The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
Open accessAbstract
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 complementary screens to identify FDA-approved drugs and drug-like small molecules with activity against T-ALL. We developed a zebrafish system to screen small molecules for toxic activity toward MYC-overexpressing thymocytes and used a human T-ALL cell line to screen for small molecules that synergize with Notch inhibitors. We identified the antipsychotic drug perphenazine in both screens due to its ability to induce apoptosis in fish, mouse, and human T-ALL cells. Using ligand-affinity chromatography coupled with mass spectrometry, we identified protein phosphatase 2A (PP2A) as a perphenazine target. T-ALL cell lines treated with perphenazine exhibited rapid dephosphorylation of multiple PP2A substrates and subsequent apoptosis. Moreover, shRNA knockdown of specific PP2A subunits attenuated perphenazine activity, indicating that PP2A mediates the drug's antileukemic activity. Finally, human T-ALLs treated with perphenazine exhibited suppressed cell growth and dephosphorylation of PP2A targets in vitro and in vivo. Our findings provide a mechanistic explanation for the recurring identification of phenothiazines as a class of drugs with anticancer effects. Furthermore, these data suggest that pharmacologic PP2A activation in T-ALL and other cancers driven by hyperphosphorylated PP2A substrates has therapeutic potential.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“PPZ exploited in this study is approved for clinical use as an anti-psychotic”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Gutierrez et al., 2014
In the citing paper
“a combination of metformin with perphenazine (PPZ), a US Food and Drug Administration-approved anti-psychotic drug that has been shown to modulate PP2A (Gutierrez et al., 2014), diminished the levels of phosphorylated GSK3 b and total MCL-1 (Figure S5B).”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Gutierrez et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,764
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706
Self-citationWhole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Puente, X. S., Pinyol, M., Quesada, V., Conde, L., Ordóñez, G. R., Villamor, N., Escaramís, G., Jares, P., Beà, S., González, M., et al. (2011) · Nature · doi:10.1038/nature10113 · Cited by 1,529
Serine/threonine phosphatases: mechanism through structure
Shi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.10.006 · Cited by 1,488
Reversible tumorigenesis by MYC in hematopoietic lineages.
Felsher, D., & Bishop, J. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80367-6 · Cited by 917
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Palomero, T., Sulis, M. L., Cortina, M. S., Real, P. J., Barnes, K., Ciofani, M., Caparrós, E., Buteau, J., Brown, K. R., Perkins, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1636 · Cited by 876
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint
Weng, A. P., Millholland, J. M., Yashiro–Ohtani, Y., Arcangeli, M.-L., Lau, A. N., Wai, C., Bianco, C. D., Rodríguez, C. G., Sai, H., Tobias, J. W., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 863
Self-citationPalomero, T., Lim, W. K., Odom, D. T., Sulis, M. L., Real, P. J., Margolin, A. A., Barnes, K., O’Neil, J., Neuberg, D. S., Weng, A. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606108103 · Cited by 821
Self-citationLister, J. A., Robertson, C. P., Lepage, T., Johnson, S. L., & Raible, D. W. (1999) · Development · doi:10.1242/dev.126.17.3757 · Cited by 819
Chen, Z., Gibson, T. B., Robinson, F. L., Silvestro, L., Pearson, G. W., Xu, B.-E., Wright, A., Vanderbilt, C. A., & Cobb, M. H. (2001) · Chemical Reviews · doi:10.1021/cr000241p · Cited by 809
Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1110 · Cited by 791
Drug Synergism: Its Detection and Applications
Tallarida, R. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29450-7 · Cited by 689
