The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
Open accessAbstract
Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte-mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mechanism of coal tar therapy is unknown. Using organotypic skin models with primary keratinocytes from AD patients and controls, we found that coal tar activated the aryl hydrocarbon receptor (AHR), resulting in induction of epidermal differentiation. AHR knockdown by siRNA completely abrogated this effect. Coal tar restored filaggrin expression in FLG-haploinsufficient keratinocytes to wild-type levels, and counteracted Th2 cytokine-mediated downregulation of skin barrier proteins. In AD patients, coal tar completely restored expression of major skin barrier proteins, including filaggrin. Using organotypic skin models stimulated with Th2 cytokines IL-4 and IL-13, we found coal tar to diminish spongiosis, apoptosis, and CCL26 expression, all AD hallmarks. Coal tar interfered with Th2 cytokine signaling via dephosphorylation of STAT6, most likely due to AHR-regulated activation of the NRF2 antioxidative stress pathway. The therapeutic effect of AHR activation herein described opens a new avenue to reconsider AHR as a pharmacological target and could lead to the development of mechanism-based drugs for AD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, coal tar has been shown to bind to AhR and to restore the expression of filaggrin, as shown by immunohistochemistry and transcriptomic analysis59.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [59]
In the citing paper
“Activation of NRF2 by AHR ligands such as coal tar abolished IL-4/IL-13–mediated inhibition of epidermal barrier proteins such as FLG and LOR (42, 56).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [56]
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., et al. (1996) · Nature · doi:10.1038/380630a0 · Cited by 1,278
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,100
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026
The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
Qiu, J., Heller, J. J., Guo, X., Chen, Z. E., Fish, K., Fu, Y., & Zhou, L. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.011 · Cited by 887
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 373
New therapies for atopic dermatitis: Additional treatment classes
Vakharia, P. P., & Silverberg, J. I. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.12.024 · Cited by 51
Li, W., & Yosipovitch, G. (2020) · American Journal of Clinical Dermatology · doi:10.1007/s40257-020-00538-8 · Cited by 54
The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
Napolitano, M., di Vico, F., Ruggiero, A., Fabbrocini, G., & Patruno, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1165098 · Cited by 52
A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases
Losol, P., Wolska, M., Wypych, T. P., Yao, L., O’Mahony, L., & Sokołowska, M. (2024) · Clinical and Translational Allergy · doi:10.1002/clt2.12339 · Cited by 54
Nakahara, T., Mitoma, C., Hashimoto-Hachiya, A., Takahara, M., Tsuji, G., Uchi, H., Yan, X., Hachisuka, J., Chiba, T., Esaki, H., et al. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3396 · Cited by 49
Hirano, A., Goto, M., Mitsui, T., Hashimoto-Hachiya, A., Tsuji, G., & Furue, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091948 · Cited by 48
Pareek, A., Kumari, L., Pareek, A., Chaudhary, S., Ratan, Y., Janmeda, P., Chuturgoon, S., & Chuturgoon, A. A. (2024) · Cells · doi:10.3390/cells13050425 · Cited by 55
Hwang, J., Newton, E. M., Hsiao, J. L., & Shi, V. Y. (2022) · Experimental Dermatology · doi:10.1111/exd.14541 · Cited by 47
Nygaard, U., van den Bogaard, E. H. J., Niehues, H., Hvid, M., Deleuran, M. S., Johansen, C., & Vestergaard, C. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2552 · Cited by 46
New Topical Therapies in Development for Atopic Dermatitis
Freitas, E., Gooderham, M., & Torres, T. R. (2022) · Drugs · doi:10.1007/s40265-022-01722-2 · Cited by 46
Zhang, Y., Heinemann, N., Rademacher, F., Darvin, M. E., Raab, C., Keck, C. M., Vollert, H., Fluhr, J. W., Gläser, R., Harder, J., et al. (2022) · Antioxidants · doi:10.3390/antiox11061071 · Cited by 46
Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, T., & Furue, M. (2015) · Clinical and Experimental Dermatology · doi:10.1111/ced.12635 · Cited by 45
Majumder, S., Kono, M., Lee, Y. T., Byrnes, C., Li, C., Tuymetova, G., & Proia, R. L. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ac119.011170 · Cited by 45
Furue, M., Hashimoto‐Hachiya, A., & Tsuji, G. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3003 · Cited by 43
AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation
Sutter, T. R., Olesen, K. M., Bhuju, J., Guo, Z., & Sutter, T. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.019 · Cited by 46
