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The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
Open accessAbstract
The pathogenesis of type 2 diabetes involves abnormalities in insulin action, insulin secretion, and endogenous glucose output (EGO). However, the sequence with which these abnormalities develop and their relative contributions to the deterioration in glucose tolerance remain unclear in the absence of a detailed longitudinal study. We measured insulin action, insulin secretion, and EGO longitudinally in 17 Pima Indians, in whom glucose tolerance deteriorated from normal (NGT) to impaired (IGT) to diabetic over 5.1 +/- 1.4 years. Transition from NGT to IGT was associated with an increase in body weight, a decline in insulin-stimulated glucose disposal, and a decline in the acute insulin secretory response (AIR) to intravenous glucose, but no change in EGO. Progression from IGT to diabetes was accompanied by a further increase in body weight, further decreases in insulin-stimulated glucose disposal and AIR, and an increase in basal EGO. Thirty-one subjects who retained NGT over a similar period also gained weight, but their AIR increased with decreasing insulin-stimulated glucose disposal. Thus, defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes. Intervention to prevent diabetes should target both abnormalities.
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In the citing paper
“Insulin resistance and concurrent relative insulin deficiency and glucagon dysregulation underlie T2D pathophysiology.33–35”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [34]
Experimental — accuracy not yet measuredIn the citing paper
“These findings derived from cross-sectional data are supported by a longitudinal study in Pima Indians that has also shown the importance of accounting for the hyperbolic relationship between insulin sensitivity and insulin secretion and demonstrated the presence of impaired beta-cell function in those destined to progress to Type 2 diabetes [95].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [95]
In the citing paper
“Seventeen (35%) of these subjects progressed from NGT to IGT and then to diabetes during follow up.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [95]
In the citing paper
“Our finding of a hyperbolic relationship between insulin sensitivity and insulin secretion in healthy subjects has been confirmed in large cohorts of Danish [94] and Pima Indian subjects [95].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [95]
In the citing paper
“During follow up, insulin secretion declined progressively by 78% while insulin sensitivity decreased by only 14%.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [95]
In the citing paper
“Based on the UKPDS [18] and the longitudinal assessment in Pima Indians [95], the major reason for the decline in glucose tolerance seems to be a progressive loss of beta-cell function.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [95]
In the citing paper
“Further progressive deterioration of β-cell function accounts for the evolving natural history of the disease from impaired glucose tolerance to type 2 diabetes10,11.”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [10]
In the citing paper
“Our results may help explain the aforementioned association between N3 lack and T2DM, as a loss in first-phase insulin secretion is both an early marker of T2DM and part of its pathogenesis (20).”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [20]
In the citing paper
“IGT and T2DM ensue when beta cell function fails to compensate.”
From The Vasculature in Prediabetes (2018) · cites this paper as [16]
In the citing paper
“Insulin resistance precedes the development of hyperglycemia and T2DM and results in compensatory hyperinsulinemia.”
From The Vasculature in Prediabetes (2018) · cites this paper as [16]
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Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041
Coated Charcoal Immunoassay of Insulin
Herbert, V. D., Lau, K., Gottlieb, C. W., & Bleicher, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,969
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689
Body composition from fluid spaces and density: analysis of methods. 1961.
Siri, W. E. (1994) · PubMed · Cited by 2,556
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · cited 5×
“It is well known that there is a hyperbolic relationship between early insulin secretion and insulin action in individuals with NGT, meaning that, cross-sectionally, insulin secretion increases with decreasing insulin action and vice versa (51, 52).”
