The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
CD4 T follicular helper cell dynamics during SIV infection
Open accessAbstract
CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not well understood. We investigated the phenotype, function, location, and molecular signature of TFH cells in rhesus macaques. Similar to their human counterparts, TFH cells in rhesus macaques represented a heterogeneous population with respect to cytokine function. In a highly differentiated subpopulation of TFH cells, characterized by CD150lo expression, production of Th1 cytokines was compromised while IL-4 production was augmented, and cells exhibited decreased survival, cycling, and trafficking capacity. TFH cells exhibited a distinct gene profile that was markedly altered by SIV infection. TFH cells were infected by SIV; yet, in some animals, these cells actually accumulated during chronic SIV infection. Generalized immune activation and increased IL-6 production helped drive TFH differentiation during SIV infection. Accumulation of TFH cells was associated with increased frequency of activated germinal center B cells and SIV-specific antibodies. Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins.
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Cites
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Bcl6 mediates the development of T follicular helper cells
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Foxp3+ follicular regulatory T cells control the germinal center response
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Self-citationHIV preferentially infects HIV-specific CD4+ T cells
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T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
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Self-citationCD 4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
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Metadata
- Authors
- Petrovas, C., Yamamoto, T., Gerner, M. Y., Boswell, K. L., Wloka, K., Smith, E. C., Ambrozak, D. R., Sandler, N. G., Timmer, K. J., Sun, X., Pan, L., Poholek, A., Rao, S. S., Brenchley, J. M., Alam, S. M., Tomaras, G. D., Roederer, M., Douek, D. C., Seder, R. A., Germain, R. N., Haddad, E. K., & Koup, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-09-04
- Volume
- 122
- Issue
- 9
- Pages
- 3281-3294
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2147365530
- Cited by
- 317
- References
- 63
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Petrovas, C., Yamamoto, T., Gerner, M. Y., Boswell, K. L., Wloka, K., Smith, E. C., Ambrozak, D. R., Sandler, N. G., Timmer, K. J., Sun, X., Pan, L., Poholek, A., Rao, S. S., Brenchley, J. M., Alam, S. M., Tomaras, G. D., Roederer, M., Douek, D. C., Seder, R. A., . . . Koup, R. A. (2012). CD4 T follicular helper cell dynamics during SIV infection. Journal of Clinical Investigation. https://doi.org/10.1172/jci63039
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