The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nanog signaling in cancer promotes stem-like phenotype and immune evasion
Open accessAbstract
Adaptation of tumor cells to the host is a major cause of cancer progression, failure of therapy, and ultimately death. Immune selection drives this adaptation in human cancer by enriching tumor cells with a cancer stem cell-like (CSC-like) phenotype that makes them resistant to CTL-mediated apoptosis; however, the mechanisms that mediate CSC maintenance and proliferation are largely unknown. Here, we report that CTL-mediated immune selection drives the evolution of tumor cells toward a CSC-like phenotype and that the CSC-like phenotype arises through the Akt signaling pathway via transcriptional induction of Tcl1a by Nanog. Furthermore, we found that hyperactivation of the Nanog/Tcl1a/Akt signaling axis was conserved across multiple types of human cancer. Inhibition of Nanog in a murine model of colon cancer rendered tumor cells susceptible to immune-mediated clearance and led to successful, long-term control of the disease. Our findings establish a firm link among immune selection, disease progression, and the development of a stem-like tumor phenotype in human cancer and implicate the Nanog/Tcl1a/Akt pathway as a central molecular target in this process.
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Tumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
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Cited by
Stem Cell-Derived Extracellular Vesicles and Immune-Modulation
Burrello, J., Monticone, S., Gai, C., Gomez, Y., Kholia, S., & Camussi, G. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00083 · Cited by 266
Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172
Huang, H., Shi, H., Liu, J., Min, Y., Wang, Y., Wang, A. Z., Wang, J., & Liu, Y. (2017) · Chemical Communications · doi:10.1039/c6cc08146k · Cited by 34
Arai, H., Millstein, J., Loupakis, F., Stintzing, S., Wang, J., Battaglin, F., Kawanishi, N., Jayachandran, P., Soni, S., Zhang, W., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.03.048 · Cited by 2
Metadata
- Authors
- Noh, K. H., Kim, B. W., Song, K.-H., Cho, H., Lee, Y.-H., Kim, J. H., Chung, J.-Y., Kim, J.-H., Hewitt, S. M., Seong, S.-Y., Mao, C.-P., Wu, T.-C., & Kim, T. W.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-10-24
- Volume
- 122
- Issue
- 11
- Pages
- 4077-4093
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1998799674
- Cited by
- 194
- References
- 4
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Noh, K. H., Kim, B. W., Song, K.-H., Cho, H., Lee, Y.-H., Kim, J. H., Chung, J.-Y., Kim, J.-H., Hewitt, S. M., Seong, S.-Y., Mao, C.-P., Wu, T.-C., & Kim, T. W. (2012). Nanog signaling in cancer promotes stem-like phenotype and immune evasion. Journal of Clinical Investigation. https://doi.org/10.1172/jci64057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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