BackgroundMethodInfluentialTechniques for Measuring Body Composition
National Research Council (1961) · National Academies Press eBooks · doi:10.17226/21603 · Cited by 1,620
Research works printed but not linked: 6
- 1998, Diabetes Care, 21(Suppl. 1), S5
- DeFronzo, 1997, Diabetes Reviews, 5, 177
- Abbott, 1990, Am J Physiol, 258, E347
- Bogardus, 1984, J Clin Invest, 78, 1568
- Schwartz, 1995, J Clin Endocrinol Metab, 80, 1571
- Luzi, 1989, Am J Physiol, 257, E241
Cited by
Sorted by citations
Items 701–800 of 1,002
Fradin, D., & Bougneres, P. F. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/647514 · Cited by 34
Clarifying the Role of Insulin in Type 2 Diabetes Management
White, J. R., Davis, S. N., Cooppan, R. M., Davidson, M. B., Mulcahy, K., Manko, G. A., & Nelinson, D. S. (2003) · Clinical Diabetes · doi:10.2337/diaclin.21.1.14 · Cited by 34
Rattarasarn, C. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2005.01521.x · Cited by 34
The metabolic response to ingestion of proline with and without glucose
Nuttall, F. Q., Gannon, M. C., & Jordan, K. (2004) · Metabolism · doi:10.1016/j.metabol.2003.09.013 · Cited by 34
Pujol, J., Christinat, N., Ratinaud, Y., Savoia, C., Mitchell, E. S., & Dioum, E. M. (2018) · Nutrients · doi:10.3390/nu10040473 · Cited by 33
Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population
Sokooti, S., Kieneker, L. M., de Borst, M. H., Kobold, A. C. M., Kootstra‐Ros, J. E., Gloerich, J., van Gool, A. J., Heerspink, H. J. L., Gansevoort, R. T., Dullaart, R. P. F., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9093001 · Cited by 33
Management of critically ill patients with type 2 diabetes: The need for personalised therapy
Kar, P. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i5.693 · Cited by 33
Alternative Medicine in Diabetes - Role of Angiogenesis, Oxidative Stress, and Chronic Inflammation
El‐Refaei, M. F., Abduljawad, S. H., & Alghamdi, A. (2014) · The Review of Diabetic Studies · doi:10.1900/rds.2014.11.231 · Cited by 33
Overweight as a risk factor in children: a focus on ethnicity.
Nesbitt, S. D., Ashaye, M. O., Stettler, N., Sorof, J. M., Goran, M. I., Parekh, R. S., & Falkner, B. E. (2004) · PubMed · Cited by 33
Vinik, A. I., Cincotta, A. H., Scranton, R. E., Bohannon, N. J. V., Ezrokhi, M., & Gaziano, J. M. (2012) · Endocrine Practice · doi:10.4158/ep12187.or · Cited by 33
Anti-diabetic effects of pentamethylquercetin in neonatally streptozotocin-induced diabetic rats
Wang, Y., Xin, X., Jin, Z., Hu, Y., Li, X., Wu, J., & Jin, M. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.022 · Cited by 33
Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus
Kashine, S., Kishida, K., Funahashi, T., Nakagawa, Y., Otuki, M., Okita, K., Iwahashi, H., Kihara, S., Nakamura, T., Matsuzawa, Y., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.025 · Cited by 33
Owei, I., UMEKWE, N. A., Wan, J. Y., & Dagogo-Jack, S. E. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216659946 · Cited by 33
Inhaled Insulin: Extending the Horizons of Inhalation Therapy
Guntur, V. P., & Dhand, R. (2007) · Respiratory Care · doi:10.4187/respcare.07520911 · Cited by 33
Dietary Fat Intake and Insulin Resistance in Black and White Children
Weigensberg, M. J., Ball, G. D. C., Shaibi, G. Q., Cruz, M. L., Gower, B. A., & Goran, M. I. (2005) · Obesity Research · doi:10.1038/oby.2005.200 · Cited by 33
Boland, C. L., DeGeeter, M., Nuzum, D. S., & Tzefos, M. (2013) · Annals of Pharmacotherapy · doi:10.1345/aph.1r444 · Cited by 32
Wang, Y., Wan, H., Chen, C., Chen, Y., Xia, F., Han, B., Qin, L., Wang, N., & Lu, Y. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-0121-x · Cited by 32