Kopalli, S. R., Prakash, A. V., & Koppula, S. (2022) · Molecules · doi:10.3390/molecules27144660 · Cited by 45
Air pollutants contribute to epithelial barrier dysfunction and allergic diseases
Kim, B. E., Hui-Beckman, J. W., Nevid, M. Z., Goleva, E., & Leung, D. Y. M. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.11.014 · Cited by 44
Cytokines as therapeutic targets in skin inflammation
Wittmann, M., McGonagle, D., & Werfel, T. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.008 · Cited by 43
Wu, Z., Uchi, H., Morino‐Koga, S., Nakamura‐Satomura, A., Kita, K., Shi, W., & Furue, M. (2014) · Experimental Dermatology · doi:10.1111/exd.12360 · Cited by 42
Review of the mechanism of action of coal tar in psoriasis
Sekhon, S., Jeon, C., Nakamura, M., Afifi, L., Yan, D., Wu, J. J., Liao, W. J., & Bhutani, T. (2017) · Journal of Dermatological Treatment · doi:10.1080/09546634.2017.1369494 · Cited by 46
Koch, M., Kockmann, T., Rodríguez, E., Wehkamp, U., Hiebert, P., Greenwald, M. B., Stölzl, D., Beer, H., Tschachler, E., Weidinger, S., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.048 · Cited by 45
Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes
Ulzii, D., Kido‐Nakahara, M., Nakahara, T., Tsuji, G., Furue, K., Hashimoto‐Hachiya, A., & Furue, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133324 · Cited by 41
Kim, K., Kim, H., & Sung, G. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113520 · Cited by 40
Tapinarof for psoriasis and atopic dermatitis: 15 years of clinical research
Bissonnette, R., Proulx, É. S., Jack, C. S., & Maari, C. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18925 · Cited by 41
An Update on Topical Therapies for Mild-Moderate Psoriasis
van de Kerkhof, P. C. M. (2014) · Dermatologic Clinics · doi:10.1016/j.det.2014.09.006 · Cited by 40
Implications of IL-13Rα2 in atopic skin inflammation
Furue, M., Ulzii, D., Nakahara, T., Tsuji, G., Furue, K., Hashimoto‐Hachiya, A., & Kido‐Nakahara, M. (2020) · Allergology International · doi:10.1016/j.alit.2020.01.005 · Cited by 40
Chen, Z., Dragan, M., Sun, P., Haensel, D., Vu, R., Cui, L., Zhu, P., Yang, N., Shi, Y., & Dai, X. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01264-z · Cited by 44
Zeze, N., Kido‐Nakahara, M., Tsuji, G., Maehara, E., Sato, Y., Sakai, S., Fujishima, K., Hashimoto‐Hachiya, A., Furue, M., & Nakahara, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073467 · Cited by 38
The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Lozza, L., Moura‐Alves, P., Domaszewska, T., Crespo, C. L., Streață, I., Kreuchwig, A., Puyskens, A., Bechtle, M., Klemm, M., Zedler, U., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47350-x · Cited by 42
Alves, L. D. F., Moore, J. B., & Kell, D. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169082 · Cited by 39
Hand dermatitis – differential diagnoses, diagnostics, and treatment options
Mahler, V. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12922 · Cited by 36
Takemura, M., Nakahara, T., Hashimoto‐Hachiya, A., Furue, M., & Tsuji, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041169 · Cited by 38
Goudarzi, H., Konno, S., Kimura, H., Araki, A., Miyashita, C., Itoh, S., Bamai, Y. A., Kimura, H., Shimizu, K., Suzuki, M., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.05.152 · Cited by 35
Zhu, C., Xie, H. Q., & Zhao, B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150610116 · Cited by 37
The role of NRF2 transcription factor in inflammatory skin diseases
Salman, S., Paulet, V., Hardonnière, K., & Kerdine‐Römer, S. (2025) · BioFactors · doi:10.1002/biof.70013 · Cited by 43
Hawerkamp, H. C., Kislat, A., Gerber, P. A., Pollet, M., Rolfes, K. M., Soshilov, A. A., Denison, M. S., Momin, A. A., Arold, S. T., Datsi, A., et al. (2019) · Allergy · doi:10.1111/all.13972 · Cited by 34
van den Bogaard, E. H. J., Esser, C., & Perdew, G. H. (2021) · Experimental Dermatology · doi:10.1111/exd.14409 · Cited by 35
The Aryl Hydrocarbon Receptor (AHR): Peacekeeper of the Skin
Dawe, H. R., & Meglio, P. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041618 · Cited by 37
Regulated genes in psoriatic skin during treatment with fumaric acid esters
Onderdijk, A. J., Balak, D., Baerveldt, E. M., Florencia, E. F., Kant, M., Laman, J. D., van IJcken, W. F. J., Rácz, E., de Ridder, D., Thio, H. B., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13128 · Cited by 33
Koch, S., Stroisch, T. J., Vorac, J., Herrmann, N., Leib, N., Schnautz, S., Kirins, H., Förster, I., Weighardt, H., & Bieber, T. R. M. (2017) · Allergy · doi:10.1111/all.13170 · Cited by 34
Critical Players and Therapeutic Targets in Chronic Itch
Hua, Y., Chen, W., Zhu, R., Wang, J., & Meng, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179935 · Cited by 34
Wang, X., Mao, D., Jia, J., & Zhang, J. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.027 · Cited by 33
Moisturizers for patients with atopic dermatitis.
