The role for autophagy in cancer

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

Cancer Genome Landscapes

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Discovery and saturation analysis of cancer genes across 21 tumour types

Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · cited 1×

Autophagy in Human Health and Disease

Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583

Autophagy: A Friend or Foe in Allergic Asthma?

Theofani, E., & Xanthou, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126314 · Cited by 44

A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo

Cassidy, L. D., Young, A. R., Pérez-Mancera, P. A., Nimmervoll, B., Jaulim, A., Chen, H.-C., McIntyre, D. J. O., Brais, R., Ricketts, T., Pacey, S., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1458172 · Cited by 40

Asbestos-Induced Chronic Inflammation in Malignant Pleural Mesothelioma and Related Therapeutic Approaches—A Narrative Review

Zolondick, A. A., Gaudino, G., Xue, J., Pass, H. I., Carbone, M., & Yang, H. (2021) · Precision Cancer Medicine · doi:10.21037/pcm-21-12 · Cited by 41

Tumor rim cells: From resistance to vascular targeting agents to complete tumor ablation

Seidi, K., Jahanban-Esfahlan, R., & Zarghami, N. (2017) · Tumor Biology · doi:10.1177/1010428317691001 · Cited by 41

The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma

Broggi, G., Ieni, A., Russo, D., Varricchio, S., Puzzo, L., Russo, A., Reibaldi, M., Longo, A., Tuccari, G., Staibano, S., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.589849 · Cited by 41

Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer

Cancemi, G., Caserta, S., Gangemi, S., Pioggia, G., & Allegra, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041153 · Cited by 42

MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases

Qi, J., Li, Q., Xin, T., Lu, Q., Lin, J., Zhang, Y., Luo, H., Zhang, F., Xing, Y., Wang, W., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2333715 · Cited by 46

The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk

Rahmati, S., Moeinafshar, A., & Rezaei, N. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05267-8 · Cited by 41

Oncogenes strike a balance between cellular growth and homeostasis

Qiu, B., & Simon, M. C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.005 · Cited by 44

Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity

Deretic, V. P. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0216-079r · Cited by 43

The role of Runx2 in facilitating autophagy in metastatic breast cancer cells

Tandon, M., Othman, A. H., Ashok, V., Stein, G. S., & Pratap, J. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25916 · Cited by 42

Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer

Wang, B., Zhou, T., Nie, C., Wan, D., & Zheng, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.091 · Cited by 41

In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis

Matsuzaki, S., Pouly, J. L., & Canis, M. J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14170 · Cited by 41

The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas

Lu, L., Shen, X., Tao, B., Lin, C., Li, K., Luo, Z. Y., & Cai, K. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03165g · Cited by 41

Physiological Stress Response by Selective Autophagy

Sánchez‐Martín, P., & Komatsu, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.013 · Cited by 41

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N., & Tran, N. L. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0116-z · Cited by 41

Molecular Determinants of Cancer Therapy Resistance to HDAC Inhibitor-Induced Autophagy

Mrakovcic, M., & Fröhlich, L. F. (2019) · Cancers · doi:10.3390/cancers12010109 · Cited by 41

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling

Nazio, F., Pò, A., Abballe, L., Ballabio, C., Diomedi‐Camassei, F., Bordi, M., Camera, A., Caruso, S., Caruana, I., Pezzullo, M., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02347-7 · Cited by 40

Fluoride in the Central Nervous System and Its Potential Influence on the Development and Invasiveness of Brain Tumours—A Research Hypothesis

Żwierełło, W., Maruszewska, A., Skórka-Majewicz, M., & Gutowska, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021558 · Cited by 40

Ferroptosis, autophagy, tumor and immunity

Xie, Y., Zhou, Y., Wang, J., Lijuan, D., Ren, Y., & Liu, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19799 · Cited by 40

Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE2 production

Pelissier-Rota, M. A., Pélosi, L., Méresse, P., & Jacquier‐Sarlin, M. R. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.06.013 · Cited by 39

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy

Li, Y.-Y., Feun, L. G., Thongkum, A., Tu, C.-H., Chen, S.-M., Wangpaichitr, M., Wu, C., Kuo, M. T., & Savaraj, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061297 · Cited by 40

Avenues to molecular imaging of dying cells: Focus on cancer

Rybczynska, A. A., Boersma, H. H., de Jong, S., Gietema, J. A., Noordzij, W., Dierckx, R., Elsinga, P. H., & van Waarde, A. (2018) · Medicinal Research Reviews · doi:10.1002/med.21495 · Cited by 40

Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation

Xie, L., Hu, W., Hu, D., Shi, G., Li, Y., Yang, J. Y., & Prins, G. S. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6471 · Cited by 39

CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy

Nardone, V., Barbarino, M., Angrisani, A., Correale, P., Pastina, P., Cappabianca, S., Reginelli, A., Mutti, L., Miracco, C., Giannicola, R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168391 · Cited by 44

Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms

Zhao, H., Han, B., Li, X., Sun, C., Zhai, Y., Li, M., Jiang, M., Zhang, W., Liang, Y., & Kai, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.872085 · Cited by 40

The role of lncRNA H19 in tumorigenesis and drug resistance of human Cancers

Zhang, X., Luo, M., Zhang, J., Guo, B., Singh, S., Lin, X., Xiong, H., Ju, S., Wang, L., Zhou, Y., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1005522 · Cited by 40

Molecular interactions of miR-338 during tumor progression and metastasis

Moghbeli, M. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00257-w · Cited by 40

Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications

Duan, Q., Zhang, S., Wang, Y., Lu, D., Sun, Y., & Wu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1069555 · Cited by 40

Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis

Yu, F., Li, J., Xie, Y., Sleightholm, R. L., & Oupický, D. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.040 · Cited by 40

Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway

Li, S., Yang, G., Zhu, X., Cheng, L., Sun, Y., & Zhao, Z. (2017) · Oncology Reports · doi:10.3892/or.2017.5849 · Cited by 39

Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin

Bigelsen, S. (2018) · Cancer Management and Research · doi:10.2147/cmar.s161824 · Cited by 39

The Oxygen-Generating Calcium Peroxide-Modified Magnetic Nanoparticles Attenuate Hypoxia-Induced Chemoresistance in Triple-Negative Breast Cancer

Cheng, F., Chan, C., Wang, B.-J., Yeh, Y.-L., Wang, Y., & Chiu, H. (2021) · Cancers · doi:10.3390/cancers13040606 · Cited by 39

AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression

Wan, L., Jia, R., Ji, L., Qin, X., Hu, L., Hu, F., Han, Y., Pan, Y., Jiang, C., & Liu, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02384-3 · Cited by 38

Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy

Brown, H., Chung, M., Üffing, A., Batistatou, N., Tsang, T., Doskocil, S. D., Mao, W., Willbold, D., Bast, R. C., Lü, Z., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c04699 · Cited by 39

Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region

Yi, F., Cai, C., Ruan, B., Hao, M., Yeo, S. K., Haas, M., Yang, F., Zhang, X., & Guan, J. (2022) · Autophagy · doi:10.1080/15548627.2022.2148432 · Cited by 39

Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases

Miceli, C., Leri, M., Stefani, M., & Bucciantini, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101967 · Cited by 39

Rapamycin‐induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition

Li, Y., Liu, F., Wang, Y., Li, D., Guo, F., Xu, L., Zeng, Z., Zhong, X., & Qian, K. (2016) · Thoracic Cancer · doi:10.1111/1759-7714.12332 · Cited by 38

The putative role of autophagy in the pathogenesis of abdominal aortic aneurysms

Ramadan, A., Al-Omran, M. A., & Verma, S. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.01.017 · Cited by 38

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

Kameyama, K., Motoyama, K., Tanaka, N., Yamashita, Y., Higashi, T., & Arima, H. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s133482 · Cited by 39

In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors

Wood, S. D., Grant, W. M., Adrados, I., Choi, J. Y., Alburger, J. M., Duckett, D. R., & Roush, W. R. (2017) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.7b00344 · Cited by 38

Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells

Liu, Y., Li, L., Xu, L., Dai, E., & Chen, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.8141 · Cited by 38

Monitoring autophagy in cancer: From bench to bedside

Long, M., & McWilliams, T. G. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.016 · Cited by 30

Autophagy Roles in Genome Maintenance

Ambrosio, S., & Majello, B. (2020) · Cancers · doi:10.3390/cancers12071793 · Cited by 38

A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy

Cui, J., Liu, J., Fan, L., Zhu, Y., Zhou, B., Wang, Y., Wei, H., Wei, W., & Sun, G. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100851 · Cited by 40

