2_4
Macrophage Lipid Uptake and Foam Cell Formation
de Villiers, W. J. S., & van der Westhuyzen, D. R. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_9
Lipoprotein metabolism and molecular pathogenesis of atherosclerosis
Sakai, N., Nishida, M., Matsuzawa, Y., & Yamashita, S. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)11026-1
Antioxidants and Chronic Vascular Disease: Animal Studies
Cyprus, T., & Praticò, D. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-29553-4_9
Zöller, M. (2008) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.8045
Alternative Nf-kb Signaling in Atherogenesis
Dühring, S. (2014) · Qucosa (Saxon State and University Library Dresden)
The Vascular Biology of Atherosclerosis
Jones, H. P., & Carter, R. (2005) · CRC Press eBooks · doi:10.1201/9781420038422.ch5
Yoshimoto, T., Takahashi, Y., Xu, W., Kinoshita, T., Sakashita, T., & Mabuchi, H. (2002) · International Congress Series · doi:10.1016/s0531-5131(02)00271-6
Vila, N. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Molecular Biology Applications in Cardiovascular Medicine
Yang, E., Wasserman, S. M., Ishida, T., Tabibiazar, R., & Quertermous, T. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-878-6_2
Persistent Inflammatory Pathways in Rheumatoid Arthritis Despite Anti-rheumatic Treatment
Gheorghe, K. R. (2010) · Figshare
Zasłona, Z., & Peters-Golden, M. L. (2012) · Critical Care · doi:10.1186/cc11519
The role of FPR2/ALX in the vascular wall
Petri, M. H. (2015) · Figshare
ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE
Rong, S. (2010) · WakeSpace Scholarship (Wake Forest University)
Metadata
- Authors
- Cyrus, T., Witztum, J. L., Rader, D. J., Tangirala, R., Fazio, S., Linton, M. F., & Funk, C. D.
- Affiliations
- University of Pennsylvania (US)
- University of California San Diego (US)
- Vanderbilt University (US)
- Corresponding author
- Funk, Colin D.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-06-01
- Volume
- 103
- Issue
- 11
- Pages
- 1597-1604
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC408369
- OpenAlex
- W2149303684
- Cited by
- 523
- References
- 63
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 4 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 17 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 20
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM 15431)
- National Heart, Lung, and Blood Institute (R01HL053558, R01HL059694, HL59694, HL-53558)
- National Institute of General Medical Sciences (GM 15431, P50GM015431, P01GM015431)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- 12/15-lipoxygenase, atherosclerosis, oxidized LDL, IgG autoantibodies, macrophages, foam cell formation, LDL oxidation, aortic lesions, atherogenesis
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Arachidonate 12-Lipoxygenase, Arachidonate 15-Lipoxygenase, Arteriosclerosis, Autoantibodies, Female, Lipoproteins, LDL, Male, Mice, Inbred C57BL, Mice, Knockout, Lipid Metabolism, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review