Maki, K. C., Rains, T. M., Dicklin, M. R., & Bell, M. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0083 · Cited by 32
Wang, X., Lu, Q., Yu, D., Chen, Y., Shang, J., Zhang, L., Sun, H., & Liu, J. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30047-9 · Cited by 32
Noordam, R., Läll, K., Smit, R. A. J., Laisk, T., Metspalu, A., Esko, T., Milani, L. A., Loos, R. J. F., Mägi, R., van Dijk, K. W., et al. (2021) · Diabetes · doi:10.2337/db20-0602 · Cited by 31
Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes
Park, J. E., Lee, J., Song, J., Sim, Y. C., Ha, S., & Hong, E. K. (2015) · Molecules · doi:10.3390/molecules20045456 · Cited by 31
Sidharta, P. N., Rave, K., Heinemann, L., Chiossi, E., Krähenbühl, S., & Dingemanse, J. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03480.x · Cited by 31
Pathogenesis of diabetes: Our current understanding
Pietropaolo, M., & Roith, D. L. (2001) · Clinical cornerstone · doi:10.1016/s1098-3597(01)90025-0 · Cited by 31
Chinese herbal medicine for impaired glucose tolerance: a randomized placebo controlled trial
Grant, S., Chang, D. H.-T., Liu, J., Wong, V., Kiat, H., & Bensoussan, A. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-104 · Cited by 31
Hruby, A., McKeown, N. M., Song, Y., & Djoussé, L. (2013) · Nutrients · doi:10.3390/nu5124990 · Cited by 31
Vrbíková, J., Stanická, S., Dvorakova, K., Hill, M., Vondra, K., Bendlová, B., & Stárka, L. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500215 · Cited by 31
Soyama, A., Nishikawa, T., Ishizuka, T., Itô, H., Saito, J., Kazuo, Y. A. G. I., & Saitō, Y. (2005) · Endocrine Journal · doi:10.1507/endocrj.52.229 · Cited by 31
Åhrén, B. (2008) · Diabetologia · doi:10.1007/s00125-008-0995-y · Cited by 31
Zangeneh, F., Kudva, Y. C., & Basu, A. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.4.471 · Cited by 31
Saloranta, C., Guitard, C., Pecher, E., de Pablos-Velasco, P. L., Lahti, K., Brunel, P., & Groop, L. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2141 · Cited by 31
Kriketos, A. D., Carey, D., Jenkins, A. B., Chisholm, D. J., Furler, S. M., & Campbell, L. V. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00938.x · Cited by 31
Huq, S., Todkar, S., & Lahiri, S. W. (2020) · Endocrine Practice · doi:10.4158/ep-2019-0452 · Cited by 30
Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease
Adem, M. A., Decourt, B., & Sabbagh, M. N. (2024) · Biomedicines · doi:10.3390/biomedicines12010099 · Cited by 30
Weyrich, P., Machicao, F. E., Staiger, H., Simon, P. D., Thamer, C., Machann, J., Schick, F., Guirguis, A., Fritsche, A., Stefan, N., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0788-8 · Cited by 30
Murphy, M. J., Hosking, J., Metcalf, B. S., Voss, L. D., Jeffery, A., Sattar, N. A., Williams, R., Jeffery, J., & Wilkin, T. J. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.103499 · Cited by 30
Functional differences between healthy and diabetic endothelial cells on topographical cues
Cutiongco, M. F. A., Chua, B. M. X., Neo, D. J. H., Rizwan, M., & Yim, E. K. F. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.037 · Cited by 30
Wang, Y., Li, Y., Qiao, J., Li, N., & Qiao, S. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3440 · Cited by 30
Johanson, E. H., Jansson, P., Lönn, L., Matsuzawa, Y., Funahashi, T., Taskinen, M., Smith, U., & Axelsen, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021961 · Cited by 30
Yuan, X., Dai, X., Liu, L., Hsue, C., Miller, J. D., Fang, Z., Li, J., Feng, J., Huang, Y., Liu, C., et al. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12955 · Cited by 29