Directed evolution of cyclic peptides for inhibition of autophagy

Gray, J. P., Uddin, M. N., Chaudhari, R. R., Sutton, M. N., Yang, H., Rask, P. J., Locke, H., Engel, B. J., Batistatou, N., Wang, J., et al. (2021) · Chemical Science · doi:10.1039/d0sc03603j · Cited by 38

Moments in autophagy and disease: Past and present

Wen, X., Yang, Y., & Klionsky, D. J. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100966 · Cited by 39

Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo

Ji, Y., Hu, W., Jin, Y., Yu, H., & Jin, F. (2021) · Bioengineered · doi:10.1080/21655979.2021.1971501 · Cited by 38

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model

Braicu, C., Pileczki, V., Pop, L., Cojocneanu, R., Chira, S., Pointiere, E., Achimaș-Cădariu, P., & Berindan‐Neagoe, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120936 · Cited by 37

G protein γ subunit 7 induces autophagy and inhibits cell division

Liu, J., Ji, X., Li, Z., Yang, X., Wang, W., & Zhang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.8559 · Cited by 37

Dysregulation of Autophagy Contributes to Anal Carcinogenesis

Carchman, E. H., Matkowskyj, K. A., Meske, L. M., & Lambert, P. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164273 · Cited by 37

Resistance to metronomic chemotherapy and ways to overcome it

Martínez, M. C. R., Parra, K., Saluja, R., Francia, G., & Emmenegger, U. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.027 · Cited by 37

Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice

Yau, J. W., Singh, K. K., Hou, Y., Lei, X., Ramadan, A., Quan, A., Teoh, H., Kuebler, W. M., Al-Omran, M. A., Yanagawa, B., et al. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.02.058 · Cited by 37

Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway

Xu, Y., Wang, Y., Yao, A., Xu, Z., Dou, H., Shen, S., Hou, Y., & Wang, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-10407-w · Cited by 38

Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: the Impact in Cancer Aggressiveness

Pizato, N., Kiffer, L. F. M. V., Luzete, B. C., Assumpção, J. A. F., Corrêa, L. H., Braz-de-Melo, H. A., de Sant’Ana, L. P., Ito, M., & Magalhães, K. G. (2019) · Nutrients · doi:10.3390/nu11061199 · Cited by 35

How autophagy can restore proteostasis defects in multiple diseases?

Joshi, V., Upadhyay, A., Prajapati, V. K., & Mishra, A. (2020) · Medicinal Research Reviews · doi:10.1002/med.21662 · Cited by 40

mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy

Pazhooh, R. D., Farnood, P. R., Asemi, Z., Mirsafaei, L., Yousefi, B., & Mirzaei, H. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103142 · Cited by 36

Differences in p53 status significantly influence the cellular response and cell survival to 1,25‐dihydroxyvitamin D3‐metformin cotreatment in colorectal cancer cells

el Maaty, M. A. A., Strassburger, W., Qaiser, T., Dabiri, Y., & Wölfl, S. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22696 · Cited by 36

Temozolomide Resistance in Glioblastoma by NRF2: Protecting the Evil

Lima, K. A., Osawa, I. Y. A., Ramalho, M. C. C., de Souza, I., Guedes, C. B., Filho, C. H. D. D. S., Monteiro, L. K. S., Latância, M. T., & Rocha, C. R. R. (2023) · Biomedicines · doi:10.3390/biomedicines11041081 · Cited by 41

Complete mutational spectrum of the autophagy interactome: a novel class of tumor suppressor genes in myeloid neoplasms

Visconte, V., Przychodzen, B. P., Han, Y. C., Nawrocki, S. T., Thota, S., Kelly, K., Patel, B. J., Hirsch, C. M., Advani, A. S., Carraway, H. E., et al. (2016) · Leukemia · doi:10.1038/leu.2016.295 · Cited by 36

SOX3 can promote the malignant behavior of glioblastoma cells

Marjanović, J., Drakulić, D., García, I., Vuković, V., Aldaz, P., Puškaš, N., Nikolić, I., Tasić, G., Raičević, S., Garros-Regulez, L., et al. (2018) · Cellular Oncology · doi:10.1007/s13402-018-0405-5 · Cited by 36

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes

Kumar, S., Xie, H. Y., Shi, H., Gao, J., Juhlin, C. C., Björnhagen, V., Höög, A., Lee, L., Larsson, C., & Lui, W. (2019) · International Journal of Cancer · doi:10.1002/ijc.32503 · Cited by 38

Multi-Habitat Radiomics Unravels Distinct Phenotypic Subtypes of Glioblastoma with Clinical and Genomic Significance