Varothai, S., Nitayavardhana, S., & Kulthanan, K. (2013) · PubMed · Cited by 32
Kim, K.-H., Shim, J. S., Kim, H.-J., & Son, E. D. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112337 · Cited by 31
Tanaka, Y., Ito, T., Tsuji, G., & Furue, M. (2020) · Antioxidants · doi:10.3390/antiox9060507 · Cited by 31
Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis
Furue, K., Ulzii, D., Tanaka, Y., Ito, T., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15507 · Cited by 31
Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D. H., Amin, S., Glick, A. B., & Perdew, G. H. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx160 · Cited by 30
Novel Therapeutic Targets for the Treatment of Atopic Dermatitis
Tsuji, G., Yamamura, K., Kawamura, K., Kido‐Nakahara, M., Ito, T., & Nakahara, T. (2023) · Biomedicines · doi:10.3390/biomedicines11051303 · Cited by 30
Radi, G., Campanati, A., Diotallevi, F., Martina, E., Marani, A., & Offidani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112700 · Cited by 27
Forrester, A. R., Elias, M. S., Woodward, E. L., Graham, M., Williams, F. M., & Reynolds, N. J. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.09.001 · Cited by 28
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Chen, Y., Peng, C., Zhu, L., Wang, J., Cao, Q., Chen, X., & Li, J. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08995-3 · Cited by 27
Kobaisi, F., Fayyad, N., Rezvani, H. R., Fayyad‐Kazan, M., Sulpice, E., Badran, B., Fayyad‐Kazan, H., Gidrol, X., & Rachidi, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4654206 · Cited by 26
Smits, J. P. H., van den Brink, N. J. M., Meesters, L. D., Hamdaoui, H., Niehues, H., Jansen, P. A. M., van Vlijmen‐Willems, I. M. J. J., Rodijk‐Olthuis, D., Evrard, C., Poumay, Y., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.02.021 · Cited by 27
Self-citationMahiout, S., Lindén, J., Esteban, J., Sánchez-Pérez, I., Sankari, S., Pettersson, L., Håkansson, H., & Pohjanvirta, R. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.04.020 · Cited by 26
Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis
Lee, J., Song, K., & Jung, C. H. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153418 · Cited by 26
Guerrina, N., Traboulsi, H., de Souza, A. R., Bossé, Y., Thatcher, T. H., Robichaud, A., Ding, J., Li, P. Z., Simon, L., Pareek, S., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002350r · Cited by 26
Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
Kim, H.-B., Um, J., Chung, B. Y., Kim, J. C., Kang, S. Y., Park, C. W., & Kim, H. O. (2022) · Biomedicines · doi:10.3390/biomedicines10051087 · Cited by 28
Dissecting key contributions of TH2 and TH17 cytokines to atopic dermatitis pathophysiology
Meesters, L. D., Roubroeks, J. A. Y., Gerritsen, A., Velthuijs, N., Klijnhout, J. A., Laberthonnìère, C., van Vlijmen-Willems, I. M., Hübenthal, M., Rodijk‐Olthuis, D., Peters, R. H. W., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.05.007 · Cited by 27
Epigenetic Regulations of AhR in the Aspect of Immunomodulation
Wajda, A., Łapczuk-Romańska, J., & Paradowska‐Gorycka, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176404 · Cited by 29
The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability
van den Bogaard, E. H. J., & Perdew, G. H. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.12.013 · Cited by 25
Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years
Disner, G. R., Lopes‐Ferreira, M., & Lima, C. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.725044 · Cited by 25
Bao, L., Alexander, J. B., Zhang, H., Shen, K., & Chan, L. S. (2016) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0056 · Cited by 25
Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2
Zazueta, C., Jiménez‐Uribe, A. P., Pedraza‐Chaverrí, J., & Buelna‐Chontal, M. (2022) · Antioxidants · doi:10.3390/antiox11030507 · Cited by 27
Adult atopic dermatitis: new and emerging therapies
Napolitano, M., Marasca, C., Fabbrocini, G., & Patruno, C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1507734 · Cited by 24