Bensellam, M., Shi, Y., Chan, J. Y., Laybutt, D. R., Chae, H., Abou‐Samra, M., Pappas, E. G., Thomas, H. E., Gilon, P., & Jonas, J. (2019) · Diabetologia · doi:10.1007/s00125-019-05008-3 · Cited by 29
Adult glucose metabolism in extremely birthweight-discordant monozygotic twins
Frost, M., Petersen, I., Brixen, K., Beck‐Nielsen, H., Holst, J. J., Christiansen, L., Højlund, K., & Christensen, K. (2012) · Diabetologia · doi:10.1007/s00125-012-2695-x · Cited by 29
Cardiometabolic Risk in Chinese Women with Prior Gestational Diabetes: A 15-Year Follow-Up Study
Tam, W. H., Ronald, C. W., Yang, X., Ko, G. T.-C., Lao, T. T.-H., Chan, M. H. M., Lam, C. W.-K., Cockram, C. S., & Chan, J. C. N. (2011) · Gynecologic and Obstetric Investigation · doi:10.1159/000329339 · Cited by 29
Pontiroli, A. E., Pizzocri, P., Caumo, A., Perseghin, G., & Luzi, L. (2004) · Acta Diabetologica · doi:10.1007/s00592-004-0147-x · Cited by 29
Rhee, S. Y., Chon, S., Oh, S., Kim, S. W., Kim, J., Kim, Y. S., & Woo, J. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.09.035 · Cited by 29
Fenik, V. B., Singletary, T., Branconi, J. L., Davies, R. O., & Kubin, L. K. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00051 · Cited by 29
Patterns of insulin resistance in the general population of southeast Spain
Rojo‐Martínez, G., Esteva, I., de Adana, S. R., Catalá, M., Merelo, M. J., Tinahones, F. J., Gómez‐Zumaquero, J. M., Cuesta, A. L., Cardona, F., & Soriguer, F. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.01.004 · Cited by 29
Bissonnette, S., Saint-Pierre, N., Lamantia, V., Cyr, Y., Wassef, H., & Faraj, M. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.30 · Cited by 29
Insulin level and insulin sensitivity indices among healthy children and adolescents
Ballerini, M. G., Bergadá, I., Rodríguez, M. E., Keselman, A. C., Bengolea, V., Pipman, V. R., Domené, H. M., Jasper, H., & Ropelato, M. G. (2016) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2016.eng.329 · Cited by 29
Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis
Kim, J.-W., Park, S., You, Y., Ham, D., Lee, S., Yang, H. K., Jeong, I., Ko, S., & Yoon, K.-H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163187 · Cited by 29
Diabetic aggravation of stroke and animal models
Rehni, A. K., Liu, A., Pérez‐Pinzón, M. A., & Dave, K. R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.03.004 · Cited by 29
Rasouli, N., Hale, T. C., Kahn, S. E., Spencer, H. J., & Elbein, S. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0048 · Cited by 29
Genetic Basis of Type 2 Diabetes Mellitus
DiStefano, J. K., & de Courten, B. V. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403040-00007 · Cited by 29
Kanauchi, M., Nakajima, M., Saito, Y., & Kanauchi, K. (2003) · Metabolism · doi:10.1053/meta.2003.50078 · Cited by 29
Song, H., Wohltmann, M., Tan, M., Bao, S. S., Ladenson, J. H., & TURK, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285114 · Cited by 28
(ESC), G. D. T. S. D. Y. E. C. D. L. S. E. D. C., & (EASD), D. L. S. E. P. E. E. D. L. D. (2007) · Revista Española de Cardiología · doi:10.1016/s0300-8932(07)75070-4 · Cited by 28
Harinarayan, C. V., Arvind, S., Joshi, S., Thennarasu, K., Vedavyas, V., & Baindur, A. (2013) · Endocrine Practice · doi:10.4158/ep13273.or · Cited by 28
Shao, S., Liu, Z., Yang, Y., Zhang, M., & Yu, X. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22750 · Cited by 28
Tan, V. M. H., Wu, T., Henry, C. J., & Lee, Y. S. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000586 · Cited by 28
β-Cell Function in Mild Type 2 Diabetic Patients