Choi, S. W., Cho, H.-H., Koo, H., Cho, K. R., Nenning, K., Langs, G., Furtner, J., Baumann, B., Wöehrer, A., Cho, H. J., et al. (2020) · Cancers · doi:10.3390/cancers12071707 · Cited by 36

MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by targeting MAP2K6

Li, X., Zhu, M., Zhao, G., Zhou, A., Min, L., Liu, S., Zhang, N., Zhu, S., Guo, Q., Zhang, S., et al. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110286 · Cited by 36

Reprogramming of central carbon metabolism in hepatocellular carcinoma

Xia, H., Huang, Z., Xu, Y., Yam, J. W. P., & Cui, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113485 · Cited by 40

Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer

Lee, J., Yi, S., Won, M., Song, Y. S., Yi, H., Park, Y. J., Park, K. C., Kim, J. T., Chang, J. Y., Lee, M. J., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0211-6 · Cited by 37

Current and future therapies for small cell lung carcinoma

Zhai, X., Zhang, Z., Chen, Y., Wu, Y., Zhen, C., Liu, Y., Lin, Y., & Chen, C. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01690-6 · Cited by 35

KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression

Santarelli, R., Granato, M., Pentassuglia, G., Lacconi, V., Montani, M. S. G., Gonnella, R., Tafani, M., Torrisi, M. R., Faggioni, A., & Cirone, M. (2016) · Autophagy · doi:10.1080/15548627.2016.1235122 · Cited by 35

Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death

Turriani, E., Lázaro, D. F., Ryazanov, S., Leonov, A., Giese, A., Schön, M., Schön, M. P., Griesinger, C., Outeiro, T. F., Arndt‐Jovin, D. J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700200114 · Cited by 35

Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes

Schroll, M. M., LaBonia, G. J., Ludwig, K. R., & Hummon, A. B. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00293 · Cited by 37

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

Yang, X., Xue, P., Liu, X., Xu, X., & Chen, Z. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0310-6 · Cited by 35

TRPM2 mediates distruption of autophagy machinery and correlates with the grade level in prostate cancer

Tektemur, A., Özaydın, S., Etem, E. Ö., Tektemur, N. K., Kuloğlu, T., Özercan, İ. H., Tekin, S., & Elyas, H. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02898-z · Cited by 35

Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway

Kulshrestha, A., Katara, G. K., Ibrahim, S. A.-S., Riehl, V. E., Sahoo, M., Dolan, J., Meinke, K. W., Pins, M. R., & Beaman, K. D. (2019) · Journal of Oncology · doi:10.1155/2019/2343876 · Cited by 36

Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes

Saxena, R., Klochkova, A., Murray, M. G., Kabir, M. F., Samad, S., Beccari, T., Gang, J., Patel, K., Hamilton, K. E., & Whelan, K. A. (2019) · Cancers · doi:10.3390/cancers11111697 · Cited by 35

A Novel Role for NUAK1 in Promoting Ovarian Cancer Metastasis through Regulation of Fibronectin Production in Spheroids

Fritz, J. L., Collins, O. M., Saxena, P., Buensuceso, A. V., Valdés, Y. R., Francis, K. E., Brown, K. R., Larsen, B. G., Colwill, K., Gingras, A., et al. (2020) · Cancers · doi:10.3390/cancers12051250 · Cited by 35

Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma

An, Y., Jiang, J., Zhou, L., Shi, J., Jin, P., Li, L., Peng, L., He, S., Zhang, W., Huang, C., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.023 · Cited by 35

Comprehensive review on signaling pathways of dietary saponins in cancer cells suppression

Zhou, Y., Farooqı, A. A., & Xu, B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2000933 · Cited by 39

Regulated cell death in cancer: Mechanisms, crosstalk, and opportunities for therapy

Meng, Y., Chen, Q., Zhou, Z., & Li, M. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218077 · Cited by 40

Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example

Badr, H. A., AlSadek, D. M. M., El-Houseini, M. E., Saeui, C. T., Mathew, M. P., Yarema, K. J., & Ahmed, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.044 · Cited by 34

Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma

Follo, C., Cheng, Y., Richards, W. G., Bueno, R., & Broaddus, V. C. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22757 · Cited by 35

A novel synthesized 3’, 5’-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways

Zhang, Y., Wen, Z., Wan, K. M., Yuan, D., Zeng, X., Liang, G., Zhu, J., Xu, B., & Luo, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.153 · Cited by 34