Kang, Y., Lee, K.-Y., & An, H. (2018) · Nutrients · doi:10.3390/nu10111657 · Cited by 24
van den Brink, N. J. M., Pardow, F., Meesters, L. D., van Vlijmen‐Willems, I. M. J. J., Rodijk‐Olthuis, D., Niehues, H., Jansen, P. A. M., Roelofs, S. H., Brewer, M. G., van den Bogaard, E. H. J., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.038 · Cited by 22
Breaking the cycle: a comprehensive exploration of topical steroid addiction and withdrawal
Maskey, A., Sasaki, A., Sargen, M., Kennedy, M., Tiwari, R. K., Geliebter, J., Safai, B., & Li, X. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1547923 · Cited by 22
Current and emerging topical therapies for atopic dermatitis
Udkoff, J., Waldman, A. R., Ahluwalia, J., Borok, J. F., & Eichenfield, L. F. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.03.010 · Cited by 22
Hu, Y., Liu, P., Mu, Z., & Zhang, J. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000591 · Cited by 22
Lee, E., Min, K., Ahn, H., Jeon, B., Park, S., Yun, C., Jeon, H., Yeon, J.-S., Kim, H., & Park, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179551 · Cited by 23
Innate lymphoid cells: a new key player in atopic dermatitis
Jia, H., Wan, H., & Zhang, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1277120 · Cited by 23
Jin, T., Park, K. Y., & Seo, S. J. (2017) · Annals of Dermatology · doi:10.5021/ad.2017.29.4.407 · Cited by 23
Jeong, H., Shin, J. Y., Kim, M., Na, J., & Ju, B. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.012 · Cited by 22
Tajima, H., Tajiki‐Nishino, R., Watanabe, Y., & Fukuyama, T. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3782 · Cited by 22
Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., ten Have, S., Whitfield, P. D., Lamond, A. I., & Brown, S. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15405.2 · Cited by 22
22 Again: IL-22 as a Risk Gene and Important Mediator in Psoriasis
Johnston, A. W. B., & Gudjonsson, J. E. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.81 · Cited by 22
Association between atopic dermatitis and squamous cell carcinoma: a case–control study
Cho, J. M., Davis, D. M. R., Wetter, D. A., Bartley, A. C., & Brewer, J. D. (2017) · International Journal of Dermatology · doi:10.1111/ijd.13857 · Cited by 22
Management of Atopic Dermatitis
Boguniewicz, M., & Leung, D. Y. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29875-9.00051-3 · Cited by 21
Bacterial Metabolites and Inflammatory Skin Diseases
Jiminez, V. S., & Yusuf, N. (2023) · Metabolites · doi:10.3390/metabo13080952 · Cited by 23
The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress
Guerrina, N., Aloufi, N., Shi, F., Prasade, K., Mehrotra, C., Traboulsi, H., Matthews, J. B., Eidelman, D. H., Hamid, Q. A., & Baglole, C. J. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00122.2020 · Cited by 21
Tsuji, G., Yamamura, K., Kawamura, K., Kido-Nakahara, M., Ito, T., & Nakahara, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914633 · Cited by 21
Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1
Tsuji, G., Hashimoto‐Hachiya, A., Vu, Y. H., Miake, S., Takemura, M., Mitamura, Y., Ito, T., Murata, M., Furue, M., & Nakahara, T. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030891 · Cited by 21
Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes
Yan, X., Tsuji, G., Hashimoto-Hachiya, A., & Furue, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216338 · Cited by 20
Skin microbiota: pathogenic roles and implications in atopic dermatitis
Huang, C., Zhuo, F., Guo, Y., Wang, S., Zhang, K., Li, X., Dai, W., Dou, X., & Yu, B. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1518811 · Cited by 22
German S1 guideline: Contact dermatitis
Dickel, H., Bauer, A., Brehler, R., Mahler, V., Merk, H. F., Neustädter, I., Strömer, K., Werfel, T., Worm, M., & Geier, J. (2022) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14734 · Cited by 20
Alessandrini, F., de Jong, R., Wimmer, M., Maier, A.-M., Fernandez, I. E., Hils, M., Buters, J., Biedermann, T., Zissler, U. M., Hoffmann, C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901194 · Cited by 20