Mari, A., Gastaldelli, A., Foley, J. E., Pratley, R. E., & Ferrannini, E. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1132 · Cited by 28
Self-citationBackx, K., McCann, A., Wasley, D., Dunseath, G. J., Luzio, S. D., & Owens, D. R. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2010.544666 · Cited by 28
Lin, H., Yin, Y., Zhang, J. X., Xuan, H., Zheng, Y., Zhan, S., Zhu, Y., & Han, X. (2012) · Diabetologia · doi:10.1007/s00125-012-2643-9 · Cited by 28
Fang, C.-C., Wang, X., Gu, X., Gu, X., Ye, T., Deng, H., Wang, X., & Shen, F. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0594-y · Cited by 28
Zsóri, G., Illés, D., Ivány, E., Kosár, K., Holzinger, G., Tajti, M., Pálinkás, E. D., Szabovik, G., Nagy, A. C., Palkó, A., et al. (2019) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0086 · Cited by 29
Liu, Z., & Лі, Б. (2021) · Food & Function · doi:10.1039/d1fo01532j · Cited by 28
Preventing Type 2 Diabetes Mellitus
Curtis, J., & Wilson, C. (2005) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.18.1.37 · Cited by 28
β‐cell deterioration – prospects for reversal or prevention
Finegood, D. T., & Topp, B. G. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00030.x · Cited by 28
Evolving Strategies for Insulin Delivery and Therapy
Cefalu, W. T. (2004) · Drugs · doi:10.2165/00003495-200464110-00001 · Cited by 28
Evaluation of alternative strategies for optimizing glycemia: progress to date
Cefalu, W. T. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01278-0 · Cited by 28
The Effects of Metabolic Surgery on Fatty Liver Disease and Nonalcoholic Steatohepatitis
Clanton, J., & Subichin, M. P. (2016) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.03.008 · Cited by 27
Alpha-to-beta cell trans-differentiation for treatment of diabetes
Saleh, M. W., Gittes, G. K., & Prasadan, K. L. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210244 · Cited by 27
Miao, L., Liu, C., Cheong, M. S., Zhong, R., Tan, Y., Rengasamy, K. R. R., Leung, S. W. S., Cheang, W. S., & Xiao, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2095349 · Cited by 27
Bi, Y., Tong, G. Y., Yang, H., Cai, M., Ma, J. H., Liang, J., Xin, B., Miao, H., Peng, Z., & Zhu, D. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2443 · Cited by 27
Hong, J., Gu, W., Zhang, Y., Yang, Y., Shen, C.-F., Xu, M., Li, X.-Y., Wang, W., & Ning, G. (2007) · Endocrine · doi:10.1007/s12020-007-0002-2 · Cited by 27
Li, Y., Li, X., Li, J., Li, H., & Cheng, S.-S. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0210-8 · Cited by 27
Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats
Moesgaard, S. G., Brand, C. L., Sturis, J., Åhrén, B., Wilken, M., Fleckner, J., Carr, R. D., Svendsen, O., Hansen, A. J., & Gram, D. X. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00356.2004 · Cited by 27
Insulin Resistance Compensation: Not Just a Matter of β-Cells?
Montanya, E. (2014) · Diabetes · doi:10.2337/db13-1843 · Cited by 27
Gu, C., Zhou, W., Wang, W., Xiang, H., Xu, H., Liang, L., Sui, H. X., Zhan, L., & Lu, X. (2017) · Oncotarget · doi:10.18632/oncotarget.14611 · Cited by 27
Wang, H., Kuang, J., Xu, M., Gao, Z., Li, Q., Liu, S., Zhang, F., Yu, Y., Liang, Z., Zhao, W., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01468 · Cited by 27
Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis
Al‐Daghri, N. M., Al-Attas, O. S., Al-Rubeaan, K. A., Mohieldin, M., Al-Katari, M., Jones, A. F., & Kumar, S. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-18 · Cited by 27
Carbohydrate Metabolism and Pathogenesis of Diabetes Mellitus in Dogs and Cats
Hoenig, M. E. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00012-0 · Cited by 27
The genetics of diabetes mellitus.