CIP2A inhibits PP2A in human malignancies
Junttila, M. R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Ala-aho, R., Nielsen, C., Ivaska, J., Taya, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.044 · Cited by 677
From Promiscuity to Precision: Protein Phosphatases Get a Makeover
Virshup, D. M., & Shenolikar, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.015 · Cited by 643
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Fabbri, G., Rasi, S., Rossi, D., Trifonov, V. A., Khiabanian, H., Ma, J., Grunn, A., Fangazio, M., Capello, D., Monti, S. M., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110921 · Cited by 624
Myc-Induced T Cell Leukemia in Transgenic Zebrafish
Langenau, D. M., Traver, D. J., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E. V., Trede, N. S., Zon, L. I., et al. (2003) · Science · doi:10.1126/science.1080280 · Cited by 541
Self-citationSachlos, E., Risueño, R. M., Laronde, S., Shapovalova, Z., Lee, J., Russell, J., Malig, M., McNicol, J. D., Fiebig‐Comyn, A., Graham, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.049 · Cited by 468
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Real, P. J., Tosello, V., Palomero, T., Castillo-Martín, M., Hernando, E., de Stanchina, E., Sulis, M. L., Barnes, K., Sawai, C. M., Homminga, I., et al. (2008) · Nature Medicine · doi:10.1038/nm.1900 · Cited by 445
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
Gutiérrez, A., Sanda, T., Grebliunaite, R., Carracedo, A., Salmena, L., Ahn, Y., Dahlberg, S. E., Neuberg, D. S., Moreau, L. A., Winter, S. S., et al. (2009) · Blood · doi:10.1182/blood-2009-02-206722 · Cited by 443
Self-citationOncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Zenatti, P. P., Ribeiro, D., Li, W., Zuurbier, L. C., da Silva, M. C., Paganin, M., Tritapoe, J. M., Hixon, J. A., Silveira, A. B., Cardoso, B. A., et al. (2011) · Nature Genetics · doi:10.1038/ng.924 · Cited by 426
Marks, D. I., Paietta, E. M., Moorman, A. V., Richards, S. M., Buck, G. A. N., Dewald, G. W., Ferrando, A. A., Fielding, A. K., Goldstone, A. H., Ketterling, R. P., et al. (2009) · Blood · doi:10.1182/blood-2009-08-231217 · Cited by 420
Goldberg, J. M., Silverman, L. B., Levy, D. E., Dalton, V. K., Gelber, R. D., Lehmann, L., Cohen, H. J., Sallan, S. E., & Asselin, B. L. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.116 · Cited by 346
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
Robinson, D. R., Sundaram, S. K., Wu, Y.-M., Shankar, S., Cao, X., Ateeq, B., Asangani, I. A., Iyer, M. K., Maher, C. A., Grasso, C. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2580 · Cited by 343
Neviani, P., Santhanam, R., Oaks, J. J., Eiring, A. M., Notari, M., Blaser, B. W., Liu, S., Trotta, R., Muthusamy, N., Gambacorti-Passerini, C. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31095 · Cited by 337
Mavrakis, K. J., Wolfe, A. L., Oricchio, E., Palomero, T., Keersmaecker, K. D., McJunkin, K., Zuber, J. A., James, T., Khan, A. A., Leslie, C. S., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2037 · Cited by 335
Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma
Kridel, R., Meissner, B., Rogić, S., Boyle, M., Telenius, A., Woolcock, B. W., Gunawardana, J., Jenkins, C. R., Cochrane, C., Ben‐Neriah, S., et al. (2011) · Blood · doi:10.1182/blood-2011-11-391474 · Cited by 335
Self-citationKau, T. R., Schroeder, F. C., Ramaswamy, S., Wojciechowski, C. L., Zhao, J. J., Roberts, T. M., Clardy, J., Sellers, W. R., & Silver, P. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00303-9 · Cited by 330
Identifying the proteins to which small-molecule probes and drugs bind in cells
Ong, S., Schenone, M., Margolin, A. A., Li, X., Do, K., Doud, M. K., Mani, D. R., Kuai, L., Wang, X., Wood, J. L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900191106 · Cited by 303
Self-citationChemBank: a small-molecule screening and cheminformatics resource database