Autophagy and its potent modulators from phytochemicals in cancer treatment

Sun, C., Zhang, Q.-Y., Zheng, G., & Feng, B. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3707-4 · Cited by 35

Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells

Zahedi, S., Fitzwalter, B. E., Morin, A., Grob, S. T., Desmarais, M., Nellan, A., Green, A. L., Vibhakar, R., Hankinson, T. C., Foreman, N. K., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1880-y · Cited by 36

Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells

Sipos, A., Kim, K., Sioutas, C., & Crandall, E. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215253 · Cited by 34

Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition

Peng, P., Zhang, X., Qi, T., Cheng, H., Kong, Q., Liu, L., Cao, X., & Ding, Z. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12820 · Cited by 35

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer

Kang, J.-S., Nam, L. B., Yoo, O.-K., & Keum, Y. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114002 · Cited by 35

PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability

Che, N., Ng, K. Y., Wong, T. L., Tong, M., Kau, P. W., Chan, L.-H., Lee, T. K., Huen, M. S. Y., Yun, J., & Ma, S. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.002 · Cited by 34

Cyanidin-3- O -glucoside represses tumor growth and invasion in vivo by suppressing autophagy via inhibition of the JNK signaling pathways

Tian, W., Ji, X., Xue, J., Gao, Y., Zhu, X., & Xiao, G. (2020) · Food & Function · doi:10.1039/d0fo02107e · Cited by 35

Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer

Ding, J., Wang, C., Sun, Y., Guo, J., Liu, S., & Cheng, Z. (2023) · Biomolecules · doi:10.3390/biom13020339 · Cited by 35

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Hall, T. M., Tétreault, M.-P., Hamilton, K. E., & Whelan, K. A. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.04.003 · Cited by 34

A novel signature based on autophagy-related lncRNA for prognostic prediction and candidate drugs for lung adenocarcinoma

Gong, Z., Li, Q., Li, J., Xie, J., & Wang, W. T. (2022) · Translational Cancer Research · doi:10.21037/tcr-21-1554 · Cited by 33

Mechanisms of exercise in the treatment of lung cancer – a mini-review

Luo, Z., Wan, R., Liu, S., Feng, X., Peng, Z., Wang, Q., Chen, S., & Shang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1244764 · Cited by 35

Nanotechnology-Based Drug Delivery Systems for Treating Acute Kidney Injury

Qin, W., Huang, J., Zhang, M., Xu, M., He, J., & Liu, Q. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01385 · Cited by 33

Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms

Eity, T. A., Bhuia, M. S., Chowdhury, R., Ahmmed, S., Sheikh, S., Akter, R., & Islam, M. T. (2024) · Journal of Tropical Medicine · doi:10.1155/2024/5594462 · Cited by 37

Dynamic autophagic activity affected the development of thoracic aortic dissection by regulating functional properties of smooth muscle cells

Wang, Y., Zhao, Z.-M., Zhang, G., Yang, F., Yan, Y., Liu, S., Li, S., Wang, G., & Xu, Z. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.080 · Cited by 34

Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease

Chang, M., & Ong, A. C. M. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx262 · Cited by 33

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Amanullah, A., Upadhyay, A., Joshi, V., Mishra, R., Jana, N. R., & Mishra, A. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.005 · Cited by 34

Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway

Lai, S.-L., Mustafa, M. R., & Wong, P. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.03.027 · Cited by 33

Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma

Kang, H. M., Noh, K. H., Chang, T. K., Park, D., Cho, H., Lim, J. H., & Jung, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1520-6 · Cited by 33

COX7A1 suppresses the viability of human non‐small cell lung cancer cells via regulating autophagy

Zhao, L., Chen, X., Feng, Y., Wang, G., Nawaz, I., Hu, L., & Liu, P. (2019) · Cancer Medicine · doi:10.1002/cam4.2659 · Cited by 33

Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by

Mathew, R., & White, E. (2015)

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

Mathew, R., & White, E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.008 · Cited by 245

Recent insights into the function of autophagy in cancerPreprint

Amaravadi, R. K., Kimmelman, A. C., & White, E. (2016) · Genes & Development · doi:10.1101/gad.287524.116 · Cited by 828

Role of Autophagy Inhibition in Tumor Proliferative Arrest

Guo, J. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00011-1

Autophagy, Metabolism, and Cancer

White, E., Mehnert, J. M., & Chan, C. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0490 · Cited by 689