Muenyi, C. S., Carrion, S. L., Jones, L. A., Kennedy, L. H., Slominski, A. T., Sutter, T. R., & Sutter, T. R. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1308045 · Cited by 20
Leman, G., Moosbrugger‐Martinz, V., Blunder, S., Pavel, P., & Dubrac, S. (2019) · Cells · doi:10.3390/cells8050489 · Cited by 20
In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators
Mahiout, S., Tagliabue, S. G., Nasri, A., Omoruyi, I. M., Pettersson, L., Bonati, L., & Pohjanvirta, R. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.06.010 · Cited by 19
Aryl Hydrocarbon Receptor in Health and Disease
Li, H., Fan, Y., Liu, J., Dong, S., Wen, B., Zhang, Y., Wang, X., Duan, X., Hu, Y., Yan, Z., et al. (2025) · MedComm · doi:10.1002/mco2.70426 · Cited by 22
Kim, J. E., Kim, H. R., Kang, S. Y., Jung, M. J., Heo, N. H., Lee, H. J., Ryu, A., Kim, H. O., Park, C. W., & Chung, B. Y. (2021) · Annals of Dermatology · doi:10.5021/ad.2021.33.2.138 · Cited by 19
Limbu, S. L., Purba, T. S., Harries, M. J., Wikramanayake, T. C., Miteva, M. I., Bhogal, R. K., O’Neill, C. A., & Paus, R. (2021) · BioEssays · doi:10.1002/bies.202100005 · Cited by 20
Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression
Okumura, N., Ito, T., Degawa, T., Moriyama, M., & Moriyama, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312973 · Cited by 20
Sutter, T. R., Azim, S., Wang, A., Bhuju, J., Simpson, A. S., Uberoi, A., Grice, E. A., & Sutter, T. R. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.03.1662 · Cited by 19
Doi, K., Mitoma, C., Nakahara, T., Uchi, H., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, M., & Furue, M. (2014) · PubMed · doi:10.15017/1495227 · Cited by 19
Meldrum, K., Gant, T. W., Macchiarulo, S., & Leonard, M. O. (2016) · Toxicology Research · doi:10.1039/c5tx00389j · Cited by 19
Furue, M., Uchi, H., Mitoma, C., Hashimoto‐Hachiya, A., Tanaka, Y., Ito, T., & Tsuji, G. (2019) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.18.06132-1 · Cited by 19
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., ten Have, S., Whitfield, P. D., Lamond, A. I., & Brown, S. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15405.1 · Cited by 19
Tofacitinib for extraintestinal manifestations of inflammatory bowel disease: A literature review
Wang, Y., Wan, Z., Jin, R., Xu, T., Ouyang, Y., Wang, B., Ruan, G., & Bai, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108517 · Cited by 18
Smits, J. P. H., Qu, J., Pardow, F., van den Brink, N. J. M., Rodijk‐Olthuis, D., van Vlijmen‐Willems, I. M. J. J., van Heeringen, S. J., Zeeuwen, P. L. J. M., Schalkwijk, J., Zhou, H., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.01.030 · Cited by 18
Self-citation
Metadata
- Authors
- van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J.
- Affiliations
- Radboud University Medical Center (NL)
- University Hospital Schleswig-Holstein (DE)
- Radboud University Nijmegen (NL)
- Venue
- Journal of Clinical Investigation
- Published
- 2013-01-25
- Volume
- 123
- Issue
- 2
- Pages
- 917-27
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3561798
- OpenAlex
- W2047893094
- Cited by
- 373
- References
- 64
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 36 · 2023: 31 · 2022: 38 · 2021: 33 · 2020: 34 · 2019: 25 · 2018: 33 · 2017: 30 · 2016: 18 · 2015: 19 · 2014: 28 · 2013: 12
- FWCI
- 30.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- coal tar, atopic dermatitis, aryl hydrocarbon receptor, skin barrier repair, filaggrin, Th2 cytokines, IL-4, IL-13, Nrf2 signaling, epidermal differentiation, keratinocytes, spongiosis, CCL26, organotypic skin model
- MeSH terms
- Filaggrin Proteins, Administration, Topical, Cell Differentiation, Cells, Cultured, Coal Tar, Dermatitis, Atopic, Humans, Intermediate Filament Proteins, Models, Biological, Signal Transduction, Keratinocytes, Up-Regulation, Cytokines, Receptors, Aryl Hydrocarbon, Oxidative Stress, Th2 Cells, RNA, Small Interfering, NF-E2-Related Factor 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
