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Cited by 434

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

Open access
Dickinson, Bonny L., Badizadegan, Kamran, Wu, Zhen, Ahouse, Jeremy C., Zhu, Xiaoping, Simister, Neil E., Blumberg, Richard S., Lencer, Wayne I.·1999·Journal of Clinical Investigation
DOI 10.1172/jci6968
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Abstract

The MHC class I-related Fc receptor, FcRn, mediates the intestinal absorption of maternal IgG in neonatal rodents and the transplacental transport of maternal IgG in humans by receptor-mediated transcytosis. In mice and rats, expression of FcRn in intestinal epithelial cells is limited to the suckling period. We have recently observed, however, clear expression of FcRn in the adult human intestine, suggesting a function for FcRn in intestinal IgG transport beyond neonatal life in humans. We tested this hypothesis using the polarized human intestinal T84 cell line as a model epithelium. Immunocytochemical data show that FcRn is present in T84 cells in a punctate apical pattern similar to that found in human small intestinal enterocytes. Solute flux studies show that FcRn transports IgG across T84 monolayers by receptor-mediated transcytosis. Transport is bidirectional, specific for FcRn, and dependent upon endosomal acidification. These data define a novel bidirectional mechanism of IgG transport across epithelial barriers that predicts an important effect of FcRn on IgG function in immune surveillance and host defense at mucosal surfaces.

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Crossref · 10.1172/jci6968

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Metadata

Authors
Dickinson, B. L., Badizadegan, K., Wu, Z., Ahouse, J. C., Zhu, X., Simister, N. E., Blumberg, R. S., & Lencer, W. I.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1999-10-01
Volume
104
Issue
7
Pages
903-911
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci6968
OpenAlex
W2113413385
Cited by
434
References
48
FWCI
12.76
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. https://app.cochat.ai/papers/10.1172/jci6968
The paper
Dickinson, B. L., Badizadegan, K., Wu, Z., Ahouse, J. C., Zhu, X., Simister, N. E., Blumberg, R. S., & Lencer, W. I. (1999). Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. Journal of Clinical Investigation. https://doi.org/10.1172/jci6968

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.