The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Molecular mechanisms of diabetic kidney disease
Open accessAbstract
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease of gene and environmental interactions. Tight glucose control significantly decreases DKD incidence, indicating that hyperglycemia-induced metabolic alterations, including changes in energy utilization and mitochondrial dysfunction, play critical roles in disease initiation. Blood pressure control, especially with medications that inhibit the angiotensin system, is the only effective way to slow disease progression. While DKD is considered a microvascular complication of diabetes, growing evidence indicates that podocyte loss and epithelial dysfunction play important roles. Inflammation, cell hypertrophy, and dedifferentiation by the activation of classic pathways of regeneration further contribute to disease progression. Concerted clinical and basic research efforts will be needed to understand DKD pathogenesis and to identify novel drug targets.
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Cites
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Cited by
Molecular mechanisms and therapeutic targets for diabetic kidney disease
Tuttle, K. R., Agarwal, R., Alpers, C. E., Bakris, G. L., Brosius, F. C., Kolkhof, P., & Uribarri, J. (2022) · Kidney International · doi:10.1016/j.kint.2022.05.012 · Cited by 668
The tubular hypothesis of nephron filtration and diabetic kidney disease
Vallon, V., & Thomson, S. C. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0256-y · Cited by 465
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09735-4 · Cited by 298
Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury
Szeto, H. H., Liu, S., Soong, Y., Alam, N., Prusky, G. T., & Seshan, S. V. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.013 · Cited by 293
Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy
Yang, J., & Liu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.816400 · Cited by 281
Metadata
- Authors
- Reidy, K., Kang, H. M., Hostetter, T., & Susztak, K.
- Venue
- Journal of Clinical Investigation
- Published
- 2014-06-02
- Volume
- 124
- Issue
- 6
- Pages
- 2333-2340
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2043873569
- Cited by
- 909
- References
- 103
- FWCI
- 33.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
