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Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
Open accessAbstract
Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic drugs and diet-derived bioactive compounds. We pay particular attention to microbial influences on host responses to xenobiotics, adding to the growing consensus that treatment outcomes reflect our intimate partnership with the microbial world, and providing an initial framework from which to consider a more comprehensive view of pharmacology and nutrition.
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“β-glucuronidases are another generalist enzyme family expressed by human-associated gut bacteria that influences the biological activity and toxicity of a wide range of drugs, dietary components, and endogenous metabolites47.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [47]
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“Many of these “diet-derived bioactive compounds” are metabolized by the gut microbiota (Fig. 4, Supplementary information S2 (table) and Supplementary information S3 (table)) and some are dependent on this transformation for activation and/or absorption47.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [47]
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“Cytochrome p450 controls mechanisms of xenobiotic metabolism in the gut (Carmody and Turnbaugh, 2014) and, together with other members of this cluster (e.g., Rdh7 or Aldh1), influences the metabolism of all trans-retinoic acid.”
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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
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Self-citation
Metadata
- Authors
- Carmody, R. N., & Turnbaugh, P. J.
- Corresponding author
- Turnbaugh, Peter J.
- Venue
- Journal of Clinical Investigation
- Published
- 2014-08-08
- Volume
- 124
- Issue
- 10
- Pages
- 4173-4181
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4191041
- OpenAlex
- W1964115194
- Cited by
- 268
- References
- 91
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 10 · 2023: 15 · 2022: 23 · 2021: 47 · 2020: 33 · 2019: 26 · 2018: 21 · 2017: 19 · 2016: 23 · 2015: 14 · 2014: 3
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Harvard University
- National Institutes of Health
- FAS Center for Systems Biology, Harvard University
- National Institute of General Medical Sciences (P50GM068763)
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK101154)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- host-microbe interactions, gut microbiota, xenobiotic metabolism, drug metabolism, therapeutic drugs, personalized medicine
- MeSH terms
- Animals, Binding Sites, Diet, Humans, Intestines, Mice, Transgenic, Protein Binding, Xenobiotics, Gene Expression Regulation, Bacterial, Probiotics, Gastrointestinal Tract, Mice, Microbial Interactions, Microbiota
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