Radha, V., Vimaleswaran, K. S., Deepa, R., & Mohan, V. (2003) · PubMed · Cited by 27
Chen, M. E., Chandramouli, A. G., Considine, R. V., Hannon, T. S., & Mather, K. J. (2018) · Diabetes Care · doi:10.2337/dc17-1373 · Cited by 26
Luther, J. M., Byrne, L. M., Yu, C., Wang, T. J., & Brown, N. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2122 · Cited by 26
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Akinsipo, O. B., Dare, E. O., & Katare, D. P. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03296 · Cited by 26
Bermúdez, V., Cano, R., Cano, C., Bermúdez, F., Leal, E., Acosta, K., Mengual, E., Arráiz, N., Briceño, C., Rivas, J. G., et al. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318160b909 · Cited by 26
Salinari, S., BERTUZZI, A., Iaconelli, A., Manco, M., & Mingrone, G. (2008) · Diabetologia · doi:10.1007/s00125-008-1007-y · Cited by 26
Ruchat, S.-M., Loos, R. J. F., Rankinen, T., Vohl, M., Weisnagel, S. J., Després, J., Bouchard, C., & Përusse, L. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02396.x · Cited by 26
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Sato, Y., Komatsu, M., Katakura, M., Ohfusa, H., Yamada, S., Yamauchi, K., Hiramatsu, K., Ichikawa, K., Aizawa, T., & Hashizume, K. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00746.x · Cited by 26
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Vahidi, O., Kwok, K. E., Gopaluni, R. B., & Sun, L. (2011) · Biochemical Engineering Journal · doi:10.1016/j.bej.2011.02.019 · Cited by 26
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Lebovitz, H. E. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0907-1 · Cited by 26
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Kaiser, N. (2009) · Frontiers in bioscience · doi:10.2741/3296 · Cited by 26
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Li, X., Li, L., Zhou, X., Chen, Y., Ren, Y., Zhou, T., & Lu, W. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.33 · Cited by 26
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Patel, D. N., Jain, M. R., Shah, S. R., Bahekar, R. H., Jadav, P., Darji, B., Siriki, Y., Bandyopadhyay, D., Joharapurkar, A. A., Kshirsagar, S. G., et al. (2011) · ChemMedChem · doi:10.1002/cmdc.201100077 · Cited by 26
Zhao, L., Hao, L., Yang, X., Ying, C., Dong, Y., & Sun, X. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508094646 · Cited by 26
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Meyer, J., Sturis, J., Katschinski, M., Arnold, R., Göke, B., & Byrne, M. M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2001 · Cited by 25
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Yu, H., Zhang, P., Liu, H., Sun, X., Liang, J., Sun, L., & Chen, Y. (2021) · Food & Function · doi:10.1039/d0fo03166f · Cited by 25
Metadata
- Authors
- Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Weyer, Christian
- Venue
- Journal of Clinical Investigation
- Published
- 1999-09-15
- Volume
- 104
- Issue
- 6
- Pages
- 787-794
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC408438
- OpenAlex
- W2077149049
- Cited by
- 1,940
- References
- 68
- Citations by year
- 2026: 24 · 2025: 53 · 2024: 53 · 2023: 74 · 2022: 63 · 2021: 80 · 2020: 64 · 2019: 64 · 2018: 61 · 2017: 72 · 2016: 88 · 2015: 81 · 2014: 91 · 2013: 85 · 2012: 83
- FWCI
- 44.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, insulin resistance, insulin secretion, impaired glucose tolerance, Pima Indians, insulin-stimulated glucose disposal, weight gain, diabetes prevention, pathogenesis
- MeSH terms
- Insulin Secretion, Adult, Anthropometry, Diabetes Mellitus, Type 2, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Obesity, Sex Factors
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