Seiler, K. P., George, G. A., Happ, M. P., Bodycombe, N. E., Carrinski, H. A., Norton, S., Brudz, S., Sullivan, J. P., Muhlich, J. L., Serrano, M., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm843 · Cited by 283
Self-citationChan, S. M., Weng, A. P., Tibshirani, R. J., Aster, J. C., & Utz, P. J. (2007) · Blood · doi:10.1182/blood-2006-08-039883 · Cited by 282
Self-citationKo, R. H., Ji, L., Barnette, P., Bostrom, B., Hutchinson, R. J., Raetz, E. A., Seibel, N. L., Twist, C. J., Eckroth, E., Sposto, R., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.2950 · Cited by 281
Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc
Sharma, V. M., Calvo, J. A., Draheim, K., Cunningham, L. A., Hermance, N. M., Beverly, L. J., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J., & Kelliher, M. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01091-06 · Cited by 265
Langenau, D. M., Feng, H., Berghmans, S., Kanki, J. P., Kutok, J. L., & Look, A. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408708102 · Cited by 259
Self-citationArnold, H. K., & Sears, R. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2832-2844.2006 · Cited by 251
Wang, H., Zou, J., Zhao, B., Johannsen, E., Ashworth, T. D., Wong, H., Pear, W. S., Schug, J., Blacklow, S. C., Arnett, K. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109023108 · Cited by 236
Self-citationLeukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia
Chiang, M. Y., Xu, L., Shestova, O. E., Histen, G., L’Heureux, S., Romany, C. A., Childs, M. E., Gimotty, P. A., Aster, J. C., & Pear, W. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35090 · Cited by 235
Self-citationDeAngelo, D. J., Stone, R. M., Silverman, L. B., Stock, W., Attar, E. C., Fearen, I., Dallob, A., Matthews, C., Stone, J. B., Freedman, S. J., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.24.18_suppl.6585 · Cited by 228
Self-citationChemical structure of phenothiazines and their biological activity
Jaszczyszyn, A., Gąsiorowski, K., Świątek, P., Malinka, W., Cieślik-Boczula, K., Petrus, J., & Czarnik‐Matusewicz, B. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70726-0 · Cited by 225
The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase
Sablina, A. A., Chen, W., Arroyo, J. D., Corral, L. G., Hector-Greene, M., Bulmer, S. E., DeCaprio, J. A., & Hahn, W. C. (2007) · Cell · doi:10.1016/j.cell.2007.03.047 · Cited by 207
Identification of PP2A Complexes and Pathways Involved in Cell Transformation
Sablina, A. A., Hector, M., Colpaert, N., & Hahn, W. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2855 · Cited by 193
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
Armstrong, F., de la Grange, P. B., Gerby, B., Rouyez, M.-C., Calvo, J., Fontenay, M., Boissel, N., Dombret, H., Baruchel, A., Landman‐Parker, J., et al. (2008) · Blood · doi:10.1182/blood-2008-02-138172 · Cited by 183
Self-citationGonzález-García, S., García-Peydró, M., Martín‐Gayo, E., Ballestar, E., Esteller, M., Bornstein, R., de la Pompa, J. L., Ferrando, A. A., & Toribio, M. L. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081922 · Cited by 169
Medyouf, H., Gusscott, S., Wang, H., Tseng, J., Wai, C., Nemirovsky, O., Trumpp, A., Pflumio, F., Carboni, J. M., Gottardis, M. M., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110121 · Cited by 167
Self-citationChiang, C.-W., Kanies, C. L., Kim, K. W., Fang, W. B., Parkhurst, C., Xie, M., Henry, T. J., & Yang, E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6350-6362.2003 · Cited by 155
Chiang, C.-W., Harris, G., Ellig, C. L., Masters, S. C., Subramanian, R. R., Shenolikar, S., Wadzinski, B. E., & Yang, E. (2001) · Blood · doi:10.1182/blood.v97.5.1289 · Cited by 154
A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells
Matsuoka, Y., Nagahara, Y., Ikekita, M., & Shinomiya, T. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705182 · Cited by 152
Liu, Q., Zhao, X. B., Frissora, F. W., Ma, Y., Santhanam, R., Jarjoura, D. G., Lehman, A., Perrotti, D., Chen, C., Dalton, J. T., et al. (2007) · Blood · doi:10.1182/blood-2006-10-053884 · Cited by 146
