Cited by 1,332Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCalcium signaling and nucleotide metabolism

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The role for autophagy in cancer

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White, Eileen·2015·Journal of Clinical Investigation

DOI 10.1172/jci73941PMC PMC4382247

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Abstract

Autophagy is a survival-promoting pathway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes. Autophagy preserves organelle function, prevents the toxic buildup of cellular waste products, and provides substrates to sustain metabolism in starvation. Although in some contexts autophagy suppresses tumorigenesis, in most contexts autophagy facilitates tumorigenesis. Cancers can upregulate autophagy to survive microenvironmental stress and to increase growth and aggressiveness. Mechanisms by which autophagy promotes cancer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic function of mitochondria. Efforts to inhibit autophagy to improve cancer therapy have thereby attracted great interest.

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Authors: White, E.
Corresponding author: White, Eileen
ORCID: White, Eileen
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2015-01-02
Volume: 125
Issue: 1
Pages: 42-46
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci73941
PMC: PMC4382247
OpenAlex: W2055811314
Cited by: 1,332
References: 58
Citations by year: 2026: 63 · 2025: 68 · 2024: 111 · 2023: 116 · 2022: 129 · 2021: 158 · 2020: 157 · 2019: 138 · 2018: 142 · 2017: 132 · 2016: 92 · 2015: 24
FWCI: 16.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Rutgers Cancer Institute of New Jersey
National Institutes of Health
National Cancer Institute (R01CA053370, R37CA053370, RC1CA147961, R01CA130893, R01CA163591)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, cancer, carcinogenesis, lysosomes, p53, mitochondrial metabolism, tumor microenvironment, starvation, cancer therapy, autophagy inhibition
MeSH terms: Animals, Autophagy, Humans, Neoplasms, Carcinogenesis

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