The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Natural killer T cells in adipose tissue prevent insulin resistance
Open accessAbstract
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell-deficient mice on a low-fat diet, considered a normal diet for mice, displayed a distinctive insulin resistance phenotype without overt adipose tissue inflammation. Insulin resistance was characterized by adipocyte dysfunction, including adipocyte hypertrophy, increased leptin, and decreased adiponectin levels. The lack of liver abnormalities in CD1d-null mice together with the enrichment of CD1d-restricted iNKT cells in both mouse and human adipose tissue indicated a specific role for adipose tissue-resident iNKT cells in the development of insulin resistance. Strikingly, iNKT cell function was directly modulated by adipocytes, which acted as lipid antigen-presenting cells in a CD1d-mediated fashion. Based on these findings, we propose that, especially under low-fat diet conditions, adipose tissue-resident iNKT cells maintain healthy adipose tissue through direct interplay with adipocytes and prevent insulin resistance.
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Cites
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Cited by
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Brennan, P. J., Brigl, M., & Brenner, M. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3369 · Cited by 835
The role of adipose tissue immune cells in obesity and low-grade inflammation
Mraz, M., & Haluzik, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0283 · Cited by 543
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Metadata
- Authors
- Schipper, H. S., Rakhshandehroo, M., van de Graaf, S. F. J., Venken, K., Koppen, A., Stienstra, R., Prop, S., Meerding, J., Hamers, N., Besra, G., Boon, L., Nieuwenhuis, E. E. S., Elewaut, D., Prakken, B., Kersten, S., Boes, M., & Kalkhoven, E.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-09-04
- Volume
- 122
- Issue
- 9
- Pages
- 3343-3354
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2089413808
- Cited by
- 212
- References
- 13
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schipper, H. S., Rakhshandehroo, M., van de Graaf, S. F. J., Venken, K., Koppen, A., Stienstra, R., Prop, S., Meerding, J., Hamers, N., Besra, G., Boon, L., Nieuwenhuis, E. E. S., Elewaut, D., Prakken, B., Kersten, S., Boes, M., & Kalkhoven, E. (2012). Natural killer T cells in adipose tissue prevent insulin resistance. Journal of Clinical Investigation. https://doi.org/10.1172/jci62739
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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