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model
Cullion, K., Draheim, K., Hermance, N. M., Tammam, J. G., Sharma, V. M., Ware, C. M., Nikov, G. N., Krishnamoorthy, V., Majumder, P. K., & Kelliher, M. A. (2009) · Blood · doi:10.1182/blood-2008-02-136762 · Cited by 144
Zhelev, Z., Ohba, H., Bakalova, R., Hadjimitova, V. A., Ishikawa, M., Shinohara, Y., & Baba, Y. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0738-1 · Cited by 138
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation
Hahn, K., Miranda, M., Francis, V. A., Vendrell, J., Zorzano, A., & Teleman, A. A. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.015 · Cited by 131
Role of dopamine in the physiology of T-cells and dendritic cells
Pacheco, R., Prado, C. E., Barrientos, M. J., & Bernales, S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.07.018 · Cited by 129
Groen, R. W. J., Noort, W. A., Raymakers, R. A. P., Prins, H., Aalders, L., Hofhuis, F. M., Moerer, P., van Velzen, J. F., Bloem, A. C., van Kessel, B., et al. (2012) · Blood · doi:10.1182/blood-2012-03-414920 · Cited by 129
Self-citationGutiérrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E. M., Mansour, M. R., Dahlberg, S. E., Neuberg, D. S., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101691 · Cited by 107
Self-citationSuppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish
Langenau, D. M., Jette, C. A., Berghmans, S., Palomero, T., Kanki, J. P., Kutok, J. L., & Look, A. T. (2004) · Blood · doi:10.1182/blood-2004-08-3073 · Cited by 107
Self-citationA new genetic lesion in B‐CLL: a NOTCH1 PEST domain mutation
Ianni, M. D., Baldoni, S., Rosati, E., Ciurnelli, R., Cavalli, L., Martelli, M. F., Marconi, P., Screpanti, I., & Falzetti, F. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07816.x · Cited by 104
Ugi, S., Imamura, T., Ricketts, W., & Olefsky, J. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2375-2387.2002 · Cited by 95
Gil‐Ad, I., Shtaif, B., Levkovitz, Y., Dayag, M., Zeldich, E., & Weizman, A. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:22:3:189 · Cited by 95
Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels
Koren, J., Jinwal, U. K., Jin, Y., O’Leary, J. C., Jones, J. R., Johnson, A. G., Blair, L. J., Abisambra, J. F., Chang, L., Miyata, Y., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057208 · Cited by 90
Targeting Nonclassical Oncogenes for Therapy in T-ALL
Subramaniam, P. S., Whye, D., Efimenko, E., Chen, J., Tosello, V., Keersmaecker, K. D., Kashishian, A., Thompson, M. A., Castillo-Martín, M., Cordon‐Cardo, C., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.029 · Cited by 89
Ashworth, T. D., Pear, W. S., Chiang, M. Y., Blacklow, S. C., Mastio, J., Xu, L., Kelliher, M. A., Kastner, P., Chan, S. H., & Aster, J. C. (2010) · Blood · doi:10.1182/blood-2010-05-286328 · Cited by 89
Self-citationRho, S. B., Kim, B.-R., & Kang, S. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.10.003 · Cited by 88
Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response
Sangodkar, J., Dhawan, N. S., Melville, H., Singh, V. J., Yuan, E., Rana, H. Q., Izadmehr, S., Farrington, C. C., Mazhar, S., Katz, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62058 · Cited by 86
Gil‐Ad, I., Shtaif, B., Levkovitz, Y., Nordenberg, J., Taler, M., Korov, I., & Weizman, A. (2006) · Oncology Reports · doi:10.3892/or.15.1.107 · Cited by 79
Blackburn, J. S., Liu, S., Raiser, D. M., Martinez, S. A., Feng, H., Meeker, N. D., Gentry, J., Neuberg, D. S., Look, A. T., Ramaswamy, S., et al. (2012) · Leukemia · doi:10.1038/leu.2012.116 · Cited by 75
Self-citationPalomero, T., & Ferrando, A. A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4864 · Cited by 72
Notch in T-ALL: new players in a complex disease
Koch, U., & Radtke, F. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.005 · Cited by 67
Dail, M., Li, Q., McDaniel, A., Wong, J. W. H., Akagi, K., Huang, B. J., Kang, H. C., Kogan, S. C., Shokat, K. M., Wolff, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001064107 · Cited by 63
Choi, J. H., Yang, Y. R., Lee, S. K., Kim, S., Kim, Y. H., Cha, J., Oh, S., Ha, J.-R., Ryu, S. H., & Suh, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1414.041 · Cited by 61
Liu, Q., Alinari, L., Chen, C., Yan, F., Dalton, J. T., Lapalombella, R., Zhang, X., Mani, R., Lin, T. S., Byrd, J. C., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2484 · Cited by 53
Dopamine receptor blockade and the neuroleptics, a crystallographic study
Horn, A. S., Post, M. L., & Kennard, O. (1975) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1975.tb09506.x · Cited by 44
Zhu, H. G. (1992) · Lung Cancer · doi:10.1016/0169-5002(92)90120-9 · Cited by 29
Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts
Yost, A., Shevchuk, O. O., Gooch, R. L., Gusscott, S., You, M. J., Ince, T. A., Aster, J. C., & Weng, A. P. (2012) · Leukemia · doi:10.1038/leu.2012.337 · Cited by 22
Self-citationSubramanyam, D., & Krishna, S. (2005) · Virology · doi:10.1016/j.virol.2005.11.028 · Cited by 17
Research works printed but not linked: 3
- Zhu, 1991, J Biol Regul Homeost Agents., 5, 52
- 10.1016/j.cell.2012.03.049 · DOI
- Gil-Ad, 2006, Oncol Rep., 15, 107
Cited by
Sorted by citations
Zebrafish as tools for drug discovery
MacRae, C. A., & Peterson, R. T. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4627 · Cited by 1,248
The Varied Roles of Notch in Cancer
Aster, J. C., Pear, W. S., & Blacklow, S. C. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 724
Self-citationResponse and resistance to BET bromodomain inhibitors in triple-negative breast cancer
Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Jin Huh, S., Liang, Y., Ryan, J., et al. (2016) · Nature · doi:10.1038/nature16508 · Cited by 632
Self-citationDopamine receptors – IUPHAR R eview 13
Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 561
Little Fish, Big Data: Zebrafish as a Model for Cardiovascular and Metabolic Disease
Gut, P., Reischauer, S., Stainier, D. Y. R., & Arnaout, R. (2017) · Physiological Reviews · doi:10.1152/physrev.00038.2016 · Cited by 339
Metadata
- Authors
- Gutierrez, A., Pan, L., Groen, R. W. J., Baleydier, F., Kentsis, A., Marineau, J., Grebliunaite, R., Kozakewich, E., Reed, C., Pflumio, F., Poglio, S., Uzan, B., Clemons, P., VerPlank, L., An, F., Burbank, J., Norton, S., Tolliday, N., Steen, H., Weng, A. P., Yuan, H., Bradner, J. E., Mitsiades, C., Look, A. T., & Aster, J. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Université Paris-Sud (FR)
- Broad Institute (US)
- BC Cancer Agency (CA)
- Corresponding author
- Aster, Jon C.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2014-01-09
- Volume
- 124
- Issue
- 2
- Pages
- 644-655
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3904599
- OpenAlex
- W2128575549
- Cited by
- 220
- References
- 73
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 19 · 2021: 14 · 2020: 27 · 2019: 26 · 2018: 22 · 2017: 14 · 2016: 30 · 2015: 16 · 2014: 10
- FWCI
- 23.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission (302428)
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400, R01CA176746, N01-CO-012400, K08CA133103, P01CA109901)
- Topics
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- T-cell acute lymphoblastic leukemia, phenothiazines, perphenazine, protein phosphatase 2A, apoptosis, antipsychotic drugs, drug repurposing, MYC overexpression, NOTCH1 mutation, Notch inhibitors, anticancer drug discovery
- MeSH terms
- Animals, Cell Survival, Chromatography, Affinity, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Perphenazine, Phenothiazines, Phosphorylation, Pigmentation, Mass Spectrometry, Time Factors, Zebrafish, Apoptosis, Dopamine Antagonists, Animals, Genetically Modified, Proteomics, Cell Line, Tumor, Mice, Receptors, Notch, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Protein Phosphatase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
